For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TASVWMASPPEVHSALLSAGPGPGPLHEAATAWTALSTEHAEAAAELTTLLGGAAAAWQGPSAQSYVDAH APYLAWLTTTSADYAATAAEHEVAAGAYTSALATMPTLAELAVNHTTHTALVATNFFGLNTIPITLNEAD YARMWIQAATTMSAYQVVSGTTLASMPHTTPAPPILNTQIGTTSALAATGQPGILSLFWEGILLLLQVPG ELLALLLAGQFLPALVLALIAVGAIFLLPIALVLDILTAFPILVQILAWLIALSIALAVLLSPLIAVLAA LSAVLAPPVSAVLLASGIATAVALTGTERGLSAAFDIDIARNLPLLPSLYAQPATVATGPANAGLATASA APVAAHTATASSANQSSAMEPTGNRPPGTMSETLLTSAPAAASPSPVAAAMFGEHQARTLGFAGTSHTES LQSPAGIAVLESSYPGGGPQLPLLPTTWSPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4266 | - | - | 100% (452) | PPE family protein |
| M. marinum M | MMAR_3379 | - | e-152 | 64.59% (449) | PPE family protein |
| M. marinum M | MMAR_3641 | - | e-143 | 61.26% (462) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 4e-82 | 41.05% (497) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-74 | 36.89% (534) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 4e-82 | 41.05% (497) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 4e-57 | 32.30% (551) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-69 | 44.92% (394) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 2e-78 | 41.61% (471) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-69 | 38.42% (505) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-66 | 47.24% (326) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2686 | - | 4e-81 | 78.89% (180) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-73 | 38.45% (515) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4266|M.marinum_M ----------MTA---SVWMASPPEVHSALLSAGPGPGPLHEAATAWTAL
MUL_2686|M.ulcerans_Agy99 ----------MVG---SAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
Mb0294|M.bovis_AF2122/97 ----------MAA---PIWMASPPEVHSALLSNGPGPGSLVAAATAWSQL
Rv0286|M.tuberculosis_H37Rv ----------MAA---PIWMASPPEVHSALLSNGPGPGSLVAAATAWSQL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
: . . *** ******::** ***.* : *. :* *
MMAR_4266|M.marinum_M STEHAEAAAELTTLLGGAAA-AWQGPSAQSYVDAHAPYLAWLTTTSADYA
MUL_2686|M.ulcerans_Agy99 AAEHASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
Mb0294|M.bovis_AF2122/97 SAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAA
Rv0286|M.tuberculosis_H37Rv SAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
:: :: * ** : . *:* :: * *: **: ** *. *
MMAR_4266|M.marinum_M ATAAEHEVAAGAYTSALATMPTLAELAVNHTTHTALVATNFFGLNTIPIT
MUL_2686|M.ulcerans_Agy99 ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
Mb0294|M.bovis_AF2122/97 GAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPIT
Rv0286|M.tuberculosis_H37Rv GAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPIT
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* . :. * ** :*: ***: **: *:. * .*: ***:*:**:**:
MMAR_4266|M.marinum_M LNEADYARMWIQAATTMSAYQVVSGTTLASMPHTTPAPPILNTQIGTTSA
MUL_2686|M.ulcerans_Agy99 VNEADYARMWVQAATTMGAYQVILGTALASMPHTTPAPLILNAEP-----
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
Mb0294|M.bovis_AF2122/97 LNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPG-GGAAS
Rv0286|M.tuberculosis_H37Rv LNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPG-GGAAS
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *. ** : : * : .** :: .
MMAR_4266|M.marinum_M ------------------LAATGQPGILSLFWE-GILLLLQVPGELLALL
MUL_2686|M.ulcerans_Agy99 -------------------------------------LILEPEIEIAKFI
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRL-YGEVLRFLFEPIFNFL
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRA-YGELLRFLFEPIFDFL
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQ-YLQGVPGGQ-AILDFL
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQY-YQDYLDQLFGPIVDFL
MAB_4783|M.abscessus_ATCC_1997 TAA-------QDATKPPPIVPDPNDPIEMLLKN-SQHFL-GMYRALKGLI
Mb0294|M.bovis_AF2122/97 ------------TVGAVNPWQWLLALLQQLWNA-YTGFYGWMLQLIWQFL
Rv0286|M.tuberculosis_H37Rv ------------TVGAVNPWQWLLALLQQLWNA-YTGFYGWMLQLIWQFL
MAV_4867|M.avium_104 ------------LAAN------------AAQNS-SGDWWQNFIQQLSQFF
MLBr_01828|M.leprae_Br4923 D---------QPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSL
: :
MMAR_4266|M.marinum_M LAG--QFLPALVLALIAVGAIFLLPIALVLDILTAFPILVQILAWLIALS
MUL_2686|M.ulcerans_Agy99 TD--------------PVGSAVMG----IWEMFCCF--------WII---
Mflv_0325|M.gilvum_PYR-GCK RDP--IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPS
Mvan_0415|M.vanbaalenii_PYR-1 RDP--LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPS
MSMEG_0619|M.smegmatis_MC2_155 KDP--LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGM
TH_3569|M.thermoresistible__bu RDP--IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAM
MAB_4783|M.abscessus_ATCC_1997 TDP--VGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAA
Mb0294|M.bovis_AF2122/97 QDP--IGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGM
Rv0286|M.tuberculosis_H37Rv QDP--IGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGM
MAV_4867|M.avium_104 QN------IQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGA
MLBr_01828|M.leprae_Br4923 TNHPFFQGMFSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLS
.
MMAR_4266|M.marinum_M IALAVLLSPLIAVLA----------------------------------A
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LFLLPLLATTLAIVA----------------------------------G
Mvan_0415|M.vanbaalenii_PYR-1 LLLLPLVATTLAIVL----------------------------------G
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG----------------------------------I
TH_3569|M.thermoresistible__bu ILASPVLIPLAITLG----------------------------------V
MAB_4783|M.abscessus_ATCC_1997 IMGP---AAGISIPL----------------------------------A
Mb0294|M.bovis_AF2122/97 ILSSPFLLPAGLGLG----------------------------------L
Rv0286|M.tuberculosis_H37Rv ILSSPFLLPAGLGLG----------------------------------L
MAV_4867|M.avium_104 ILTAPFLLPLLLGIG----------------------------------L
MLBr_01828|M.leprae_Br4923 QTFAFIGADLAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIE
MMAR_4266|M.marinum_M LSAVLAPPVSAVLLASGIATAVALTGTERGLSAAFDIDIARNLPLLPSLY
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK VGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGA
Mvan_0415|M.vanbaalenii_PYR-1 VGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSA
MSMEG_0619|M.smegmatis_MC2_155 TGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSA
TH_3569|M.thermoresistible__bu AGLVMIADQAQP-----PAEEAAPEEDVAAP-------------------
MAB_4783|M.abscessus_ATCC_1997 ITLASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--T
Mb0294|M.bovis_AF2122/97 AAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGA
Rv0286|M.tuberculosis_H37Rv AAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGA
MAV_4867|M.avium_104 SSLLAAPAEIAP--VAAPAAITPVLASNKPP-TLPAAVALAPSVATPAGA
MLBr_01828|M.leprae_Br4923 QSFVLLPMILPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPP
MMAR_4266|M.marinum_M AQPATVATGPAN------AGLATASAAPVAAHTATASSANQSSAMEPTGN
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK PIAANTVSAGSP------PAPGAPAAAAATFVPYVVAGRDPYEGFSPTVR
Mvan_0415|M.vanbaalenii_PYR-1 AATVGTVATGTA------PAPGAPAAATASFVPYAVAGRDPGTGFSPTVR
MSMEG_0619|M.smegmatis_MC2_155 ATAAAPAPAPAG------TTVAAPAPAAATFVPYAVANRDPGEGFTPTLG
TH_3569|M.thermoresistible__bu VRAEPQNPLPLT------XXX-----------------------------
MAB_4783|M.abscessus_ATCC_1997 PTTTSPATPGSA------PAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIG
Mb0294|M.bovis_AF2122/97 ATPAAGAAPSAG------AAPAPAAPATASFAYAVGGSGDWGPSLGPTVG
Rv0286|M.tuberculosis_H37Rv ATPAAGAAPSAG------AAPAPAAPATASFAYAVGGSGDWGPSLGPTVG
MAV_4867|M.avium_104 PASTVAAGSGAA------AAPGPAA-AAGNFAYLVAFGGDPDTGVGPTLS
MLBr_01828|M.leprae_Br4923 VAAVAPVVPPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVT
MMAR_4266|M.marinum_M RPPGTMS-------ETLLTSAPAAASPSPVAA------------------
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DSTGAKA-------PAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 DSTSAKA-------PASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MSMEG_0619|M.smegmatis_MC2_155 NKSQVAA-------PASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 ASTGATA-------HAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
Mb0294|M.bovis_AF2122/97 GRGGIKA-------PAATVPAAAAAAATRGQSRARRRRRS----ELRDYG
Rv0286|M.tuberculosis_H37Rv GRGGIKA-------PAATVPAAAAAAATRGQSRARRRRRS----ELRDYG
MAV_4867|M.avium_104 GRGGAKA-------PAATIPAAGAAAPARAEARARRRRRA----ALHDYS
MLBr_01828|M.leprae_Br4923 GAGVESFGYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQAR
MMAR_4266|M.marinum_M ------------------------AMFGEHQARTLGFAGTSHTESLQSPA
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPR---VTASTRGAGPMGFAGTVSRG-DEQAG
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPR---IAATERGAGPMGFAGTVSRD-AAQAG
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPR---VRASERGSDAMGFTGTVTRH-DVTAA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGP--QDPVT---AVASGTGAGRLGFAGVHTATTAVEAT
Mb0294|M.bovis_AF2122/97 DEFLDMDSDSGFGPSTGDHG----AQASERGAGTLGFAGTATKERRVRAV
Rv0286|M.tuberculosis_H37Rv DEFLDMDSDSGFGPSTGDHG----AQASERGAGTLGFAGTATKERRVRAV
MAV_4867|M.avium_104 DEFLDMDSGFGVPPDYGAEEELAAAVASGQGAGTLGFAGTQQRRKAFQAA
MLBr_01828|M.leprae_Br4923 SRWRRRAKVTPFDSSGSPNPK-AAPTASDQGAGTLGLAGTARQASSGPAT
MMAR_4266|M.marinum_M GIAVLESSYPGGGPQLPLLPTTWSPS-----------------------
MUL_2686|M.ulcerans_Agy99 -------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK GLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-
MSMEG_0619|M.smegmatis_MC2_155 GLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-
TH_3569|M.thermoresistible__bu -------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GLSTLDGDAEN--RTIPMLPGTWDVTDDDR-------------------
Mb0294|M.bovis_AF2122/97 GLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK
Rv0286|M.tuberculosis_H37Rv GLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK
MAV_4867|M.avium_104 GLTKLADDDFGGSPRMPMVPGTWEQDTQNGAHPTEPGKGG---------
MLBr_01828|M.leprae_Br4923 GLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE----