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ILDFAWLPPEINSARIFSGAGSGPLHMAAAAWQGLAADLAASAASFNSVISSLASGPWSGPASVSMAAAA APYVGWLDAAAGQAAAAASQARVAATAFETALSATVHPAAVTANRTSLVSLITTNFLGQNTPAIAATEFD YVEMWAQDVGAMVGYDAGATSVAAALTPFSIPPLDLAGLAAGINAQVAGVATAMTAAISPAAQGAIAGLP GVVAGVQSAAAAVPLQSVMQVAQIGMYPASMMMSPMMQLLNSANSAGLAGTQAAGFAAADMPKMVDAVSP MKGLGGAGLGAGMAADLGKARLVGAMSVPPTWEGSIPKGLSTSAMAGLGAMPAEIAEAGRAPMGMMPMPM GMGGAGAGMPGGMLGRGGASPHVVQSRPSVVPRIGVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3664 | - | - | 100% (388) | PPE family protein |
| M. marinum M | MMAR_3661 | - | 0.0 | 95.88% (388) | PPE family protein |
| M. marinum M | MMAR_4324 | - | e-139 | 66.33% (398) | PPE family protein, PPE49 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3148c | PPE49 | 1e-127 | 60.00% (395) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-31 | 36.67% (210) | PPE protein |
| M. tuberculosis H37Rv | Rv2352c | PPE38 | 1e-161 | 71.68% (392) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-42 | 33.49% (430) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-29 | 40.96% (166) | PPE family protein |
| M. avium 104 | MAV_2910 | - | 5e-63 | 39.36% (404) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-33 | 40.64% (219) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-35 | 30.38% (418) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 2e-61 | 40.51% (395) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-35 | 28.99% (407) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3664|M.marinum_M -----------MILDFAWLPPEINSARIFSGAGSGPLHMAAAAWQGLAAD
Rv2352c|M.tuberculosis_H37Rv -----------MILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAAD
Mb3148c|M.bovis_AF2122/97 -----------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVD
MAV_2910|M.avium_104 ------------MLDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAE
MUL_3074|M.ulcerans_Agy99 ---------MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :* : *.*...: *. * *. .
MMAR_3664|M.marinum_M LAASAASFNSVISSLASGPWSGPASVSMAAAAAPYVGWLDAAAGQAAAAA
Rv2352c|M.tuberculosis_H37Rv LRASASSFDAVIAGLAAGPWSGPASVAMAGAAAPYVGWLSAAAGQAELSA
Mb3148c|M.bovis_AF2122/97 LWASASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAA
MAV_2910|M.avium_104 LQSVGASYGSTVETLTTGPWTGPSSIAMAAAAAPYVAWLQATGAQAEQAG
MUL_3074|M.ulcerans_Agy99 LRVTVLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
: : : * .: . ** *: . . .
MMAR_3664|M.marinum_M SQARVAATAFETALSATVHPAAVTANRTSLVSLITTNFLGQNTPAIAATE
Rv2352c|M.tuberculosis_H37Rv GQATAAATAFEAALAATVHPAAVTANRVLLGALVATNILGQNTPAIAATE
Mb3148c|M.bovis_AF2122/97 IQARAAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATE
MAV_2910|M.avium_104 AQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNILGQNTPAIAATE
MUL_3074|M.ulcerans_Agy99 VQAAAAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* ** *. :*:: : *:. *: :*.:* *: .* *
MMAR_3664|M.marinum_M FDYVEMWAQDVGAMVGYDAGATSVAAALTPFSIPP--LDLAGLAAGINAQ
Rv2352c|M.tuberculosis_H37Rv FDYVEMWAQDVGAMVGYHAGAAAVAETLTPFSVPP--LDLAGLASQAGAQ
Mb3148c|M.bovis_AF2122/97 FDYLEMWAQDVAAMVGYHAGAKSVAATLAPFSLPP--VSLAGLAAQVGTQ
MAV_2910|M.avium_104 AHYMEMWAQDAAAMYAY-AASSASAAQLTPFTEPPRTTNESAGPLQSAAV
MUL_3074|M.ulcerans_Agy99 AQYCEMWAQDAMAMYGY-AGSSAAATRLSEFLAPQHNTNPAGLLAQQSTL
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
.* .** * . :* * : .
MMAR_3664|M.marinum_M VAGVATAMTAAISPAAQGAIAG----------------------------
Rv2352c|M.tuberculosis_H37Rv LTGMATSVSAALSPIAEGAVEG----------------------------
Mb3148c|M.bovis_AF2122/97 VAGMATTASAAVTPVVEGAMAS----------------------------
MAV_2910|M.avium_104 AQSAAQSGSNTAAHLSQLSATA----------------------------
MUL_3074|M.ulcerans_Agy99 AQLMS-----AVPNVLQGLASS----------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG----------------------
MMAR_3664|M.marinum_M -----------LPGVVAG---VQSAAAAVPLQSVMQVAQIGMYP------
Rv2352c|M.tuberculosis_H37Rv -----------VPAVVAA---AQSVAAGLPVDAALQVGQAAAYP------
Mb3148c|M.bovis_AF2122/97 -----------VPTVMSG---MQSLVSQLP----LQHASMLFLP------
MAV_2910|M.avium_104 -----------QPAAQAAGNAASTTAASTQLTTPSFITNWNEFWSVVTGV
MUL_3074|M.ulcerans_Agy99 -----------NTSASAPSGLLSTLLSGNGQS--WLATLWSEFGPNAN--
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 -----------MEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGF
MMAR_3664|M.marinum_M ------ASMMMSPMMQLLNS---------------ANSAGLAGTQAAGFA
Rv2352c|M.tuberculosis_H37Rv ------ASMLIGPMMQLAQMGTT------------ANTAGLAGAEAAGLA
Mb3148c|M.bovis_AF2122/97 ------VRILTSPITTLASMAR--------------ESATRLGPPAGGLA
MAV_2910|M.avium_104 YSPQSWTTIPGGPFLSFGQAYAWG-----------QNGQGAAAYLAGPKA
MUL_3074|M.ulcerans_Agy99 ----IWNTIASTGFLLPSNMVTPF-----------LGMLDTAAVADAAED
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 AQHLSPINDTLSMINNHAGMANAG-----LSLVNGMGSAMKSLAPTTTKA
:
MMAR_3664|M.marinum_M AADMPKMVD-AVSPMKGLGGAG-LGAGMAADLGKARLVGAMSVPPTWEGS
Rv2352c|M.tuberculosis_H37Rv AADVPTFAG-DIASGTGLGGAGGLGAGMSAELGKARLVGAMSVPPTWEGS
Mb3148c|M.bovis_AF2122/97 AANTPNPSGAAIPAFKPLGGRE-LGAGMSAGLGQAQLVGSMSVPPTWQGS
MAV_2910|M.avium_104 ISGALAPLASGGNAVKPMLSSAVGAGQVSGSMGKAALVGSMSVPQGWTEA
MUL_3074|M.ulcerans_Agy99 ALRTTGSGALGGALSAPLGS--VGGQAGLAAAGNAAIVGKLSVPPSWTGA
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MLBr_01182|M.leprae_Br4923 AESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTA
. .
MMAR_3664|M.marinum_M IPKG--LSTSAMAGLGAMP-----AEIAEAGR--APMGMMPMPMGMGGAG
Rv2352c|M.tuberculosis_H37Rv VPAR--MASSAMAGLGAMP-----AEVPAAG---GPMGMMPMPMGMGGAG
Mb3148c|M.bovis_AF2122/97 IPIS--MASSAMSGLGVPPNPVALTQAAGAAG--GGMPMMLMPMSISGAG
MAV_2910|M.avium_104 APAIRTLAQVLPGNMAAAP-----AAMAGEEGVFSQMALSSLAGRAVAAA
MUL_3074|M.ulcerans_Agy99 APLASPLGSALGGTPMVAP-----PPTAAAG--MPGMPFGNMAG------
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
MLBr_01182|M.leprae_Br4923 SQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNT
MMAR_3664|M.marinum_M AGMPGG-----------------------------------------MLG
Rv2352c|M.tuberculosis_H37Rv AGMPAG-----------------------------------------MMG
Mb3148c|M.bovis_AF2122/97 AGMPGG-----------------------------------------LMD
MAV_2910|M.avium_104 ATRPVGG---------------------------------------AASA
MUL_3074|M.ulcerans_Agy99 --QPFG----------------------------------------RALP
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
MLBr_01182|M.leprae_Br4923 ALRLQP--------------------------------------------
MMAR_3664|M.marinum_M RGGASPHVVQSRPSVVPRIGVG----------------------------
Rv2352c|M.tuberculosis_H37Rv RGGANPHVVQARPSVVPRVGIG----------------------------
Mb3148c|M.bovis_AF2122/97 RDGAGWHVTQARLTVIPRTGVG----------------------------
MAV_2910|M.avium_104 ASSLGGVAAEADPAAATIIVIPCIEE------------------------
MUL_3074|M.ulcerans_Agy99 QYGFRPTFVARPPAAG----------------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
MLBr_01182|M.leprae_Br4923 ----RAFVMPRNPAAG----------------------------------
.
MMAR_3664|M.marinum_M ---------------
Rv2352c|M.tuberculosis_H37Rv ---------------
Mb3148c|M.bovis_AF2122/97 ---------------
MAV_2910|M.avium_104 ---------------
MUL_3074|M.ulcerans_Agy99 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------
MLBr_01182|M.leprae_Br4923 ---------------