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VTASVWMASPPEVHSALLSAGPGPGPLYEAATAWTALSAEHASVAEELTTLLGGAAATWEGTSAQSYVDA HAPYLAWLTTTSADYAATAAEHEVAAGAYTSALATMPTLAELAVNHTTHTALVATNFFGLNTIPITLNEA DYARMWIQAATTMSAYQVISGTTLASMPHTTPAPPVLKAEIGTLAGALSDALVPAPLFLWETILAIIAFI AKLAEFIYLFVSELIALLIAGELLQALMFVIGTVAFVVWALATVVIENIIPIMIALLAAAIAPVPLALAV AASSPFAVATACALTGTERGLSAAFDIDIAQNLPFLLSLYAQPASVGVPPADAGLATASAKPVAAHTGAK PLWDSSSAVASAGDGPPSVAPEARLVATSTLAHPNTTATTVACQQDSKAPGFAGTLSAKSHASPAGVTVL ESNDFSDSPRLPMLPNSWDTDWTNATSGEPVPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3641 | - | - | 100% (453) | PPE family protein |
| M. marinum M | MMAR_4266 | - | e-143 | 61.26% (462) | PPE family protein |
| M. marinum M | MMAR_3379 | - | e-128 | 57.14% (448) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 1e-80 | 42.76% (449) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-74 | 37.11% (512) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 5e-80 | 41.63% (454) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 9e-59 | 30.81% (555) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-72 | 37.13% (501) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 1e-78 | 40.08% (489) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-70 | 36.64% (524) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-66 | 46.75% (308) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2686 | - | 6e-81 | 71.98% (207) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-71 | 36.31% (526) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MMAR_3641|M.marinum_M ----------MTA---SVWMASPPEVHSALLSAGPGPGPLYEAATAWTAL
MUL_2686|M.ulcerans_Agy99 ----------MVG---SAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
: . . *:* ******::** ***.* : *. * *
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MMAR_3641|M.marinum_M SAEHASVAEELTTLLGGAAA-TWEGTSAQSYVDAHAPYLAWLTTTSADYA
MUL_2686|M.ulcerans_Agy99 AAEHASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
:: :: * ** : . *:* :: : *: **: ** *. *
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MMAR_3641|M.marinum_M ATAAEHEVAAGAYTSALATMPTLAELAVNHTTHTALVATNFFGLNTIPIT
MUL_2686|M.ulcerans_Agy99 ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* . :. * .* :*: ***: **: *: * .*: ***:*:**:**:
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
MMAR_3641|M.marinum_M LNEADYARMWIQAATTMSAYQVISGTTLASMPHTTPAPPVLKAEIGTLAG
MUL_2686|M.ulcerans_Agy99 VNEADYARMWVQAATTMGAYQVILGTALASMPHTTPAPLILNAEP-----
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *.:*: : : : * : .** :: .
Mb3047c|M.bovis_AF2122/97 AVAA-------------------ATITPFPFGELAKFLE-MAAQAF----
Rv3018c|M.tuberculosis_H37Rv AVAA-------------------ATITPFPWHEIVQFLE-ETFAAY----
MMAR_3641|M.marinum_M ALSD----------A-------LVPAPLFLWETILAIIA-FIAKLA----
MUL_2686|M.ulcerans_Agy99 ----------------------------LILEPEIEIAK-FITDP-----
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAA-------QAGAAFDVSNIIADIIR-LYGEVLRFLF
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAA-------EAGSALDLSNIIADLIR-AYGELLRFLF
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAA-------ESGSSLDLSSIISDLLN-QYLQGVPGGQ
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAA-------DSGTALNLSDLIANLLQ-YYQDYLDQLF
MAB_4783|M.abscessus_ATCC_1997 TAA-------QDATK-------PPPIVPDPNDPIEMLLK-NSQHFL-GMY
MAV_4867|M.avium_104 LAAN---------AA-------QNSS----GDWWQNFIQ-QLSQFF----
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
:
Mb3047c|M.bovis_AF2122/97 -------------------TE--------------------------VGE
Rv3018c|M.tuberculosis_H37Rv -------------------DQ--------------------------YLS
MMAR_3641|M.marinum_M ---------------EFIYLF--------------------------VSE
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EPIFNFLRDPIGNTFALITDF--------------------------LTN
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLRDPLGNTIKLITDF--------------------------LTN
MSMEG_0619|M.smegmatis_MC2_155 -AILDFLKDPLGNLGRLLTDF--------------------------MTN
TH_3569|M.thermoresistible__bu GPIVDFLRDPIGNLFQLIDDF--------------------------LTN
MAB_4783|M.abscessus_ATCC_1997 RALKGLITDPVGTIVRIIIDF--------------------------STN
MAV_4867|M.avium_104 -----------QNIQKMLQDF--------------------------WAN
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
Mb3047c|M.bovis_AF2122/97 LIMKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFFATVGFALGVFVLV
Rv3018c|M.tuberculosis_H37Rv ALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVA
MMAR_3641|M.marinum_M LIALLIAGELLQALMFVIGTVAFVVWALATVVIENIIPIMIALLAAAIAP
MUL_2686|M.ulcerans_Agy99 -----------------VGSAVMGIWEMFCCFWII---------------
Mflv_0325|M.gilvum_PYR-GCK PVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQ
Mvan_0415|M.vanbaalenii_PYR-1 PAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGA
MSMEG_0619|M.smegmatis_MC2_155 PAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGL
TH_3569|M.thermoresistible__bu PAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGL
MAB_4783|M.abscessus_ATCC_1997 PAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAITL
MAV_4867|M.avium_104 LPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAP---FLLPLLLGIGL
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
Mb3047c|M.bovis_AF2122/97 PLLEFAVVLELAILSIGWIISNIFGAIPVLAGPLLGALAAAVVPG-VAGV
Rv3018c|M.tuberculosis_H37Rv VGLLYAIAGVIDIV-VEWVIGNLFGVVPLLGGPLLGALAAAVVPG-VAGL
MMAR_3641|M.marinum_M VPLALAVAA---SSPFAVATACALTGTERGLSAAFDIDIAQNLPFLLSLY
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK HLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIA
Mvan_0415|M.vanbaalenii_PYR-1 YLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAAT
MSMEG_0619|M.smegmatis_MC2_155 VLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATA
TH_3569|M.thermoresistible__bu VMIADQAQP-----PAEEAAPEEDVAAP-------------------VRA
MAB_4783|M.abscessus_ATCC_1997 ASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTT
MAV_4867|M.avium_104 SSLLAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPAS
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
Mb3047c|M.bovis_AF2122/97 TGLAGLAAVPAVGAAAGAPAALVG-------------SVAPVS-------
Rv3018c|M.tuberculosis_H37Rv AGVAGLAALPAVGAAAGAPAALVG-------------SVAPVS-------
MMAR_3641|M.marinum_M AQPASVGVPPADAGLATASAKPVAAHTG--------AKPLWDS-------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDS-------
Mvan_0415|M.vanbaalenii_PYR-1 VGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDS-------
MSMEG_0619|M.smegmatis_MC2_155 AAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNK-------
TH_3569|M.thermoresistible__bu EPQNPLPLTXXX--------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TSPATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGAS-------
MAV_4867|M.avium_104 TVAAGSGAAAAP-GPAAAAGNFAYLVAFGGDPDTGVGPTLSGR-------
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
Mb3047c|M.bovis_AF2122/97 --GGVVSPQARLVSAVEPAPASTSVS------------------------
Rv3018c|M.tuberculosis_H37Rv --GGVVSPQARLVSAVEPAPASTSVS------------------------
MMAR_3641|M.marinum_M --SSAVASAGDGPPSVAPEARLVATSTLAHPN------------------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK --TGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYE
Mvan_0415|M.vanbaalenii_PYR-1 --TSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYE
MSMEG_0619|M.smegmatis_MC2_155 --SQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --TGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMD
MAV_4867|M.avium_104 --GGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFG
MLBr_01828|M.leprae_Br4923 LVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKV
Mb3047c|M.bovis_AF2122/97 --------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DEF
Rv3018c|M.tuberculosis_H37Rv --------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DEF
MMAR_3641|M.marinum_M ----------TTATTVACQQDSKAPGFAGTLSAKSHASPAGVTVLESNDF
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSF
Mvan_0415|M.vanbaalenii_PYR-1 PEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPF
MSMEG_0619|M.smegmatis_MC2_155 E-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTF
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAE
MAV_4867|M.avium_104 VPPDYGAEEELAA-AVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDDF
MLBr_01828|M.leprae_Br4923 TPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGTF
Mb3047c|M.bovis_AF2122/97 GDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV-
Rv3018c|M.tuberculosis_H37Rv GDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV-
MMAR_3641|M.marinum_M SDSPRLPMLPNSWDTDWTNA--------TSGEPVPA---
MUL_2686|M.ulcerans_Agy99 ---------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-
Mvan_0415|M.vanbaalenii_PYR-1 GGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-
MSMEG_0619|M.smegmatis_MC2_155 DDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-
TH_3569|M.thermoresistible__bu ---------------------------------------
MAB_4783|M.abscessus_ATCC_1997 N--RTIPMLPGTWDVTDDDR-------------------
MAV_4867|M.avium_104 GGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG--
MLBr_01828|M.leprae_Br4923 SDSPRAPMLPRTWGADPTFCYN----AADIGPAGGWDDE