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QMTGNTVLVTGGGTGIGRGLAEAFHRLGNRVIIAARRGEQLRAVAEANPGIQTLSLDLGDPADIRRFATE VTDHYPDLNVVVNNAGMQRVEDLISGNAGLAEQTVAVNLLGPIRLIATLLPALLRRPHAAILNVTSGLAF MPSALTPTYCASKAALHSYTQSLRFQLRETPVQVIEIIPPQVQTALQGERGFDPRAMPLDEYITETMTLL QTQPQADEIVVERVKAFRFAERDGTFDDIYPGFNEAMTAASDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5225 | - | - | 100% (254) | DltE protein |
| M. avium 104 | MAV_2098 | - | 2e-20 | 31.12% (196) | short chain dehydrogenase |
| M. avium 104 | MAV_0056 | - | 2e-18 | 36.26% (182) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3199 | - | 2e-16 | 30.26% (195) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4818 | - | 4e-19 | 31.55% (187) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3174 | - | 8e-17 | 30.77% (195) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 1e-15 | 29.10% (189) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4750 | - | 5e-53 | 45.34% (247) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3561 | - | 6e-23 | 33.51% (185) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2013 | - | 2e-18 | 33.88% (183) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2589 | - | 2e-23 | 36.32% (190) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 3e-23 | 33.51% (185) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0894 | - | 3e-19 | 32.22% (180) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5225|M.avium_104 -------------------MQMTGNTVLVTGGGTGIGRGLAEAFHRLGNR
MAB_4750|M.abscessus_ATCC_1997 -------------------MQISGNTVFIPGATSGIGLELALALQAKGNT
Mb3199|M.bovis_AF2122/97 ------------------MTSLAERTALVTGANRGMGREYVAQLLGRKVA
Rv3174|M.tuberculosis_H37Rv ------------------MTSLAERTVLVTGANRGMGREYVAQLLGRKVA
MMAR_3561|M.marinum_M -------------------MTSTPPVALITGVSSGIGAAIAVRLASAGFR
MUL_2794|M.ulcerans_Agy99 -------------------MTSTPPVALITGVSSGIGAAIAVRLASAGFR
Mflv_4818|M.gilvum_PYR-GCK ----------MDRASFDRLFDMTDRTVVVTGGTRGIGLALAEGYALAGAR
TH_2589|M.thermoresistible__bu ----------VDRQTFDKLFDMTGRTVVVTGGTRGIGLALAEGYVLAGAR
Mvan_0894|M.vanbaalenii_PYR-1 MTVDIAREQPATAPRPDQMFDLTGRTALVTGASSGLGVQFALALRSAGAE
MSMEG_2013|M.smegmatis_MC2_155 --------------------MITGRTALVTGAGNGLGRAIALALAHNGAR
MLBr_01740|M.leprae_Br4923 --------------MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAE
.:.* *:* .
MAV_5225|M.avium_104 VIIAARRGEQLRAVAEANPGIQT-----LSLDLGDPADIRRFATEVTDHY
MAB_4750|M.abscessus_ATCC_1997 VIVGGRRIELLDQIRRDHPGVST-----VRIDISDPASIDIAAQQVLTDH
Mb3199|M.bovis_AF2122/97 KVYAATRNP--LAIDVSDPRVIP-----LQLDVTDAVSVAEAADLAT---
Rv3174|M.tuberculosis_H37Rv KVYAATRNP--LAIDVSDPRVIP-----LQLDVTDAVSVAEAADLAT---
MMAR_3561|M.marinum_M VVGTSRAPQR----LAPIPGVET-----LALDVTDDTAVRSVVSEVIDRT
MUL_2794|M.ulcerans_Agy99 VVGTSRAPQR----LAPIPGVET-----LALDVTDDTAVRSVVSEVIDRT
Mflv_4818|M.gilvum_PYR-GCK VVVASRKADACEQAAHHLRELGAQA-IGVPTHLGQVDDLGALVERTVAEF
TH_2589|M.thermoresistible__bu VVVASRKSDACERAAAHLRALGGDA-IGVPTHLGDIDACEALVRRTVDEF
Mvan_0894|M.vanbaalenii_PYR-1 VVVAARRADRLAELCEAHEGLS-----AVSCDVADPASIESAYQCVEERV
MSMEG_2013|M.smegmatis_MC2_155 VVLVGRRREPLAAVAQEIGEAAR----WVDCDTSDPAAVAALGAALSDE-
MLBr_01740|M.leprae_Br4923 LYLTDRHCDGLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARH
. :
MAV_5225|M.avium_104 PDLNVVVNNAGMQRVEDLISGN--AGLAEQTVAVNLLGPIRLIATLLPAL
MAB_4750|M.abscessus_ATCC_1997 PTLNILVTMAGIMRVEDWHHPESFLQSAEEIVTTNVLGPIRLIAAFIEHL
Mb3199|M.bovis_AF2122/97 -DVGILINNAGISRASSVLDKD--TSALRGELETNLFGPLALASAFADRI
Rv3174|M.tuberculosis_H37Rv -DVGILINNAGISRASSVLDKD--TSALRGELETNLFGPLALASAFADRI
MMAR_3561|M.marinum_M GRIDVLVNNAGLGIAGAAEESS--IDQARSLFDTNFFGLIRLTNEVLPHM
MUL_2794|M.ulcerans_Agy99 GHIDVLVNNAGLGIAGAAEESS--IDQARSLFDTNFFGLIRLTNEVLPHM
Mflv_4818|M.gilvum_PYR-GCK GGLDVLVNNAANPLAQPFGHMT--VDALSKSFEVNLQGPVMLTQEALPHL
TH_2589|M.thermoresistible__bu GGIDVLVNNAANALTQPLGELT--VDAWTKSFEVNLRGPVFLVQAALPHL
Mvan_0894|M.vanbaalenii_PYR-1 GAVDILVNNAGTSIPARAEDES--LTDFQYVLDVNLVGAFRLTQLVGRKM
MSMEG_2013|M.smegmatis_MC2_155 -DISILVNNAGVAGPVAALTDIE-PHEWDEVFAVNVRGVYLMCRQFLPAM
MLBr_01740|M.leprae_Br4923 PSMDIVMNIAGVSVWGTVDRLT--HDQWSNVVAINLMGPIHIIETFVPAI
:.:::. *. . *. * : :
MAV_5225|M.avium_104 LRRP-HAAILNVTSGLAFMPSA--LTPTYCASKAALHSYTQSLRFQLRET
MAB_4750|M.abscessus_ATCC_1997 QVRP-EATIITVSSGLAFAPLK--VTPSYNASKAAIHMLSESLRLQLADT
Mb3199|M.bovis_AF2122/97 AER--SGAIVNVSSVLAWLPLG--MS--YGVSKAAMWSATESMRIELAPR
Rv3174|M.tuberculosis_H37Rv AER--SGAIVNVSSVLAWLPLG--MS--YGVSKAAMWSATESMRIELAPR
MMAR_3561|M.marinum_M RRRG-SGRIINISSVLGFLPAP--YAALYAASKHAVEGYTESLDHELREY
MUL_2794|M.ulcerans_Agy99 RRRG-SGRIINISSVLGFLPAP--YAALYAASKHAVEGYTESLDHELREY
Mflv_4818|M.gilvum_PYR-GCK KASD-HAAVLNMVSVGAFIFAP--MLSIYASMKAAMMSFTRSMAAEFVHD
TH_2589|M.thermoresistible__bu KTSP-HAAVLNMVSVGAFLFSP--GTAMYSAGKAALMSFTRSMAAQFAPL
Mvan_0894|M.vanbaalenii_PYR-1 IERG-EGSIVNVASILGMVAAAPNRQAAYCASKGGLINLTRELAVQWARY
MSMEG_2013|M.smegmatis_MC2_155 TTRG-RGDIINVASVSGKRPLP--RRTPYTASKMAVIGLTSTLAFEVGPL
MLBr_01740|M.leprae_Br4923 LAAGRGGHLVNVSSAAGLVALP--WHAAYSASKYGLRGLSEVLRFDLARY
. ::.: * . * * .: : : :
MAV_5225|M.avium_104 PVQVIEIIPPQVQTALQG------------------------ERGFDPRA
MAB_4750|M.abscessus_ATCC_1997 RVEVKELLPPAVRTNLMP------------------------GQQESEFA
Mb3199|M.bovis_AF2122/97 GVQVVGVYVGLVDTDMG--------------------------RFADAPK
Rv3174|M.tuberculosis_H37Rv GVQVVGVYVGLVDTDMG--------------------------RFADAPK
MMAR_3561|M.marinum_M GVRALLVEPSYTRTDFESNMWEA-----------DTPQAAYADNRAAVRA
MUL_2794|M.ulcerans_Agy99 GVRALLVEPSYTRTDFESNMWEA-----------DTPQAAYADNRAAVRA
Mflv_4818|M.gilvum_PYR-GCK GIRVNALAPGPVDTDMMR----------------------------KNPQ
TH_2589|M.thermoresistible__bu GIRVNALAPGPVDTDMMR----------------------------NNPQ
Mvan_0894|M.vanbaalenii_PYR-1 NVRVNALAPGFFPSELTT----------------------------ELLD
MSMEG_2013|M.smegmatis_MC2_155 GVNVNTLSPGPVDGPRMDRN-------------------FALEAKTLGIS
MLBr_01740|M.leprae_Br4923 RIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAA
: . :
MAV_5225|M.avium_104 MPLDEYITETMTLLQTQPQADEIVVERVKAFRFAERDGTFDDIYPGFNEA
MAB_4750|M.abscessus_ATCC_1997 MPLKDFIDEVIALLESEPDAHEIQVERVKFLRYGEVRGDYDDVVATLNAS
Mb3199|M.bovis_AF2122/97 SDPADVVRQVLDGIEAG--KEDVLADEMSRQVRASLNVPARERIARLMGN
Rv3174|M.tuberculosis_H37Rv SDPADVVRQVLDGIEAG--KEDVLADEMSRQVRASLNVPARERIARLMGN
MMAR_3561|M.marinum_M VVADKIRNAELPAVVADATYAAATDKRIKLRYPAGRHARQLALLKRIAPA
MUL_2794|M.ulcerans_Agy99 VVANKIRNAELPAVVADATYAAAIDKRIKLRYPAGRHARQLALLKRIAPA
Mflv_4818|M.gilvum_PYR-GCK EAIDGMVG--GTLVGRLASADEMVGAALLLTSDAGSYITGQVIIADGGGT
TH_2589|M.thermoresistible__bu EVVDMMAG--ATLMKRLATPDEMVGAALLLTSDAGSYITGTVLIADGGGT
Mvan_0894|M.vanbaalenii_PYR-1 DDAGGAYIRRNTPMARAGRAGELSGALLLLASGAGSFITGQVIAVDGGWT
MSMEG_2013|M.smegmatis_MC2_155 EDQAREAFVGRAALRRMVTEEEVAAAAVAMLNMPGLCGADIDLSAGMIAR
MLBr_01740|M.leprae_Br4923 EKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALR
:
MAV_5225|M.avium_104 MTAASDR-----------------------
MAB_4750|M.abscessus_ATCC_1997 DPHARR------------------------
Mb3199|M.bovis_AF2122/97 ------------------------------
Rv3174|M.tuberculosis_H37Rv ------------------------------
MMAR_3561|M.marinum_M AVLDNGIRKQTGLNSPRPTPVLAER-----
MUL_2794|M.ulcerans_Agy99 AVLDNGIRKQTGLNSPRPTPVLAER-----
Mflv_4818|M.gilvum_PYR-GCK PR----------------------------
TH_2589|M.thermoresistible__bu PR----------------------------
Mvan_0894|M.vanbaalenii_PYR-1 AR----------------------------
MSMEG_2013|M.smegmatis_MC2_155 ------------------------------
MLBr_01740|M.leprae_Br4923 PSPATMRCVEPIKVGVYSQPRSGEGGKSGN