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TAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAA YVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEA DYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFA AYDQYLSALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDI VVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVS PQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGPD LVGVAGDGGLVSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | - | 100% (434) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3021c | PPE47 | e-148 | 77.68% (354) | PPE family protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 4e-88 | 41.24% (531) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3043c | PPE46 | 0.0 | 99.54% (431) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-71 | 43.95% (380) | PPE protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-57 | 35.89% (443) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 2e-70 | 36.98% (503) | PPE family protein |
| M. marinum M | MMAR_3006 | - | 1e-87 | 46.17% (444) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 7e-85 | 42.36% (484) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-79 | 38.55% (511) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-77 | 50.00% (336) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 1e-86 | 42.18% (505) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-81 | 39.19% (518) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3018c|M.tuberculosis_H37Rv ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Mb3043c|M.bovis_AF2122/97 -------MSSHRTPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
MMAR_3006|M.marinum_M ----------------MAAPPEVHAASLSTGPGPGPLQNAAAAWASLSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
:* *****:: ** ***...: *. * :**:
Rv3018c|M.tuberculosis_H37Rv YAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
Mb3043c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
MMAR_3006|M.marinum_M YASVAEELAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYAVMA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
** * ** :: . *:* :. :. :: ** ** : *. * *
Rv3018c|M.tuberculosis_H37Rv GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Mb3043c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
MMAR_3006|M.marinum_M AEHEAAAAEYVAALAAMPTLAELAINHAAHAVLLGTNFFGINTIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
:. *. * :** ***:.** *: * **: ***:*:*:**** .*
Rv3018c|M.tuberculosis_H37Rv ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
Mb3043c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
MMAR_3006|M.marinum_M ADYARMWVQAATVMSVYEAGSTAALAAAPRGVPAPVVLKAGAAEG---VS
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGG-EANNLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSRMSA
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
** ***::** *. *: .: ::. ..* :: .. : .
Rv3018c|M.tuberculosis_H37Rv AATITPFPWHEIV-------------------------------------
Mb3043c|M.bovis_AF2122/97 AATITPFPWHEIV-------------------------------------
MMAR_3006|M.marinum_M AAALP---------------------------------------------
MAV_4867|M.avium_104 NAAQNSSG-------DWWQNF-----------------------------
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQLL-----------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQ-AGAAFDV-----------------------------
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAE-AGSALDL-----------------------------
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAE-SGSSLDL-----------------------------
TH_3569|M.thermoresistible__bu TTQQIGSQATAAD-SGTALNL-----------------------------
MAB_0047|M.abscessus_ATCC_1997 DMMSMAAQPQAAE-SGSALDS-----------------------------
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
Rv3018c|M.tuberculosis_H37Rv ----------------------------------QFLEETFAAYDQYLSA
Mb3043c|M.bovis_AF2122/97 ----------------------------------QFLEETFAAYDQYLSA
MMAR_3006|M.marinum_M ------------------------------------------AAAAELPI
MAV_4867|M.avium_104 -----------IQQLS------------------QFFQN----IQKMLQD
MUL_1208|M.ulcerans_Agy99 -----------WQLLQYLWNAYTGFNTWMFDLIWEFLQDPIGNTIKIIIA
Mflv_0325|M.gilvum_PYR-GCK -----------SNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITD
Mvan_0415|M.vanbaalenii_PYR-1 -----------SNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIKLITD
MSMEG_0619|M.smegmatis_MC2_155 -----------SSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLGRLLTD
TH_3569|M.thermoresistible__bu -----------SDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQLIDD
MAB_0047|M.abscessus_ATCC_1997 -----------SNNIMDQL--------------MRFMTNPLGTLQDMIED
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
:
Rv3018c|M.tuberculosis_H37Rv LLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAV
Mb3043c|M.bovis_AF2122/97 LLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAV
MMAR_3006|M.marinum_M IIVILIQIILVLLEILYAIVAYTII--LSIILPIIVVVEAFVLSVVAVIL
MAV_4867|M.avium_104 FWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAPFLLPLLLGIG
MUL_1208|M.ulcerans_Agy99 FLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSPFLLPAALGLA
Mflv_0325|M.gilvum_PYR-GCK FLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVA
Mvan_0415|M.vanbaalenii_PYR-1 FLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVL
MSMEG_0619|M.smegmatis_MC2_155 FMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALG
TH_3569|M.thermoresistible__bu FLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLG
MAB_0047|M.abscessus_ATCC_1997 FMRNPVAAFFAWFPLLFFIAYEAFFIPFGFTFWGVLLSAPAWLPIVLGLA
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
:: : .
Rv3018c|M.tuberculosis_H37Rv GLLYAIAGVIDIVVEWVIGNLFGV-VPLLGGP------------------
Mb3043c|M.bovis_AF2122/97 GLLYAIAGVIDIVVEWVIGNLFGV-VPLLGGP------------------
MMAR_3006|M.marinum_M GTPILLVSSPFLLTGSLIGLTAGVPVSLATAL------------------
MAV_4867|M.avium_104 LSSLLAAPAEIAP---VAAPAAITPVLASNKPPTLPAAVALAPSVATPAG
MUL_1208|M.ulcerans_Agy99 LSAIAFTPIQIAA---EVPAAAAPLAAAAVTAKSVFPAASLASPGTGSAG
Mflv_0325|M.gilvum_PYR-GCK GVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSG
Mvan_0415|M.vanbaalenii_PYR-1 GVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSS
MSMEG_0619|M.smegmatis_MC2_155 ITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGS
TH_3569|M.thermoresistible__bu VAGLVMIADQAQP-----PAEEAAPEEDVAAP------------------
MAB_0047|M.abscessus_ATCC_1997 LSALVPPAGIEEPGQEDEPGREPTRIE-RRSPQQDLQLAHVPSGSPTPGG
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
Rv3018c|M.tuberculosis_H37Rv -LLGALAAAV--VPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSG
Mb3043c|M.bovis_AF2122/97 -LLGALAAAV--VPGVAGLAGVAGLAAVPAVGAAAGAPAALVGSVAPVSG
MMAR_3006|M.marinum_M -PIGIPAYLA--DQSRRDELNDTDQEHVVFVGARAGMAPLLTASTAP---
MAV_4867|M.avium_104 APASTVAAGS--GAAAAPGP-AAAAGNFAYLVAFGGDPDTGVGPTLSGRG
MUL_1208|M.ulcerans_Agy99 APASGAGAGA--PGTAPPGPGAPAPASFLYAVGGSGDWGPSLGPTVGGRS
Mflv_0325|M.gilvum_PYR-GCK APIAANTVSA--GSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDST
Mvan_0415|M.vanbaalenii_PYR-1 AAATVGTVAT--GTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDST
MSMEG_0619|M.smegmatis_MC2_155 AATAAAPAPA--PAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKS
TH_3569|M.thermoresistible__bu -VRAEPQNPL--PLTXXX--------------------------------
MAB_0047|M.abscessus_ATCC_1997 STTTTVTSGG--SAPPAP-APATATPAYMVYAVQEDPPAARFGPTLNEGS
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVG
Rv3018c|M.tuberculosis_H37Rv GVVSPQARLVSAVEPAPASTS-----------------------------
Mb3043c|M.bovis_AF2122/97 GVVSPQARLVSAVEPAPASTS-----------------------------
MMAR_3006|M.marinum_M ---APAAGLASAGSAVPASNS-----------------------------
MAV_4867|M.avium_104 GAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFGVPP
MUL_1208|M.ulcerans_Agy99 GAKAPAVTIPAAGAAAASRASARSRRRRRTEMRDYGDEFLDMDAN-GVT-
Mflv_0325|M.gilvum_PYR-GCK GAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELP
Mvan_0415|M.vanbaalenii_PYR-1 SAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEP
MSMEG_0619|M.smegmatis_MC2_155 QVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-P
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 GAKAPAAGISAAAA-AAASARSRARRKRAARIKDPAPQFMDMNSSVAPDF
MLBr_01828|M.leprae_Br4923 RLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTPF
Rv3018c|M.tuberculosis_H37Rv ---------VSVLASDRGAGALGFVGTAGKES-VGQPAGLT---VLAD-E
Mb3043c|M.bovis_AF2122/97 ---------VSVLASDRGAGALGFVGTAGKES-VGQPAGLT---VLAD-E
MMAR_3006|M.marinum_M ---------VSTVASERGADMSSFAGTSTKGS-VGQPAGLT---ALGGSE
MAV_4867|M.avium_104 DYGAEEELAAAV-ASGQGAGTLGFAGTQQRRK-AFQAAGLT---KLADDD
MUL_1208|M.ulcerans_Agy99 --GPAATDDAAR-ASERGAGQFGFAGTVSTEA-VLQAAGLT---ELAVDE
Mflv_0325|M.gilvum_PYR-GCK DDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQAGGLT---TLAGDS
Mvan_0415|M.vanbaalenii_PYR-1 DDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQAGGLT---TLPGDP
MSMEG_0619|M.smegmatis_MC2_155 DEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VTAAGLT---TLTGDT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 SES-AARQTTGVGASARGAGRLGFAGTAPAAAGTTAAAGLVERDSGTAEA
MLBr_01828|M.leprae_Br4923 DSSGSPNPKAAPTASDQGAGTLGLAGTARQAS-SGPATGLV---TLSNGT
Rv3018c|M.tuberculosis_H37Rv FGDGAPVPMLPGSWGPDLVGV----------AGDGGLVSV
Mb3043c|M.bovis_AF2122/97 FGDGAPVPMLPGSWGPDLVGV----------AGDGGLVSV
MMAR_3006|M.marinum_M FEGGSREPMLPATWGPALVGV----------AN-------
MAV_4867|M.avium_104 FGGSPRMPMVPGTWEQDTQNG--------AHPTEPGKGG-
MUL_1208|M.ulcerans_Agy99 FGNGPRMPMVPGSWDSPQEGR--------EDGLQSE----
Mflv_0325|M.gilvum_PYR-GCK FGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-
Mvan_0415|M.vanbaalenii_PYR-1 FGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-
MSMEG_0619|M.smegmatis_MC2_155 FDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-
TH_3569|M.thermoresistible__bu ----------------------------------------
MAB_0047|M.abscessus_ATCC_1997 LDGARTVPMLPTSWGTDSEHG-------PDRPAEGGSST-
MLBr_01828|M.leprae_Br4923 FSDSPRAPMLPRTWGADPTFCYN----AADIGPAGGWDDE