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MTSLAERTVLVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAIDVSDPRVIPLQLDVTDAVSVAEAADL ATDVGILINNAGISRASSVLDKDTSALRGELETNLFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGM SYGVSKAAMWSATESMRIELAPRGVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLA DEMSRQVRASLNVPARERIARLMGN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3174 | - | - | 100% (235) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2129c | - | 1e-17 | 33.16% (193) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 1e-15 | 35.48% (186) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3199 | - | 1e-126 | 99.57% (235) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5243 | - | 2e-17 | 37.20% (164) | short-chain dehydrogenase/reductase SDR |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-17 | 36.46% (192) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4428 | - | 8e-41 | 38.72% (235) | short chain dehydrogenase |
| M. marinum M | MMAR_1614 | - | 1e-18 | 35.91% (181) | short chain dehydrogenase |
| M. avium 104 | MAV_2376 | - | 7e-18 | 31.77% (192) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6581 | - | 4e-50 | 47.44% (215) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4244 | - | 3e-16 | 32.81% (192) | PUTATIVE putative Dehydrogenase/decarboxylase protein |
| M. ulcerans Agy99 | MUL_3423 | - | 2e-18 | 35.36% (181) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0234 | - | 6e-51 | 48.23% (226) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3174|M.tuberculosis_H37Rv --------------------------------------------------
Mb3199|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6581|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0234|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4428|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1614|M.marinum_M --------------------------------------------------
MUL_3423|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
TH_4244|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAV_2376|M.avium_104 --------------------------------------------------
Rv3174|M.tuberculosis_H37Rv --------------------------------------------------
Mb3199|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6581|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0234|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4428|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1614|M.marinum_M --------------------------------------------------
MUL_3423|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
TH_4244|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAV_2376|M.avium_104 --------------------------------------------------
Rv3174|M.tuberculosis_H37Rv --------------------------------------------------
Mb3199|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6581|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0234|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4428|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1614|M.marinum_M --------------------------------------------------
MUL_3423|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
TH_4244|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAV_2376|M.avium_104 --------------------------------------------------
Rv3174|M.tuberculosis_H37Rv --------------------------------------------------
Mb3199|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6581|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0234|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4428|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1614|M.marinum_M --------------------------------------------------
MUL_3423|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
TH_4244|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAV_2376|M.avium_104 --------------------------------------------------
Rv3174|M.tuberculosis_H37Rv --------------------------------------------------
Mb3199|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6581|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0234|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4428|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1614|M.marinum_M --------------------------------------------------
MUL_3423|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
TH_4244|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAV_2376|M.avium_104 --------------------------------------------------
Rv3174|M.tuberculosis_H37Rv --------------------------------------------------
Mb3199|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6581|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0234|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4428|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1614|M.marinum_M --------------------------------------------------
MUL_3423|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5243|M.gilvum_PYR-GCK --------------------------------------------------
TH_4244|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAV_2376|M.avium_104 --------------------------------------------------
Rv3174|M.tuberculosis_H37Rv ----------------------MTSLAERTVLVTGANRGMGREYVAQLLG
Mb3199|M.bovis_AF2122/97 ----------------------MTSLAERTALVTGANRGMGREYVAQLLG
MSMEG_6581|M.smegmatis_MC2_155 -----------------------MKIQGSVAFVTGANRGLGRQFAEQLLA
Mvan_0234|M.vanbaalenii_PYR-1 ----------------------MTDTEHTTALVTGANRGLGRRFAEALVA
MAB_4428|M.abscessus_ATCC_1997 ------------------------MIKDTVVLVTGGRRGLGAAIVDEVLN
MMAR_1614|M.marinum_M ---------------------------MSTWLITGCSTGLGRALAEAVID
MUL_3423|M.ulcerans_Agy99 ---------------------------MSTWLITGCSTGLGRALAEAVID
Mflv_5243|M.gilvum_PYR-GCK ---------------------------MATVLITGCSSGYGRATALKFLA
TH_4244|M.thermoresistible__bu --------------------------------VTGAARGIGRSIVTQLAD
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAV_2376|M.avium_104 ----------------------MTSLRDKVVFITGGARGIGAEVARRLNA
:** * * . .
Rv3174|M.tuberculosis_H37Rv RKVAKVYAATRNPL------AIDVSDPRVIPLQLDVTDAVSVAEAADLAT
Mb3199|M.bovis_AF2122/97 RKVAKVYAATRNPL------AIDVSDPRVIPLQLDVTDAVSVAEAADLAT
MSMEG_6581|M.smegmatis_MC2_155 RG-AKVYAGARNPE------TVTLDG--VIPVRIDITDPASVQAAAELAA
Mvan_0234|M.vanbaalenii_PYR-1 RG-AKVYAAARRPE------TIDIPG--VVPIQLDITDPESVRRAAEQAT
MAB_4428|M.abscessus_ATCC_1997 RGARKVYSTARAP--------FEDPRAQVVTKQLEVTSAESVDALARDLT
MMAR_1614|M.marinum_M AG-HHTVATARSVGGV--ADLVQRSPERVLPLALDITEPDQITAAVQAAQ
MUL_3423|M.ulcerans_Agy99 AG-HHTVATARSVGGV--ADLAQRSPERVLPLALDITEPDQITAAMQAAQ
Mflv_5243|M.gilvum_PYR-GCK EG-WNVVATMRNP-----RPDVLPASDRLRVSALDVTDPESIASAVEAAG
TH_4244|M.thermoresistible__bu SG-WDVVAGVRTEQDA--ENIVALNPARITSVLLDVTEADHIAALDRSLD
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
MAV_2376|M.avium_104 KGARLVLTDLNDAELT--SLAAELGEERVLTAVADVRDLSAMQAAADRAV
. : :: . :
Rv3174|M.tuberculosis_H37Rv D----VGILINNAGISRASSVLDKDTSALRGELETNLFGPLALASAFADR
Mb3199|M.bovis_AF2122/97 D----VGILINNAGISRASSVLDKDTSALRGELETNLFGPLALASAFADR
MSMEG_6581|M.smegmatis_MC2_155 D----PTILVNNAGTTSYNGLLDGPMDDIRAQMESHFFGTLNVTRAFVPH
Mvan_0234|M.vanbaalenii_PYR-1 D----VTVVINNAGVSTRAGLLDGTLEDIRLEMDTHYFGTLAVTRAFVPV
MAB_4428|M.abscessus_ATCC_1997 D----VEIVVNNAGVLHPDPLLTGDFDRIDATFQTNVFGPLRIARAFAPI
MMAR_1614|M.marinum_M QRFGGIDVLVNNAGYGYRAAVEEGDDAEVRDLFETHFFGTVALIKAVLPD
MUL_3423|M.ulcerans_Agy99 QRFGGIDVLVNNAGYGYRAAVEEGDDAEVRDLFETHFFGTVALIKAVLPD
Mflv_5243|M.gilvum_PYR-GCK P----LDAVVNNAGIGAVGAFEATPMSTIRELFDTNTFGVMAMTQAVVPQ
TH_4244|M.thermoresistible__bu G---RLDAVINNAGVVVPGPLETVSPQDLRRQFDVNVIGHLAVTQAVLPR
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQR
MAV_2376|M.avium_104 ERFGGIDVVLANAGIASYGSVAQVDPDAFRRVLDINVLGVFHTVRATLPA
:: *** . . : : * . *
Rv3174|M.tuberculosis_H37Rv IAERS--GAIVNVSSVLAWLPLGMS--YGVSKAAMWSATESMRIELAPRG
Mb3199|M.bovis_AF2122/97 IAERS--GAIVNVSSVLAWLPLGMS--YGVSKAAMWSATESMRIELAPRG
MSMEG_6581|M.smegmatis_MC2_155 LVANAP-GAILNIASILSWKHIPGIGAYAAAKAALWAQTDAVREELAPKG
Mvan_0234|M.vanbaalenii_PYR-1 IERNGG-GAILNVLSVLSWLHPPTSGAYSAAKAAGWAMTDALRAELAPRG
MAB_4428|M.abscessus_ATCC_1997 LKANGG-GAIVNIHSVLSWL--GGAGAYGASKAAIWSVSNTLRLELEAQH
MMAR_1614|M.marinum_M MRARRS-GAIVNISSIAVALTPVGSGYYAAAKAAMEGMSGALHGELAPLG
MUL_3423|M.ulcerans_Agy99 MRARRS-GAIVNISSIAVALTPVGSGYYAAAKAAMEGMSGALHGELAPLG
Mflv_5243|M.gilvum_PYR-GCK MRERRS-GVVVNVTSSTTLAPMPLAAAYTASKSAIEGFTGSLALELGFFG
TH_4244|M.thermoresistible__bu LRDSR--GRIVFISSLNGRISVPLMGAYCASKFALEAVADALRMELAPWR
MLBr_00862|M.leprae_Br4923 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVG
MAV_2376|M.avium_104 VIERR--GYVLIVSSLAAYAACPGLAPYNASKAGVEMLANALRLEVARHG
: * :: : * * .:* . : : *:
Rv3174|M.tuberculosis_H37Rv VQVVGVYVG---------------------------LVDTDMGRFADAP-
Mb3199|M.bovis_AF2122/97 VQVVGVYVG---------------------------LVDTDMGRFADAP-
MSMEG_6581|M.smegmatis_MC2_155 VAVTGLYVG---------------------------FMDTDMAAGVDAE-
Mvan_0234|M.vanbaalenii_PYR-1 IHVAALHVG---------------------------FMDTDMVSYIPADQ
MAB_4428|M.abscessus_ATCC_1997 THVLGVHAA---------------------------FIDTDMVSALPVP-
MMAR_1614|M.marinum_M ISVTVVEPGAFRTDFAGRSL--VQSTRMINDYAATAGQRRKENDTMHGNQ
MUL_3423|M.ulcerans_Agy99 ISVTVVEPGAFRTDFAGRSL--VQSTRMINDYAATAGQRRKENDTMHGNQ
Mflv_5243|M.gilvum_PYR-GCK VRAKLVEPG----------------------YGPGTQFTSNGVERMAGLI
TH_4244|M.thermoresistible__bu IPVIVIQPTQTDTDMVRG--------ADVMVEQTAAAMRPEHRDLYARHI
MLBr_00862|M.leprae_Br4923 VGLTTICPGVIDTNIIQS------------TRIDTPTAKQERVRDRRGQL
MAV_2376|M.avium_104 VKVGSAHMSWINTALVRDTQNDLPAFDRLLASLPWPLNKTTTVDKCAAAF
Rv3174|M.tuberculosis_H37Rv ---------------KSDPADVVRQVLDGIEAGK--------EDVLADEM
Mb3199|M.bovis_AF2122/97 ---------------KSDPADVVRQVLDGIEAGK--------EDVLADEM
MSMEG_6581|M.smegmatis_MC2_155 ---------------KSDPAHIAAAALDGVEAGV--------AEVLGDEQ
Mvan_0234|M.vanbaalenii_PYR-1 ---------------KTDPAVVAELALDGLFAGQ--------PEILADEL
MAB_4428|M.abscessus_ATCC_1997 ---------------KTPPSAIAARIIDALDKGD--------NEVLTDDL
MMAR_1614|M.marinum_M ---------------PGDPAKAAAAIITAVESPAPPAFLLLGPDALMAYR
MUL_3423|M.ulcerans_Agy99 ---------------PGDPAKAAAAIITAVESPAPPAFLLLGPDALMAYR
Mflv_5243|M.gilvum_PYR-GCK ---------------PAEYQDFAAPVFEEFRSPG----MVTTPDEVADVV
TH_4244|M.thermoresistible__bu GG--MRKFIRQFHPSAVPADNVAAAVVNALTVRRPRSRYIVGITHQFPRL
MLBr_00862|M.leprae_Br4923 DM--MFRLR------RYGPDKVADTILSAIKKNKP-------IRPVAPEA
MAV_2376|M.avium_104 VKGIQRRRTRIYCPRWVALFRWAKPVLSSRLGEMPLHSPTAELLPALDAQ
. .
Rv3174|M.tuberculosis_H37Rv SRQVRASLNVPARERIARLMGN---
Mb3199|M.bovis_AF2122/97 SRQVRASLNVPARERIARLMGN---
MSMEG_6581|M.smegmatis_MC2_155 TRAVKASLSA---------------
Mvan_0234|M.vanbaalenii_PYR-1 TRNVKAQLSAAPA------------
MAB_4428|M.abscessus_ATCC_1997 TVQIKSQLAGPVEKLAYRPGH----
MMAR_1614|M.marinum_M HIAQRRDVEITDWEQLTAGTNLTP-
MUL_3423|M.ulcerans_Agy99 HIAQRRDVEITDWEQLTAGTNLTP-
Mflv_5243|M.gilvum_PYR-GCK FQAATDTSGRLRFAAGADAVALAQ-
TH_4244|M.thermoresistible__bu QAIILPNLPPAARDPLLRRLGSQP-
MLBr_00862|M.leprae_Br4923 YALYGISRVLPQVLRSTARIRVI--
MAV_2376|M.avium_104 VAALGRSMSAANVELLRPDRGSARN