For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVDLYSAASSCQSVIWGLAFGQWVGASASLMGAAAA PYVAWLGATATQAELAANQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTEAEY GEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGLVKQTAAVGQAIDSAAAGQLMSNVPQALQQL AATAPQGASTATAPKSLLQSVTSSFSSSNLSTIVGMENTHLSMANSGASILKTMGDSVKGFIPSASKAAE TAVEHAARNAVSMVGGGGPAGIGGWAPQGGVGQALSVGGLKVPQAWAEANQAVVPAARALPISPVTGAVE GAHGAPLPGMPFGQLAGNGGNGVSGVLRVTPKAYVMPRPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0947 | - | - | 100% (393) | PPE family protein |
| M. ulcerans Agy99 | MUL_2096 | - | 1e-71 | 41.40% (401) | PPE family protein |
| M. ulcerans Agy99 | MUL_3072 | - | 5e-67 | 42.05% (390) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1228 | PPE18 | 1e-122 | 56.74% (393) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-24 | 38.39% (211) | PPE protein |
| M. tuberculosis H37Rv | Rv1196 | PPE18 | 1e-120 | 56.57% (396) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-65 | 39.48% (423) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-27 | 36.42% (173) | PPE-family protein |
| M. marinum M | MMAR_4240 | - | 0.0 | 97.96% (393) | PPE family protein, PPE18 |
| M. avium 104 | MAV_2924 | - | 4e-73 | 42.35% (425) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-28 | 36.20% (221) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 6e-28 | 36.79% (212) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-27 | 39.41% (203) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
MUL_0947|M.ulcerans_Agy99 -------------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVD
MMAR_4240|M.marinum_M -------------MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVD
Mb1228|M.bovis_AF2122/97 ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
Rv1196|M.tuberculosis_H37Rv ------------MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASD
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
: : .** :* : *.*...::.*. * :. :
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
MUL_0947|M.ulcerans_Agy99 LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAA
MMAR_4240|M.marinum_M LYSAASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATRAELAA
Mb1228|M.bovis_AF2122/97 LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
Rv1196|M.tuberculosis_H37Rv LFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
:* . : : : * :: ** *: : . *
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
MUL_0947|M.ulcerans_Agy99 NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
MMAR_4240|M.marinum_M NQARGAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTE
Mb1228|M.bovis_AF2122/97 AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
Rv1196|M.tuberculosis_H37Rv AQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
: :* ** :* . : *: * :*.:* *: ** *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGV--------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGV--------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGV--------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGV--------
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG---------
MUL_0947|M.ulcerans_Agy99 AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
MMAR_4240|M.marinum_M AEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG--------
Mb1228|M.bovis_AF2122/97 AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
Rv1196|M.tuberculosis_H37Rv AEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGG--------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAG-QSASASKVTPFQKAPQVTNPSG--------
*:* . * * *::* * . .*
MSMEG_0619|M.smegmatis_MC2_155 --GEAGSASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-
TH_3569|M.thermoresistible__bu --SEAADAMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFG
Mflv_0325|M.gilvum_PYR-GCK --GEAGRAAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFE
Mvan_0415|M.vanbaalenii_PYR-1 --GEAGRAAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFE
MAB_0669|M.abscessus_ATCC_1997 --GEARSDQSDVPGSPDQ---------------IMKMLQGFQQWFEKMG-
MUL_0947|M.ulcerans_Agy99 ----LVKQTAAVGQAIDSAAAGQLMSN------VPQALQQL--AATAPQG
MMAR_4240|M.marinum_M ----LVNQTAAVGQAIDSAAAGQLMSN------VPQALQQL--AAPAPQG
Mb1228|M.bovis_AF2122/97 ----LLEQAAAVEEASDTAAANQLMNN------VPQALQQL--AQPT-QG
Rv1196|M.tuberculosis_H37Rv ----LLEQAAAVEEASDTAAANQLMNN------VPQALQQL--AQPT-QG
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
MAV_2924|M.avium_104 ----QAAQSAAVSTATANSTSTNTTKALQS---LAQPASSSTTATKAATT
: .
MSMEG_0619|M.smegmatis_MC2_155 AILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP
TH_3569|M.thermoresistible__bu PIVDFLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWP
Mflv_0325|M.gilvum_PYR-GCK PIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 PIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASI
MAB_0669|M.abscessus_ATCC_1997 -FNPATSAVLAVIMLFLYDLLWYPY-----YASYLLPFLIPALSGLSG-L
MUL_0947|M.ulcerans_Agy99 AST---ATAPKSLLQSVTSSFSSSNLSTIVGMENTHLSMA-----NSGAS
MMAR_4240|M.marinum_M AST---ATAPKSLLQSVTSSFSLSNLSTIVGMENTHLSMA-----NSGAS
Mb1228|M.bovis_AF2122/97 TTP---SSKLGGLWKTVSP--HLSPISNMVSMANNHVSMT-----NSGVS
Rv1196|M.tuberculosis_H37Rv TTP---SSKLGGLWKTVSP--HRSPISNMVSMANNHMSMT-----NSGVS
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQ--HLSPINDTLSMINNHAGMA-----NAGLS
MAV_2924|M.avium_104 AASTTSTDPLSEIWFLLTG--QTSLPTNLGTLVNGYSPFAGLFYNTEGLP
. . .
MSMEG_0619|M.smegmatis_MC2_155 TWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
TH_3569|M.thermoresistible__bu TWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAA
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPS
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPT
MAB_0669|M.abscessus_ATCC_1997 AALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPS
MUL_0947|M.ulcerans_Agy99 ILKT-MGDSVKGFIP-SASKAAETAVEHAARNAVSMVGGGGPAGIGGWAP
MMAR_4240|M.marinum_M IFKT-MGDSVKGFIP-SASKAAETAVEHAARNAVSMVGGGGPAGIGGWAP
Mb1228|M.bovis_AF2122/97 MTNT-LSSMLKGFAP-AAAQAVETAAQNGVRAMSSLGSSLGSSGLGGGVA
Rv1196|M.tuberculosis_H37Rv MTNT-LSSMLKGFAPAAAAQAVQTAAQNGVRAMSSLGSSLGSSGLGGGVA
MLBr_01182|M.leprae_Br4923 LVNG-MGSAMKSLAP-TTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVT
MAV_2924|M.avium_104 YFSTGMANTFTQIAKSVGAIGGAAPAAAKALPGLGGLGGMLGGGAAAAHP
: . .
MSMEG_0619|M.smegmatis_MC2_155 PRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAV
TH_3569|M.thermoresistible__bu P-------------------VRAEPQNPLPLTXXX---------------
Mflv_0325|M.gilvum_PYR-GCK RPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVV
Mvan_0415|M.vanbaalenii_PYR-1 RADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAV
MAB_0669|M.abscessus_ATCC_1997 GG---------------SSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLV
MUL_0947|M.ulcerans_Agy99 QGG----------VGQALSVG-GLKVPQAWAEANQAVVPAARALPISPVT
MMAR_4240|M.marinum_M QGG----------VGQALSVG-GLKVPQAWAEANQSVVPAARALPISPVT
Mb1228|M.bovis_AF2122/97 AN-----------LGRAASVG-SLSVPQAWAAANQAVTPAARALPLTSLT
Rv1196|M.tuberculosis_H37Rv AN-----------LGRAASVG-SLSVPQAWAAANQAVTPAARALPLTSLT
MLBr_01182|M.leprae_Br4923 AQ-----------LGRAASIG-SLRVPQTWTTASQPVTAATRALSPARVA
MAV_2924|M.avium_104 VAA----------LGGAGSIGGKLSVPVAWSGA-PATPALGHAIPVSSIS
MSMEG_0619|M.smegmatis_MC2_155 ANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQ
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEE
Mvan_0415|M.vanbaalenii_PYR-1 AGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDE
MAB_0669|M.abscessus_ATCC_1997 P---PGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNKAE
MUL_0947|M.ulcerans_Agy99 GAVEGAHGA--PLPG-MPFGQLAGNGGNGVSGV---LRVTPKAYVMPRPP
MMAR_4240|M.marinum_M GAVEGAHGA--PLPG-MPFGQLAGNGGNGVSGV---LRVTPKAYVMPRPP
Mb1228|M.bovis_AF2122/97 SAAERGPGQ--MLGG-LPVGQMGARAGGGLSGV---LRVPPRPYVMPHSP
Rv1196|M.tuberculosis_H37Rv SAAERGPGQ--MLGG-LPVGQMGARAGGGLSGV---LRVPPRPYVMPHSP
MLBr_01182|M.leprae_Br4923 VATESESAP--LLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP
MAV_2924|M.avium_104 AAPEAAGGPGNLLGG-MPLAGAG-AGGHGAAGP----KYGFRPTVMARPP
MSMEG_0619|M.smegmatis_MC2_155 IEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDV
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK IKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDE
Mvan_0415|M.vanbaalenii_PYR-1 IAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAA
MAB_0669|M.abscessus_ATCC_1997 AGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAGTAPAAAS
MUL_0947|M.ulcerans_Agy99 AAG-----------------------------------------------
MMAR_4240|M.marinum_M AAG-----------------------------------------------
Mb1228|M.bovis_AF2122/97 AAG-----------------------------------------------
Rv1196|M.tuberculosis_H37Rv AAG-----------------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
MAV_2924|M.avium_104 FAG-----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MAB_0669|M.abscessus_ATCC_1997 THVAATVRLS-SDEARQVIPMLPSTWDADGGDQN----------------
MUL_0947|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4240|M.marinum_M --------------------------------------------------
Mb1228|M.bovis_AF2122/97 --------------------------------------------------
Rv1196|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAV_2924|M.avium_104 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 -
TH_3569|M.thermoresistible__bu -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MAB_0669|M.abscessus_ATCC_1997 -
MUL_0947|M.ulcerans_Agy99 -
MMAR_4240|M.marinum_M -
Mb1228|M.bovis_AF2122/97 -
Rv1196|M.tuberculosis_H37Rv -
MLBr_01182|M.leprae_Br4923 -
MAV_2924|M.avium_104 -