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VGRSDARRNRQRLLEAATAAFTAHGASVSLESIARDAGVGIGTLYRHFPNREALVEAVYRAELAEVAAAA AQLLQRHPPKAALRRWMDRYATFVATKRGMAESLQAIFESGALVPSQTRDSIVGAVETLLRAGADDASLR ADVQADDVVSSLIGIFLVSGSPEQTGRMLDLLVAGVTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4593 | - | - | 100% (179) | TetR family protein transcriptional regulator |
| M. avium 104 | MAV_2463 | - | 3e-12 | 33.33% (147) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2097 | - | 4e-08 | 32.17% (143) | transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0068c | - | 3e-20 | 35.03% (177) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0142 | - | 8e-17 | 35.10% (151) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0067c | - | 3e-20 | 35.03% (177) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 2e-17 | 33.90% (177) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1873c | - | 1e-42 | 49.15% (177) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3161 | - | 5e-07 | 38.75% (80) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_3452 | - | 1e-36 | 44.94% (178) | TetR family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3536 | - | 8e-09 | 28.04% (189) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2922 | - | 9e-08 | 29.70% (165) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1059 | - | 8e-21 | 32.40% (179) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4593|M.avium_104 -----------------MVGRS-------------DARRNRQRLLEAATA
MAB_1873c|M.abscessus_ATCC_199 ----------MSEA-ELRTPRA-------------DAARNRDQLLAAATR
MSMEG_3452|M.smegmatis_MC2_155 -----------MAN-PTRRTRS-------------DALQNRARILEVAAK
Mb0068c|M.bovis_AF2122/97 -----------MAP-TDRRVRA-------------DAARNRARVLEVAYQ
Rv0067c|M.tuberculosis_H37Rv -----------MAP-TDRRVRA-------------DAARNRARVLEVAYQ
MLBr_00316|M.leprae_Br4923 MSVPRSGLSVQMAQ-PARPLRA-------------DAARNRARILGVAYE
Mflv_0142|M.gilvum_PYR-GCK ---------------MTRPLRA-------------DAARNRARVLEVAYD
Mvan_1059|M.vanbaalenii_PYR-1 ----------MIDK-PCRGLRK-------------DAERNRQRVLTAARE
TH_3536|M.thermoresistible__bu -----VVGRPQLTS-EQRNVRKSAHTLASVAGRAYDDGTRRTEILQTAAR
MMAR_3161|M.marinum_M -----------MRWGAAAPS---------------DRDSARDRLLDAAER
MUL_2922|M.ulcerans_Agy99 --------------------------------------METERLLRAAAD
.:* .*
MAV_4593|M.avium_104 AFTAHGAS-VSLESIARDAGVGIGTLYRHFPNREALVEAVYR---AELAE
MAB_1873c|M.abscessus_ATCC_199 AFASADSE-PSMRAIARQAGVGIATLYRHFPTRESLVDAVYR---DQVVR
MSMEG_3452|M.smegmatis_MC2_155 AFAEQGLD-TAPAAIAKLAGVGIGTLYRHFPTRETLIDAAYR---HQLTR
Mb0068c|M.bovis_AF2122/97 TFAADGLS-VPVDEIARRAGVGAGTVYRHFPTKEALFQAVIA---DRMHR
Rv0067c|M.tuberculosis_H37Rv TFAADGLS-VPVDEIARRAGVGAGTVYRHFPTKEALFQAVIA---DRMHR
MLBr_00316|M.leprae_Br4923 AFATEGLS-VPIDEIARRAGVGAGTVYRHFPTKEALCAAVIG---DRMPH
Mflv_0142|M.gilvum_PYR-GCK TFAAEGLT-VPIDEIARRAGVGAGTVYRHFPTKEALVVAVAE---DRVRR
Mvan_1059|M.vanbaalenii_PYR-1 LFAVEGME-ASLNDVARHAGVGVGTVYRRFATKEELVEAIFE---SGVDE
TH_3536|M.thermoresistible__bu LIASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILVELLRRYHTDLDT
MMAR_3161|M.marinum_M CLESCGVVGTTMEDIGRTAGVSRATVYRYFPNREAVMSGVIIR---AAER
MUL_2922|M.ulcerans_Agy99 FLSTRPNA--TLDEIGAAAGVSHSTLYRHFDGRTALLEALDH---AAIEQ
: . :. **: .::*: * : :
MAV_4593|M.avium_104 VAAAAAQLLQR-HPPKA--ALRRWMDRYATFVATKRGMAESLQAIFE---
MAB_1873c|M.abscessus_ATCC_199 LTTGAHELLGQ-LPPAT--AMRRWMDSFGDWIATKNGMLDTLHTMIE---
MSMEG_3452|M.smegmatis_MC2_155 VCDAVADLAAR-HPGDE--ATRRWMERFIDYATAKSGMSEALNAVIA---
Mb0068c|M.bovis_AF2122/97 IIDKGHALLKSKHPGDA--LFAFLRSMVLQWGATDRGLVEALAGVG----
Rv0067c|M.tuberculosis_H37Rv IIDKGHALLKSKHPGDA--LFAFLRSMVLQWGATDRGLVEALAGVG----
MLBr_00316|M.leprae_Br4923 LVDDGYVLLKSAGPGEA--LFTYLRSLVLHWGATDRGLVDALAGAGG---
Mflv_0142|M.gilvum_PYR-GCK IAERARTLLAVEGPGQA--LFVFFRDMVRS-AAVDHGLVDALMNQG----
Mvan_1059|M.vanbaalenii_PYR-1 VVCLAEAALRH-QDSWE--GFVWFVERQCLLTATDRGLREMVYSKAY---
TH_3536|M.thermoresistible__bu IAAHAQERLDDPDPRSPSDRITDLGVAIARCAVTHRAALQMTFYEGPTSH
MMAR_3161|M.marinum_M YLDRINPRIAEHTDLGS--ALVDFVEYTVEAARREEIIGLLFGSDEE---
MUL_2922|M.ulcerans_Agy99 MRDALKTSHWQEYSPTD------ALRILVAACEPVAGYLTLRYVQGQ---
MAV_4593|M.avium_104 SGALVPS-QTRDSIVGAVETLLRAGADD--ASLRADVQA----DDVVSS-
MAB_1873c|M.abscessus_ATCC_199 SGHIGHA-ETRAELLKAVTTILDAGHAA--GDLRADVTA----EDIAAS-
MSMEG_3452|M.smegmatis_MC2_155 SGADPFA-DSLSMLTEAVGTLLEAGRRD--HTLRTDVTA----GDVLLF-
Mb0068c|M.bovis_AF2122/97 IEISSAAPEAEADFLDLLTDLLRAAQRA--GTVRPDVDV----LEVKTL-
Rv0067c|M.tuberculosis_H37Rv IEISSAAPEAEADFLDLLTDLLRAAQRA--GTVRPDVDV----LEVKTL-
MLBr_00316|M.leprae_Br4923 IDILGVAPDAEDAFLTILSDLLYAAQYA--GTARTDVGV----REVKSI-
Mflv_0142|M.gilvum_PYR-GCK LDLEAVAPGVEAAFLSTLGDLLSAAQGA--GTVRPDVDV----AVVKAL-
Mvan_1059|M.vanbaalenii_PYR-1 GGNRVER--VRERLAPLMKELVERARRD--GYLRPDVES----TDMPVIG
TH_3536|M.thermoresistible__bu PEVTALAQQRPTGILEAMLQTLRAARWS--GYLRADIDLPILADRIVQTM
MMAR_3161|M.marinum_M LAGVGLAAGTSTSLFELVTEFLRPIFRRHWSYVEPGVSVDDAAEWVLRTI
MUL_2922|M.ulcerans_Agy99 SFETRKSVAEWREINSEIEEIFLRGQRA--GEFRTDVTADWLTEAFFSLV
: : . ...: .
MAV_4593|M.avium_104 -LIGIFLVSGSPEQ---TGRMLDLLVAGVTR-------------------
MAB_1873c|M.abscessus_ATCC_199 -LIGIFTVAPRPEQEAQADRLLNLLMDGLRPAARQAHS------------
MSMEG_3452|M.smegmatis_MC2_155 -MGGIAYAAQHGTR-DQARRLVDLFIDALTKDTRPDT-------------
Mb0068c|M.bovis_AF2122/97 -LVGCQAMQSYNAE--LAAKVTDVALDGLRANRK----------------
Rv0067c|M.tuberculosis_H37Rv -LVGCQAMQSYNAE--LAAKVTDVALDGLRANRK----------------
MLBr_00316|M.leprae_Br4923 -LVGCQAMEAYNSA--LAERVTDVVVDGLRAAR-----------------
Mflv_0142|M.gilvum_PYR-GCK -LVVCKVPQVFDSE--VTERVTRVIEDGLRPLR-----------------
Mvan_1059|M.vanbaalenii_PYR-1 LLAGTVGEWAGDVDPELWRRYVELLLEGMRCRPDQKPLDVDALGEEQMHA
TH_3536|M.thermoresistible__bu LQVGLDVIRHNASPDKAATLLCRILLEGLATVLPTDEELDGSAAFRAADE
MMAR_3161|M.marinum_M LSLLTVRGPRERSRDGLRTFLSRFLLPAILASDHCRPM------------
MUL_2922|M.ulcerans_Agy99 SGAGWSVQLGRVARREFTARRANPAWRD----------------------
MAV_4593|M.avium_104 --------------------------------------------------
MAB_1873c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3452|M.smegmatis_MC2_155 --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1059|M.vanbaalenii_PYR-1 AMHGWDPSG-----------------------------------------
TH_3536|M.thermoresistible__bu VVQSWSLEAEAEADDKAAHVRAVARAEFGRRGYEGTTIRDIARAAGLGTG
MMAR_3161|M.marinum_M --------------------------------------------------
MUL_2922|M.ulcerans_Agy99 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
MAB_1873c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3452|M.smegmatis_MC2_155 --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1059|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3536|M.thermoresistible__bu TVYRLIGSKEELLASIMRSFGEKIAVGWTDVLRTDAPAIAKLDALSWVNT
MMAR_3161|M.marinum_M --------------------------------------------------
MUL_2922|M.ulcerans_Agy99 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
MAB_1873c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3452|M.smegmatis_MC2_155 --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1059|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3536|M.thermoresistible__bu NALDRFGDEFRIQLAWMRQSPPDTPNPGWLFAKRVRQVKSLLAAAIRSGE
MMAR_3161|M.marinum_M --------------------------------------------------
MUL_2922|M.ulcerans_Agy99 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
MAB_1873c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3452|M.smegmatis_MC2_155 --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1059|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3536|M.thermoresistible__bu ISIDSPSNELLARSVIGVGWVPENILRQIGTRAAQILVRDTVLRGAADRD
MMAR_3161|M.marinum_M --------------------------------------------------
MUL_2922|M.ulcerans_Agy99 --------------------------------------------------
MAV_4593|M.avium_104 ---
MAB_1873c|M.abscessus_ATCC_199 ---
MSMEG_3452|M.smegmatis_MC2_155 ---
Mb0068c|M.bovis_AF2122/97 ---
Rv0067c|M.tuberculosis_H37Rv ---
MLBr_00316|M.leprae_Br4923 ---
Mflv_0142|M.gilvum_PYR-GCK ---
Mvan_1059|M.vanbaalenii_PYR-1 ---
TH_3536|M.thermoresistible__bu VTR
MMAR_3161|M.marinum_M ---
MUL_2922|M.ulcerans_Agy99 ---