For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSYTMAGRRVLITGASSGVGAALARMLAARGTTVGLIARRRDRLEEVLADCRKTSPQSVMWVADLCDTAG AARLALQAWQAMGGIDVLVNNAAIPKRREVSALRPTEVEQVMGVNFFAPMRMTLALLPRMLARGSGTIVN VSSVGGRLGIIHESAYCASKFALCGWSESIAVDLAGSGVSVRLIQPGPVDTEIWDRPDNEDPLYRGPKVP ADLVAEGIIAAIGSDRFEHYLPEMMALKDIVDAKNADLDTFLTAAAAMIWQLKALVYGVALEPFEIDEPA NPLACNLARTPTALRELADPRPLRPDWVITRPRLTGICGSDSKQILLDFGEQDADNALAAFCSFPQVMGH EVVADVVELGPEAGGLEVGQRVVLNPWLSCRPRGIEPPCPACQSGDYSLCWSFTDGGIQPGIHTGVSANV TGGYAELMPAHDSMLFPVPGPISDEAAVFADPFSVSLHAITRHPPPRSGRVLVYGAGSLGLCAIAILRAL YPDVAVAVVARFATQGELAGRFGAAKVVAHEPRLAIIEELVAWGGGRLRQALLGLPMAHPGAVDVVYDTV GKPETFEIGVRVLNSRGTLVKAGVHAPGRWEWSPLYFKEISWVGSNAFGVEEVEGVRKHAIAHYFDLVAD DRLDLRSMLTHTFALPQWRDAFLAIANQGESGAVKVAFDQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0819 | adh_1 | - | 100% (671) | short-chain dehydrogenase Adh_1 |
| M. ulcerans Agy99 | MUL_4828 | - | 1e-26 | 36.40% (228) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_3139 | - | 1e-25 | 34.07% (226) | short-chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3083c | - | 7e-25 | 32.22% (239) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0026 | - | 3e-26 | 37.95% (224) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3057c | - | 7e-25 | 32.22% (239) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 3e-23 | 31.09% (238) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2540c | - | 5e-26 | 36.46% (192) | putative Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0295 | - | 2e-26 | 36.40% (228) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_4440 | - | 0.0 | 80.00% (410) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_5569 | - | 4e-27 | 37.19% (199) | clavaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2552 | - | 9e-25 | 36.70% (188) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4623 | - | 3e-28 | 34.71% (242) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4623|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_5569|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0819|M.ulcerans_Agy99 MSYTMAGRRVLITGASSGVGAALARMLAARGTTVGLIARRRDRLEEVLAD
MAV_4440|M.avium_104 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4623|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_5569|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0819|M.ulcerans_Agy99 CRKTSPQSVMWVADLCDTAGAARLALQAWQAMGGIDVLVNNAAIPKRREV
MAV_4440|M.avium_104 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4623|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_5569|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0819|M.ulcerans_Agy99 SALRPTEVEQVMGVNFFAPMRMTLALLPRMLARGSGTIVNVSSVGGRLGI
MAV_4440|M.avium_104 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4623|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_5569|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0819|M.ulcerans_Agy99 IHESAYCASKFALCGWSESIAVDLAGSGVSVRLIQPGPVDTEIWDRPDNE
MAV_4440|M.avium_104 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
Mflv_0026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4623|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_5569|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0819|M.ulcerans_Agy99 DPLYRGPKVPADLVAEGIIAAIGSDRFEHYLPEMMALKDIVDAKNADLDT
MAV_4440|M.avium_104 --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 ---------------------MSTVLPSGPSPVVHHPLAR----------
MMAR_0295|M.marinum_M ---------------------MN-----LATQALAKAFER----------
Mflv_0026|M.gilvum_PYR-GCK ---------------------MRSSRKSASEVLLECEFGAGNRLRGVTSR
Mvan_4623|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 --------------------------------------------------
Rv3057c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
MSMEG_5569|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0819|M.ulcerans_Agy99 FLTAAAAMIWQLKALVYGVALEPFEIDEPANPLACNLARTPTALRELADP
MAV_4440|M.avium_104 -----------MKALVYGVAPEPVAVPDDANPLVQNLARTPTGLRDVPEP
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_2540c|M.abscessus_ATCC_199 -------------AAAYLIGPRGLRGTERLRSEVAGKIVVITGASYGLGA
MMAR_0295|M.marinum_M -------------ASNGLANPATLADPDRLRGAVTGKTALVTGASYGIGE
Mflv_0026|M.gilvum_PYR-GCK NPLRRLADQVVLTSMRPPILPALLNRPTRETIELRGKRVLLTGASSGIGE
Mvan_4623|M.vanbaalenii_PYR-1 -------------------------------MELRGKRVLITGASRGIGE
Mb3083c|M.bovis_AF2122/97 ------------------------MLQRGAGQYFAGKRCFVTGAASGIGR
Rv3057c|M.tuberculosis_H37Rv ------------------------MLQRGAGQYFAGKRCFVTGAASGIGR
MLBr_01740|M.leprae_Br4923 ------------------------MVKT--AQYFVGKRCFVTGAASGIGR
MSMEG_5569|M.smegmatis_MC2_155 -----------------------------MSPKLTGTVALVTGASSGIGA
MUL_0819|M.ulcerans_Agy99 RPLRPDWVITRPRLTGICGSDSKQILLDFGEQDADNALAAFCSFPQVMGH
MAV_4440|M.avium_104 VLPHEDWVLTRPRLTGICGSDAKQILMDFGEGDADNAMSAFCSFPQVMGH
TH_2552|M.thermoresistible__bu --------------------------------VLSDSVALITGASGGIGR
. . . . :*
MAB_2540c|M.abscessus_ATCC_199 ATAELFAQAGAQVVLAARSLEQLRLVAAGIAEKGG---------EAAVYR
MMAR_0295|M.marinum_M ATARKLAAAGATVLMVARSAERLEDLVSAIAAGGG---------AAVAYP
Mflv_0026|M.gilvum_PYR-GCK AAAEKLARRGATVVAVARRQDLLDELVTRIADAGG---------DARAHA
Mvan_4623|M.vanbaalenii_PYR-1 SLAHNFAGAGARVALVARSRDSLESLAVELG--------------GTVHP
Mb3083c|M.bovis_AF2122/97 ATALRLAAQGAELYLTDRDRDGLAQTVCDARALGAQ--------VPEHRV
Rv3057c|M.tuberculosis_H37Rv ATALRLAAQGAELYLTDRDRDGLAQTVCDARALGAQ--------VPEHRV
MLBr_01740|M.leprae_Br4923 ATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQ--------VPEYRA
MSMEG_5569|M.smegmatis_MC2_155 ATARHLAEHGATVALVARRKDRLVTLVADIERDGG---------AATAVE
MUL_0819|M.ulcerans_Agy99 EVVADVVELGPEAGGLEVGQRVVLNPWLSCRPRGIEPPCPACQSGDYSLC
MAV_4440|M.avium_104 EVVADVVALGPGARGLAVGQRVVLNPWLSCGPRGIQPPCPACEAGDYSLC
TH_2552|M.thermoresistible__bu VLARRYAQRGARVALVARRRDELNVTAAAVTEAGG---------EALVLV
. . *. :
MAB_2540c|M.abscessus_ATCC_199 LDLTSEESITEFTEAVLHDF-GEVDYLIHNAGKSLRRSIHLSYDRPKDVN
MMAR_0295|M.marinum_M TDLTDEAAVGVLTKQVNQNH-GPLDIVVSNAGKSLRRSLHDQYDRPHDFQ
Mflv_0026|M.gilvum_PYR-GCK CDLSDLDAVDELVATVEKDL-GGIDILVNNAGRSIRRPLEESLERWHDVE
Mvan_4623|M.vanbaalenii_PYR-1 ADLSDSTQVSGLIRRVEDDG-GPIDVLVNNAGIESTACFTDAPE--DELR
Mb3083c|M.bovis_AF2122/97 LDVSDYQDVAAFAADIHARH-PSMDVVLNIAGVSAWGTVDQLTH--DQWS
Rv3057c|M.tuberculosis_H37Rv LDVSDYQDVAAFAADIHARH-PSMDVVLNIAGVSAWGTVDQLTH--DQWS
MLBr_01740|M.leprae_Br4923 LDISDYDEVAAFGADIHARH-PSMDIVMNIAGVSVWGTVDRLTH--DQWS
MSMEG_5569|M.smegmatis_MC2_155 ADVSDRAQADAAVAETVQRF-GRLDIVVNNAGLMLLGPVAGADA--QDWD
MUL_0819|M.ulcerans_Agy99 WSFTDGGIQPGIHTGVSANVTGGYAELMPAHDSMLFPVPGPISDEAAVFA
MAV_4440|M.avium_104 WSFADGDLKPGIHTGVSADVTGGYAELMPAHDSMLFAVPERVPDEMAVFA
TH_2552|M.thermoresistible__bu ADIRDETQCADAVAATVARW-GRLDVLVNNAAVPGSDQSVAEAT-VDNWN
.. . ::
MAB_2540c|M.abscessus_ATCC_199 ATSGANYVGPMRLT-LALLPGMRARGSGH--------------IVNVSTV
MMAR_0295|M.marinum_M RTIDINYLGPIWLL-LGLLPAMRESGRGH--------------VVNVSSV
Mflv_0026|M.gilvum_PYR-GCK RTMTLNYYGPLRLI-RGLAPGMLARGDGH--------------IINVSTW
Mvan_4623|M.vanbaalenii_PYR-1 RVTDVNYLAPAELC-RQAIPGMLRRGGGH--------------IVNVSSL
Mb3083c|M.bovis_AF2122/97 RMVAINLMGPIHVI-ETLVPPMVAAGRGG-------------HLVNVSSA
Rv3057c|M.tuberculosis_H37Rv RMVAINLMGPIHVI-ETLVPPMVAAGRGG-------------HLVNVSSA
MLBr_01740|M.leprae_Br4923 NVVAINLMGPIHII-ETFVPAILAAGRGG-------------HLVNVSSA
MSMEG_5569|M.smegmatis_MC2_155 RMIAVNVSGLLNTT-HAALPHLLAAAEDGP--------REVADIVNVSSV
MUL_0819|M.ulcerans_Agy99 DPFSVSLHAITRHP-PPRSGRVLVYGAGSLGLCAIAILRALYPDVAVAVV
MAV_4440|M.avium_104 DPFSVSLHAITRHP-PPRSGRALVYGAGSLGLCAVAILRALYPEVAVAVV
TH_2552|M.thermoresistible__bu QVLATNLVAPMVLSREALCQAMIPAGSGN---------------IQFLSS
. . . . : .
MAB_2540c|M.abscessus_ATCC_199 GVMFGVVPKWGFYLSSKAAFDIWMRAVGMEARGDGVT-LTTFYAGLMHTR
MMAR_0295|M.marinum_M GVRLVPGPQWGAYQASKGAFDRWLRSVAPELHGDGVD-VTSVYFALVRTR
Mflv_0026|M.gilvum_PYR-GCK GVKTESPPLFGVYNASKAALSSVSRIIETEWSGRGVH-ATTLYYPLVKTP
Mvan_4623|M.vanbaalenii_PYR-1 SG-IVLFPGLVSYSASKAALSHFTAGLRTDFRGLPIG-TTLVELGPIPTD
Mb3083c|M.bovis_AF2122/97 AG-LVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIG-VSVVVPGAVKTP
Rv3057c|M.tuberculosis_H37Rv AG-LVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIG-VSVVVPGAVKTP
MLBr_01740|M.leprae_Br4923 AG-LVALPWHAAYSASKYGLRGLSEVLRFDLARYRIG-VSVVVPGAVRTP
MSMEG_5569|M.smegmatis_MC2_155 AG-RNASEGYGVYSLTKFGVNGFTESLRQEVTRRHVR-VGVIEPGGVNTE
MUL_0819|M.ulcerans_Agy99 ARFATQGELAGRFGAAKVVAHEPRLAIIEELVAWGGGRLRQALLGLPMAH
MAV_4440|M.avium_104 ARFDAQAELARRFGAAKVVAHEPRTAVIEELVGWGGGRLRRPLLGLPMAH
TH_2552|M.thermoresistible__bu AAARNVAPGKAHYAAAKLALSALGQTLALEVGGTGIR-VNTLVVGSVEGE
. : :* : :
MAB_2540c|M.abscessus_ATCC_199 MSAPSRWMRLLPG---------------QTPLDAAKVLARAVVD-KPRTL
MMAR_0295|M.marinum_M MIEPTPMLGRLPG---------------LEPDQAADAVAKAIVE-RPRTN
Mflv_0026|M.gilvum_PYR-GCK MIAPTRAYDGLPG---------------LSADEAAGWIVTAARH-RPVSI
Mvan_4623|M.vanbaalenii_PYR-1 LLAKIDNYEPTAKS--FQRAYRWGVAVDTPRERVAEEVVKAVLKGRRHVR
Mb3083c|M.bovis_AF2122/97 LVNTVEIAGVDRDDPRVNRWVERFSGHAVTPEKAADKILAGVTRNRYLVY
Rv3057c|M.tuberculosis_H37Rv LVNTVEIAGVDRDDPRVNRWVERFSGHAVTPEKAADKILAGVTRNRYLVY
MLBr_01740|M.leprae_Br4923 LVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVAKNRYLIY
MSMEG_5569|M.smegmatis_MC2_155 LGSHNSSAIQARIIEPFN-----ASVEALAPEDVAESIGYMVTR------
MUL_0819|M.ulcerans_Agy99 PGAVDVVYDTVGKPETFEIGVRVLNSRGTLVKAGVHAPGRWEWSPLYFKE
MAV_4440|M.avium_104 PGAVDVVYDTVGKPETLEVAVRLLRSRGTLVKAGVHAPGRWEDSPLYFKE
TH_2552|M.thermoresistible__bu LLDRYVARRAAADG--------------VSPDEVLSGLARSTKLGRLISP
MAB_2540c|M.abscessus_ATCC_199 TPAYGHPFAILAPVLRFPLEPILGFVYRRLGDTQASLARVTAGQSTTTRI
MMAR_0295|M.marinum_M EPPWLWPAELASVLLAGPAEQAARVWHRRFFAPTA-----EAGKS-----
Mflv_0026|M.gilvum_PYR-GCK APRIAVTAHAINSVAPGAVDTIMKRQRMQPRD------------------
Mvan_4623|M.vanbaalenii_PYR-1 LPKRSAPLAMLAEAPRRIAEIILTGVPHQAKS------------------
Mb3083c|M.bovis_AF2122/97 TSADIRALYAFKRYAWWPYTLVMRRVNVFFTRALRPGP------------
Rv3057c|M.tuberculosis_H37Rv TSADIRALYAFKRYAWWPYTLVMRRVNVFFTRALRPGP------------
MLBr_01740|M.leprae_Br4923 TSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVG
MSMEG_5569|M.smegmatis_MC2_155 -----------------PRHAAIGELWIMPTEQLV---------------
MUL_0819|M.ulcerans_Agy99 ISWVGSNAFGVEEVEGVRKHAIAHYFDLVADDRLDLRSMLTHTFALPQWR
MAV_4440|M.avium_104 IALVGSNAFGVEEVDGQRRHAIAHYLDLAAAGRVDLRPMLTHTFTLDRWR
TH_2552|M.thermoresistible__bu EEVADVSLWLAS-----DAASAITGQDIFVTGG-----------------
MAB_2540c|M.abscessus_ATCC_199 DAPERIGVHAE-----------
MMAR_0295|M.marinum_M ----------------------
Mflv_0026|M.gilvum_PYR-GCK ----------------------
Mvan_4623|M.vanbaalenii_PYR-1 ----------------------
Mb3083c|M.bovis_AF2122/97 ----------------------
Rv3057c|M.tuberculosis_H37Rv ----------------------
MLBr_01740|M.leprae_Br4923 VYSQPRSGEGGKSGN-------
MSMEG_5569|M.smegmatis_MC2_155 ----------------------
MUL_0819|M.ulcerans_Agy99 DAFLAIANQGESGAVKVAFDQR
MAV_4440|M.avium_104 DAFHALADQGRTGAVKVAFDQR
TH_2552|M.thermoresistible__bu ----------------------