For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TNIAAGAPQVTTSRVARTGGPGRLTLEDRKIASPHNGEAVVRVENVTLCGTDLHIWEGEYLNPFPIVQGH EAAGIVESVGDPADASSLTGTRVVISPVRSCGDCHACRTGRENVCERVSVLGCYEDGTLATRVVVPVSAL HQVPDAVPSELAPLSEPASIALQAVRRGRPVAGELALVLGCGPIGLITIMALRRAGVDVVAVDTVEERAR FAERFGAVATIAVAPGQRCPSHEEVAAAAGSGPTRAVSLVIEATGSPAALASAIDVVSHAGRVVIVGISD QDVTLPHRTIAFKELDVLGSRNSVGLIPDGLGLIAQNQAAFSSLITHRFPFEETADALRTLRTDTAHVRK VLISMGASV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1795 | - | - | 100% (360) | 2-deoxy-scyllo-inosamine dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3603 | - | 2e-42 | 34.74% (331) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3605 | - | 3e-41 | 30.06% (356) | sorbitol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 6e-29 | 30.42% (355) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_0125 | - | 3e-32 | 29.97% (337) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 6e-29 | 30.42% (355) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-20 | 29.54% (281) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 5e-23 | 27.64% (351) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0405 | adhE | 3e-30 | 30.39% (362) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 4e-31 | 31.58% (361) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4631 | - | 2e-28 | 33.76% (237) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 2e-25 | 28.77% (351) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1380 | - | 2e-33 | 30.99% (355) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
MAB_2084|M.abscessus_ATCC_1997 ---------------------MKTRAAVLWGLEQKWEVEEVDLDPPGPGE
MUL_2962|M.ulcerans_Agy99 -----------------------MRTVVIDGPGSIRVDNRPDPALPGSDG
Mvan_1380|M.vanbaalenii_PYR-1 -----------------------MLAMVYDGPGRRSWRSVPEPVIQQGTD
MSMEG_1795|M.smegmatis_MC2_155 -----------MTNIAAGAPQVTTSRVARTGGPGRLTLEDRKIASPHNGE
TH_4631|M.thermoresistible__bu --------------------------------------------------
Mflv_0125|M.gilvum_PYR-GCK -----------------------MRAAVYYGPNK-LEVDDVPEPEARPGT
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDG----------TRVRPVP-ILLGHEAAGIVE
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDG----------TRVRPVP-ILLGHEAAGIVE
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDG----------NRVRPVP-MLLGHEAAGIVE
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDG----------NRVRPVP-MLLGHEAAGIVE
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREG----------GINDRYP-FLLGHEAAGTVE
MAB_2084|M.abscessus_ATCC_1997 VLVRLAATGLCHSDEHLVTG----------DLPIPLP-VVGGHEGAGTVV
MUL_2962|M.ulcerans_Agy99 VIVVVSAAGICGSDLHFYEG----------EYPLAEP-VALGHEAVGTVV
Mvan_1380|M.vanbaalenii_PYR-1 AIVRVDAVTICGTDLHILKG----------DVPEVEPGRVLGHEAVGTVT
MSMEG_1795|M.smegmatis_MC2_155 AVVRVENVTLCGTDLHIWEG----------EYLNPFP-IVQGHEAAGIVE
TH_4631|M.thermoresistible__bu --------------------------------------------------
Mflv_0125|M.gilvum_PYR-GCK VKLKVGFNGICGTDLHEYYAGPIFVPTAPHPLTGAQLPLTMGHEFSGTIT
Mb0167c|M.bovis_AF2122/97 QVG-DGVDGVAVGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTL
Rv0162c|M.tuberculosis_H37Rv QVG-DGVDGVAVGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTL
MMAR_0405|M.marinum_M RVG-DRVDDLAVGQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTL
MAV_5022|M.avium_104 RVG-PGVADLAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTL
MLBr_01784|M.leprae_Br4923 VVG-PGVTAVEPGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTL
MAB_2084|M.abscessus_ATCC_1997 ECG-EGVEDLSEGDSVILTFLPSCGRCSYCARGMGNLCELG-AALMMGPQ
MUL_2962|M.ulcerans_Agy99 EKG-PDVHTVEVGDQVMVSSVAGCGACAGCATRDPAMCVSGPQIFGS---
Mvan_1380|M.vanbaalenii_PYR-1 EVG-PAVQTLSVGDRVLVSCISACGACRYCRQGQYGQCLGGGGWILG---
MSMEG_1795|M.smegmatis_MC2_155 SVGDPADASSLTGTRVVISPVRSCGDCHACRTGRENVCERV---------
TH_4631|M.thermoresistible__bu ----------VNGX-----------XXEETRRGRYNLCPHM---------
Mflv_0125|M.gilvum_PYR-GCK AVG-DGVTGWQEGDRVAVEPIYKCDQCGPCRAGNYNVCQQIG--------
* *
Mb0167c|M.bovis_AF2122/97 LGGGIRLSRGGRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLG
Rv0162c|M.tuberculosis_H37Rv LGGGIRLSRGGRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLG
MMAR_0405|M.marinum_M LGGGIRISRSGQPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLG
MAV_5022|M.avium_104 LGGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLG
MLBr_01784|M.leprae_Br4923 IDG--------TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLG
MAB_2084|M.abscessus_ATCC_1997 IDGTYRFHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIG
MUL_2962|M.ulcerans_Agy99 --------------GALGGAQADLLAVPATDFQVLKIPAAITTEQALLLT
Mvan_1380|M.vanbaalenii_PYR-1 --------------HLIDGTQAEYVRVPFADNSTHKVPEGVSDEQMIVLA
MSMEG_1795|M.smegmatis_MC2_155 -----------SVLG-CYEDGTLATRVVVPVSALHQVPDAVPSELAPLSE
TH_4631|M.thermoresistible__bu -----------RFYGTPPVDGALCEYVTIGAAFAHPVPAEMTDNAAALCE
Mflv_0125|M.gilvum_PYR-GCK -------------FHGLMSDGGMAEYTVVPTGMLHRLPDTVSLELGALVE
. : :
Mb0167c|M.bovis_AF2122/97 CAVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVD
Rv0162c|M.tuberculosis_H37Rv CAVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVD
MMAR_0405|M.marinum_M CAVLTGGGAVLNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVD
MAV_5022|M.avium_104 CAVLTGGGAVLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVD
MLBr_01784|M.leprae_Br4923 CGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVD
MAB_2084|M.abscessus_ATCC_1997 CGVTTGYGSAVRTGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVD
MUL_2962|M.ulcerans_Agy99 DNLATGWAAARRA-DIPFGATVAVIGLGAVGLCAVRSALAQGAATVFAVD
Mvan_1380|M.vanbaalenii_PYR-1 DILPTSYEVGVLAGAVSPGDVVAIVGAGPIGLAAVLTAKLYSPSHIVVID
MSMEG_1795|M.smegmatis_MC2_155 PASIA--LQAVRRGRPVAGELALVLGCGPIGLITIMALRRAG-VDVVAVD
TH_4631|M.thermoresistible__bu PLSVA--IATVDKAAVAGGSRVLIAGAGPIGLMTAQVARAYGATDIVVTD
Mflv_0125|M.gilvum_PYR-GCK PMSVAY--HAATLGEVSAGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVE
: . . : * * :* :. :
Mb0167c|M.bovis_AF2122/97 QLPEKLSAAKALGAHEIY--------TPQQATAGG------VKAAVVVEA
Rv0162c|M.tuberculosis_H37Rv QLPEKLSAAKALGAHEIY--------TPQQATAGG------VKAAVVVEA
MMAR_0405|M.marinum_M QLPQKLSAAEALGASATY--------TPQQAAAAG------VKADVVIEA
MAV_5022|M.avium_104 QLPEKLAAARRLGAHQAY--------TPQQAVEAR------VKAAVVIEA
MLBr_01784|M.leprae_Br4923 IDDTKLEWARTFGATHTVNALELEVVKTIQDLTSG------FGVDVVIDT
MAB_2084|M.abscessus_ATCC_1997 PVNFKREQASGFGATHTAAS-MDEAWSLVSDMTRG------KLADVCILT
MUL_2962|M.ulcerans_Agy99 RVQGRLQRAAEWGATAVASP----AAEAIVAATSG------RGADSVIDA
Mvan_1380|M.vanbaalenii_PYR-1 VADARLDAARRFGADTVVNSSTRSARDVIDELTGG------LGADVAMEA
MSMEG_1795|M.smegmatis_MC2_155 TVEERARFAERFGAVATIAVAPGQRCPSHEEVAAAAGSGPTRAVSLVIEA
TH_4631|M.thermoresistible__bu LDPHRRRLAHRFGATTTLDPQTDDVTG--------------LRVDAFIDA
Mflv_0125|M.gilvum_PYR-GCK PSPTRRTAIEALGARTLDPTADDVPAFIADHTGGD-------GADAVFDA
: ** . . :
Mb0167c|M.bovis_AF2122/97 VGHPAALHTAIGLTAPG--GRTITVGLPPPD-VRISLSPLDFVTEGRSLI
Rv0162c|M.tuberculosis_H37Rv VGHPAALHTAIGLTAPG--GRTITVGLPPPD-VRISLSPLDFVTEGRSLI
MMAR_0405|M.marinum_M AGHPAALETAIGLTAPG--GRTITVGLPPPD-ARISVAPLGFVAEGRSLI
MAV_5022|M.avium_104 VGHPAALQTAIDLTAPG--GRTITVGLPPPD-ARITVSPLGFVAEGRSLI
MLBr_01784|M.leprae_Br4923 VGRPETWKQAFYARDLA--GTVVLVGVPTPD-MRLDMPLLDFFSHGGSLK
MAB_2084|M.abscessus_ATCC_1997 TDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIR
MUL_2962|M.ulcerans_Agy99 VDTDASMTDALNAVRAG--GTVSVVGVHDLQPFPLPALTCLLRS-----I
Mvan_1380|M.vanbaalenii_PYR-1 VGLPETFEESVALVRPG--GHVANIGVHG-APATLHLEQIWIKN-----L
MSMEG_1795|M.smegmatis_MC2_155 TGSPAALASAIDVVSHA--GRVVIVGISDQD-VTLPHRTIAFKE------
TH_4631|M.thermoresistible__bu SGAPAAVMSGLAAVRPA--GRAVLVGMGAET-MELPVQTIQNRE------
Mflv_0125|M.gilvum_PYR-GCK AGVTPAVATALGCVGSR--KPMISVAIYEKPLETPLLNLVMNES------
. . .:
Mb0167c|M.bovis_AF2122/97 GSYLGSAVPSHDIPRFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADG
Rv0162c|M.tuberculosis_H37Rv GSYLGSAVPSHDIPRFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADG
MMAR_0405|M.marinum_M GSYLGSAVPSRDIPRFVSLWQSGRLPVESLVSATIRLDDLNEAMDHLADG
MAV_5022|M.avium_104 GSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLADG
MLBr_01784|M.leprae_Br4923 SSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGG
MAB_2084|M.abscessus_ATCC_1997 GALYGSSNAPHDIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSG
MUL_2962|M.ulcerans_Agy99 TLRLTIAPVQRTWSELIPLLESGRLDVDGIFTTSLPLDEAAKGYSIAGSR
Mvan_1380|M.vanbaalenii_PYR-1 TITTGLVDTHSTP-TLIRLVANHQLDTAAMITHRFPMDEFDTAYDVFGDA
MSMEG_1795|M.smegmatis_MC2_155 LDVLGSRNSVGLIPDGLGLIAQNQAAFSSLITHRFPFEETADALRTLRTD
TH_4631|M.thermoresistible__bu LILTGVFRYANTWPAAIALIRTGRVDVDALITGRYPLEKTAEALESDRIP
Mflv_0125|M.gilvum_PYR-GCK RIQGSLCYTGADFESVIALMADGRYDTTGWVTRIPIDDVVDEGFEALHAG
: * .: .
Mb0167c|M.bovis_AF2122/97 IAVRQLISFTGDL--
Rv0162c|M.tuberculosis_H37Rv IAVRQLISFTGDL--
MMAR_0405|M.marinum_M TAVRQIIVF------
MAV_5022|M.avium_104 TAVRQLIRFDA----
MLBr_01784|M.leprae_Br4923 KVLRSVVML------
MAB_2084|M.abscessus_ATCC_1997 RNIRGLVRF------
MUL_2962|M.ulcerans_Agy99 SGN-DVKVLLKV---
Mvan_1380|M.vanbaalenii_PYR-1 AHSGALKVLLTASP-
MSMEG_1795|M.smegmatis_MC2_155 TAHVRKVLISMGASV
TH_4631|M.thermoresistible__bu GN--IKSVVEVGTS-
Mflv_0125|M.gilvum_PYR-GCK TKMKVLVDPNGAQ--