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MDFGALPPEINSTRMYAGAGATPMMAAAAAWNRLAVELGTTAASFESVVTQLTTEQWMGPASTSMAVAVQ PYLAWLTYTAESAAHAGAQATASAAAFEAAFAATVPPAAVAANRAQLAMLVSTNILGQNTPAIAATEAQY GEMWAQDALAMYGYAASSAAAGTLNPLTTPAQIANPAGLASQAAAVSQAAAATTVEQVGLGNLITNVPGA VMGLASPAASLVDATGLSTLVQDISSVLGTPFLQNAINGAVNTAAWFVMAAIPNSVFLGHTLNAIETAGA PVAADLAPALAPAAGLRHAVAPLSFGGAGVEAGLGQAAGVGKLSVPVGWSSAAPALTSGTTALDGSGWAV PEESGPIAAMPGGPGMAVAGKGGGFAGPRYGFKPTVMPKQVVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1950 | - | - | 100% (393) | PPE family protein, PPE15_1 |
| M. marinum M | MMAR_4452 | - | e-136 | 63.41% (399) | PPE family protein, PPE15 |
| M. marinum M | MMAR_1947 | - | e-109 | 55.44% (395) | PPE family protein, PPE44 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2790c | PPE43 | 1e-165 | 74.37% (394) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-31 | 30.71% (394) | PPE protein |
| M. tuberculosis H37Rv | Rv2768c | PPE43 | 1e-166 | 74.62% (394) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-49 | 34.76% (397) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 5e-28 | 28.46% (397) | PPE family protein |
| M. avium 104 | MAV_1347 | - | 1e-101 | 52.79% (394) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-31 | 31.62% (370) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-37 | 34.73% (383) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4621 | - | 1e-137 | 63.82% (398) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-34 | 31.67% (401) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2790c|M.bovis_AF2122/97 -------------MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVE
Rv2768c|M.tuberculosis_H37Rv -------------MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVE
MMAR_1950|M.marinum_M -------------MDFGALPPEINSTRMYAGAGATPMMAAAAAWNRLAVE
MUL_4621|M.ulcerans_Agy99 -------------MDFGALPPEINSARMYAGAGAGPMMAASAAWNGLAVE
MAV_1347|M.avium_104 -----------MTFDFGALPPEVNSTRMYTGAGAAPMMAAAAAFSNLADE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :*: : *.*. .: :*. :: *: *
Mb2790c|M.bovis_AF2122/97 LSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAA
Rv2768c|M.tuberculosis_H37Rv LSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAA
MMAR_1950|M.marinum_M LGTTAASFESVVTQLTTEQWMGPASTSMAVAVQPYLAWLTYTAESAAHAG
MUL_4621|M.ulcerans_Agy99 LGTTAASYESVITRLTTESWMGPASMAMIAAAQPYLAWLTYTSEAAMHAG
MAV_1347|M.avium_104 LSTTAAATQSAIANLTGEEWMGPSAAAMVTAVQPYVQWMHTTAGQLQQAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
::* : : : * .: ** *: : ..
Mb2790c|M.bovis_AF2122/97 AQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATE
Rv2768c|M.tuberculosis_H37Rv AQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATE
MMAR_1950|M.marinum_M AQATASAAAFEAAFAATVPPAAVAANRAQLAMLVSTNILGQNTPAIAATE
MUL_4621|M.ulcerans_Agy99 AQAAASAAAYEAAFAMTVPPPVVAANRSLLAALVATNFLGINTPAIMATE
MAV_1347|M.avium_104 AQAMASAAAYETAFAMTVPPALVAANRAQLAALIASNVLGQNAAAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.* .:* *. *:: . : *:: *: :*.:* *: .* .*
Mb2790c|M.bovis_AF2122/97 AHYGEMWAQDALAMYGYAASSAAAG-RLNPLITPSQTANMAGLA------
Rv2768c|M.tuberculosis_H37Rv AHYGEMWAQDALAMYGYAASSAAAG-RLNPLITPSQTANMAGLA------
MMAR_1950|M.marinum_M AQYGEMWAQDALAMYGYAASSAAAG-TLNPLTTPAQIANPAGLA------
MUL_4621|M.ulcerans_Agy99 ALYAEMWAQDAGAMYGYAAASSTSG-SLQPLSTPQQTTNPGGLA------
MAV_1347|M.avium_104 AQYGEMWAQDAAAMYGYAASSATAG-KLSPLTSPAPTNQPGGLG------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAAL-AATPTSAPAPSVLLPGVG----EA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAAL-AATPTATPAPFVLAPGVG----EA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAV-AAAPVSAPAPFLLKPGVG----EA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSV-SAAPPTSPAPPVLSPDSG----AA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAV-SATPRTVAPPPILGAGTG----ES
* * .** * * .* * : : . . . .
Mb2790c|M.bovis_AF2122/97 ----------GQAAAVSHAAAASTVQQVGLGSLISNLP------------
Rv2768c|M.tuberculosis_H37Rv ----------GQAAAVSHAAAASTVQQVGLGSLISNLP------------
MMAR_1950|M.marinum_M ----------SQAAAVSQAAAATTVEQVGLGNLITNVP------------
MUL_4621|M.ulcerans_Agy99 ----------AQSAAVSQAAAS-AAATDGTTSLLSNLP------------
MAV_1347|M.avium_104 ----------AQAAAVSGATAT-SAQTSGLQGTVANVP------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVD------------
Mflv_0325|M.gilvum_PYR-GCK GRAAADMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG----------EV
Mvan_0415|M.vanbaalenii_PYR-1 GRAAADVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG----------EL
MSMEG_0619|M.smegmatis_MC2_155 GSASASVQQMSAQATAAESGSSLD-LSSIISDLLNQYL----------QG
MAB_4783|M.abscessus_ATCC_1997 ART-------AAQDATKPPPIVPD-PNDPIEMLLKNS-----------QH
TH_3113|M.thermoresistible__bu ATAAITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGL
. .
Mb2790c|M.bovis_AF2122/97 --------------------NAVMGFASPLTSAADAAGLGGIIQDIEELL
Rv2768c|M.tuberculosis_H37Rv --------------------NAVMGFASPLTSAADAAGLGGIIQDIEELL
MMAR_1950|M.marinum_M --------------------GAVMGLASPAASLVDATGLSTLVQDISSVL
MUL_4621|M.ulcerans_Agy99 --------------------NTIMGLASPITSAIDATGLGGIIQDIEDFL
MAV_1347|M.avium_104 --------------------NVVRTLAAP----ADPPGLS----ALDNLL
MLBr_01182|M.leprae_Br4923 --------------------QQVNVDVATPQTAVPDSSSAAAPQLWGGFA
Mflv_0325|M.gilvum_PYR-GCK LRFLFEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQ
Mvan_0415|M.vanbaalenii_PYR-1 LRFLFEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQ
MSMEG_0619|M.smegmatis_MC2_155 VPGG-QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQ
MAB_4783|M.abscessus_ATCC_1997 FLGMYRALKGLIT---DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYA
TH_3113|M.thermoresistible__bu LGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVH
Mb2790c|M.bovis_AF2122/97 GITFVQNAINGAVNTTAWFVMATIRNAVFLGHAFAALN------------
Rv2768c|M.tuberculosis_H37Rv GITFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALN------------
MMAR_1950|M.marinum_M GTPFLQNAINGAVNTAAWFVMAAIPNSVFLGHTLNAIE------------
MUL_4621|M.ulcerans_Agy99 GIPFVANVINGAVNTAAWYTTATIPTAIFLANALNTGA------------
MAV_1347|M.avium_104 GNPVVNNVGNAGFNVVSWNVFNTIVSNILYNHTLDTAA------------
MLBr_01182|M.leprae_Br4923 QHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLA------------
Mflv_0325|M.gilvum_PYR-GCK A----VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTP
Mvan_0415|M.vanbaalenii_PYR-1 A----VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAP
MSMEG_0619|M.smegmatis_MC2_155 VFFNLVGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVP
MAB_4783|M.abscessus_ATCC_1997 A-----TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAP
TH_3113|M.thermoresistible__bu TTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVP
. .
Mb2790c|M.bovis_AF2122/97 PATVTA-AADAVP-AAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLS
Rv2768c|M.tuberculosis_H37Rv PATVTA-AADAVP-AAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLS
MMAR_1950|M.marinum_M TAGAPV-AADLAP-ALAPAAGLRHAVAPLSFGGAGVEAGLGQAAGVGKLS
MUL_4621|M.ulcerans_Agy99 PVIAAEGAIEAAEGAAAATAGLANTVTPTGVG-----AALGEATLVGKLA
MAV_1347|M.avium_104 AAGVAGEVGGAVG--GGALVGAAAPAT-AGVGAAPVLASMGSAATVGELS
MLBr_01182|M.leprae_Br4923 PTTTKA--AESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLR
Mflv_0325|M.gilvum_PYR-GCK PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-
Mvan_0415|M.vanbaalenii_PYR-1 AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-
MSMEG_0619|M.smegmatis_MC2_155 AEDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-
MAB_4783|M.abscessus_ATCC_1997 PVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-
TH_3113|M.thermoresistible__bu AADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAG
. . .
Mb2790c|M.bovis_AF2122/97 ---------VPAGWSTAAPAMTSGTTALEGSGWAVPEEAGPVAAMPGMAG
Rv2768c|M.tuberculosis_H37Rv ---------VPAGWSTAAPAMTSGTTALEGSGWAVPEEAGPVAAMPGMAG
MMAR_1950|M.marinum_M ---------VPVGWSSAAPALTSGTTALDGSGWAVPEESGPIAAMPGGPG
MUL_4621|M.ulcerans_Agy99 ---------VPTSWSNALPKTAATTGALGGSGWTVPEEAAPVSGVAGVPG
MAV_1347|M.avium_104 ---------TPATWSAPTPEPAATT--VGATEWASPAEEPHTAWATGMPA
MLBr_01182|M.leprae_Br4923 ---------VPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLP
Mflv_0325|M.gilvum_PYR-GCK ----PAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPA
Mvan_0415|M.vanbaalenii_PYR-1 ----PAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPA
MSMEG_0619|M.smegmatis_MC2_155 ----TTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPA
MAB_4783|M.abscessus_ATCC_1997 ----PAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAV
TH_3113|M.thermoresistible__bu HSVPPAPHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGS
. : .
Mb2790c|M.bovis_AF2122/97 ISGAAKGAGAYAG-----PRYGFKPIVMPKQVVV----------------
Rv2768c|M.tuberculosis_H37Rv ISGAAKGAGAYAG-----PRYGFKPIVMPKQVVV----------------
MMAR_1950|M.marinum_M MAVAGKG-GGFAG-----PRYGFKPTVMPKQVVV----------------
MUL_4621|M.ulcerans_Agy99 MAAAAKGAGAYAG-----PRYGFKPIVMPKQVVV----------------
MAV_1347|M.avium_104 VASAGRG-GYGMG-----PRYGVKPKVMPTRLPV----------------
MLBr_01182|M.leprae_Br4923 MAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG---------------
Mflv_0325|M.gilvum_PYR-GCK AASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPR
Mvan_0415|M.vanbaalenii_PYR-1 AASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPR
MSMEG_0619|M.smegmatis_MC2_155 AASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPR
MAB_4783|M.abscessus_ATCC_1997 SAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVT
TH_3113|M.thermoresistible__bu AAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AA
: .
Mb2790c|M.bovis_AF2122/97 --------------------------------------------------
Rv2768c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1950|M.marinum_M --------------------------------------------------
MUL_4621|M.ulcerans_Agy99 --------------------------------------------------
MAV_1347|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK VTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWD
Mvan_0415|M.vanbaalenii_PYR-1 IAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWD
MSMEG_0619|M.smegmatis_MC2_155 VRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWD
MAB_4783|M.abscessus_ATCC_1997 AVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWD
TH_3113|M.thermoresistible__bu TAPSAAGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRP
Mb2790c|M.bovis_AF2122/97 ------------------------
Rv2768c|M.tuberculosis_H37Rv ------------------------
MMAR_1950|M.marinum_M ------------------------
MUL_4621|M.ulcerans_Agy99 ------------------------
MAV_1347|M.avium_104 ------------------------
MLBr_01182|M.leprae_Br4923 ------------------------
Mflv_0325|M.gilvum_PYR-GCK PDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 PDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GDENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 VTDDDR------------------
TH_3113|M.thermoresistible__bu AEPN--------------------