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VGSAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVLAAEHASAAEELTSIVGGAAAAWEGPSAQSYVDAH VPYLTWLATTSADYAATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPITVNEAD YARMWVQAATTMGAYQVILGTALASMPHTTPAPLILNAEPLILEPEIEIAKFITDPVGSAVMGIWEMFCC FWII*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2686 | - | - | 100% (215) | PPE family protein |
| M. ulcerans Agy99 | MUL_2247 | - | 5e-61 | 61.67% (180) | PPE family protein |
| M. ulcerans Agy99 | MUL_1154 | - | 8e-60 | 61.24% (178) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 7e-61 | 62.01% (179) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-60 | 63.58% (173) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 7e-61 | 62.01% (179) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-47 | 51.69% (178) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 4e-56 | 57.46% (181) | PPE family protein |
| M. marinum M | MMAR_3378 | - | 1e-115 | 98.09% (209) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 4e-62 | 65.34% (176) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-60 | 60.67% (178) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-61 | 61.80% (178) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 8e-60 | 61.80% (178) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2686|M.ulcerans_Agy99 ----------MVG---SAWMALPPEVHSAFLSAGPGPGLLREAAAAWTVL
MMAR_3378|M.marinum_M ----------MVG---SAWMALPPEVHSALLSAGPGPGPLREAAAAWTVL
Mb0294|M.bovis_AF2122/97 ----------MAA---PIWMASPPEVHSALLSNGPGPGSLVAAATAWSQL
Rv0286|M.tuberculosis_H37Rv ----------MAA---PIWMASPPEVHSALLSNGPGPGSLVAAATAWSQL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
: . . *** ******::** ***.* : *. :* *
MUL_2686|M.ulcerans_Agy99 AAEHASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYA
MMAR_3378|M.marinum_M AAEHASAAEELTSIVGGAAA-AWEGPSAQSYVDAHVPYLTWLATTSADYA
Mb0294|M.bovis_AF2122/97 SAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAA
Rv0286|M.tuberculosis_H37Rv SAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
:: :: * ** : . *:* :: * *: **: ** *. *
MUL_2686|M.ulcerans_Agy99 ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
MMAR_3378|M.marinum_M ATAIEHEVAADAYAGALTAMPTLAELAANRTTHTALVATNFFGLNTVPIT
Mb0294|M.bovis_AF2122/97 GAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPIT
Rv0286|M.tuberculosis_H37Rv GAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPIT
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* . :. * ** :*: ***: **: *:. * .*: ***:*:**:**:
MUL_2686|M.ulcerans_Agy99 VNEADYARMWVQAATTMGAYQVILGTALASMPHTTPAPLILNAEP-----
MMAR_3378|M.marinum_M VNEADYARMWVQAATTMGAYQVISGTALASMPHTTPAPLILNAEP-----
Mb0294|M.bovis_AF2122/97 LNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGG-----
Rv0286|M.tuberculosis_H37Rv LNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGG-----
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGG-----
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *. ** : : * : .** :: .
MUL_2686|M.ulcerans_Agy99 ------------------------------------LILEPEIEIAKFIT
MMAR_3378|M.marinum_M ------------------------------------LILEPEIEIAKFIA
Mb0294|M.bovis_AF2122/97 --------GAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQ
Rv0286|M.tuberculosis_H37Rv --------GAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQ
MAV_4867|M.avium_104 --------EANNLAAN------------AAQNSSGDWWQNFIQQLSQFFQ
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLR
MAB_4783|M.abscessus_ATCC_1997 --------TAAQDATKPPPIVPDPNDPIEMLLKNSQHFLGMYRALKGLIT
MLBr_01828|M.leprae_Br4923 --------DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLT
: :
MUL_2686|M.ulcerans_Agy99 DP------------------------------------------VGSAVM
MMAR_3378|M.marinum_M DP------------------------------------------VGSAVM
Mb0294|M.bovis_AF2122/97 DP------------------------------------------IGNSIK
Rv0286|M.tuberculosis_H37Rv DP------------------------------------------IGNSIK
MAV_4867|M.avium_104 N----------------------------------------------IQK
Mflv_0325|M.gilvum_PYR-GCK DP------------------------------------------IGNTFA
Mvan_0415|M.vanbaalenii_PYR-1 DP------------------------------------------LGNTIK
MSMEG_0619|M.smegmatis_MC2_155 DP------------------------------------------LGNLGR
TH_3569|M.thermoresistible__bu DP------------------------------------------IGNLFQ
MAB_4783|M.abscessus_ATCC_1997 DP------------------------------------------VGTIVR
MLBr_01828|M.leprae_Br4923 NHPFFQGMFSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQ
:
MUL_2686|M.ulcerans_Agy99 GIWEMF--------------------------------------------
MMAR_3378|M.marinum_M GIWEMFLLLLDNIVQLLVLIVAGQFLIAFLQLIWTLAIF-------VLLL
Mb0294|M.bovis_AF2122/97 IIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWG--------MILS
Rv0286|M.tuberculosis_H37Rv IIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWG--------MILS
MAV_4867|M.avium_104 MLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWG--------AILT
Mflv_0325|M.gilvum_PYR-GCK LITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYP--------SLFL
Mvan_0415|M.vanbaalenii_PYR-1 LITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYP--------SLLL
MSMEG_0619|M.smegmatis_MC2_155 LLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWG--------MIFA
TH_3569|M.thermoresistible__bu LIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWA--------MILA
MAB_4783|M.abscessus_ATCC_1997 IIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYA--------AIMG
MLBr_01828|M.leprae_Br4923 TFAFIGADLAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQ
: :
MUL_2686|M.ulcerans_Agy99 ------CCFWII--------------------------------------
MMAR_3378|M.marinum_M VEIIKEFAFFLVVAGLAALGAWHVL-------------------------
Mb0294|M.bovis_AF2122/97 SPFLLPAGLGLGLAAIAFLPIVLAP-AVIPPASTPLAAAAVAAGSVWPAV
Rv0286|M.tuberculosis_H37Rv SPFLLPAGLGLGLAAIAFLPIVLAP-AVIPPASTPLAAAAVAAGSVWPAV
MAV_4867|M.avium_104 APFLLPLLLGIGLSSLLAAPAEIAP-VAAPAAITPVLASNKPP-TLPAAV
Mflv_0325|M.gilvum_PYR-GCK LPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSF
Mvan_0415|M.vanbaalenii_PYR-1 LPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSP
MSMEG_0619|M.smegmatis_MC2_155 SPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPL
TH_3569|M.thermoresistible__bu SPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP------
MAB_4783|M.abscessus_ATCC_1997 PAAGISIPLAITLASLSQMP--EAP-PVDAPAET-VPARIDQPHAVAMGG
MLBr_01828|M.leprae_Br4923 SFVLLPMILPLLTAPLAVATAGAAG-SFAGLSELAGLVGVAPPGLPSAPP
:
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3378|M.marinum_M ----------LGLELCIVSAPLGACVLSCVERGLSAAFNIDIAQS----L
Mb0294|M.bovis_AF2122/97 SMAVTGAGTAGAATPAAGAAPS-AGAAPAPAAPATASFAYAVGGSGDWGP
Rv0286|M.tuberculosis_H37Rv SMAVTGAGTAGAATPAAGAAPS-AGAAPAPAAPATASFAYAVGGSGDWGP
MAV_4867|M.avium_104 ALAPSVATPAGAPASTVAAGSG-AAAAPGPAA-AAGNFAYLVAFGGDPDT
Mflv_0325|M.gilvum_PYR-GCK PATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 AIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGT
MSMEG_0619|M.smegmatis_MC2_155 AVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu -------------VRAEPQNPLPLTXXX----------------------
MAB_4783|M.abscessus_ATCC_1997 APAPTASTAAPTPTTTSPATPG-SAPAPTPPPAGAEGLG-YAVRGDGPGF
MLBr_01828|M.leprae_Br4923 VAAVAPVVPPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVT
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3378|M.marinum_M SFLPSLYGQP---APLGMLRADGGAASATLASAHNGELRMPN--------
Mb0294|M.bovis_AF2122/97 SLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----ELRDYG
Rv0286|M.tuberculosis_H37Rv SLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----ELRDYG
MAV_4867|M.avium_104 GVGPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRA----ALHDYS
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
MLBr_01828|M.leprae_Br4923 GAGVESFGYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQAR
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3378|M.marinum_M -------------------------DASPVESTDNGRPSTVSQVQLLTTT
Mb0294|M.bovis_AF2122/97 DEFLDMDSDSGFGPSTGDHG----AQASERGAGTLGFAGTATKERRVRAV
Rv0286|M.tuberculosis_H37Rv DEFLDMDSDSGFGPSTGDHG----AQASERGAGTLGFAGTATKERRVRAV
MAV_4867|M.avium_104 DEFLDMDSGFGVPPDYGAEEELAAAVASGQGAGTLGFAGTQQRRKAFQAA
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPR---VTASTRGAGPMGFAGTVSRG-DEQAG
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPR---IAATERGAGPMGFAGTVSRD-AAQAG
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPR---VRASERGSDAMGFTGTVTRH-DVTAA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGPQDPVTA-----VASGTGAGRLGFAGVHTATTAVEAT
MLBr_01828|M.leprae_Br4923 SRWRRRAKVTPFDSSGSPNPK-AAPTASDQGAGTLGLAGTARQASSGPAT
MUL_2686|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3378|M.marinum_M ----APGYSSTTAPALPPLRTSC---------------------------
Mb0294|M.bovis_AF2122/97 GLTALAGDEFGNGPRMPMVPGTWEQGSNEPE----APDGSGRGGGDGLPH
Rv0286|M.tuberculosis_H37Rv GLTALAGDEFGNGPRMPMVPGTWEQGSNEPE----APDGSGRGGGDGLPH
MAV_4867|M.avium_104 GLTKLADDDFGGSPRMPMVPGTWEQDTQNGA----HPTEPGKGG------
Mflv_0325|M.gilvum_PYR-GCK GLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP--
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ--
MSMEG_0619|M.smegmatis_MC2_155 GLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR--
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GLSTLDGD--AENRTIPMLPGTWDVTDDDR--------------------
MLBr_01828|M.leprae_Br4923 GLVTLSNGTFSDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE--
MUL_2686|M.ulcerans_Agy99 ---
MMAR_3378|M.marinum_M ---
Mb0294|M.bovis_AF2122/97 DSK
Rv0286|M.tuberculosis_H37Rv DSK
MAV_4867|M.avium_104 ---
Mflv_0325|M.gilvum_PYR-GCK ---
Mvan_0415|M.vanbaalenii_PYR-1 ---
MSMEG_0619|M.smegmatis_MC2_155 ---
TH_3569|M.thermoresistible__bu ---
MAB_4783|M.abscessus_ATCC_1997 ---
MLBr_01828|M.leprae_Br4923 ---