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MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYL VWLEQTSINNAITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNEADYVRM WVQAADTMATYQAISEAVTATILPTQVAPPILAPGSATQNVLQSVPDWIVQLLTDILDFIADPYKYFLRF FQRLGFRPAIAVVLAIIALQLYDFLWYPYYASYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGS HPDNNAGPRIHVGVAPPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSSGPKAGT KSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTATMADTVDAPDHSEPTSHTISN HSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_01991 | PPE | - | 100% (468) | PPE-family protein |
M. leprae Br4923 | MLBr_00539 | PPE | 4e-47 | 30.71% (534) | PPE-family protein |
M. leprae Br4923 | MLBr_01828 | PPE | 1e-44 | 44.73% (237) | PPE-family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0099 | PPE1 | 1e-145 | 57.78% (469) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 2e-67 | 35.42% (511) | PPE protein |
M. tuberculosis H37Rv | Rv0096 | PPE1 | 1e-145 | 57.78% (469) | PPE family protein |
M. abscessus ATCC 19977 | MAB_0669 | - | 1e-105 | 46.09% (473) | PPE-family protein |
M. marinum M | MMAR_0261 | - | 1e-139 | 56.57% (472) | PPE family protein, PPE1 |
M. avium 104 | MAV_4872 | - | 9e-70 | 36.22% (497) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-68 | 38.26% (507) | PPE family protein |
M. thermoresistible (build 8) | TH_3569 | - | 1e-59 | 44.67% (300) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_4853 | - | 1e-139 | 56.57% (472) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-67 | 36.23% (530) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_0261|M.marinum_M ----------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQELSAQ MUL_4853|M.ulcerans_Agy99 ----------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQELSAQ Mb0099|M.bovis_AF2122/97 ----------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQ Rv0096|M.tuberculosis_H37Rv ----------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQ MLBr_01991|M.leprae_Br4923 ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE MAV_4872|M.avium_104 ----------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSET ** .***** :**:* *. .:* *. * :. MMAR_0261|M.marinum_M YSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSSVTA MUL_4853|M.ulcerans_Agy99 YSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSSVTA Mb0099|M.bovis_AF2122/97 YALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTA Rv0096|M.tuberculosis_H37Rv YALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTA MLBr_01991|M.leprae_Br4923 YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA MAV_4872|M.avium_104 YASAAAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVA *: : .** * .:: :*.* :: .::*** .** ** : : .: * MMAR_0261|M.marinum_M AQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIALNE MUL_4853|M.ulcerans_Agy99 AQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIALNE Mb0099|M.bovis_AF2122/97 AQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNE Rv0096|M.tuberculosis_H37Rv AQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNE MLBr_01991|M.leprae_Br4923 KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE MAV_4872|M.avium_104 AQQETAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNE :: :* .* :*:*:*** .**: *: :. *: ***:*:*::***:.* MMAR_0261|M.marinum_M ADYVRMWIQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG--------- MUL_4853|M.ulcerans_Agy99 ADYVRMWVQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG--------- Mb0099|M.bovis_AF2122/97 ADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG--------- Rv0096|M.tuberculosis_H37Rv ADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG--------- MLBr_01991|M.leprae_Br4923 ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPG--------- MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG--------- Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA MAV_4872|M.avium_104 ADYARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNSTSSDG--SDS ***.***:*** :*::**: : . : : .* : . MMAR_0261|M.marinum_M ----------GESQAAASGIGSWIGQLLR-----------DILSFLADPY MUL_4853|M.ulcerans_Agy99 ----------GGSQAAASGIGSWIGQLLR-----------DILSFLADPY Mb0099|M.bovis_AF2122/97 ----------GDAADTWLDVLSSIGQLIR-----------DILDFIANPY Rv0096|M.tuberculosis_H37Rv ----------GDAADTRLDVLSSIGQLIR-----------DILDFIANPY MLBr_01991|M.leprae_Br4923 ----------SATQNVLQSVPDWIVQLLT-----------DILDFIADPY MAB_0669|M.abscessus_ATCC_1997 ----------GEARSDQSDVPGSPDQIMK-----------MLQG------ Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI MAV_4872|M.avium_104 DDSGDDGGIVDNDGGNPYQLSWWVNRFLEIFQTIG----RDLEEFPENPS : :: : MMAR_0261|M.marinum_M KYFLEFFQRMGFSPAVAVILAIIALQLYDFLWYPYYASYGLLLLPFFTPA MUL_4853|M.ulcerans_Agy99 KYFLEFFQRMGFSPAVAVILAIIALQLYDFLWYPYYASYGLLLLPFFTPA Mb0099|M.bovis_AF2122/97 KYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPT Rv0096|M.tuberculosis_H37Rv KYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPT MLBr_01991|M.leprae_Br4923 KYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYYASYGMLLLPFFAPA MAB_0669|M.abscessus_ATCC_1997 --FQQWFEKMGFNPATSAVLAVIMLFLYDLLWYPYYASY---LLPFLIPA Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV MAV_4872|M.avium_104 AALTQLLRDIWLLIVDEIGHAIEAFQAFAPQIAAFSLALPAGAAAGLAGL : : . : . MMAR_0261|M.marinum_M LSALSALSALA--YLANRTPITAPVAAPAERS-----VADLAGPQPVVGL MUL_4853|M.ulcerans_Agy99 LSALSVLSALA--YLANRTPITAPVAAPAERS-----VADLAGPQPVVGL Mb0099|M.bovis_AF2122/97 LSALTALSALI--HLLN-LPPAGLLPIAAALG-----PGDQWGANLAVAV Rv0096|M.tuberculosis_H37Rv LSALTALSALI--HLLN-LPPAGLLPIAAALG-----PGDQWGANLAVAV MLBr_01991|M.leprae_Br4923 LSVLGTLS-----VLWNGQLSAGLPPNPAGSH-----PDNNAGPRIHVGV MAB_0669|M.abscessus_ATCC_1997 LSGLSGLAALM--HLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALP Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------- MAV_4872|M.avium_104 SG-LAAIQKAAPLPALPAAPPPQPSSMPAVVAGPAMGAAAVAAP------ : MMAR_0261|M.marinum_M TPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAPPGVSS MUL_4853|M.ulcerans_Agy99 TPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAPPGVSS Mb0099|M.bovis_AF2122/97 TPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSS Rv0096|M.tuberculosis_H37Rv TPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSS MLBr_01991|M.leprae_Br4923 APPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSS MAB_0669|M.abscessus_ATCC_1997 LPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVPPGVSF Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFS Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFS MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFT TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX------------------------- MAV_4872|M.avium_104 ---APASAGAPAPASATVTASGAAPPPPSGIGGTAYPYLIGG--PTIGSG MMAR_0261|M.marinum_M GPRATTGAAATATDTTRAAAPAALSS--SRASRRKRSKNRVGVRGYRDEF MUL_4853|M.ulcerans_Agy99 GPGATTGAAATATDTTRPAAPAALSS--SRAGRRKRSKNRVGVRGYRDEF Mb0099|M.bovis_AF2122/97 GPKAGTKSPDTAADTLATAGAARPGL--ARAHRRKRSESGVGIRGYRDEF Rv0096|M.tuberculosis_H37Rv GPKAGTKSPDTAADTLATAGAARPGL--ARAHRRKRSESGVGIRGYRDEF MLBr_01991|M.leprae_Br4923 GPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEF MAB_0669|M.abscessus_ATCC_1997 GPKSTEKSSESAVDTVAAVAAARGAVA-AQARRRLRGKNKAEAGGRRHEY Mflv_0325|M.gilvum_PYR-GCK PTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAY Mvan_0415|M.vanbaalenii_PYR-1 PTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAY MSMEG_0619|M.smegmatis_MC2_155 PTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAY TH_3569|M.thermoresistible__bu -------------------------------------------------- MAV_4872|M.avium_104 TGMGSGAQRKASEPDPAAAAAPAGASASERARARRRRRAAMKDRYRGYEF MMAR_0261|M.marinum_M LQEPATMDSPIDAPGTAEPAPSPSS-QGAGPLGLTGTAASHDG-AAAGMV MUL_4853|M.ulcerans_Agy99 LQEPATMDSPIDAPGTAEPAPSPSS-QGAGPLGLTGTAASHDG-AAAGMV Mb0099|M.bovis_AF2122/97 LDATATVDAATDVP---APANAAGS-QGAGTLGFAGTAPTTSG-AAAGMV Rv0096|M.tuberculosis_H37Rv LDATATVDAATDVP---APANAAGS-QGAGTLGFAGTAPTTSG-AAAGMV MLBr_01991|M.leprae_Br4923 VEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTAS-TPTGMA MAB_0669|M.abscessus_ATCC_1997 LEETAGMGATATAD---VPAYAATG-RGTGPLGFAGTAPAAASTHVAATV Mflv_0325|M.gilvum_PYR-GCK ADYEELPDDGPPEQPA--PRVTAST-RGAGPMGFAGTVSRGDE-QAGGLT Mvan_0415|M.vanbaalenii_PYR-1 ADYEPEPDDEPPVRQE--PRIAATE-RGAGPMGFAGTVSRDAA-QAGGLT MSMEG_0619|M.smegmatis_MC2_155 MDYEE-PDEDPAPQPE--PRVRASE-RGSDAMGFTGTVTRHDV-TAAGLT TH_3569|M.thermoresistible__bu -------------------------------------------------- MAV_4872|M.avium_104 MDVEPDAGPEPETDS-----VTASD-RGAGPLGFAGTAPSAPA-QATGLA MMAR_0261|M.marinum_M RLSSH--GTSTAVPLLPATWTNDSEGRPEGE-------------- MUL_4853|M.ulcerans_Agy99 RLSSH--GTSTAVPLLPATWTNDSEGRPEGE-------------- Mb0099|M.bovis_AF2122/97 QLSSH--STSTTVPLLPTTWTTDAEQ------------------- Rv0096|M.tuberculosis_H37Rv QLSSH--STSTTVPLLPTTWTTDAEQ------------------- MLBr_01991|M.leprae_Br4923 AS------TSSSVPLLPTTWITGTSETAVHE-------------- MAB_0669|M.abscessus_ATCC_1997 RLSSD--EARQVIPMLPSTWDADGGDQN----------------- Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR TH_3569|M.thermoresistible__bu --------------------------------------------- MAV_4872|M.avium_104 TLAGDEFGTGPSMPMVPGNWTGE----------------------