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SKRRDVKHVTTGGGRGARRRILDTATELFYRDGINATGVERLAAEASVSKRTLYQHFPSKNAVVEEYLRG IQQAVGDPIHPEADATNRSPRARLLALFDTPAPGDALMRGCPFHNAAVEAGQTMPEVRSIVREHKRTYID GLAELARRAGASDPQLLGNQLAVLYEGAAALSTSLNDPSPWAHARAAAHTLIDRAVSRDDGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2097 | - | - | 100% (203) | transcriptional regulator |
| M. avium 104 | MAV_1243 | - | 7e-33 | 47.03% (185) | transcriptional regulator |
| M. avium 104 | MAV_3517 | - | 4e-16 | 31.75% (189) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3198c | - | 3e-67 | 69.47% (190) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3237 | - | 8e-10 | 28.42% (190) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3173c | - | 3e-67 | 69.47% (190) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01070 | - | 9e-07 | 24.48% (192) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2458c | - | 3e-18 | 34.64% (179) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2062 | - | 2e-12 | 30.43% (184) | hypothetical protein MMAR_2062 |
| M. smegmatis MC2 155 | MSMEG_2153 | - | 7e-51 | 58.15% (184) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3775 | - | 1e-18 | 37.36% (182) | PUTATIVE TetR-family protein transcriptional regulator |
| M. ulcerans Agy99 | MUL_4837 | - | 1e-08 | 30.50% (141) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4792 | - | 4e-19 | 37.66% (154) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3198c|M.bovis_AF2122/97 -----------MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATG
Rv3173c|M.tuberculosis_H37Rv -----------MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATG
MAV_2097|M.avium_104 -----------MSKRRDVKHVTTGGGRGARRRILDTATELFYRDGINATG
MSMEG_2153|M.smegmatis_MC2_155 -----------MSDTT----AERRGGRGARERLLSSASRLFYRNGIHATG
TH_3775|M.thermoresistible__bu -----------------------MAETDDKNRVLATATTLFNERGVQAVG
Mvan_4792|M.vanbaalenii_PYR-1 -----------------------MPAEDPRQRAIDAAVELFHREGFGAVG
MAB_2458c|M.abscessus_ATCC_199 --------MSSATVPTAADSARTARVLGPADRLLQTATDLFATQGIRSVG
MMAR_2062|M.marinum_M ----------------MAIPEATTAAVPARERILGAAYDLFSRRGIRAVG
Mflv_3237|M.gilvum_PYR-GCK -----------------------MTEPTTRDRILDAAAELYRRQGMSATG
MUL_4837|M.ulcerans_Agy99 -------------MGTETSTDGVESITDLDRTILDTAHAVFETYGVRRAN
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
: * : . .
Mb3198c|M.bovis_AF2122/97 VELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGE-ADK-MPKASN
Rv3173c|M.tuberculosis_H37Rv VELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGE-ADK-MPKASN
MAV_2097|M.avium_104 VERLAAEASVSKRTLYQHFPSKNAVVEEYLRGIQQAVGD-PIHPEADATN
MSMEG_2153|M.smegmatis_MC2_155 VEALIQHANVSKRTLYQHFSSKNELVEHYLRRIDGAGGS-PMEKPLLNQE
TH_3775|M.thermoresistible__bu MDAIRDAAGISLKRLYSCFRSKADLVAAVLEQRDADVRR-AMTEYVQSRA
Mvan_4792|M.vanbaalenii_PYR-1 IDRLTTSIGMSKRTLYKYFDSKDDLLLAVLDSCEGMALR-DLPD--EDDD
MAB_2458c|M.abscessus_ATCC_199 IDQILREAGVAKASLYSSFGSKDALVVAYLEELDQRDRN-RWN-AAVAAQ
MMAR_2062|M.marinum_M TDEVIERAGVARATLYRHFATKDDLVLAVLQRREELWTFGLIEQKSRARG
Mflv_3237|M.gilvum_PYR-GCK LKQISAAARAPFGSIYHHFPGGKEAISAEVIRSEGIRYAAFVG--AQLAD
MUL_4837|M.ulcerans_Agy99 IEDVATRAGVSRSTIYRRFPTKDELFERVVRREAELFFA---ALNQATNG
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRS----AVEALAE
. : . :* * . :
Mb3198c|M.bovis_AF2122/97 ATPRERLLALFDRPNR---GDGRMRGCPFH-NAAVEAAGEMPGVERIVHS
Rv3173c|M.tuberculosis_H37Rv ATPRERLLALFDRPNR---GDGRMRGCPFH-NAAVEAAGEMPGVERIVHS
MAV_2097|M.avium_104 RSPRARLLALFDTPAP---GDALMRGCPFH-NAAVEAGQTMPEVRSIVRE
MSMEG_2153|M.smegmatis_MC2_155 LPPRDRLLAIFDAVP-----VARFRGCPFH-NAAVESAGELSAVEDIVRD
TH_3775|M.thermoresistible__bu ADPRDRILAVFDFLAHWF-AESDFRGCMFI-NTIGELGGTSTDVRRIARL
Mvan_4792|M.vanbaalenii_PYR-1 SSPRDRILAVFDAQAKYC-TDPDFAGCFFV-NIATEFRDPDHRAVRIAAD
MAB_2458c|M.abscessus_ATCC_199 RDPIAKVLTFFDLAATAA-ESRNFRGCLYA-NAATEFPG---LQLEPVRT
MMAR_2062|M.marinum_M NTPEEQLLAIFDVLHEWFQSRDGYEGCSFI-NVLLELGADHPAGRACIG-
Mflv_3237|M.gilvum_PYR-GCK INPANGIEAVFASAAELLESQDYSEACSIE-TIALEVASTNERLRGEAAE
MUL_4837|M.ulcerans_Agy99 HNPREAVIEAFTLGVR-LIRDSPLYSRIAE-SEPELFGMFSRSHVFPIGQ
MLBr_01070|M.leprae_Br4923 QLPADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQ
* .
Mb3198c|M.bovis_AF2122/97 HKRDYIKGLARLAREAGAAHPRS--LGNQLAVLFEGAAALSTSLDDAGPW
Rv3173c|M.tuberculosis_H37Rv HKRDYIKGLARLAREAGAAHPRS--LGNQLAVLFEGAAALSTSLDDAGPW
MAV_2097|M.avium_104 HKRTYIDGLAELARRAGASDPQL--LGNQLAVLYEGAAALSTSLNDPSPW
MSMEG_2153|M.smegmatis_MC2_155 HKRRFAELLVQVATEAGAADPYA--LGPQLLVLFEGAAALATSLNDTGAF
TH_3775|M.thermoresistible__bu HKTAVRDYLA--DLVAAAELPSE--LAEQLAILADGAIVAATIWGDGTDA
Mvan_4792|M.vanbaalenii_PYR-1 HKAKLTQFLVRQARLAGVAAPDD--LAEQLTVLHTGAADYALLYGHYPDS
MAB_2458c|M.abscessus_ATCC_199 HREWFRATVAALLREAGLARPDS--IARQVQLLYDGALTGSKIDKSVVPI
MMAR_2062|M.marinum_M HIDHVRGIVRERAVAAGLHDVED--FAWSWHILMKGAIILAAVGDPDSAR
Mflv_3237|M.gilvum_PYR-GCK VFETWLHQLAGWFGQLDIGDEQSRRLATVMLTALEGAFVLCRTLRSVEPM
MUL_4837|M.ulcerans_Agy99 FADGIAHTLRRCGADAPDADLAN--IADILLRVAVGIIMFPTERLDTSDD
MLBr_01070|M.leprae_Br4923 QWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTERVMAATFSDEKPL
Mb3198c|M.bovis_AF2122/97 AHARAAAEVLIDQATARPV--
Rv3173c|M.tuberculosis_H37Rv AHARAAAEVLIDQATARPV--
MAV_2097|M.avium_104 AHARAAAHTLIDRAVSRDDGD
MSMEG_2153|M.smegmatis_MC2_155 VHARAAAAQLIDCAVRGQIGR
TH_3775|M.thermoresistible__bu AAAARRAAATLISAS------
Mvan_4792|M.vanbaalenii_PYR-1 TRTAVAALLTAAGL-------
MAB_2458c|M.abscessus_ATCC_199 TLARRLTRQLIG---------
MMAR_2062|M.marinum_M RAQRMAQVLIEQHRAAGAAAC
Mflv_3237|M.gilvum_PYR-GCK LIAGHGVQAAVHAVLASAQ--
MUL_4837|M.ulcerans_Agy99 AAVREYAARYLIPIITL----
MLBr_01070|M.leprae_Br4923 IPDKKVIDTLVHIWLASIYGS