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QAMVYTGPGQRSWQTVPDPVLVDATDAIVRVDTVTICGTDLHILKGDVPEVESGRILGHEAVGTVTAIGS AVQTLSVGDRVLVSCISSCGACRYCRQGHYGQCLGGGGWILGHLIDGTQAEYVRVPFADNSTHKVPAGVS DEQMIVLADILPTSYEVGVLAGRVGPGDVVAIVGAGPIGLAAVLTAKLYSPSHIVVIDVADTRLEAAKKL GADVTVNSRSRRPRDVIDELTGGLGADVVMEAVGLPETFEESVDLVRPCGHVANIGVHGAPATLHLERIW IKNLTITTGLVDTHSTPTLISLVANGRLDAATMITHRYPMDEFDTAYQVFGDAANSGALKVVLTATS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4997 | - | - | 100% (348) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3148 | - | 2e-49 | 34.03% (385) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1966 | - | 5e-38 | 29.70% (394) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 5e-29 | 30.18% (328) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. tuberculosis H37Rv | Rv1895 | - | 1e-44 | 33.33% (330) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-28 | 28.96% (335) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 7e-31 | 31.20% (343) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_2790 | - | 6e-46 | 33.82% (346) | dehydrogenase |
| M. avium 104 | MAV_2804 | - | 3e-46 | 34.39% (346) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0671 | - | 3e-49 | 33.25% (385) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. thermoresistible (build 8) | TH_2319 | - | 2e-33 | 35.39% (243) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. ulcerans Agy99 | MUL_2962 | - | 5e-44 | 32.95% (346) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1380 | - | 1e-175 | 86.74% (347) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4997|M.gilvum_PYR-GCK ----MQAMVYTGPGQRSWQTVPDPVLVDATDAIVRVDTVTICGTDLHILK
Mvan_1380|M.vanbaalenii_PYR-1 ----MLAMVYDGPGRRSWRSVPEPVIQQGTDAIVRVDAVTICGTDLHILK
MSMEG_0671|M.smegmatis_MC2_155 ----MRAMVYRGPYKIRLEDKPIPAIEHPNDAIVRVTKAAICGSDLHLYH
MMAR_2790|M.marinum_M ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGSDLHFYE
MUL_2962|M.ulcerans_Agy99 ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLHFYE
Rv1895|M.tuberculosis_H37Rv ----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFYE
MAV_2804|M.avium_104 ----MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGSDLHFYE
Mb2283|M.bovis_AF2122/97 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MAB_1869c|M.abscessus_ATCC_199 ----------------MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYRE
TH_2319|M.thermoresistible__bu -------VTWHGRRKVSVDTVPDPAIMEPTDAIIRVTSTNICGSDLHLYE
.:: * :* :** .
Mflv_4997|M.gilvum_PYR-GCK GDVPEVESGRILGHEAVGTVTAIGSAVQTLSVGDRVLVSCISSCGACRYC
Mvan_1380|M.vanbaalenii_PYR-1 GDVPEVEPGRVLGHEAVGTVTEVGPAVQTLSVGDRVLVSCISACGACRYC
MSMEG_0671|M.smegmatis_MC2_155 GMMPDTRVGTTFGHEFIGVVEKVGPSVQNLSVGDRVMVPFNIFCGSCYFC
MMAR_2790|M.marinum_M GEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGACAGC
MUL_2962|M.ulcerans_Agy99 GEYPLAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGACAGC
Rv1895|M.tuberculosis_H37Rv GEYPFTEP-VALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGC
MAV_2804|M.avium_104 ADFPMPDP-IALGHEAIGTVVEAGPQVRNVKVGDQVMVSSVAGCGSCAGC
Mb2283|M.bovis_AF2122/97 GGINDEYP-FLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRAC
MLBr_01784|M.leprae_Br4923 GGINDRYP-FLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC
MAB_1869c|M.abscessus_ATCC_199 GGINDEFP-FLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVCRAC
TH_2319|M.thermoresistible__bu VLSAFMSPGDILGHEAMGVVEEVGPEVGALQAGDRVVIPFNISCGTCWMC
:*** * : * * : ** *:: ** * *
Mflv_4997|M.gilvum_PYR-GCK RQGHYGQCLGGG-------GWILGH-----LIDGTQAEYVRVPFADNSTH
Mvan_1380|M.vanbaalenii_PYR-1 RQGQYGQCLGGG-------GWILGH-----LIDGTQAEYVRVPFADNSTH
MSMEG_0671|M.smegmatis_MC2_155 ARGLYSNCHNVNPNA-TAVGGIYGYSHTCGGYDGGQAEFVRVPFADVGPS
MMAR_2790|M.marinum_M ATRDPAMCVSGP--------QIFGSG----ALGGAQADLLAVPAADFQVL
MUL_2962|M.ulcerans_Agy99 ATRDPAMCVSGP--------QIFGSG----ALGGAQADLLAVPATDFQVL
Rv1895|M.tuberculosis_H37Rv ETHDPVMCFSGP--------MIFGAG----VLGGAQADLLAVPAADFQVL
MAV_2804|M.avium_104 ATRDPVLCHSGF--------QIFGGG----VLGGAQADLLAVPAADFQLL
Mb2283|M.bovis_AF2122/97 KRGRPRYCFDTFN---AEQKMTLTDGTELTAALGIGAFADKTLVHSGQCT
MLBr_01784|M.leprae_Br4923 KRGRPSYCFDTFN---AQQKMTLIDGTELTPALGIGAFADKTLVHSGQCT
MAB_1869c|M.abscessus_ATCC_199 KRGRPQYCFDTFN---AAQKMTLTDGTELTPALGIGAFIEKTLVHAGQCT
TH_2319|M.thermoresistible__bu AQGLQSQCETTQNRDQGTGAALFGYSKLYGEVAGGQAEYLRVPQAQYTHI
* * * .
Mflv_4997|M.gilvum_PYR-GCK KVPAGVSDEQMIVLADILPTSYEVGVLAGRVGPGDVVAIVGAGPIGLAAV
Mvan_1380|M.vanbaalenii_PYR-1 KVPEGVSDEQMIVLADILPTSYEVGVLAGAVSPGDVVAIVGAGPIGLAAV
MSMEG_0671|M.smegmatis_MC2_155 IIPDRLDDEDALLLTDALATGY-FGAQLGNIAEGDTVVVFGAGPVGLFAA
MMAR_2790|M.marinum_M KIPAAITTEQALLLTDNLATGWAAARRA-DILFGATVAVIGLGAVGLCAV
MUL_2962|M.ulcerans_Agy99 KIPAAITTEQALLLTDNLATGWAAARRA-DIPFGATVAVIGLGAVGLCAV
Rv1895|M.tuberculosis_H37Rv KIPEGITTEQALLLTDNLATGWAAAQRA-DISFGSAVAVIGLGAVGLCAL
MAV_2804|M.avium_104 KIPEGISTEQALLLTDNLATGWAAAQRA-DIPFGGTVAVIGLGAVGLCAL
Mb2283|M.bovis_AF2122/97 KVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAI
MLBr_01784|M.leprae_Br4923 KVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAI
MAB_1869c|M.abscessus_ATCC_199 KVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVGDAAI
TH_2319|M.thermoresistible__bu TVPHDGPDDRYVYLSDVLPTAWQGVEYA-AVPDGGTLVVLGLGPIGSMAC
: * : :. : . .:.:.* * :* *
Mflv_4997|M.gilvum_PYR-GCK LTAKLYSPSHIVVIDVADTRLEAAKKLGADVTVNSRSRRPRDV-IDELTG
Mvan_1380|M.vanbaalenii_PYR-1 LTAKLYSPSHIVVIDVADARLDAARRFGADTVVNSSTRSARDV-IDELTG
MSMEG_0671|M.smegmatis_MC2_155 KSAWLMGAGRVIVIDHLEYRLEKARTFAHAETINFVDCDDIVVKMKRTTD
MMAR_2790|M.marinum_M RSALAQGAATVFAVDRVQGRLQRASEWGATAVAS-----PAAEAIVAATG
MUL_2962|M.ulcerans_Agy99 RSALAQGAATVFAVDRVQGRLQRAAEWGATAVAS-----PAAEAIVAATS
Rv1895|M.tuberculosis_H37Rv RSAFIHGAATVFAVDRVKGRLQRAATWGATPIPS-----PAAETILAATR
MAV_2804|M.avium_104 RSALFQGAATVFAVDQVDGRLARAARWGATPLKA-----PALEAILAATG
Mb2283|M.bovis_AF2122/97 AGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIGGLTD
MLBr_01784|M.leprae_Br4923 SGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELE-VVKTIQDLTS
MAB_1869c|M.abscessus_ATCC_199 AGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQELTD
TH_2319|M.thermoresistible__bu RIAAHRGNCRVIGVDRVPERIEKVRPYCADVLNVDT--DDVEAAVREQTG
* . :. :* :: . : *
Mflv_4997|M.gilvum_PYR-GCK GLGADVVMEAVG---------------------LPETFEESVDLVRPCGH
Mvan_1380|M.vanbaalenii_PYR-1 GLGADVAMEAVG---------------------LPETFEESVALVRPGGH
MSMEG_0671|M.smegmatis_MC2_155 HLGADVAIDAAGAEADGNFLQHVTATKLKLQGGSPIALNWAIDSVRKGGT
MMAR_2790|M.marinum_M GRGADSVIDAVG---------------------TDASMTDALNAVRAGGT
MUL_2962|M.ulcerans_Agy99 GRGADSVIDAVD---------------------TDASMTDALNAVRAGGT
Rv1895|M.tuberculosis_H37Rv GRGADSVIDAVG---------------------TDASMSDALNAVRPGGT
MAV_2804|M.avium_104 GRGADAVIDAVA---------------------TDASLTEALNAVRPGGT
Mb2283|M.bovis_AF2122/97 GFGADVVIDAVG---------------------RPETYQQAFYARDLAGT
MLBr_01784|M.leprae_Br4923 GFGVDVVIDTVG---------------------RPETWKQAFYARDLAGT
MAB_1869c|M.abscessus_ATCC_199 EFGADVVIDAVG---------------------RPETWKQAFYARDLAGT
TH_2319|M.thermoresistible__bu GXXVQTPPDPRRQSADCEN----HADQHGRPEHPPEELHHQADDQRQRRH
.: :.
Mflv_4997|M.gilvum_PYR-GCK VANIGVHG--APATLHLERIWIKNLTIT--------------TGLVDTH-
Mvan_1380|M.vanbaalenii_PYR-1 VANIGVHG--APATLHLEQIWIKNLTIT--------------TGLVDTH-
MSMEG_0671|M.smegmatis_MC2_155 VSVVGAYGP-MFSAVKFGDAFNKGLTLR--------------MNQCPVKR
MMAR_2790|M.marinum_M VSVVGVHDL-QPFPLPALTCLLRSITLR--------------LTIAPVQR
MUL_2962|M.ulcerans_Agy99 VSVVGVHDL-QPFPLPALTCLLRSITLR--------------LTIAPVQR
Rv1895|M.tuberculosis_H37Rv VSVVGVHDL-QPFPVPALTCLLRSITLR--------------MTMAPVQR
MAV_2804|M.avium_104 VSVVGVHDM-NPFPLNALGCLIRSITLR--------------MTTAPVQR
Mb2283|M.bovis_AF2122/97 VVLVGVPTPDMRLDMPLVDFFSHGGALKSS-----------WYGDCLPES
MLBr_01784|M.leprae_Br4923 VVLVGVPTPDMRLDMPLLDFFSHGGSLKSS-----------WYGDCLPER
MAB_1869c|M.abscessus_ATCC_199 VVLVGVPTPDMTLEMPLIDFFSRGGSLKSS-----------WYGDCLPER
TH_2319|M.thermoresistible__bu ERDAATAGSPPLPSPWPDRTTTHRHTWRRLGGMELLRDVVVLLHIVGFAV
.. : :
Mflv_4997|M.gilvum_PYR-GCK STPTLISLVANGRLDAATMITHRYPMDEFD---------TAYQVFGDAAN
Mvan_1380|M.vanbaalenii_PYR-1 STPTLIRLVANHQLDTAAMITHRFPMDEFD---------TAYDVFGDAAH
MSMEG_0671|M.smegmatis_MC2_155 EWPRLLSHIKNGYLKPNDIVTHRIPLEHIA---------EGYHIFSAKLD
MMAR_2790|M.marinum_M TWSELIPLLESGRLDVDGIFTTSLPLDEAA---------KGYSIAGSRSG
MUL_2962|M.ulcerans_Agy99 TWSELIPLLESGRLDVDGIFTTSLPLDEAA---------KGYSIAGSRSG
Rv1895|M.tuberculosis_H37Rv TWPELIPLLQSGRLDVDGIFTTTLPLDEAA---------KGYATARARSG
MAV_2804|M.avium_104 TWPELIPLLQSGRLDVDGIFTTTMPLDEAA---------IGYATAGSRSG
Mb2283|M.bovis_AF2122/97 DFPTLIDLYLQGRLPLQRFVSERIGLEDVE---------EAFHKMHGGKV
MLBr_01784|M.leprae_Br4923 DFPTLVDLYLQGRLPLGKFVSERIGLGDVE---------EAFHKIHGGKV
MAB_1869c|M.abscessus_ATCC_199 DFPTLVSLYQQGRLPLDRFVSERIGIESIE---------AAFEKMHHGEV
TH_2319|M.thermoresistible__bu TFGAWTAEAVARRFRTTRLMDYGLLLSLITGLALAAPWPAGIVLNYPKIG
: :. : .
Mflv_4997|M.gilvum_PYR-GCK SGALKVVLTATS--------------------------------------
Mvan_1380|M.vanbaalenii_PYR-1 SGALKVLLTASP--------------------------------------
MSMEG_0671|M.smegmatis_MC2_155 DCIKPIIVPTAS--------------------------------------
MMAR_2790|M.marinum_M NDVKVLLKV-----------------------------------------
MUL_2962|M.ulcerans_Agy99 NDVKVLLKV-----------------------------------------
Rv1895|M.tuberculosis_H37Rv EELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSM
MAV_2804|M.avium_104 DDVKILLKP-----------------------------------------
Mb2283|M.bovis_AF2122/97 LRSVVML-------------------------------------------
MLBr_01784|M.leprae_Br4923 LRSVVML-------------------------------------------
MAB_1869c|M.abscessus_ATCC_199 LRSVVVL-------------------------------------------
TH_2319|M.thermoresistible__bu LKLVLLVALGAVLGIGGAHQRRTGNPVPRPLFVTAGVLSFAAAAVAVLW-
:
Mflv_4997|M.gilvum_PYR-GCK --
Mvan_1380|M.vanbaalenii_PYR-1 --
MSMEG_0671|M.smegmatis_MC2_155 --
MMAR_2790|M.marinum_M --
MUL_2962|M.ulcerans_Agy99 --
Rv1895|M.tuberculosis_H37Rv LN
MAV_2804|M.avium_104 --
Mb2283|M.bovis_AF2122/97 --
MLBr_01784|M.leprae_Br4923 --
MAB_1869c|M.abscessus_ATCC_199 --
TH_2319|M.thermoresistible__bu --