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M. leprae Br4923 MLBr_01991 (PPE)

annotation: PPE-family protein
coordinates: 2378419 - 2379825
length: 468

MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYL
VWLEQTSINNAITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNEADYVRM
WVQAADTMATYQAISEAVTATILPTQVAPPILAPGSATQNVLQSVPDWIVQLLTDILDFIADPYKYFLRF
FQRLGFRPAIAVVLAIIALQLYDFLWYPYYASYGMLLLPFFAPALSVLGTLSVLWNGQLSAGLPPNPAGS
HPDNNAGPRIHVGVAPPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSSGPKAGT
KSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEFVEGTATMADTVDAPDHSEPTSHTISN
HSAGPIGFAGTVPTTASTPTGMAASTSSSVPLLPTTWITGTSETAVHE
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_01991PPE-100% (468)PPE-family protein
M. leprae Br4923MLBr_00539PPE4e-4730.71% (534) PPE-family protein
M. leprae Br4923MLBr_01828PPE1e-4444.73% (237) PPE-family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0099PPE11e-14557.78% (469) PPE family protein
M. gilvum PYR-GCKMflv_0325-2e-6735.42% (511) PPE protein
M. tuberculosis H37RvRv0096PPE11e-14557.78% (469) PPE family protein
M. abscessus ATCC 19977MAB_0669-1e-10546.09% (473) PPE-family protein
M. marinum MMMAR_0261-1e-13956.57% (472) PPE family protein, PPE1
M. avium 104MAV_4872-9e-7036.22% (497) PPE family protein
M. smegmatis MC2 155MSMEG_0619-8e-6838.26% (507) PPE family protein
M. thermoresistible (build 8)TH_3569-1e-5944.67% (300) PUTATIVE PPE protein
M. ulcerans Agy99MUL_4853-1e-13956.57% (472) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-3e-6736.23% (530) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0261|M.marinum_M               ----------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQELSAQ
MUL_4853|M.ulcerans_Agy99           ----------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQELSAQ
Mb0099|M.bovis_AF2122/97            ----------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQ
Rv0096|M.tuberculosis_H37Rv         ----------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQ
MLBr_01991|M.leprae_Br4923          ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ
MAB_0669|M.abscessus_ATCC_1997      ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu      ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAV_4872|M.avium_104                ----------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSET
                                                    ** .***** :**:* *. .:* *.  *  :.  

MMAR_0261|M.marinum_M               YSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSSVTA
MUL_4853|M.ulcerans_Agy99           YSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSSVTA
Mb0099|M.bovis_AF2122/97            YALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTA
Rv0096|M.tuberculosis_H37Rv         YALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTA
MLBr_01991|M.leprae_Br4923          YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA
MAB_0669|M.abscessus_ATCC_1997      YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu      YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAV_4872|M.avium_104                YASAAAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVA
                                    *: : .**   *  .:: :*.* :: .::*** .** ** : :  .:  *

MMAR_0261|M.marinum_M               AQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIALNE
MUL_4853|M.ulcerans_Agy99           AQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIALNE
Mb0099|M.bovis_AF2122/97            AQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNE
Rv0096|M.tuberculosis_H37Rv         AQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNE
MLBr_01991|M.leprae_Br4923          KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997      AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu      GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAV_4872|M.avium_104                AQQETAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNE
                                     ::  :* .* :*:*:*** .**: *:  :. *: ***:*:*::***:.*

MMAR_0261|M.marinum_M               ADYVRMWIQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG---------
MUL_4853|M.ulcerans_Agy99           ADYVRMWVQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG---------
Mb0099|M.bovis_AF2122/97            ADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG---------
Rv0096|M.tuberculosis_H37Rv         ADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG---------
MLBr_01991|M.leprae_Br4923          ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPG---------
MAB_0669|M.abscessus_ATCC_1997      ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG---------
Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu      ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAV_4872|M.avium_104                ADYARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNSTSSDG--SDS
                                    ***.***:*** :*::**: : .   :   :  .* :  .          

MMAR_0261|M.marinum_M               ----------GESQAAASGIGSWIGQLLR-----------DILSFLADPY
MUL_4853|M.ulcerans_Agy99           ----------GGSQAAASGIGSWIGQLLR-----------DILSFLADPY
Mb0099|M.bovis_AF2122/97            ----------GDAADTWLDVLSSIGQLIR-----------DILDFIANPY
Rv0096|M.tuberculosis_H37Rv         ----------GDAADTRLDVLSSIGQLIR-----------DILDFIANPY
MLBr_01991|M.leprae_Br4923          ----------SATQNVLQSVPDWIVQLLT-----------DILDFIADPY
MAB_0669|M.abscessus_ATCC_1997      ----------GEARSDQSDVPGSPDQIMK-----------MLQG------
Mflv_0325|M.gilvum_PYR-GCK          DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1       DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155      SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu      TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
MAV_4872|M.avium_104                DDSGDDGGIVDNDGGNPYQLSWWVNRFLEIFQTIG----RDLEEFPENPS
                                                       :      ::             :        

MMAR_0261|M.marinum_M               KYFLEFFQRMGFSPAVAVILAIIALQLYDFLWYPYYASYGLLLLPFFTPA
MUL_4853|M.ulcerans_Agy99           KYFLEFFQRMGFSPAVAVILAIIALQLYDFLWYPYYASYGLLLLPFFTPA
Mb0099|M.bovis_AF2122/97            KYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPT
Rv0096|M.tuberculosis_H37Rv         KYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPT
MLBr_01991|M.leprae_Br4923          KYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYYASYGMLLLPFFAPA
MAB_0669|M.abscessus_ATCC_1997      --FQQWFEKMGFNPATSAVLAVIMLFLYDLLWYPYYASY---LLPFLIPA
Mflv_0325|M.gilvum_PYR-GCK          GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1       GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MSMEG_0619|M.smegmatis_MC2_155      GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu      GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
MAV_4872|M.avium_104                AALTQLLRDIWLLIVDEIGHAIEAFQAFAPQIAAFSLALPAGAAAGLAGL
                                          :  :    .         :            .            

MMAR_0261|M.marinum_M               LSALSALSALA--YLANRTPITAPVAAPAERS-----VADLAGPQPVVGL
MUL_4853|M.ulcerans_Agy99           LSALSVLSALA--YLANRTPITAPVAAPAERS-----VADLAGPQPVVGL
Mb0099|M.bovis_AF2122/97            LSALTALSALI--HLLN-LPPAGLLPIAAALG-----PGDQWGANLAVAV
Rv0096|M.tuberculosis_H37Rv         LSALTALSALI--HLLN-LPPAGLLPIAAALG-----PGDQWGANLAVAV
MLBr_01991|M.leprae_Br4923          LSVLGTLS-----VLWNGQLSAGLPPNPAGSH-----PDNNAGPRIHVGV
MAB_0669|M.abscessus_ATCC_1997      LSGLSGLAALM--HLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALP
Mflv_0325|M.gilvum_PYR-GCK          LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1       VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MSMEG_0619|M.smegmatis_MC2_155      LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu      LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
MAV_4872|M.avium_104                SG-LAAIQKAAPLPALPAAPPPQPSSMPAVVAGPAMGAAAVAAP------
                                                                :                     

MMAR_0261|M.marinum_M               TPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAPPGVSS
MUL_4853|M.ulcerans_Agy99           TPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAPPGVSS
Mb0099|M.bovis_AF2122/97            TPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSS
Rv0096|M.tuberculosis_H37Rv         TPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSS
MLBr_01991|M.leprae_Br4923          APPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSS
MAB_0669|M.abscessus_ATCC_1997      LPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVPPGVSF
Mflv_0325|M.gilvum_PYR-GCK          MSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFS
Mvan_0415|M.vanbaalenii_PYR-1       VSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFS
MSMEG_0619|M.smegmatis_MC2_155      ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFT
TH_3569|M.thermoresistible__bu      ----------VRAEPQNPLPLTXXX-------------------------
MAV_4872|M.avium_104                ---APASAGAPAPASATVTASGAAPPPPSGIGGTAYPYLIGG--PTIGSG
                                                                                      

MMAR_0261|M.marinum_M               GPRATTGAAATATDTTRAAAPAALSS--SRASRRKRSKNRVGVRGYRDEF
MUL_4853|M.ulcerans_Agy99           GPGATTGAAATATDTTRPAAPAALSS--SRAGRRKRSKNRVGVRGYRDEF
Mb0099|M.bovis_AF2122/97            GPKAGTKSPDTAADTLATAGAARPGL--ARAHRRKRSESGVGIRGYRDEF
Rv0096|M.tuberculosis_H37Rv         GPKAGTKSPDTAADTLATAGAARPGL--ARAHRRKRSESGVGIRGYRDEF
MLBr_01991|M.leprae_Br4923          GPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGYRYEF
MAB_0669|M.abscessus_ATCC_1997      GPKSTEKSSESAVDTVAAVAAARGAVA-AQARRRLRGKNKAEAGGRRHEY
Mflv_0325|M.gilvum_PYR-GCK          PTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAY
Mvan_0415|M.vanbaalenii_PYR-1       PTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAY
MSMEG_0619|M.smegmatis_MC2_155      PTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAY
TH_3569|M.thermoresistible__bu      --------------------------------------------------
MAV_4872|M.avium_104                TGMGSGAQRKASEPDPAAAAAPAGASASERARARRRRRAAMKDRYRGYEF
                                                                                      

MMAR_0261|M.marinum_M               LQEPATMDSPIDAPGTAEPAPSPSS-QGAGPLGLTGTAASHDG-AAAGMV
MUL_4853|M.ulcerans_Agy99           LQEPATMDSPIDAPGTAEPAPSPSS-QGAGPLGLTGTAASHDG-AAAGMV
Mb0099|M.bovis_AF2122/97            LDATATVDAATDVP---APANAAGS-QGAGTLGFAGTAPTTSG-AAAGMV
Rv0096|M.tuberculosis_H37Rv         LDATATVDAATDVP---APANAAGS-QGAGTLGFAGTAPTTSG-AAAGMV
MLBr_01991|M.leprae_Br4923          VEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTAS-TPTGMA
MAB_0669|M.abscessus_ATCC_1997      LEETAGMGATATAD---VPAYAATG-RGTGPLGFAGTAPAAASTHVAATV
Mflv_0325|M.gilvum_PYR-GCK          ADYEELPDDGPPEQPA--PRVTAST-RGAGPMGFAGTVSRGDE-QAGGLT
Mvan_0415|M.vanbaalenii_PYR-1       ADYEPEPDDEPPVRQE--PRIAATE-RGAGPMGFAGTVSRDAA-QAGGLT
MSMEG_0619|M.smegmatis_MC2_155      MDYEE-PDEDPAPQPE--PRVRASE-RGSDAMGFTGTVTRHDV-TAAGLT
TH_3569|M.thermoresistible__bu      --------------------------------------------------
MAV_4872|M.avium_104                MDVEPDAGPEPETDS-----VTASD-RGAGPLGFAGTAPSAPA-QATGLA
                                                                                      

MMAR_0261|M.marinum_M               RLSSH--GTSTAVPLLPATWTNDSEGRPEGE--------------
MUL_4853|M.ulcerans_Agy99           RLSSH--GTSTAVPLLPATWTNDSEGRPEGE--------------
Mb0099|M.bovis_AF2122/97            QLSSH--STSTTVPLLPTTWTTDAEQ-------------------
Rv0096|M.tuberculosis_H37Rv         QLSSH--STSTTVPLLPTTWTTDAEQ-------------------
MLBr_01991|M.leprae_Br4923          AS------TSSSVPLLPTTWITGTSETAVHE--------------
MAB_0669|M.abscessus_ATCC_1997      RLSSD--EARQVIPMLPSTWDADGGDQN-----------------
Mflv_0325|M.gilvum_PYR-GCK          TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1       TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155      TLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu      ---------------------------------------------
MAV_4872|M.avium_104                TLAGDEFGTGPSMPMVPGNWTGE----------------------