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VITGRTALVTGAGNGLGRAIALALAHNGARVVLVGRRREPLAAVAQEIGEAARWVDCDTSDPAAVAALGA ALSDEDISILVNNAGVAGPVAALTDIEPHEWDEVFAVNVRGVYLMCRQFLPAMTTRGRGDIINVASVSGK RPLPRRTPYTASKMAVIGLTSTLAFEVGPLGVNVNTLSPGPVDGPRMDRNFALEAKTLGISEDQAREAFV GRAALRRMVTEEEVAAAAVAMLNMPGLCGADIDLSAGMIAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2013 | - | - | 100% (251) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_1689 | - | 1e-31 | 38.60% (228) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_3607 | - | 7e-30 | 35.96% (267) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 3e-28 | 38.10% (189) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 5e-31 | 40.21% (189) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 3e-28 | 38.10% (189) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-23 | 38.67% (181) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4022c | - | 5e-27 | 35.94% (217) | oxidoreductase |
| M. marinum M | MMAR_0387 | fabG3 | 4e-30 | 39.25% (186) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. avium 104 | MAV_2509 | - | 7e-28 | 37.63% (186) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_2552 | - | 5e-31 | 34.12% (255) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 8e-30 | 38.71% (186) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_1975 | fabG | 4e-29 | 35.62% (233) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2013|M.smegmatis_MC2_155 --------------------------------------------------
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2013|M.smegmatis_MC2_155 --------------------------------------------------
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2013|M.smegmatis_MC2_155 --------------------------------------------------
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2013|M.smegmatis_MC2_155 --------------------------------------------------
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAB_4022c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2013|M.smegmatis_MC2_155 --------------------------------------------------
Mb2025|M.bovis_AF2122/97 ------------------------------MSGRLIGK------------
Rv2002|M.tuberculosis_H37Rv ------------------------------MSGRLIGK------------
MAV_2509|M.avium_104 ------------------------------MAERLAGK------------
Mflv_4505|M.gilvum_PYR-GCK ------------------------------MTGRLAGK------------
MMAR_0387|M.marinum_M -------------------------------MGRVDGK------------
MUL_1037|M.ulcerans_Agy99 -------------------------------MGRVDGK------------
Mvan_1975|M.vanbaalenii_PYR-1 -------------------------MRMGEQVSLLTGQ------------
TH_2552|M.thermoresistible__bu ---------------------------------VLSDS------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAB_4022c|M.abscessus_ATCC_199 ----------------------------MVKLNQLQPQ------------
MSMEG_2013|M.smegmatis_MC2_155 -----------------------------MITGR----------------
Mb2025|M.bovis_AF2122/97 -----------------------------VALVSGGARGMGASHVRAMVA
Rv2002|M.tuberculosis_H37Rv -----------------------------VALVSGGARGMGASHVRAMVA
MAV_2509|M.avium_104 -----------------------------VALVSGGARGMGASHVRSLVA
Mflv_4505|M.gilvum_PYR-GCK -----------------------------VALISGAARGMGASHARVMAG
MMAR_0387|M.marinum_M -----------------------------VALISGGARGMGASHARLLVQ
MUL_1037|M.ulcerans_Agy99 -----------------------------VALISGGARGMGASHARLLVQ
Mvan_1975|M.vanbaalenii_PYR-1 -----------------------------TAVITGGAQGLGFAIAQRFVE
TH_2552|M.thermoresistible__bu -----------------------------VALITGASGGIGRVLARRYAQ
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAB_4022c|M.abscessus_ATCC_199 -----------------------------LVVVTGAGSGIGRATAIRFAK
MSMEG_2013|M.smegmatis_MC2_155 -----------------------------TALVTGAGNGLGRAIALALAH
. ::*.. *:* . .
Mb2025|M.bovis_AF2122/97 EGAKVVFGDILDEEGKAVAAELA---DAARYVHLDVTQPAQWTAAVDTAV
Rv2002|M.tuberculosis_H37Rv EGAKVVFGDILDEEGKAVAAELA---DAARYVHLDVTQPAQWTAAVDTAV
MAV_2509|M.avium_104 EGAKVVFGDILDDEGKAVAAEVG---EATRYLHLDVTKPEDWDAAVATAL
Mflv_4505|M.gilvum_PYR-GCK HGAKVVCGDILDSDGEAVAAELG---DAARYVHLDVTSPDDWDRAVAAAV
MMAR_0387|M.marinum_M EGAKVVIGDILDEEGKALAEEIG---DAARYVHLDVTQPDQWEAAVATAV
MUL_1037|M.ulcerans_Agy99 EGAKVVIGDILDEEGKALAEEIG---DAARYVHLDVTQPDQWEAAVATAV
Mvan_1975|M.vanbaalenii_PYR-1 EGARVVLGDVNLDATVAAAEKLGGE-DVARAVRCDVTDSAEVDALIAAAV
TH_2552|M.thermoresistible__bu RGARVALVARRRDELNVTAAAVTEAGGEALVLVADIRDETQCADAVAATV
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
MAB_4022c|M.abscessus_ATCC_199 RGAHVVVSDMDLDSAHATTAMIQADGNTASAVQLDVTDPDQWETFARDVL
MSMEG_2013|M.smegmatis_MC2_155 NGARVVLVGRRREPLAAVAQEIG---EAARWVDCDTSDPAAVAALGAALS
.**.*. : : : * .
Mb2025|M.bovis_AF2122/97 TAFGGLHVLVNNAGILNIG-TIEDYALTEWQRILDVNLTG-VFLGIRAVV
Rv2002|M.tuberculosis_H37Rv TAFGGLHVLVNNAGILNIG-TIEDYALTEWQRILDVNLTG-VFLGIRAVV
MAV_2509|M.avium_104 AEFGRIDVLVNNAGIINIG-TLEDYALSEWQRILDINLTG-VFLGIRAVV
Mflv_4505|M.gilvum_PYR-GCK ADFGGLDVLVNNAGILNIG-TVEDYELSEWHRILDVNLTG-VFLGIRAAT
MMAR_0387|M.marinum_M DEFGKLDVLVNNAGIVALG-QLKKFDLGKWQKVIDVNLTG-TFLGMRAAV
MUL_1037|M.ulcerans_Agy99 DEFGKLDVLVNNVGIVALG-QLKKFDLGKWQKVIDVNLTG-TFLGMRAAV
Mvan_1975|M.vanbaalenii_PYR-1 DGFGSLDIMVNNAGITRDA-TMRKMTEEQFDQVIAVHLKG-TWNGLRAAA
TH_2552|M.thermoresistible__bu ARWGRLDVLVNNAAVPGSDQSVAEATVDNWNQVLATNLVAPMVLSREALC
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAG-RFLDTPPEEFDRVLAVNLGG-VVNCCRAFG
MAB_4022c|M.abscessus_ATCC_199 ADHGVADVLVNNAGIALGG-PFLKLTPADWDRLLSVNLMG-VVHGCRVFG
MSMEG_2013|M.smegmatis_MC2_155 DED--ISILVNNAGVAGPVAALTDIEPHEWDEVFAVNVRG-VYLMCRQFL
::***..: . . .:..:: :: . .
Mb2025|M.bovis_AF2122/97 KPMKEAGRG-SIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGP
Rv2002|M.tuberculosis_H37Rv KPMKEAGRG-SIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGP
MAV_2509|M.avium_104 KPMKKAGRG-SIINISSIEGMAGTIACHGYTATKFAVRGLTKSAALELGP
Mflv_4505|M.gilvum_PYR-GCK PTMKAAGRG-SIINIASIEGMAGTVGCHGYTATKFAVRGLTKSTALELGP
MMAR_0387|M.marinum_M EPMTAAGSG-SIINVSSIEGLRGAPAVHPYVASKWAVRGLTKSAALELAP
MUL_1037|M.ulcerans_Agy99 EPMTAAGSG-SIINVSSIEGLRGAPAVHPYVASKWAVRGLTKSAALELAP
Mvan_1975|M.vanbaalenii_PYR-1 AVMREQKRG-AIVNMSSISGKVGMVGQTNYSAAKAGIVGMTKAASKELAY
TH_2552|M.thermoresistible__bu QAMIPAGSG-NIQFLSSAAARNVAPGKAHYAAAKLALSALGQTLALEVGG
MLBr_00862|M.leprae_Br4923 QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
MAB_4022c|M.abscessus_ATCC_199 EQMVERGSG-HIVNIASAAAFTPTAVMAPYSVSKAGVKMLTECLRLELGP
MSMEG_2013|M.smegmatis_MC2_155 PAMTTRGRG-DIINVASVSGKRPLPRRTPYTASKMAVIGLTSTLAFEVGP
: * * ::* . * .:* . : . *:
Mb2025|M.bovis_AF2122/97 SGIRVNSIHPGLVK---------------TPMTDWVPEDIFQ-----TAL
Rv2002|M.tuberculosis_H37Rv SGIRVNSIHPGLVK---------------TPMTDWVPEDIFQ-----TAL
MAV_2509|M.avium_104 SGIRVNSIHPGLIK---------------TPMTEWVPEDIFQ-----SAL
Mflv_4505|M.gilvum_PYR-GCK FGIRVNSVHPGLVK---------------TPMADWVPEDIFQ-----SAL
MMAR_0387|M.marinum_M LNIRVNSIHPGFIR---------------TPMTANLPDDMVT-----IPL
MUL_1037|M.ulcerans_Agy99 LNIRVNSIHPGFIR---------------TPMTANLPDDMVT-----IPL
Mvan_1975|M.vanbaalenii_PYR-1 LGVRVNAIQPGLIR---------------SAMTEAMPQRIWDSKVAEVPM
TH_2552|M.thermoresistible__bu TGIRVNTLVVGSVEG----ELLDRYVARRAAADGVSPDEVLSGLARSTKL
MLBr_00862|M.leprae_Br4923 VGVGLTTICPGVIDTNIIQS---TRIDTPTAKQER-VRDRRGQLDMMFRL
MAB_4022c|M.abscessus_ATCC_199 KGVGVSAICPGFINTNIGLNGITVGVDQEMVQRGKEIMRRAQEFAAHLPF
MSMEG_2013|M.smegmatis_MC2_155 LGVNVNTLSPGPVDG----PRMDRNFALEAKTLGISEDQAREAFVGRAAL
.: :.:: * : :
Mb2025|M.bovis_AF2122/97 GRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVS
Rv2002|M.tuberculosis_H37Rv GRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVS
MAV_2509|M.avium_104 GRAAEPKEVSNLVVYLASDESSYSTGSEFVVDGGTTAGLGHKDFSNVETD
Mflv_4505|M.gilvum_PYR-GCK GRIAQPHEVSNLVVYLASDESSYSTGAEFVVDGGTLAGLAHKDFSAVDVD
MMAR_0387|M.marinum_M GRPAESREVSTFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF------
MUL_1037|M.ulcerans_Agy99 GRPAESREVSTFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF------
Mvan_1975|M.vanbaalenii_PYR-1 GRAGEPEEVANVALFLASDLSSYMTGTVLEVTGGRHL-------------
TH_2552|M.thermoresistible__bu GRLISPEEVADVSLWLASDAASAITGQDIFVTGG----------------
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIR
MAB_4022c|M.abscessus_ATCC_199 SPMSPDLVARAVTRAVRYDLAVVPVRTEAWLGYVLGRVAPGINRRTTQAF
MSMEG_2013|M.smegmatis_MC2_155 RRMVTEEEVAAAAVAMLNMPG--LCGADIDLSAGMIAR------------
. :
Mb2025|M.bovis_AF2122/97 SQPEWVT--------------------------------
Rv2002|M.tuberculosis_H37Rv SQPEWVT--------------------------------
MAV_2509|M.avium_104 AQPDWVT--------------------------------
Mflv_4505|M.gilvum_PYR-GCK QQPEWIT--------------------------------
MMAR_0387|M.marinum_M ---------------------------------------
MUL_1037|M.ulcerans_Agy99 ---------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 ---------------------------------------
TH_2552|M.thermoresistible__bu ---------------------------------------
MLBr_00862|M.leprae_Br4923 VI-------------------------------------
MAB_4022c|M.abscessus_ATCC_199 SIERAERWGAWALGKLDDLNLLSRQGGVEEDRKPTAARR
MSMEG_2013|M.smegmatis_MC2_155 ---------------------------------------