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M. avium 104 MAV_4440 (-)

annotation: oxidoreductase, zinc-binding dehydrogenase family protein
coordinates: 4575049 - 4576281
length: 410

KALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDVPEPVLPHEDWVLTRPRLTGICGSDAKQILMDFGEG
DADNAMSAFCSFPQVMGHEVVADVVALGPGARGLAVGQRVVLNPWLSCGPRGIQPPCPACEAGDYSLCWS
FADGDLKPGIHTGVSADVTGGYAELMPAHDSMLFAVPERVPDEMAVFADPFSVSLHAITRHPPPRSGRAL
VYGAGSLGLCAVAILRALYPEVAVAVVARFDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPL
LGLPMAHPGAVDVVYDTVGKPETLEVAVRLLRSRGTLVKAGVHAPGRWEDSPLYFKEIALVGSNAFGVEE
VDGQRRHAIAHYLDLAAAGRVDLRPMLTHTFTLDRWRDAFHALADQGRTGAVKVAFDQR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_4440--100% (410)oxidoreductase, zinc-binding dehydrogenase family protein
M. avium 104MAV_2804-1e-2128.61% (353) zinc-binding dehydrogenase
M. avium 104MAV_4173-2e-1827.37% (380) oxidoreductase, zinc-binding dehydrogenase family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1557adh4e-1928.46% (369) alcohol dehydrogenase adh
M. gilvum PYR-GCKMflv_4997-1e-2729.59% (392) alcohol dehydrogenase
M. tuberculosis H37RvRv1530adh4e-1928.46% (369) alcohol dehydrogenase adh
M. leprae Br4923MLBr_01784adhE23e-1426.07% (349) putative alcohol dehydrogenase (Zn dependent)
M. abscessus ATCC 19977MAB_2041c-4e-1729.65% (317) zinc-containing alcohol dehydrogenase
M. marinum MMMAR_3529-1e-1927.49% (382) dehydrogenase
M. smegmatis MC2 155MSMEG_1795-9e-2328.02% (364) 2-deoxy-scyllo-inosamine dehydrogenase
M. thermoresistible (build 8)TH_4349-9e-1630.08% (379) PUTATIVE Alcohol dehydrogenase GroES domain protein
M. ulcerans Agy99MUL_0819adh_10.080.00% (410) short-chain dehydrogenase Adh_1
M. vanbaalenii PYR-1Mvan_1380-4e-3030.69% (378) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MAV_4440|M.avium_104                --------------------------------------------------
MUL_0819|M.ulcerans_Agy99           MSYTMAGRRVLITGASSGVGAALARMLAARGTTVGLIARRRDRLEEVLAD
Mb1557|M.bovis_AF2122/97            --------------------------------------------------
Rv1530|M.tuberculosis_H37Rv         --------------------------------------------------
MAB_2041c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_4997|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1380|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3529|M.marinum_M               --------------------------------------------------
MSMEG_1795|M.smegmatis_MC2_155      --------------------------------------------------
TH_4349|M.thermoresistible__bu      --------------------------------------------------
MLBr_01784|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MAV_4440|M.avium_104                --------------------------------------------------
MUL_0819|M.ulcerans_Agy99           CRKTSPQSVMWVADLCDTAGAARLALQAWQAMGGIDVLVNNAAIPKRREV
Mb1557|M.bovis_AF2122/97            --------------------------------------------------
Rv1530|M.tuberculosis_H37Rv         --------------------------------------------------
MAB_2041c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_4997|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1380|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3529|M.marinum_M               --------------------------------------------------
MSMEG_1795|M.smegmatis_MC2_155      --------------------------------------------------
TH_4349|M.thermoresistible__bu      --------------------------------------------------
MLBr_01784|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MAV_4440|M.avium_104                --------------------------------------------------
MUL_0819|M.ulcerans_Agy99           SALRPTEVEQVMGVNFFAPMRMTLALLPRMLARGSGTIVNVSSVGGRLGI
Mb1557|M.bovis_AF2122/97            --------------------------------------------------
Rv1530|M.tuberculosis_H37Rv         --------------------------------------------------
MAB_2041c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_4997|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1380|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3529|M.marinum_M               --------------------------------------------------
MSMEG_1795|M.smegmatis_MC2_155      --------------------------------------------------
TH_4349|M.thermoresistible__bu      --------------------------------------------------
MLBr_01784|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MAV_4440|M.avium_104                --------------------------------------------------
MUL_0819|M.ulcerans_Agy99           IHESAYCASKFALCGWSESIAVDLAGSGVSVRLIQPGPVDTEIWDRPDNE
Mb1557|M.bovis_AF2122/97            --------------------------------------------------
Rv1530|M.tuberculosis_H37Rv         --------------------------------------------------
MAB_2041c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_4997|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1380|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3529|M.marinum_M               --------------------------------------------------
MSMEG_1795|M.smegmatis_MC2_155      --------------------------------------------------
TH_4349|M.thermoresistible__bu      --------------------------------------------------
MLBr_01784|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MAV_4440|M.avium_104                --------------------------------------------------
MUL_0819|M.ulcerans_Agy99           DPLYRGPKVPADLVAEGIIAAIGSDRFEHYLPEMMALKDIVDAKNADLDT
Mb1557|M.bovis_AF2122/97            --------------------------------------------------
Rv1530|M.tuberculosis_H37Rv         --------------------------------------------------
MAB_2041c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_4997|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1380|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3529|M.marinum_M               --------------------------------------------------
MSMEG_1795|M.smegmatis_MC2_155      --------------------------------------------------
TH_4349|M.thermoresistible__bu      --------------------------------------------------
MLBr_01784|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MAV_4440|M.avium_104                -----------MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDVPEP
MUL_0819|M.ulcerans_Agy99           FLTAAAAMIWQLKALVYGVALEPFEIDEPANPLACNLARTPTALRELADP
Mb1557|M.bovis_AF2122/97            --------------MSDGAVVRALVLEAPR-----RLVVRQYRLPRIGD-
Rv1530|M.tuberculosis_H37Rv         --------------MSDGAVVRALVLEAPR-----RLVVRQYRLPRIGD-
MAB_2041c|M.abscessus_ATCC_199      ------------------MIAEAMVLTGPR-----SLQRRQMIIPDVGD-
Mflv_4997|M.gilvum_PYR-GCK          --------------------MQAMVYTGPG----------QRSWQTVPDP
Mvan_1380|M.vanbaalenii_PYR-1       --------------------MLAMVYDGPG----------RRSWRSVPEP
MMAR_3529|M.marinum_M               --------------------MRSAVVTTPG----------HTDVIEAPDP
MSMEG_1795|M.smegmatis_MC2_155      ---------------MTNIAAGAPQVTTSRVARTGGPGRLTLEDRKIASP
TH_4349|M.thermoresistible__bu      --------------------MKALRLMDWK---------SEPELVEVPDP
MLBr_01784|M.leprae_Br4923          ----------------MSQTVRGVISRKKD-------EPVELVDIVIPDP
                                                                                    . 

MAV_4440|M.avium_104                VLPHEDWVLTRPRLTGICGSD-AKQILMDFGEGDADNAMSAFCSFPQVMG
MUL_0819|M.ulcerans_Agy99           RPLRPDWVITRPRLTGICGSD-SKQILLDFGEQDADNALAAFCSFPQVMG
Mb1557|M.bovis_AF2122/97            -----DDALVRVEACGLCGTD-HEQYTGELAGG-----------FAFVPG
Rv1530|M.tuberculosis_H37Rv         -----DDALVRVEACGLCGTD-HEQYTGELAGG-----------FAFVPG
MAB_2041c|M.abscessus_ATCC_199      -----RGAILRVEACGLCGTD-HEQFTGHLPAG-----------FSFVPG
Mflv_4997|M.gilvum_PYR-GCK          VLVDATDAIVRVDTVTICGTD-LHILKGDVPEVE----------SGRILG
Mvan_1380|M.vanbaalenii_PYR-1       VIQQGTDAIVRVDAVTICGTD-LHILKGDVPEVE----------PGRVLG
MMAR_3529|M.marinum_M               Q-VGPKDVLVKIRACGICGTDSFYISIGGLPPHRG----------RMPLG
MSMEG_1795|M.smegmatis_MC2_155      ---HNGEAVVRVENVTLCGTD-LHIWEGEYLNP-----------FPIVQG
TH_4349|M.thermoresistible__bu      TP-GPGQVLVKIGGAGACHSDLHLMHDFEPGMMP--------WQLPFTLG
MLBr_01784|M.leprae_Br4923          ---GPGEAVVDVTACGVCHTD-LTYREGGINDR-----------YPFLLG
                                           .:        * :*                            *

MAV_4440|M.avium_104                HEVVADVVALGPGAR---GLAVGQRVVLNPWLSCGPRGIQPPCPACEAGD
MUL_0819|M.ulcerans_Agy99           HEVVADVVELGPEAG---GLEVGQRVVLNPWLSCRPRGIEPPCPACQSGD
Mb1557|M.bovis_AF2122/97            HETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCR------QCANCRGGE
Rv1530|M.tuberculosis_H37Rv         HETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCR------QCANCRGGE
MAB_2041c|M.abscessus_ATCC_199      HEIVGIVEHVGAAAGQRWGVQAGQRVAVEVFRSCR------DCPECRRGE
Mflv_4997|M.gilvum_PYR-GCK          HEAVGTVTAIGSAVQT---LSVGDRVLVSCISSCG------ACRYCRQGH
Mvan_1380|M.vanbaalenii_PYR-1       HEAVGTVTEVGPAVQT---LSVGDRVLVSCISACG------ACRYCRQGQ
MMAR_3529|M.marinum_M               HEPAGEVVAVGSRVSG---LAVGDHVVINPMAAPN---------------
MSMEG_1795|M.smegmatis_MC2_155      HEAAGIVESVGDPADAS--SLTGTRVVISPVRSCG------DCHACRTGR
TH_4349|M.thermoresistible__bu      HENAGWVAAVGAGVGT---VTEGDAVAVYGPWGCG------TCERCMGGA
MLBr_01784|M.leprae_Br4923          HEAAGTVEVVGPGVTA---VEPGDFVILNWRAVCG------QCRACKRGR
                                    ** .. :  :*  .        *  * :                      

MAV_4440|M.avium_104                YSLCWSFADGDLKPGIHTGVSA--DVTGGYAELMP-AHDSMLFAVPERV-
MUL_0819|M.ulcerans_Agy99           YSLCWSFTDGGIQPGIHTGVSA--NVTGGYAELMP-AHDSMLFPVPGPI-
Mb1557|M.bovis_AF2122/97            YRRCVRHGLADMYGFIPVDREP--GLWGGYAEYQYLAPDSMVLRVAGDL-
Rv1530|M.tuberculosis_H37Rv         YRRCVRHGLADMYGFIPVDREP--GLWGGYAEYQYLAPDSMVLRVAGDL-
MAB_2041c|M.abscessus_ATCC_199      YRRCAVNGIATMFGFVDVEIGA--GLWGGYATHVELPWDAMLLPIAEDM-
Mflv_4997|M.gilvum_PYR-GCK          YGQCLGGGGWILGHLIDGTQAE--YVR------VPFADNSTHKVPAGVS-
Mvan_1380|M.vanbaalenii_PYR-1       YGQCLGGGGWILGHLIDGTQAE--YVR------VPFADNSTHKVPEGVS-
MMAR_3529|M.marinum_M               -------------GIIGNGGAS--GALADYLLIEEAVRGVSLEVIPEHI-
MSMEG_1795|M.smegmatis_MC2_155      ENVCER-----------VSVLG--CYEDGTLATRVVVPVSALHQVPDAV-
TH_4349|M.thermoresistible__bu      ENYCENPAG---APVLSGGAGL--GMDGGMAEYLLVPAERLVVKLPESMT
MLBr_01784|M.leprae_Br4923          PSYCFDTFNAQQKMTLIDGTELTPALGIGAFADKTLVHSGQCTKVDPAAD
                                                                                      

MAV_4440|M.avium_104                PDEMAVFADPFSVSLHAITR-HPPPRSG-RALVYGAGSLGLCAVAILRAL
MUL_0819|M.ulcerans_Agy99           SDEAAVFADPFSVSLHAITR-HPPPRSG-RVLVYGAGSLGLCAIAILRAL
Mb1557|M.bovis_AF2122/97            SPEVATLFNPLGAGIRWGVT-IPETKPGDVVAVLGPGIRGLCAAAAAKGA
Rv1530|M.tuberculosis_H37Rv         SPEVATLFNPLGAGIRWGVT-IPETKPGDVVAVLGPGIRGLCAAAAAKGA
MAB_2041c|M.abscessus_ATCC_199      DPVLATLFNPLGAGIQWGAT-LPDTKAGDVVAILGPGIRGICAAVAAKEA
Mflv_4997|M.gilvum_PYR-GCK          DEQMIVLADILPTSYEVGVL-AGRVGPGDVVAIVGAGPIGLAAVLTAKLY
Mvan_1380|M.vanbaalenii_PYR-1       DEQMIVLADILPTSYEVGVL-AGAVSPGDVVAIVGAGPIGLAAVLTAKLY
MMAR_3529|M.marinum_M               PFEVAALNEPMAVARHAVNQ-CKP-KPSDKVLIFGAGPIGLGAVLAFKSA
MSMEG_1795|M.smegmatis_MC2_155      PSELAPLSEPASIALQAVRR-GRP-VAGELALVLGCGPIGLITIMALRRA
TH_4349|M.thermoresistible__bu      PVTAAALTDAGLTPYHAIRRSWPKLTPTSTAVVIGVGGLGHVAVQLVKAT
MLBr_01784|M.leprae_Br4923          PAVAGLLGCGVMAGLGAAIN-TAAVSRDDTVAVIGCGGVGDAAISGAALV
                                          :                       . : * *  *  :       

MAV_4440|M.avium_104                YP--EVAVAVVARFDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRL
MUL_0819|M.ulcerans_Agy99           YP--DVAVAVVARFATQGELAGRFGAAKVVAHEPRLAIIEELVAWGGGRL
Mb1557|M.bovis_AF2122/97            GAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDPVAALTEQTGG---
Rv1530|M.tuberculosis_H37Rv         GAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDPVAALTEQTGG---
MAB_2041c|M.abscessus_ATCC_199      GAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATALQRETGGR--
Mflv_4997|M.gilvum_PYR-GCK          SPSHIVVIDVA---DTRLEAAKKLGADVTVNSRSRRPRDVIDELTGG---
Mvan_1380|M.vanbaalenii_PYR-1       SPSHIVVIDVA---DARLDAARRFGADTVVNSSTRSARDVIDELTGG---
MMAR_3529|M.marinum_M               GAAHVAVVDLIP---SRLDKALQVGADAVINSAEEDLTRRLIDLHGPGQA
MSMEG_1795|M.smegmatis_MC2_155      GVDVVAVDTVE----ERARFAERFGAVATIAVAPGQRCPSHEEVAAAAGS
TH_4349|M.thermoresistible__bu      TAARLIAVDNRS---EALELAREMGADHVVRSD-EQAVEAIWELTGG---
MLBr_01784|M.leprae_Br4923          GANRIIAVDIDD---TKLEWARTFGATHTVNALELEVVKTIQDLTSG---
                                                        *  .*.   :               .    

MAV_4440|M.avium_104                RRPLLGLPMAHPGAVDVVYDTVGKPETLEVAVRLLRSRGTLVKAGVHAPG
MUL_0819|M.ulcerans_Agy99           RQALLGLPMAHPGAVDVVYDTVGKPETFEIGVRVLNSRGTLVKAGVHAPG
Mb1557|M.bovis_AF2122/97            ------------LADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVG
Rv1530|M.tuberculosis_H37Rv         ------------LADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVG
MAB_2041c|M.abscessus_ATCC_199      ------------LADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGG
Mflv_4997|M.gilvum_PYR-GCK          ------------LGADVVMEAVGLPETFEESVDLVRPCGHVANIGVHGAP
Mvan_1380|M.vanbaalenii_PYR-1       ------------LGADVAMEAVGLPETFEESVALVRPGGHVANIGVHGAP
MMAR_3529|M.marinum_M               LFPG-------KAGTDIYLDAAGAPAAVNSALTNAKKGATIGIVAVHKKP
MSMEG_1795|M.smegmatis_MC2_155      GP---------TRAVSLVIEATGSPAALASAIDVVSHAGRVVIVGISDQD
TH_4349|M.thermoresistible__bu      ------------RGADVLLDFVGADATIELARAAARPLGDVTIVGIAGGS
MLBr_01784|M.leprae_Br4923          ------------FGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPD
                                                 .  :    .    :   .       . :   .     

MAV_4440|M.avium_104                ----RWEDSPLYFKEIALVGSNAFGVEEVDGQRRHAIAHYLDLAAAGRVD
MUL_0819|M.ulcerans_Agy99           ----RWEWSPLYFKEISWVGSNAFGVEEVEGVRKHAIAHYFDLVADDRLD
Mb1557|M.bovis_AF2122/97            SGAPGFSPDVVVFKELRVLG--ALGVDAT------AYRAALDLLVSGRYP
Rv1530|M.tuberculosis_H37Rv         SGAPGFSPDVVVFKELRVLG--ALGVDAT------AYRAALDLLVSGRYP
MAB_2041c|M.abscessus_ATCC_199      -GAPRFEPDLLVYKELHVVG--ALGVEYP------AYRAALEILAMGRWP
Mflv_4997|M.gilvum_PYR-GCK          ---ATLHLERIWIKNLTITT----GLVDT-----HSTPTLISLVANGRLD
Mvan_1380|M.vanbaalenii_PYR-1       ---ATLHLEQIWIKNLTITT----GLVDT-----HSTPTLIRLVANHQLD
MMAR_3529|M.marinum_M               ---VEVDLVTVMSHEITLVG----SIGYP-----TEIFDVTKDIVADWQK
MSMEG_1795|M.smegmatis_MC2_155      ---VTLPHRTIAFKELDVLG----SRNSVG-----LIPDGLGLIAQNQAA
TH_4349|M.thermoresistible__bu      VPLSFFSQPYEVSIQTTYWG---------------TRPELVELLDLAARG
MLBr_01784|M.leprae_Br4923          MRLDMPLLDFFSHGGSLKSSWYGDCLPER------DFPTLVDLYLQGRLP
                                                                                      

MAV_4440|M.avium_104                LRPMLTHTFTLDRWRDAFHALADQ--GRTGAVKVAFDQR-
MUL_0819|M.ulcerans_Agy99           LRSMLTHTFALPQWRDAFLAIANQ--GESGAVKVAFDQR-
Mb1557|M.bovis_AF2122/97            FASLPRRCVRLEGAEDLLATMAGERDGVP-PIHGVLTP--
Rv1530|M.tuberculosis_H37Rv         FASLPRRCVRLEGAEDLLATMAGERDGVP-PIHGVLTP--
MAB_2041c|M.abscessus_ATCC_199      FDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP
Mflv_4997|M.gilvum_PYR-GCK          AATMITHRYPMDEFDTAYQVFGDA--ANSGALKVVLTATS
Mvan_1380|M.vanbaalenii_PYR-1       TAAMITHRFPMDEFDTAYDVFGDA--AHSGALKVLLTASP
MMAR_3529|M.marinum_M               YALIVDRTIAFDNVQDALAAAATP--GTADKIVVTFP---
MSMEG_1795|M.smegmatis_MC2_155      FSSLITHRFPFEETADALRTLRTDTAHVRKVLISMGASV-
TH_4349|M.thermoresistible__bu      LVHVESTTYPLDDALQAYRDLRAGRVRGRAVIVP------
MLBr_01784|M.leprae_Br4923          LGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-------
                                       .      :                    :