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TASVWMASPPEVHSALLSAGPGPGPLHEAATAWTALCAEHTSAAEELTTLLGGVQAAAWQGTSAQSYVDA HAPYLAWLTTTSADYAATAAEHEVAAGAYTSALAAMPTLAELTANHTTHTALVATNFFGLNTIPITLNEA DYARMWVQAATTMSAYQVVSGTTLASMPHTTPAPPILNTQIGTATNVAAPLLAQPLDIIEIILAILINLI AITFFLVFAIIAYTIIFAILLIPILIALAFSVVVFAFYIAIAIIIVTPPLLAALLPVALVSSLIGIPIAL ATTLPIALPVGIGQYLADQTRLETESVDQRQETAGTELAAAEDNWQLGGMPDAGLASTTTPAPTIGKVPE VASEQNAMGFAGTAVNRPVQSPAGLTILGNGESGHGSRVPMLPAAWEHGLTEATSGRALPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0787 | - | - | 100% (412) | PPE family protein |
| M. marinum M | MMAR_3641 | - | e-112 | 52.75% (455) | PPE family protein |
| M. marinum M | MMAR_4266 | - | e-110 | 53.11% (450) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 9e-80 | 43.60% (422) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-69 | 48.71% (310) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 5e-79 | 42.38% (420) | PPE family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 3e-55 | 47.92% (265) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-71 | 41.50% (400) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 1e-74 | 41.05% (497) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-64 | 61.05% (190) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-66 | 43.32% (337) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2686 | - | 9e-80 | 75.00% (196) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 6e-67 | 42.11% (361) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0787|M.marinum_M ----------MTA---SVWMASPPEVHSALLSAGPGPGPLHEAATAWTAL
MUL_2686|M.ulcerans_Agy99 ----------MVG---SAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVL
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MLBr_01991|M.leprae_Br4923 -------------------MAIPPEVHSVLLSAGQGAESLLVAATQWQEL
:* ****** :**:* *. : *. * *
MMAR_0787|M.marinum_M CAEHTSAAEELTTLLGGVQAAAWQGTSAQSYVDAHAPYLAWLTTTSADYA
MUL_2686|M.ulcerans_Agy99 AAEHASAAEELTSIVGG-AAAAWEGPSAQSYVDAHVPYLTWLATTSADYA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MLBr_01991|M.leprae_Br4923 SKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNA
. ::: .* **: : : * * *: : *: .*: ** * *
MMAR_0787|M.marinum_M ATAAEHEVAAGAYTSALAAMPTLAELTANHTTHTALVATNFFGLNTIPIT
MUL_2686|M.ulcerans_Agy99 ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MLBr_01991|M.leprae_Br4923 ITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIA
.* . : ** .* **: ***: **: *: : *:.***:*:**:**:
MMAR_0787|M.marinum_M LNEADYARMWVQAATTMSAYQVVSGTTLASMPHTTPAPPILNTQIGTATN
MUL_2686|M.ulcerans_Agy99 VNEADYARMWVQAATTMGAYQVILGTALASMPHTTPAPLILN--------
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MLBr_01991|M.leprae_Br4923 LNEADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPG----SA
:.**** ***:*** *.:*: : : : : ** ::
MMAR_0787|M.marinum_M VAAPLLAQPL-----------------DIIEIILAILINLIA--------
MUL_2686|M.ulcerans_Agy99 -AEPLILEP-----------------------------------------
Mb3047c|M.bovis_AF2122/97 AVAAATITPFPFGELAKFLEMAAQAFTEVGELIMKSAEAWAV--------
Rv3018c|M.tuberculosis_H37Rv AVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAW--------
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLR
MAV_4867|M.avium_104 LAAN---------AAQNSSGDWWQNFIQQLSQFFQN--------------
MAB_4783|M.abscessus_ATCC_1997 TAAQDATKPPPIVPDPNDPIEMLLKNSQHFLGMYRALKGLIT--------
MLBr_01991|M.leprae_Br4923 TQNVLQSVPDWIVQLLTDILDFIADPYKYFLRFFQR--------------
MMAR_0787|M.marinum_M ----ITFFLVFAIIAYTIIFAILLIPILIALAFSVVVFAFYIAIAIIIVT
MUL_2686|M.ulcerans_Agy99 ----------------------------------------EIEIAKFITD
Mb3047c|M.bovis_AF2122/97 ----GFVELITGLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPLLEFAV
Rv3018c|M.tuberculosis_H37Rv ----VWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAI
Mflv_0325|M.gilvum_PYR-GCK DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFL
Mvan_0415|M.vanbaalenii_PYR-1 DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLL
MSMEG_0619|M.smegmatis_MC2_155 DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFA
TH_3569|M.thermoresistible__bu DPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILA
MAV_4867|M.avium_104 -----IQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILT
MAB_4783|M.abscessus_ATCC_1997 DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMG
MLBr_01991|M.leprae_Br4923 ------LGFRPAIAVVLAIIALQLYDFLWYPYYASYGMLLLPFFAPALSV
MMAR_0787|M.marinum_M PPLLAALLPVALVSSLIGIPIALAT-----TLPIALPVGIGQYLAD----
MUL_2686|M.ulcerans_Agy99 P----------VGSAVMGIWEMFCC-----FWII----------------
Mb3047c|M.bovis_AF2122/97 VLELAILSIGWIISNIFGAIPVLAG-----PLLGALAAAVVPGVAG----
Rv3018c|M.tuberculosis_H37Rv AGVIDIV-VEWVIGNLFGVVPLLGG-----PLLGALAAAVVPGVAG----
Mflv_0325|M.gilvum_PYR-GCK LPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSF
Mvan_0415|M.vanbaalenii_PYR-1 LPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSP
MSMEG_0619|M.smegmatis_MC2_155 SPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPL
TH_3569|M.thermoresistible__bu SPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP------
MAV_4867|M.avium_104 APFLLPLLLGIGLSSLLAAPAEIAP----VAAPAAITPVLASNKPPTLPA
MAB_4783|M.abscessus_ATCC_1997 PAAGISIPLAITLASLSQMPEAPPVDAPAETVPARIDQPHAVAMGG----
MLBr_01991|M.leprae_Br4923 LGTLSVLWNGQLSAGLPPNPAGSHP---DNNAGPRIHVGVAPPASATS--
MMAR_0787|M.marinum_M -----------QTRLE-TESVDQRQETAGTELAAAEDNWQ----------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 -----------VTGLAGLAAVPAVGAAAGAPAALVGSVAP----------
Rv3018c|M.tuberculosis_H37Rv -----------LAGVAGLAALPAVGAAAGAPAALVGSVAP----------
Mflv_0325|M.gilvum_PYR-GCK PATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 AIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGT
MSMEG_0619|M.smegmatis_MC2_155 AVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu -------------VRAEPQNPLPLTXXX----------------------
MAV_4867|M.avium_104 AVALAPSVATPAGAPASTVAAGSGAAAAPGPAAAAGNFAYLVAFGGDPDT
MAB_4783|M.abscessus_ATCC_1997 --APAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGF
MLBr_01991|M.leprae_Br4923 -----------SGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPE
MMAR_0787|M.marinum_M -------LGG---MPDAGLASTTTPAPTIGKVP-----------------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 -------VSGGVVSPQARLVSAVEPAPASTSVS-----------------
Rv3018c|M.tuberculosis_H37Rv -------VSGGVVSPQARLVSAVEPAPASTSVS-----------------
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 GVGPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFL
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
MLBr_01991|M.leprae_Br4923 VSSGPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYR
MMAR_0787|M.marinum_M ------------------------EVASEQNA--MGFAGTAVNRPVQSPA
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ------------------------VLASDRGAGALGFVGTAGKESVGQPA
Rv3018c|M.tuberculosis_H37Rv ------------------------VLASDRGAGALGFVGTAGKESVGQPA
Mflv_0325|M.gilvum_PYR-GCK DAYAD---YEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSR-GDEQAG
Mvan_0415|M.vanbaalenii_PYR-1 DAYAD---YEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSR-DAAQAG
MSMEG_0619|M.smegmatis_MC2_155 DAYMD---YEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTR-HDVTAA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 DMDSG---FGVPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRKAFQAA
MAB_4783|M.abscessus_ATCC_1997 HEYAT---MDDHTPTG--PQDPVTAVASGTGAGRLGFAGVHTATTAVEAT
MLBr_01991|M.leprae_Br4923 YEFVEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPT-TASTPT
MMAR_0787|M.marinum_M GLTILGNGESGHGSRVPMLPAAWEHGLTEA---------TSGRALPT-
MUL_2686|M.ulcerans_Agy99 ------------------------------------------------
Mb3047c|M.bovis_AF2122/97 GLTVLAD-EFGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv GLTVLAD-EFGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Mflv_0325|M.gilvum_PYR-GCK GLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ------------------------------------------------
MAV_4867|M.avium_104 GLTKLADDDFGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
MAB_4783|M.abscessus_ATCC_1997 GLSTLDGDAENR--TIPMLPGTWDVTDDDR------------------
MLBr_01991|M.leprae_Br4923 GMAASTS------SSVPLLPTTWITGTSET---------AVHE-----