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VALSRTHRVVAGVAHTRVYKKIWKYWYPLMTRGLGADELVFINWAYEEDPPMDLPLEATDEPDRCHINLY HRTATQADLSGKRVLEVSCGHGGGASYLTRTLGPASYTALDLNPAGIKFCQQRHHLPGLDFVQGDAEDLP FEDESFDVVLNVEASHCYPRFPVFLEEVKRVLRPGGYFAYADIRPCTEIAEWEAALAAAGLQQISHREIN AEVLRGIDINTPKSRELVKRHLPIFLRAAGRNYIGATGTPLYRLMQSGDISYRMYCFVKE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1766 | - | - | 100% (270) | methyltransferase |
| M. marinum M | MMAR_3170 | - | e-110 | 69.26% (270) | methyltransferase |
| M. marinum M | MMAR_1663 | - | 4e-11 | 36.11% (108) | hypothetical protein MMAR_1663 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2976 | - | 1e-119 | 73.70% (270) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4269 | - | 2e-10 | 35.78% (109) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2952 | - | 1e-119 | 73.70% (270) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 1e-114 | 68.52% (270) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4103c | - | 9e-79 | 58.00% (250) | methyltransferase |
| M. avium 104 | MAV_3903 | - | 1e-10 | 36.45% (107) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 8e-77 | 55.38% (260) | Fmt protein |
| M. thermoresistible (build 8) | TH_1636 | - | 1e-81 | 60.57% (246) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2009 | - | 1e-148 | 99.60% (250) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2090 | - | 2e-10 | 35.78% (109) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1766|M.marinum_M MALSRTHRVVAGVAHTRVY-----------KKIWKYWYPLMTRGLGADEL
MUL_2009|M.ulcerans_Agy99 MALSRTHRVVAGVAHTRVY-----------KKIWKYWYPLMTRGLGADEL
Mb2976|M.bovis_AF2122/97 MAFSRTHSLLARAGSTSTY-----------KRVWRYWYPLMTRGLGNDEI
Rv2952|M.tuberculosis_H37Rv MAFSRTHSLLARAGSTSTY-----------KRVWRYWYPLMTRGLGNDEI
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMY-----------KRVWRFWYPLMTHKLGTDEI
MSMEG_0393|M.smegmatis_MC2_155 ---MEARDRVAWRLNIKVA-----------QQAQKLVYRYATRRLKDDDV
TH_1636|M.thermoresistible__bu --VRESRDQVFRKLNEKLT-----------QHGQKFIYSYASRRLDDDDV
MAB_4103c|M.abscessus_ATCC_199 --MQRSRDWVMFKLNAVFT-----------QRVQKFIYRHATRKLETEDV
Mflv_4269|M.gilvum_PYR-GCK --MTETKEPGAYPDVAVPAPT---------PHATKEQVEAALHDTKLAQV
Mvan_2090|M.vanbaalenii_PYR-1 --MTETKEPGTYPDVAVPAPTPDVAVPAPTPRATKEQVEAAMHDTKLAQV
MAV_3903|M.avium_104 --MTRSTD-------AVPT-----------PHATAEQVEAARHDSKLAQV
. : : ::
MMAR_1766|M.marinum_M VFINWAYEE-DPPMDLPLEA-TDEPDRCHINLYHRTATQADLSGKRVLEV
MUL_2009|M.ulcerans_Agy99 VFINWAYEE-DPPMDLPLEA-TDEPDRCHINLYHRTATQADLSGKRVLEV
Mb2976|M.bovis_AF2122/97 VFINWAYEE-DPPMDLPLEA-SDEPNRAHINLYHRTATQVDLGGKQVLEV
Rv2952|M.tuberculosis_H37Rv VFINWAYEE-DPPMDLPLEA-SDEPNRAHINLYHRTATQVDLGGKQVLEV
MLBr_00130|M.leprae_Br4923 MFINWAYEE-DPPMALPLEA-SDEPNRAHINLYHRTATQVNLSGKRILEV
MSMEG_0393|M.smegmatis_MC2_155 VFLNYGYEE-DPPMGIPLSE-SDELNRYSIQLYHSTAAQADVEGKRVLEV
TH_1636|M.thermoresistible__bu VFLNYGYEE-DPPMGLPLSE-TDEPNRYSIQLYHRTAGQADLTGKRVLEV
MAB_4103c|M.abscessus_ATCC_199 VFLNYGYEE-EPAMGVPLSA-SDEPDRYSIQLYHSTATQADLGGQRVLEV
Mflv_4269|M.gilvum_PYR-GCK LYHDWEAETYDDKWSISYDQRCVDYARGRFDAAVPEEVQRELPYDRALEL
Mvan_2090|M.vanbaalenii_PYR-1 LYHDWEAETYDEKWSISYDQRCVDYARGRFDAAVPEEVQRELPYDRALEL
MAV_3903|M.avium_104 LYHDWEAETYDEKWSISYDQRCIDYARGRFDAIVPEHVLRELPYDRALEL
:: :: * : :. . : * :: :: .: **:
MMAR_1766|M.marinum_M SCGHGGGASYLTRTLGPASYTALDLNPAGIKFCQQRHHLPGLDFVQ--GD
MUL_2009|M.ulcerans_Agy99 SCGHGGGASYLTRTLGPASYTALDLNPAGIKFCQQRHHLPGLDFVQ--GD
Mb2976|M.bovis_AF2122/97 SCGHGGGASYLTRTLHPASYTGLDLNQAGIKLCKKRHRLPGLDFVR--GD
Rv2952|M.tuberculosis_H37Rv SCGHGGGASYLTRTLHPASYTGLDLNQAGIKLCKKRHRLPGLDFVR--GD
MLBr_00130|M.leprae_Br4923 SCGHGGGASYLTRALHPASYTGLDLNPAGIKLCQKRHQLPGLEFVR--GD
MSMEG_0393|M.smegmatis_MC2_155 GCGHGGGASYLARTFRPATYTGLDLNSDGINFCRRRHNIAGLEFVQ--GD
TH_1636|M.thermoresistible__bu GCGHGGGASYLMRTLGPMSYVGLDLNPAGIEFCRKKHRLPGLEFVV--GD
MAB_4103c|M.abscessus_ATCC_199 GCGHGGGASYLVRALQPASYTGLDLNPDGISFCRRRHDLPGLEFVQ--GD
Mflv_4269|M.gilvum_PYR-GCK GCGTGFFLLNLIQAGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVAD
Mvan_2090|M.vanbaalenii_PYR-1 GCGTGFFLLNLIQAGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVAD
MAV_3903|M.avium_104 GCGTGFFLLNLIQSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVAD
.** * * :: . **. :... :. **:: .*
MMAR_1766|M.marinum_M AEDLPFEDESFDVVLNVEASHCYPRFPVFLEEVKRVLRPGGYFAYADIRP
MUL_2009|M.ulcerans_Agy99 AEDLPFEDESFDVVLNVEASHCYPRFPVFLEEVKRVLRPGGYFAYADIRP
Mb2976|M.bovis_AF2122/97 AENLPFDDESFDVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRP
Rv2952|M.tuberculosis_H37Rv AENLPFDDESFDVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRP
MLBr_00130|M.leprae_Br4923 AENLPFDNESFDVVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRP
MSMEG_0393|M.smegmatis_MC2_155 AQDLPFPDKNFDAVLNVESSHLYPRFDVFLTEVARVLRPGGYFLYTDARP
TH_1636|M.thermoresistible__bu AQDLPFGAESFDAVINIESSHLYPRFSRFLSEVARVLRPGGHFLYADARQ
MAB_4103c|M.abscessus_ATCC_199 AEDLPFPDESFDAVINVESSHLYPHFPVFLTEVARVLRPGGNFLYTDARS
Mflv_4269|M.gilvum_PYR-GCK AEGIPYEDNTFDLVVGHAVLHHIPDVELSLREVVRVLKPGGRFVFAGEPT
Mvan_2090|M.vanbaalenii_PYR-1 AEGIPYEDNTFDLVVGHAVLHHIPDVELSLREVVRVLKPGGRFVFAGEPT
MAV_3903|M.avium_104 AEGIPYEDDTFDLVVGHAVLHHIPDVELSLREVIRVLRPGGRFVFAGEPT
*:.:*: ..** *:. * * . * ** ***:*** : ::.
MMAR_1766|M.marinum_M CT--------EIAEWEAALAAAGLQQIS-HREINAEVLRGIDINTPKSRE
MUL_2009|M.ulcerans_Agy99 CT--------EIAEWEAALAAAGLQQIS-HREINAEVLRGIDINTPKSRE
Mb2976|M.bovis_AF2122/97 NN--------EIAAWEADLAATPLRQLS-QRQINAEVLRGIGNNSQKSRD
Rv2952|M.tuberculosis_H37Rv NN--------EIAAWEADLAATPLRQLS-QRQINAEVLRGIGNNSQKSRD
MLBr_00130|M.leprae_Br4923 SN--------KVGEWEVDFANSRLQQLS-QREINAEVLRGIASNSQKSRD
MSMEG_0393|M.smegmatis_MC2_155 RY--------DIPEWERALADAPLQMLS-QRAINFEVVRGMEKNLDALES
TH_1636|M.thermoresistible__bu PH--------EFAEWEAALAAAPLDMVS-ARVINAEVVRGMEQILPVWED
MAB_4103c|M.abscessus_ATCC_199 VQ--------DVAGWKVALANAPLRMVS-ERGINAEVRRGMEKNLARWRY
Mflv_4269|M.gilvum_PYR-GCK TVGNRYARELSTLTWHAATNIMKLPMLSDWRRPQAELDESSRAAALEAVV
Mvan_2090|M.vanbaalenii_PYR-1 TVGNRYARELSTLTWHAATTLTKLPWLDGWRRPQAELDESSRAAALEAVV
MAV_3903|M.avium_104 SAGDVYARELSTLTWRIATNVTKLPGLGSWRRPQAELDESSRAAALEAIV
. *. * :. * : *: ..
MMAR_1766|M.marinum_M LVKRHLPIFLRAAGRNYIGATGTPLYRLMQSGDISYRMYCFVKE------
MUL_2009|M.ulcerans_Agy99 RVKRHLPIFLRAAGRNYIGATGTPPIPPDAKR------------------
Mb2976|M.bovis_AF2122/97 LVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD------
Rv2952|M.tuberculosis_H37Rv LVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD------
MLBr_00130|M.leprae_Br4923 LVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYSFAKD------
MSMEG_0393|M.smegmatis_MC2_155 VVDRVAPALLRDWIQKYGPAR-RAYEELR-ENTTEYRMYCFVKPAE----
TH_1636|M.thermoresistible__bu VIERVAPAFLRRRVREFAPAR-RAWEELRTEGSTEYRMYCFTKPPEHADI
MAB_4103c|M.abscessus_ATCC_199 VIDRATPAPLRGIVRRFAPAQ-RAYDDLRAGGSVEYRMYRFVKA------
Mflv_4269|M.gilvum_PYR-GCK DLHTFDPADLERMAANAGAVEVRTASEEFTAAMLGWPVRTFEAAVPPGRL
Mvan_2090|M.vanbaalenii_PYR-1 DLHTFDPADLERMAVNAGAVEVRTASEEFTAAMLGWPIRTFEAAVPPGRL
MAV_3903|M.avium_104 DLHTFTPGDLERMAANAGATEVRTVSEEFTAAMFGWPVRTFEASVPPGRL
:. * *. . .
MMAR_1766|M.marinum_M -------------------------------------------
MUL_2009|M.ulcerans_Agy99 -------------------------------------------
Mb2976|M.bovis_AF2122/97 -------------------------------------------
Rv2952|M.tuberculosis_H37Rv -------------------------------------------
MLBr_00130|M.leprae_Br4923 -------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 -------------------------------------------
TH_1636|M.thermoresistible__bu P------------------------------------------
MAB_4103c|M.abscessus_ATCC_199 -------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK GWGWAKFAFGSWTTLSWVDANVWRRIVPKGWFYNVMVTGVKPS
Mvan_2090|M.vanbaalenii_PYR-1 GWGWAKFAFGSWTTLSWVDANIWRRVVPKGWFYNVMVTGVKPS
MAV_3903|M.avium_104 GWGWAKFAFNGWKTLSWVDANIWRRVVPKGWFYNVMVTGVKPT