For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQYATAAAELSALLGEAQAGSWEGESAAQY AAAHLPYLAWLQQASADSAGAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAV NEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGEANNLAANAAQNSSGDWWQNFIQQLS QFFQNIQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAPFLLPLLLGIGLSSLLAAP AEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPASTVAAGSGAAAAPGPAAAAGNFAYLVAF GGDPDTGVGPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFGVPPDYGA EEELAAAVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDDFGGSPRMPMVPGTWEQDTQNGAHPTEPGK GG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4867 | - | - | 100% (493) | PPE family protein |
| M. avium 104 | MAV_4872 | - | e-107 | 49.40% (496) | PPE family protein |
| M. avium 104 | MAV_4879 | - | e-106 | 47.28% (533) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 1e-148 | 56.24% (505) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-112 | 47.22% (521) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 1e-148 | 56.24% (505) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 6e-81 | 38.17% (545) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 1e-120 | 50.00% (514) | PPE family protein |
| M. marinum M | MMAR_0545 | - | 1e-145 | 55.93% (506) | PPE family protein, PPE4 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-120 | 47.29% (535) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-85 | 53.02% (315) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 1e-144 | 55.34% (506) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-114 | 48.65% (518) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
MLBr_00539|M.leprae_Br4923 -----------MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
*:* ****:*::*. *.* ..:: :. **::
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
* .*:*: :* . . .*:* : :..: *:: ** : :* *
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
::. *.**: *: :*** ** *: : **:.***:*:*:***::.*
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHL--
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHL--
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGE-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR---
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR---
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS---
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD---
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSR---
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
:* :**::**: *. *.. : :*: ::. : *.* :: ..
Mb0294|M.bovis_AF2122/97 ---------AASTVGAVNPWQWLLAL--LQQLWNAYTGFYGWMLQLIWQF
Rv0286|M.tuberculosis_H37Rv ---------AASTVGAVNPWQWLLAL--LQQLWNAYTGFYGWMLQLIWQF
MMAR_0545|M.marinum_M AADAAQAQSGAAAAGGSDPWQLLWQL--LQYLWNAYTGFNTWMFDLIWEF
MUL_1208|M.ulcerans_Agy99 AADAARAQSGAAAAGGSDPWQLLWQL--LQYLWNAYTGFNTWMFDLIWEF
MAV_4867|M.avium_104 ------ANNLAANAAQNSSGDWWQNF--IQQLS---------------QF
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNI--IADIIRLYGEVLRFLFEPIFNF
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNI--IADLIRAYGELLRFLFEPIFDF
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSI--ISDLLNQYLQGVPGGQ-AILDF
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDL--IANLLQYYQDYLDQLFGPIVDF
MAB_0047|M.abscessus_ATCC_1997 MSADMMSMAAQPQAAESGSALDSSNN--IMDQL--------------MRF
MLBr_00539|M.leprae_Br4923 SRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVY
. . :
Mb0294|M.bovis_AF2122/97 LQDPIGNSIKIIIAFLTN-------PIQALITYGPLLFALGYQIFFNLVG
Rv0286|M.tuberculosis_H37Rv LQDPIGNSIKIIIAFLTN-------PIQALITYGPLLFALGYQIFFNLVG
MMAR_0545|M.marinum_M LQDPIGNTIKIIIAFLTN-------PLQAIITYGPLLFALSYQIFFNLVG
MUL_1208|M.ulcerans_Agy99 LQDPIGNTIKIIIAFLTN-------PLQAIITYGPLLFALSYQIFFNLVG
MAV_4867|M.avium_104 FQN----IQKMLQDFWAN-------LPAFLAANGPLLFFVAYQVFFNAVG
Mflv_0325|M.gilvum_PYR-GCK LRDPIGNTFALITDFLTN-------PVQALITWGPFLLAVVYQAVSWVGA
Mvan_0415|M.vanbaalenii_PYR-1 LRDPLGNTIKLITDFLTN-------PAQALITWGPFLAAVAYQAVSWVGA
MSMEG_0619|M.smegmatis_MC2_155 LKDPLGNLGRLLTDFMTN-------PAGALATWWPFLFGVAYQVFFNLVG
TH_3569|M.thermoresistible__bu LRDPIGNLFQLIDDFLTN-------PAGALVTWWPLLFAVAYQVFTNLVG
MAB_0047|M.abscessus_ATCC_1997 MTNPLGTLQDMIEDFMRN-------PVAAFFAWFPLLFFIAYEAFFIPFG
MLBr_00539|M.leprae_Br4923 PGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQ
: : * . : :* : :
Mb0294|M.bovis_AF2122/97 WPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAP--AVIPPAST------
Rv0286|M.tuberculosis_H37Rv WPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAP--AVIPPAST------
MMAR_0545|M.marinum_M WPTWALILSSPFLLPAALGLALSAIAFTPIQIA---AEVPAAAA------
MUL_1208|M.ulcerans_Agy99 WPTWALILSSPFLLPAALGLALSAIAFTPIQIA---AEVPAAAA------
MAV_4867|M.avium_104 WPTWGAILTAPFLLPLLLGIGLSSLLAAPAEIAP--VAAPAAIT------
Mflv_0325|M.gilvum_PYR-GCK SILYPSLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEP------
Mvan_0415|M.vanbaalenii_PYR-1 SILYPSLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEP------
MSMEG_0619|M.smegmatis_MC2_155 WPTWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDE------
TH_3569|M.thermoresistible__bu WPTWAMILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEA------
MAB_0047|M.abscessus_ATCC_1997 FTFWGVLLSAPAWLPIVLGLALSALVPPAGIEEPGQEDEPGREP------
MLBr_00539|M.leprae_Br4923 LGTWLAEYPQLLLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVVPE
: . : . .
Mb0294|M.bovis_AF2122/97 -PLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPA
Rv0286|M.tuberculosis_H37Rv -PLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPA
MMAR_0545|M.marinum_M -PLAAAAVTAKSVFPAASLASPGTGSAGAPASGAGAGAPGSAPPGPAAPA
MUL_1208|M.ulcerans_Agy99 -PLAAAAVTAKSVFPAASLASPGTGSAGAPASGAGAGAPGTAPPGPGAPA
MAV_4867|M.avium_104 -PVLASNKPP-TLPAAVALAPSVATPAGAPASTVAAGSGAAAAPGP-AAA
Mflv_0325|M.gilvum_PYR-GCK -APAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAA
Mvan_0415|M.vanbaalenii_PYR-1 -AASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAA
MSMEG_0619|M.smegmatis_MC2_155 -APQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPA
TH_3569|M.thermoresistible__bu -APEEDVAAP-------------------VRAEPQNPLPLTXXX------
MAB_0047|M.abscessus_ATCC_1997 -TRIE-RRSPQQDLQLAHVPSGSPTPGGSTTTTVTSGGSAPPAP-APATA
MLBr_00539|M.leprae_Br4923 SAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTG
. . .
Mb0294|M.bovis_AF2122/97 TASFAYAVGGSGDWGPSLG----PTVGGRGGIKAPAATVPAAAAAAATRG
Rv0286|M.tuberculosis_H37Rv TASFAYAVGGSGDWGPSLG----PTVGGRGGIKAPAATVPAAAAAAATRG
MMAR_0545|M.marinum_M PASFLYAVGGSGDWGPSLG----PTVGGRSGAKAPAATIPAAGAAAASRA
MUL_1208|M.ulcerans_Agy99 PASFLYAVGGSGDWGPSLG----PTVGGRSGAKAPAVTIPAAGAAAASRA
MAV_4867|M.avium_104 AGNFAYLVAFGGDPDTGVG----PTLSGRGGAKAPAATIPAAGAAAPARA
Mflv_0325|M.gilvum_PYR-GCK AATFVPYVVAGRDPYEGFS----PTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 TASFVPYAVAGRDPGTGFS----PTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 AATFVPYAVANRDPGEGFT----PTLGNKSQVAAPASGVPAAASGVAASL
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 TPAYMVYAVQEDPPAARFG----PTLNEGSGAKAPAAGISAAAA-AAASA
MLBr_00539|M.leprae_Br4923 FGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQASARE
Mb0294|M.bovis_AF2122/97 QSRARRRR-RSELRDYGDEFLDMDS-----DSGFGPSTGDHGAQASERGA
Rv0286|M.tuberculosis_H37Rv QSRARRRR-RSELRDYGDEFLDMDS-----DSGFGPSTGDHGAQASERGA
MMAR_0545|M.marinum_M SARSRRRR-RTEMRDYGDEFLDMDA-----NGVTGPAATDDAARASERGA
MUL_1208|M.ulcerans_Agy99 SARSRRRR-RTEMRDYGDEFLDMDA-----NGVTGPAATDDAARASERGA
MAV_4867|M.avium_104 EARARRRR-RAALHDYSDEFLDMDSGFGV-PPDYGAEEELAAAVASGQGA
Mflv_0325|M.gilvum_PYR-GCK AERRKRRR-RQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGA
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRR-RQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGA
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRR-KKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGS
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 RSRARRKR-AARIKDPAPQFMDMNSSVAPDFSES-AARQTTGVGASARGA
MLBr_00539|M.leprae_Br4923 QARAWRRRSAAKERGYREEVITMNTG---FDAAIPSPVDQTGSRVSDCGA
Mb0294|M.bovis_AF2122/97 GTLGFAGTATKER-RVRAVGLT---ALAGDEFGNGPRMPMVPGTWEQGSN
Rv0286|M.tuberculosis_H37Rv GTLGFAGTATKER-RVRAVGLT---ALAGDEFGNGPRMPMVPGTWEQGSN
MMAR_0545|M.marinum_M GQFGFAGTVSTEA-VLQAAGLT---ELAVDEFGNGPRMPMVPGSWDS---
MUL_1208|M.ulcerans_Agy99 GQFGFAGTVSTEA-VLQAAGLT---ELAVDEFGNGPRMPMVPGSWDS---
MAV_4867|M.avium_104 GTLGFAGTQQRRK-AFQAAGLT---KLADDDFGGSPRMPMVPGTWEQD--
Mflv_0325|M.gilvum_PYR-GCK GPMGFAGTVSRGD--EQAGGLT---TLAGDSFGGGPREPMLPGTWDPDA-
Mvan_0415|M.vanbaalenii_PYR-1 GPMGFAGTVSRDA--AQAGGLT---TLPGDPFGGGPKAPMLPGTWDPDT-
MSMEG_0619|M.smegmatis_MC2_155 DAMGFTGTVTRHD--VTAAGLT---TLTGDTFDDRPVTPMLPGTWDGDE-
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 GRLGFAGTAPAAAGTTAAAGLVERDSGTAEALDGARTVPMLPTSWGTDS-
MLBr_00539|M.leprae_Br4923 GSFGFAGTVSKEA-VVEVAGLT---TLAGDDFGGGPTMPMVPGTWAPAR-
Mb0294|M.bovis_AF2122/97 EPEAPDGSGRGGGDGLPHDSK-
Rv0286|M.tuberculosis_H37Rv EPEAPDGSGRGGGDGLPHDSK-
MMAR_0545|M.marinum_M -PQE------GREDGLQSE---
MUL_1208|M.ulcerans_Agy99 -PQE------GREDGLQSE---
MAV_4867|M.avium_104 -TQN------GAHPTEPGKGG-
Mflv_0325|M.gilvum_PYR-GCK -TDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -EPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 -NPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ----------------------
MAB_0047|M.abscessus_ATCC_1997 -EHG-------PDRPAEGGSST
MLBr_00539|M.leprae_Br4923 ------------ESSDEGR---