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MESQVDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVELSTAASAIESVITRLSSDQWLGTASLSMA AAAQPLLAWLSYTAESSALAAAQAAASVAAFETAFAMTVPPAEVAANRARLAELMATNIFGQNVPAIAAT EARYGEMWAQDASAMYGYAASCAGAVRLNPLTRPSETTNPGGIARQAAAVSHAAASVSVQQAGFENLIST VSDAVMSLSAPVTSSPHVTSLGAFIEDIIFLDIPRFVESAFHGLGATADYATMIAANLLTLQTSANTATS AGGVAPAAAAGSALAQTVTSAGVGDASSVGALSVPVGWTTAAPAATGGAASDGTGWAVPDEDVPSPAGMV AGTNGAGARPGPRYGVKPRVMPKKVLV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1947 | - | - | 100% (377) | PPE family protein, PPE44 |
| M. marinum M | MMAR_1950 | - | e-109 | 55.44% (395) | PPE family protein, PPE15_1 |
| M. marinum M | MMAR_4452 | - | e-100 | 53.69% (393) | PPE family protein, PPE15 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2792c | PPE44 | 1e-128 | 64.75% (383) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-28 | 29.51% (366) | PPE protein |
| M. tuberculosis H37Rv | Rv2770c | PPE44 | 1e-127 | 64.49% (383) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-42 | 32.60% (411) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 4e-26 | 37.06% (197) | PPE family protein |
| M. avium 104 | MAV_1347 | - | 9e-81 | 46.94% (392) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-28 | 35.41% (209) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-31 | 30.39% (408) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2167 | - | 0.0 | 98.66% (373) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-29 | 30.27% (370) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1947|M.marinum_M ---------MESQVDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVE
MUL_2167|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYFGAGAAPLLGAAAAWNDIAVE
Mb2792c|M.bovis_AF2122/97 -------------MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVE
Rv2770c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
* .** :*: : *.*.. : *. : :: :
MMAR_1947|M.marinum_M LSTAASAIESVITRLSSDQWLGTASLSMAAAAQPLLAWLSYTAESSALAA
MUL_2167|M.ulcerans_Agy99 LSTAASAIESVITRLSSDQWLGTASLSMAAAAQPLLAWLSYTAESSALAA
Mb2792c|M.bovis_AF2122/97 VSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAA
Rv2770c|M.tuberculosis_H37Rv VSTAASSVGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAA
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : : * .: . * *: : .
MMAR_1947|M.marinum_M AQAAASVAAFETAFAMTVPPAEVAANRARLAELMATNIFGQNVPAIAATE
MUL_2167|M.ulcerans_Agy99 AQAAASVAAFETAFAMTVPPAEVAANRARLAALMATNIFGQNVPAIAATE
Mb2792c|M.bovis_AF2122/97 AQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATE
Rv2770c|M.tuberculosis_H37Rv AQAMASAAAFETAFALTVPPAEVVANRALLAELTATNILGQNVSAIAATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
. .:. *. :*:: . : *: * :*.:* * .** .*
MMAR_1947|M.marinum_M ARYGEMWAQDASAMYGYAASCAGAVRLN-PLTRPSETTNPGGIARQAAAV
MUL_2167|M.ulcerans_Agy99 ARYGEMWAQDASAMYGYAASCAGAVRLN-PLTRPSETTNPGGIASQAVAV
Mb2792c|M.bovis_AF2122/97 ARYGEMWAQDASAMYGYAAASAVAARLN-PLTRPSHITNPAGLAHQAAAV
Rv2770c|M.tuberculosis_H37Rv ARYGEMWAQDASAMYGYAAASAVAARLN-PLTRPSHITNPAGLAHQAAAV
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAGKLS-PLTSPAPTNQPGGLGAQAAAV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAAT-PTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAAT-PTATPAPFVLAPGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAA-PVSAPAPFLLKPGVGEAGSAS
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSV-APTPPAPTIMAPG-GEMSRMS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSAT-PRTVAPPPILGAGTGESATAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * .** * *::* * . * . : .. * .
MMAR_1947|M.marinum_M SHAAASVSVQQAG---------------------------------FENL
MUL_2167|M.ulcerans_Agy99 SHAAASVSVQQAG---------------------------------FENL
Mb2792c|M.bovis_AF2122/97 GQAGASASARQVG---------------------------------LSHL
Rv2770c|M.tuberculosis_H37Rv GQAGASAFARQVG---------------------------------LSHL
MAV_1347|M.avium_104 SGATATS-AQTSG---------------------------------LQGT
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDP
MAB_2230c|M.abscessus_ATCC_199 ADMSGMAAQAQAAESGMALDDSESFFDKLMR----------QIQEFFSDP
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG-----------------MEATV
MMAR_1947|M.marinum_M ISTVSDAVMSLSAPVTSSPHVTS---------------------------
MUL_2167|M.ulcerans_Agy99 ISTVSDAVTSLSGPVTSSPHVTS---------------------------
Mb2792c|M.bovis_AF2122/97 ISDVADAVLSFASPVMSAADTG----------------------------
Rv2770c|M.tuberculosis_H37Rv ISDVADAVLSFASPVMSAADTG----------------------------
MAV_1347|M.avium_104 VANVPNVVRTLAAPADPPGLS-----------------------------
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSL
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSL
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
MAB_2230c|M.abscessus_ATCC_199 LGTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAP
TH_3113|M.thermoresistible__bu LGTLLAPLLPGATGDGPPMATIMSFLLMGLSNP----------AYLFPVL
MLBr_01182|M.leprae_Br4923 VPQVDQQVNVDVATPQTAVPDSSS--------------------------
: : .
MMAR_1947|M.marinum_M --------------LGAFIEDIIFLDIPRFVESAFHGLGATADYATMIAA
MUL_2167|M.ulcerans_Agy99 --------------LGAFIEDIIFLDIPRFVESAFHGLGATADYATMIAA
Mb2792c|M.bovis_AF2122/97 ---------------LEAVRQFLNLDVPLFVESAFHGLGGVADFATAAIG
Rv2770c|M.tuberculosis_H37Rv ---------------LEAVRQFLNLDVPLFVESAFHGLGGVADFATAAIG
MAV_1347|M.avium_104 -----------------ALDNLLGNPVVNNVGNAGFNVVSWNVFNTIVSN
Mflv_0325|M.gilvum_PYR-GCK FLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQ
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQ
MAB_2230c|M.abscessus_ATCC_199 LWLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSP
TH_3113|M.thermoresistible__bu VYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGL
MLBr_01182|M.leprae_Br4923 -----------AAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVN
MMAR_1947|M.marinum_M NLLTLQTSANTATSAGGVAPAAAAGSALAQTVTS--AGVG---------D
MUL_2167|M.ulcerans_Agy99 NLLTLQTSANTATSAGGVAPAAAAGSALAQTVTS--AGVG---------D
Mb2792c|M.bovis_AF2122/97 NMTLLADAMG---TVGGAAPGGGAAAAVAHAVAP--AGVGGTALTADLGN
Rv2770c|M.tuberculosis_H37Rv NMTLLADAMG---TVGGAAPGGGAAAAVAHAVAP--AGVGGTALTADLGN
MAV_1347|M.avium_104 ILYNHTLDTAAAAGVAGEVGGAVGGGALVGAAAPATAGVGAAPVLASMGS
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAG
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAG
MSMEG_0619|M.smegmatis_MC2_155 P-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVAN
MAB_2230c|M.abscessus_ATCC_199 QQQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQE
TH_3113|M.thermoresistible__bu AGLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTG---SAAPTTG
MLBr_01182|M.leprae_Br4923 GMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGR
. . .
MMAR_1947|M.marinum_M ASSVGALSVPVGWTTAAPAATGGAASDGTGWAVPDED-------------
MUL_2167|M.ulcerans_Agy99 ASSVGALSVPVGWTTAAPAATGGAASDGTGWAVPDED-------------
Mb2792c|M.bovis_AF2122/97 ASVVGRLSVPASWSTAAPATAAGAALDGTGWAVPEEDG------------
Rv2770c|M.tuberculosis_H37Rv ASVVGRLSVPASWSTAAPATAAGAALDGTGWAVPEEDG------------
MAV_1347|M.avium_104 AATVGELSTPATWSAPTPEPAA-TTVGATEWASPAEEP------------
Mflv_0325|M.gilvum_PYR-GCK RDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIK
Mvan_0415|M.vanbaalenii_PYR-1 RDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIA
MSMEG_0619|M.smegmatis_MC2_155 RDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIE
MAB_2230c|M.abscessus_ATCC_199 DPPAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDP
TH_3113|M.thermoresistible__bu TAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG-VARRSAG
MLBr_01182|M.leprae_Br4923 AASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESE-----------
. : . .
MMAR_1947|M.marinum_M ------------------------------------------------VP
MUL_2167|M.ulcerans_Agy99 ------------------------------------------------VP
Mb2792c|M.bovis_AF2122/97 --------------------------------------------PIAVMP
Rv2770c|M.tuberculosis_H37Rv --------------------------------------------PIAVMP
MAV_1347|M.avium_104 --------------------------------------------HTAWAT
Mflv_0325|M.gilvum_PYR-GCK GRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--E
Mvan_0415|M.vanbaalenii_PYR-1 GRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--A
MSMEG_0619|M.smegmatis_MC2_155 ERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--V
MAB_2230c|M.abscessus_ATCC_199 APQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTT
TH_3113|M.thermoresistible__bu ARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS-M
MLBr_01182|M.leprae_Br4923 -----------------------------------------SAPLLGGGL
MMAR_1947|M.marinum_M SPAGMVAGTNGAGARPGPRYGVKPRVMPKKVLV-----------------
MUL_2167|M.ulcerans_Agy99 SPAGMVAGTNGAGARPGPRYGVKPRVMPKKVLV-----------------
Mb2792c|M.bovis_AF2122/97 PAPGMVVAANSVGADSGPRYGVKPIVMPKHGLF-----------------
Rv2770c|M.tuberculosis_H37Rv PAPGMVVAANSVGADSGPRYGVKPIVMPKHGLF-----------------
MAV_1347|M.avium_104 GMP-AVASAGRGGYGMGPRYGVKPKVMPTRLPV-----------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKE
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKD
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGP
MAB_2230c|M.abscessus_ATCC_199 SAAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPP
TH_3113|M.thermoresistible__bu SAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRP
MLBr_01182|M.leprae_Br4923 PMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------
MMAR_1947|M.marinum_M -------
MUL_2167|M.ulcerans_Agy99 -------
Mb2792c|M.bovis_AF2122/97 -------
Rv2770c|M.tuberculosis_H37Rv -------
MAV_1347|M.avium_104 -------
Mflv_0325|M.gilvum_PYR-GCK KP-----
Mvan_0415|M.vanbaalenii_PYR-1 SQ-----
MSMEG_0619|M.smegmatis_MC2_155 RR-----
MAB_2230c|M.abscessus_ATCC_199 GERGAST
TH_3113|M.thermoresistible__bu AEPN---
MLBr_01182|M.leprae_Br4923 -------