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MQISGNTVFIPGATSGIGLELALALQAKGNTVIVGGRRIELLDQIRRDHPGVSTVRIDISDPASIDIAAQ QVLTDHPTLNILVTMAGIMRVEDWHHPESFLQSAEEIVTTNVLGPIRLIAAFIEHLQVRPEATIITVSSG LAFAPLKVTPSYNASKAAIHMLSESLRLQLADTRVEVKELLPPAVRTNLMPGQQESEFAMPLKDFIDEVI ALLESEPDAHEIQVERVKFLRYGEVRGDYDDVVATLNASDPHARR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4750 | - | - | 100% (255) | putative short chain dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_4022c | - | 7e-19 | 29.00% (200) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3420c | - | 5e-18 | 30.81% (198) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 9e-15 | 30.69% (202) | ketoacyl reductase |
| M. gilvum PYR-GCK | Mflv_4313 | - | 1e-16 | 29.56% (203) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1544 | - | 1e-14 | 30.69% (202) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 8e-16 | 31.28% (195) | short chain dehydrogenase |
| M. marinum M | MMAR_1932 | ephD_1 | 9e-17 | 31.96% (194) | short-chain dehydrogenase EphD_1 |
| M. avium 104 | MAV_5225 | - | 5e-53 | 45.34% (247) | DltE protein |
| M. smegmatis MC2 155 | MSMEG_2872 | - | 9e-17 | 31.82% (198) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3427 | - | 2e-15 | 28.44% (225) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 3e-15 | 29.79% (188) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0894 | - | 9e-19 | 33.51% (185) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4750|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5225|M.avium_104 --------------------------------------------------
Mb1571|M.bovis_AF2122/97 --------------------------------------------------
Rv1544|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSG--QPEGPAIVLVHGFPDSHVL
MMAR_1932|M.marinum_M ------MNTASRTGITASDGATLAVYHYTPLDPQRPTILAIHGWPDNHHL
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4313|M.gilvum_PYR-GCK --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4750|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5225|M.avium_104 --------------------------------------------------
Mb1571|M.bovis_AF2122/97 --------------------------------------------------
Rv1544|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 WDGVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDEL
MMAR_1932|M.marinum_M WDPVAELLGDRYNVVAYDVRGSGESSCPASRSGYRLEQLVSDTGAVIDSL
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4313|M.gilvum_PYR-GCK --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4750|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5225|M.avium_104 --------------------------------------------------
Mb1571|M.bovis_AF2122/97 --------------------------------------------------
Rv1544|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYIL
MMAR_1932|M.marinum_M GVDR-VHLLAHDWGSIQGWAAVTADSVMEKVASFTSISGP----HLQYAG
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4313|M.gilvum_PYR-GCK --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4750|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5225|M.avium_104 --------------------------------------------------
Mb1571|M.bovis_AF2122/97 --------------------------------------------------
Rv1544|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR--
MMAR_1932|M.marinum_M AFLRSGRTPRSVAQVARQLASSGYIGFFLCPVVPELFFRSGIGVKLVGAF
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4313|M.gilvum_PYR-GCK --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4750|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5225|M.avium_104 --------------------------------------------------
Mb1571|M.bovis_AF2122/97 --------------------------------------------------
Rv1544|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVN
MMAR_1932|M.marinum_M ERIGQSSTRSQRGQTPRSIGDYVNALNLYRANMPAGFVTD--GSSLPQTS
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4313|M.gilvum_PYR-GCK --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4750|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5225|M.avium_104 --------------------------------------------------
Mb1571|M.bovis_AF2122/97 --------------------------------------------------
Rv1544|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAA
MMAR_1932|M.marinum_M VPVQVLVPRKDMFVTPALQRFTGAIPGGGRVVPIEGGHWVVTSRPDVVAR
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4313|M.gilvum_PYR-GCK --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MUL_2794|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0894|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4750|M.abscessus_ATCC_1997 --------------------MQISG---------NTVFIPGATSGIGLEL
MAV_5225|M.avium_104 --------------------MQMTG---------NTVLVTGGGTGIGRGL
Mb1571|M.bovis_AF2122/97 -----------------MSLPKPNN--------QTTVVITGASSGIGVEL
Rv1544|M.tuberculosis_H37Rv -----------------MSLPKPNN--------QTTVVITGASSGIGVEL
MLBr_00862|M.leprae_Br4923 AVHDLAD-LVDGK-QPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRET
MMAR_1932|M.marinum_M LTADWVDRVVAGTGDAAATVVRAGPGEVR----GQLALVTGAGAGIGRAT
MSMEG_2872|M.smegmatis_MC2_155 --------------------MRIA---------DRVFVVTGAGNGMGREV
Mflv_4313|M.gilvum_PYR-GCK ------------------MAQRSGSDRFS----GKRCFVTGAASGIGRAT
TH_3427|M.thermoresistible__bu -------------------MDNIRG---------KTIAITGAARGIGYAT
MUL_2794|M.ulcerans_Agy99 --------------------MTSTP---------PVALITGVSSGIGAAI
Mvan_0894|M.vanbaalenii_PYR-1 -MTVDIAREQPATAPRPDQMFDLTG---------RTALVTGASSGLGVQF
:.* *:*
MAB_4750|M.abscessus_ATCC_1997 ALALQAKGNTVIVGGRRIE-----LLDQIRRDHPGVSTVRIDISDPASID
MAV_5225|M.avium_104 AEAFHRLGNRVIIAARRGE-----QLRAVAEANPGIQTLSLDLGDPADIR
Mb1571|M.bovis_AF2122/97 ARGLAGRGFPLMLVARRRERLDELADQLRQEHCVGVEVLPLDLADTQARA
Rv1544|M.tuberculosis_H37Rv ARGLAGRGFPLMLVARRRERLDELADQLRQEHCVGVEVLPLDLADTQARA
MLBr_00862|M.leprae_Br4923 ALALARRGA-EVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVE
MMAR_1932|M.marinum_M AVELARQGARMVIIADRDLAAANESATQVRAAGAAAAVYQVDVSDETAMN
MSMEG_2872|M.smegmatis_MC2_155 ALGLARRGA-HVAAVDLDEAGLAGTAERARGTGARMSTHVLNVTDRDAVA
Mflv_4313|M.gilvum_PYR-GCK ALKLAARGAELYLTDRDADGLALTVADARALGGVVAEHRALDISDHDAVV
TH_3427|M.thermoresistible__bu ATALLARGARVVIGDRDVALQESAVAQLGRLG--PVSGYPLDVTDRESFA
MUL_2794|M.ulcerans_Agy99 AVRLASAGFRVVGTS---------RAPQRLAPIPGVETLALDVTDDTAVR
Mvan_0894|M.vanbaalenii_PYR-1 ALALRSAGAEVVVAARRAD-----RLAELCEAHEGLSAVSCDVADPASIE
* : * :: *
MAB_4750|M.abscessus_ATCC_1997 IAAQQVLTD-HPTLNILVTMAGIMRVEDWHHPESFLQSAEEIVTTNVLGP
MAV_5225|M.avium_104 RFATEVTDH-YPDLNVVVNNAGMQRVEDLISGN--AGLAEQTVAVNLLGP
Mb1571|M.bovis_AF2122/97 QLADRLR---SDAIAGLCNSAGFG-TSGRFWELP-FARESEEVVLNALAL
Rv1544|M.tuberculosis_H37Rv QLADRLR---SDAIAGLCNSAGFG-TSGRFWELP-FARESEEVVLNALAL
MLBr_00862|M.leprae_Br4923 AFAEQVSAK-HGVPDIVVNNAGIG-QAGRFLDTP-PEEFDRVLAVNLGGV
MMAR_1932|M.marinum_M DLAAQVLDE-HGVVDILVNNAGIG-MAGRFLETT-PQHWDAILGINVGGV
MSMEG_2872|M.smegmatis_MC2_155 GLPDAVLDV-HGQIDGLVNIAGIAQRFALFTDLE-ADQIDRVTTVNFLGT
Mflv_4313|M.gilvum_PYR-GCK AFADDIHSR-HPAMDVVMNIAGIS--AWGTVDKLTHDDWTSLININLMGP
TH_3427|M.thermoresistible__bu TFLDKARTDGGGHIDVLINNAGVMPIGPFLEQSE--QAIRSSIEVNLYGV
MUL_2794|M.ulcerans_Agy99 SVVSEVIDR-TGHIDVLVNNAGLG-IAGAAEESS-IDQARSLFDTNFFGL
Mvan_0894|M.vanbaalenii_PYR-1 SAYQCVEER-VGAVDILVNNAGTS-IPARAEDES-LTDFQYVLDVNLVGA
: . ** * .
MAB_4750|M.abscessus_ATCC_1997 IRLIAAFIEHLQVRPE-ATIITVSSGLAFAPLK--VTPSYNASKAAIHML
MAV_5225|M.avium_104 IRLIATLLPALLRRPH-AAILNVTSGLAFMPSA--LTPTYCASKAALHSY
Mb1571|M.bovis_AF2122/97 MELTHAALPGMVKRGA-GAVLNIASIAGFQPIP--YMAVYSATKAFVLTF
Rv1544|M.tuberculosis_H37Rv MELTHAALPGMVKRGA-GAVLNIASIAGFQPIP--YMAVYSATKAFVLTF
MLBr_00862|M.leprae_Br4923 VNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQ--SLSAYCTSKAATYMF
MMAR_1932|M.marinum_M ISGSRAFGAQMVERGQGGTIINIASAAAYLPSK--SMVAYSTTKAAVLGF
MSMEG_2872|M.smegmatis_MC2_155 VQMCRAFLPVLRQRPE-ANITNMSSLSALVPFA--SQVLYSASKAAVQQF
Mflv_4313|M.gilvum_PYR-GCK IHVIETFVPPMMEARRGGHLVNVSSAAGIVALP--WHAAYSASKYGLRGL
TH_3427|M.thermoresistible__bu LTGCQLALPDMVRRRS-GHIINIASMSGLIPVP--GQVPYNAAKFGVVGL
MUL_2794|M.ulcerans_Agy99 IRLTNEVLPHMRRRGS-GRIINISSVLGFLPAP--YAALYAASKHAVEGY
Mvan_0894|M.vanbaalenii_PYR-1 FRLTQLVGRKMIERGE-GSIVNVASILGMVAAAPNRQAAYCASKGGLINL
. : . : .::* . . * ::*
MAB_4750|M.abscessus_ATCC_1997 SESLRLQLADTRVEVKELLPPAVRTNLMPGQQESEFAMPLK---------
MAV_5225|M.avium_104 TQSLRFQLRETPVQVIEIIPPQVQTALQGERGFDPRAMPLD---------
Mb1571|M.bovis_AF2122/97 SEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLA---------
Rv1544|M.tuberculosis_H37Rv SEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLA---------
MLBr_00862|M.leprae_Br4923 SDCLRAELDAVGVGLTTICPGVIDTNIIQSTRID-TPTAKQERVRDRRGQ
MMAR_1932|M.marinum_M SEALRADLADEGISVTAVCPGFVNTNIAKSTVYAGMSTEQQERARQK---
MSMEG_2872|M.smegmatis_MC2_155 SEGLDAELADTNVRVVTVFPGQVSTNLAQNSGVKMLDAGGR---------
Mflv_4313|M.gilvum_PYR-GCK SEVLRFDLARYRIGVSVVVPGAVRTPLVDTVRIAGVDRDDPRVQKWTN--
TH_3427|M.thermoresistible__bu SVALADEMAPYGVEVSVVMPPFTRTELISGTKETAATKPAEPEDIAAAIV
MUL_2794|M.ulcerans_Agy99 TESLDHELREYGVRALLVEPSYTRTDFESNMWEADTPQAAYADNRAAVRA
Mvan_0894|M.vanbaalenii_PYR-1 TRELAVQWARYNVRVNALAPGFFPSELTTELLDDDAGG------------
: : : : : * :
MAB_4750|M.abscessus_ATCC_1997 -------------DFIDEVIALLESEPD-------------AHEIQVERV
MAV_5225|M.avium_104 -------------EYITETMTLLQTQPQ-------------ADEIVVERV
Mb1571|M.bovis_AF2122/97 --------QVSPHDVAEAAIAGMLSGKR-------------TVVPGIVPK
Rv1544|M.tuberculosis_H37Rv --------QVSPHDVAEAAIAGMLSGKR-------------TVVPGIVPK
MLBr_00862|M.leprae_Br4923 LDMMFRLRRYGPDKVADTILSAIKKNKP-------------IRPVAPEAY
MMAR_1932|M.marinum_M ADAAYRRRNFTPEATARAIVKAIRSGPA-------------VLPVAAESK
MSMEG_2872|M.smegmatis_MC2_155 -----RAPVTTPEAAGRKIVTGIAKDRY-------------RVIIGTDAH
Mflv_4313|M.gilvum_PYR-GCK ---RFSGHAVSPDVAADKILDGVARNRY-------------LIYTSLDIR
TH_3427|M.thermoresistible__bu KTLDKPKTHVSVPGPLRFIAQAAQTLGPRGRRWLNKRLGLDTVFLEFDQQ
MUL_2794|M.ulcerans_Agy99 VVANKIRNAELPAVVADATYAAAIDKRIK-----------LRYPAGRHAR
Mvan_0894|M.vanbaalenii_PYR-1 -------------AYIRRNTPMARAGRAG------------ELSGALLLL
MAB_4750|M.abscessus_ATCC_1997 KFLRYGEVRGDYDDVVATLNASDPHARR--------
MAV_5225|M.avium_104 KAFRFAERDGTFDDIYPGFNEAMTAASDR-------
Mb1571|M.bovis_AF2122/97 FVSTSGRFAPRSLLLPAIRIGNRLRGGPSR------
Rv1544|M.tuberculosis_H37Rv FVSTSGRFAPRSLLLPAIRIGNRLRGGPSR------
MLBr_00862|M.leprae_Br4923 ALYGISRVLPQVLRSTARIRVI--------------
MMAR_1932|M.marinum_M VGYAMRRISPSMIRMFARLDIRQR------------
MSMEG_2872|M.smegmatis_MC2_155 VLYTLSRLAPRRTARMVAKQIKSVL-----------
Mflv_4313|M.gilvum_PYR-GCK ALYLFKRTMWLPYSIAMKQVNPLFTRALRPKTKQR-
TH_3427|M.thermoresistible__bu ARQGYEQRAQQALGVLEGGNKQQDRSGQKS------
MUL_2794|M.ulcerans_Agy99 QLALLKRIAPAAVLDNGIRKQTGLNSPRPTPVLAER
Mvan_0894|M.vanbaalenii_PYR-1 ASGAGSFITGQVIAVDGGWTAR--------------