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APTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHR IIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRAAQ RAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0067c | - | - | 100% (189) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY) |
| M. tuberculosis H37Rv | Rv0232 | - | 6e-10 | 30.54% (167) | TetR/ACRR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3295 | - | 7e-08 | 27.39% (157) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0068c | - | 1e-102 | 100.00% (189) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0142 | - | 5e-55 | 61.75% (183) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 3e-68 | 68.25% (189) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0647 | - | 3e-64 | 67.22% (180) | transcriptional regulator TetR |
| M. marinum M | MMAR_2984 | - | 4e-08 | 41.56% (77) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4593 | - | 4e-20 | 35.03% (177) | TetR family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0878 | - | 8e-64 | 66.29% (178) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3536 | - | 2e-08 | 26.80% (153) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_1152 | - | 3e-07 | 28.14% (167) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0763 | - | 3e-56 | 63.33% (180) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0067c|M.tuberculosis_H37Rv ------------------MAPTDRRVRA--DAARNRARVLEVAYQTFAAD
Mb0068c|M.bovis_AF2122/97 ------------------MAPTDRRVRA--DAARNRARVLEVAYQTFAAD
MLBr_00316|M.leprae_Br4923 -------MSVPRSGLSVQMAQPARPLRA--DAARNRARILGVAYEAFATE
MAB_0647|M.abscessus_ATCC_1997 ------------------MDQPARPLRA--DAARNRARVLEVAYQTFAEE
Mflv_0142|M.gilvum_PYR-GCK ---------------------MTRPLRA--DAARNRARVLEVAYDTFAAE
Mvan_0763|M.vanbaalenii_PYR-1 ---------------------MTRPLRA--DAARNRARVLEVAYDTFAAE
MSMEG_0878|M.smegmatis_MC2_155 -----------------------MSMRA--DAARNRARVLEVAYEAFAQD
MAV_4593|M.avium_104 -----------------------MVGRS--DARRNRQRLLEAATAAFTAH
TH_3536|M.thermoresistible__bu VVGRPQLTSEQRNVRKSAHTLASVAGRAY-DDGTRRTEILQTAARLIASS
MMAR_2984|M.marinum_M -------------MTTSDRGAPAQANRSERRKRRTRTALLRAAQRLIAEG
MUL_1152|M.ulcerans_Agy99 ---------------------MPTVTWARVDPAR-RAAIVEAAEAEFGAH
: * :: .* :
Rv0067c|M.tuberculosis_H37Rv GLS-VPVDEIARRAGVGAGTVYRHFPTKEALFQAVIA---DRMHRIIDKG
Mb0068c|M.bovis_AF2122/97 GLS-VPVDEIARRAGVGAGTVYRHFPTKEALFQAVIA---DRMHRIIDKG
MLBr_00316|M.leprae_Br4923 GLS-VPIDEIARRAGVGAGTVYRHFPTKEALCAAVIG---DRMPHLVDDG
MAB_0647|M.abscessus_ATCC_1997 GLG-VPIDEIARRAGVGAGTVYRHFPAKEDLYRAIAE---DRMGSVIDKG
Mflv_0142|M.gilvum_PYR-GCK GLT-VPIDEIARRAGVGAGTVYRHFPTKEALVVAVAE---DRVRRIAERA
Mvan_0763|M.vanbaalenii_PYR-1 GLG-VPIDEIARRAGVGAGTVYRHFPTKQALVVAVAE---DRVRRIVDHA
MSMEG_0878|M.smegmatis_MC2_155 GLA-VPIDEIARRAGVGAGTVYRHFPSKEDLYRAVVA---ERIREIVDQG
MAV_4593|M.avium_104 GAS-VSLESIARDAGVGIGTLYRHFPNREALVEAVYR---AELAEVAAAA
TH_3536|M.thermoresistible__bu GLR-TSLQEIADAAGILPGSLYHHFESKEAILVELLRRYHTDLDTIAAHA
MMAR_2984|M.marinum_M KLN-VPVLEITQAADVGMGSFYNHFDSKEQLFEAAVADVLDAHGALLDRC
MUL_1152|M.ulcerans_Agy99 GFSQGSLNVIARRARVAKGSLFQYFADKRDLYAYIADIANQRVRTHIEGL
.: *: * : *:.:.:* :. :
Rv0067c|M.tuberculosis_H37Rv HALLKSKHPGD--------ALFAFLRSMVLQWGATDRGLVEALAGVG---
Mb0068c|M.bovis_AF2122/97 HALLKSKHPGD--------ALFAFLRSMVLQWGATDRGLVEALAGVG---
MLBr_00316|M.leprae_Br4923 YVLLKSAGPGE--------ALFTYLRSLVLHWGATDRGLVDALAGAGG--
MAB_0647|M.abscessus_ATCC_1997 RELLAAVDPGE--------ALFEFLRS-MMDWGGTDQGLVDALSGAG---
Mflv_0142|M.gilvum_PYR-GCK RTLLAVEGPGQ--------ALFVFFRD-MVRSAAVDHGLVDALMNQG---
Mvan_0763|M.vanbaalenii_PYR-1 RTLLAAEGPGE--------ALFVFLRD-MVRSAAADYGLVDALVGYG---
MSMEG_0878|M.smegmatis_MC2_155 QALLADGDPGE--------ALFDYLRLMVLQCGAADRGLVEALAGAG---
MAV_4593|M.avium_104 AQLLQRHPPKA--------ALRRWMDR-YATFVATKRGMAESLQAIF---
TH_3536|M.thermoresistible__bu QERLDDPDPRSPS------DRITDLGVAIARCAVTHRAALQMTFYEGPTS
MMAR_2984|M.marinum_M TASIEDPAETFAASFRLTGRLFRRRPQESEILLANGAALLSSDRGLAP--
MUL_1152|M.ulcerans_Agy99 IRELDSSRPFF-------EFLTDLLDGWVAYFAEHPRERALHAAATLEVD
:
Rv0067c|M.tuberculosis_H37Rv -IEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVG---
Mb0068c|M.bovis_AF2122/97 -IEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVG---
MLBr_00316|M.leprae_Br4923 -IDILGVAPDAEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVG---
MAB_0647|M.abscessus_ATCC_1997 -IDVQALIPHIEESFYAVLGDLLRAAQQAGTVRSDVGVHEVKALLVG---
Mflv_0142|M.gilvum_PYR-GCK -LDLEAVAPGVEAAFLSTLGDLLSAAQGAGTVRPDVDVAVVKALLVV---
Mvan_0763|M.vanbaalenii_PYR-1 -LDLEVAAPGAEAAFLATLGELLAAAQRAGTVRADVDVAVIKALLVV---
MSMEG_0878|M.smegmatis_MC2_155 -IDVKTMVPDAEDEYMEMLGGLLRAAQRAGTVRGDVTATDVKALLVG---
MAV_4593|M.avium_104 -ESGALVPSQTRDSIVGAVETLLRAGADDASLRADVQADDVVSSLIG---
TH_3536|M.thermoresistible__bu HPEVTALAQQRPTGILEAMLQTLRAARWSGYLRADIDLPILADRIVQTML
MMAR_2984|M.marinum_M -RALRDIKAASDAGRFRVEDPELALAMAGGALLGLGTLLRADPQRDG---
MUL_1152|M.ulcerans_Agy99 TDARISVRSVIHRHYLEVLRPLVRDALARGDLRADSDTDALLSLLLMIFP
: . .
Rv0067c|M.tuberculosis_H37Rv -------------CQAMQSYNAELAAKVTDVALDGLRANRK---------
Mb0068c|M.bovis_AF2122/97 -------------CQAMQSYNAELAAKVTDVALDGLRANRK---------
MLBr_00316|M.leprae_Br4923 -------------CQAMEAYNSALAERVTDVVVDGLRAAR----------
MAB_0647|M.abscessus_ATCC_1997 -------------CQAMQSYNKDVSRQVTDVVFDGLRPRP----------
Mflv_0142|M.gilvum_PYR-GCK -------------CKVPQVFDSEVTERVTRVIEDGLRPLR----------
Mvan_0763|M.vanbaalenii_PYR-1 -------------CKVPQVYDGEVSERVVRVIEDGLRVRSSV--------
MSMEG_0878|M.smegmatis_MC2_155 -------------CQAMQAYDATAAEHLTGVVFDGLRVAPASVPSR----
MAV_4593|M.avium_104 -------------IFLVSGS-PEQTGRMLDLLVAGVTR------------
TH_3536|M.thermoresistible__bu QVGLD--------VIRHNASPDKAATLLCRILLEGLATVLPTDEELDGSA
MMAR_2984|M.marinum_M -------------CAAADAVTEDLLRLFGLDAEQARAICRRPLPDLDGWD
MUL_1152|M.ulcerans_Agy99 HLALAPYMRGLDPILGLDEPTPEQPALAVRRLVAVLTAAYSPSLTVEVRK
.
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MAB_0647|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0763|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0878|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
TH_3536|M.thermoresistible__bu AFRAADEVVQSWSLEAEAEADDKAAHVRAVARAEFGRRGYEGTTIRDIAR
MMAR_2984|M.marinum_M QPDSAA--------------------------------------------
MUL_1152|M.ulcerans_Agy99 VT------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MAB_0647|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0763|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0878|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
TH_3536|M.thermoresistible__bu AAGLGTGTVYRLIGSKEELLASIMRSFGEKIAVGWTDVLRTDAPAIAKLD
MMAR_2984|M.marinum_M --------------------------------------------------
MUL_1152|M.ulcerans_Agy99 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MAB_0647|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0763|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0878|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
TH_3536|M.thermoresistible__bu ALSWVNTNALDRFGDEFRIQLAWMRQSPPDTPNPGWLFAKRVRQVKSLLA
MMAR_2984|M.marinum_M --------------------------------------------------
MUL_1152|M.ulcerans_Agy99 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0068c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00316|M.leprae_Br4923 --------------------------------------------------
MAB_0647|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0142|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0763|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0878|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4593|M.avium_104 --------------------------------------------------
TH_3536|M.thermoresistible__bu AAIRSGEISIDSPSNELLARSVIGVGWVPENILRQIGTRAAQILVRDTVL
MMAR_2984|M.marinum_M --------------------------------------------------
MUL_1152|M.ulcerans_Agy99 --------------------------------------------------
Rv0067c|M.tuberculosis_H37Rv ----------
Mb0068c|M.bovis_AF2122/97 ----------
MLBr_00316|M.leprae_Br4923 ----------
MAB_0647|M.abscessus_ATCC_1997 ----------
Mflv_0142|M.gilvum_PYR-GCK ----------
Mvan_0763|M.vanbaalenii_PYR-1 ----------
MSMEG_0878|M.smegmatis_MC2_155 ----------
MAV_4593|M.avium_104 ----------
TH_3536|M.thermoresistible__bu RGAADRDVTR
MMAR_2984|M.marinum_M ----------
MUL_1152|M.ulcerans_Agy99 ----------