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IAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGA AAGQRWGVQAGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEIGAGLWGGYATHVELPWDA MLLPIAEDMDPVLATLFNPLGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGP RDEQRLAIARSFGVDLPIDVSQDDAATALQRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGT RGGGGAPRFEPDLLVYKELHVVGALGVEYPAYRAALEILAMGRWPFDRITRESTGFAGLAQLLTSLADES ARSSGALHNVFLPTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2041c | - | - | 100% (366) | zinc-containing alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1869c | - | 8e-20 | 27.25% (345) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. abscessus ATCC 19977 | MAB_2084 | - | 5e-14 | 28.89% (270) | zinc-type alcohol dehydrogenase AdhD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 1e-123 | 61.14% (350) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_4626 | - | 1e-152 | 69.61% (362) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1530 | adh | 1e-123 | 61.14% (350) | alcohol dehydrogenase adh |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-17 | 28.62% (269) | putative alcohol dehydrogenase (Zn dependent) |
| M. marinum M | MMAR_3163 | - | 0.0 | 91.53% (366) | Zn-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_2804 | - | 1e-19 | 31.54% (279) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3265 | - | 1e-25 | 27.89% (337) | arabitol-phosphate dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 1e-21 | 30.86% (269) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 1e-21 | 30.37% (326) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_2879 | - | 4e-25 | 30.49% (328) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 ------------MSQTVRGVISRKKDEPVELVDIVIPDP-GPGEAVVDVT
TH_4627|M.thermoresistible__bu ------------MSQSVRGVIARKKDEPVEVVDIVIPDP-GPGEVVVKVT
MAB_2041c|M.abscessus_ATCC_199 ---------------MIAEAMVLTGPRSLQRRQMIIPDV-GDRGAILRVE
MMAR_3163|M.marinum_M ---------------MIAEAMVLTGPRNLERRQMTIPDV-GDRGAILRVE
Mflv_4626|M.gilvum_PYR-GCK ---------------MNADALVLTKPRTLERRHLPVPRI-DDESGLLRIE
Mb1557|M.bovis_AF2122/97 -----------MSDGAVVRALVLEAPRRLVVRQYRLPRI-GDDDALVRVE
Rv1530|M.tuberculosis_H37Rv -----------MSDGAVVRALVLEAPRRLVVRQYRLPRI-GDDDALVRVE
MUL_0495|M.ulcerans_Agy99 MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPTP-GYGEALVKLE
MAV_2804|M.avium_104 -----------------MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVS
MSMEG_3265|M.smegmatis_MC2_155 ---------MSNQVPEKMQAVVCHGPHDYRLEEVAVPQR-KPGEALIRVE
Mvan_2879|M.vanbaalenii_PYR-1 ---------MSRAPFTGRIARFDEPGKPFDIETVTLPEV-GPGEILIKVT
. . * :: :
MLBr_01784|M.leprae_Br4923 ACGVCHTDLTYREGGINDR----------YPFLLGHEAAGTVEVVGPGVT
TH_4627|M.thermoresistible__bu ACGVCHTDLHYREGGINDE----------FPFLLGHEAAGTVESVGSGVT
MAB_2041c|M.abscessus_ATCC_199 ACGLCGTDHEQFTGHLPAG----------FSFVPGHEIVGIVEHVGAAAG
MMAR_3163|M.marinum_M ACGLCGTDHEQFTGHLPAG----------FSFVPGHEIVGIVEHVGNAAS
Mflv_4626|M.gilvum_PYR-GCK ACGLCGTDHEQFSGHLPTG----------FAFIPGHEIIGVIEGIGDAAR
Mb1557|M.bovis_AF2122/97 ACGLCGTDHEQYTGELAGG----------FAFVPGHETVGTIAAIGPRAE
Rv1530|M.tuberculosis_H37Rv ACGLCGTDHEQYTGELAGG----------FAFVPGHETVGTIAAIGPRAE
MUL_0495|M.ulcerans_Agy99 TSGVCHTDLHAAHGDWPVKP--------APPFVPGHEGCGTVVALGDGVT
MAV_2804|M.avium_104 AAGICGSDLHFYEADFPMP----------DPIALGHEAIGTVVEAGPQVR
MSMEG_3265|M.smegmatis_MC2_155 AVGICASDLKCYHGAAKFWGDENRPAWAETMVIPGHEFVGRVVELDDEAA
Mvan_2879|M.vanbaalenii_PYR-1 RANICGSDVHAWHGTFATRG-----LGGQLPTVLGHEMVGAVEELGAGVT
.:* :* . *** * : . .
MLBr_01784|M.leprae_Br4923 A------VEPGDFVILNWRA-VCGQCRACKRGRPSYCFDTFNAQQKMTLI
TH_4627|M.thermoresistible__bu N------VEPGDFVVLNWRA-VCGQCRACKRGRPHLCFDTFNATQKMTLG
MAB_2041c|M.abscessus_ATCC_199 QRWG---VQAGQRVAVEVFR-SCRDCPECRRGEYRRCAV--NGIATMFGF
MMAR_3163|M.marinum_M ERWC---VRAGQRVAVEVFR-SCRDCPECRRGEYRRCAV--NGIATMFGF
Mflv_4626|M.gilvum_PYR-GCK ERWG---VSVGQRVAVEVFR-SCRECDSCGRGEYRRCSS--NGLATMFGF
Mb1557|M.bovis_AF2122/97 QRWG---VSAGDRVAVEVFQ-SCRQCANCRGGEYRRCVR--HGLADMYGF
Rv1530|M.tuberculosis_H37Rv QRWG---VSAGDRVAVEVFQ-SCRQCANCRGGEYRRCVR--HGLADMYGF
MUL_0495|M.ulcerans_Agy99 D------LKVGDKVGNAWLWSACGSCEQCRTGWETLCENQRNGGYTVN--
MAV_2804|M.avium_104 N------VKVGDQVMVSSVA-GCGSCAGCATRDPVLCHS---GFQIFGG-
MSMEG_3265|M.smegmatis_MC2_155 QRWG---IAVGDRVVSEQIV-PCWECLFCKRGQYHMCQP-----HDLYGF
Mvan_2879|M.vanbaalenii_PYR-1 ADSNGKPLELGTRVVFPYFF-CCHTCRNCLAGRRNACLN-----LKMAML
: * * * * * * .
MLBr_01784|M.leprae_Br4923 DGTELTPALGIGAFADKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGL
TH_4627|M.thermoresistible__bu DGTELTPALGIGAFAEKTLVHEG--QCTKVDPAADPAVAGLLGCGVMAGV
MAB_2041c|M.abscessus_ATCC_199 VDVEIGAGLWGGYATHVELPWDA--MLLPIAEDMDPVLATLFNP-LGAGI
MMAR_3163|M.marinum_M VDVEIGAGLWGGYATHVELPWDA--MLLPIAEDMDPVLATLFNP-LGAGI
Mflv_4626|M.gilvum_PYR-GCK VDVNIPPGLWGGYATHLHLPFDS--MPLPVPDGLDPIVATLFNP-LGAGI
Mb1557|M.bovis_AF2122/97 IPVDREPGLWGGYAEYQYLAPDS--MVLRVAGDLSPEVATLFNP-LGAGI
Rv1530|M.tuberculosis_H37Rv IPVDREPGLWGGYAEYQYLAPDS--MVLRVAGDLSPEVATLFNP-LGAGI
MUL_0495|M.ulcerans_Agy99 -----------GSFGTYMLVNAD--YAARIPDGADPLEVAPILC-AGVTV
MAV_2804|M.avium_104 -------GVLGGAQADLLAVPAADFQLLKIPEGISTEQALLLTDNLATG-
MSMEG_3265|M.smegmatis_MC2_155 KR-------RTPGAMASYMVYPAEALVHKVSPDIPAQHAAFAEP--LSCS
Mvan_2879|M.vanbaalenii_PYR-1 GRADEPPYFVGGYADYFVLPAGA--VVYTVPDAVSDDIAAGANC-ALSQV
: .
MLBr_01784|M.leprae_Br4923 GAAINTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDI---DDT
TH_4627|M.thermoresistible__bu GAAINTGAVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDT---DAK
MAB_2041c|M.abscessus_ATCC_199 QWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQ
MMAR_3163|M.marinum_M QWGKTLPDTKAGGIVAILGPGIRGICAAVAAKEAGAAFVAMTGIGPRDDQ
Mflv_4626|M.gilvum_PYR-GCK KWAAMLPETSPGDVVAVLGPGIRGICAAVAAKEAGAAFVAMTGVGPRDRT
Mb1557|M.bovis_AF2122/97 RWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDAD
Rv1530|M.tuberculosis_H37Rv RWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDAD
MUL_0495|M.ulcerans_Agy99 YKGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMGLRVVAIDID----DD
MAV_2804|M.avium_104 WAAAQRADIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQ---VDG
MSMEG_3265|M.smegmatis_MC2_155 LHAVERAQITFEDTVVVAGCGPIGLGMIAGAKAKSPMRVIALDMAP---D
Mvan_2879|M.vanbaalenii_PYR-1 MYGLERVDQQLGEYVVVQGAGALGLYAVAVAKARGAAKVIAIDG---VPE
. *.: * * * * . :
MLBr_01784|M.leprae_Br4923 KLEWARTFGATHTVNALEL---EVVKTIQDLTSGFGVDVVIDTVGR-PET
TH_4627|M.thermoresistible__bu KLDWAREFGATHTIDASST---DVVEAIQELTDGFGADVVVDAVGR-PET
MAB_2041c|M.abscessus_ATCC_199 RLAIARSFGVDLPIDVSQD---DAATALQRETGGRLADVVVDVTAKAPSA
MMAR_3163|M.marinum_M RLAIARSFGVDLPIDVSQD---DAVTALQRETGGQLADVVIDVTAKAPSA
Mflv_4626|M.gilvum_PYR-GCK RLAAAHQFGVDLTIDVTED---DPAQALQMATG-RLADVVVDVTAKAPAA
Mb1557|M.bovis_AF2122/97 RLALAAQFGADLAVDVAID---DPVAALTEQTG-GLADVVVDVTAKAPAA
Rv1530|M.tuberculosis_H37Rv RLALAAQFGADLAVDVAID---DPVAALTEQTG-GLADVVVDVTAKAPAA
MUL_0495|M.ulcerans_Agy99 KLALAARLGAELVVNARTS---DVVAQVQEATG---GVHGVLVTAVHPQA
MAV_2804|M.avium_104 RLARAARWGATPLKAP-------ALEAILAATGGRGADAVIDAVAT-DAS
MSMEG_3265|M.smegmatis_MC2_155 KLKLAEKCGADLTINIAEQ---DAEKIIKDLTGGYGADVYIEGTGH-TSA
Mvan_2879|M.vanbaalenii_PYR-1 RLELATAFGADAVIDITATTDKDRAKIVRSLTDGQGADVVVEVVGH-PSA
:* * *. : *. : .. :
MLBr_01784|M.leprae_Br4923 WKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGDCLP
TH_4627|M.thermoresistible__bu WEQAFYARDLAGTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYGDCLP
MAB_2041c|M.abscessus_ATCC_199 FADAVGLARPGGTIVVAGTRGGG-GAPRFEPDLLVYKELHVVGALGVEYP
MMAR_3163|M.marinum_M FADAVALARPGGRVVVAGTRGGG-GAPGFEPDTLVYKELHIAGALGVEYP
Mflv_4626|M.gilvum_PYR-GCK FADAVALAQPGGRVVVAGTRGGG-GAPGFEPDLLVFKELRIFGSLGVDYP
Mb1557|M.bovis_AF2122/97 FAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDAT
Rv1530|M.tuberculosis_H37Rv FAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDAT
MUL_0495|M.ulcerans_Agy99 FGQAIGLARRGGTIVFNGLPPGD--FPAPIFVIVLKGLTIRGSIVGTRQD
MAV_2804|M.avium_104 LTEALNAVRPGGTVSVVGVHDMN-PFPLNALGCLIRSITLRMTTAPVQRT
MSMEG_3265|M.smegmatis_MC2_155 VPQGLNLLRKLGRYVEYGVFGSD-----VTVDWSIISDDKELDVLGAHLG
Mvan_2879|M.vanbaalenii_PYR-1 IDEGLKLLGQFGRYVEIGNINIG-RTFEFDPSRFVFANKTMVGVSLYDPS
:.. * * .
MLBr_01784|M.leprae_Br4923 ERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML
TH_4627|M.thermoresistible__bu ERDFPTLINLYLQGRLPLEKFVTERIALDEVEGAFEKMQRGEVLRSVVVL
MAB_2041c|M.abscessus_ATCC_199 --AYRAALEILAMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALH
MMAR_3163|M.marinum_M --AYRAALEILATRRWPFDRITRESTGFAGLAPLLSSLADENAKSSAALH
Mflv_4626|M.gilvum_PYR-GCK --AYQSAIELLVSRRWPFEELHREITGFAGLPRLLDLLAGNEPDRVPALH
Mb1557|M.bovis_AF2122/97 --AYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGER-DGVPPIH
Rv1530|M.tuberculosis_H37Rv --AYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGER-DGVPPIH
MUL_0495|M.ulcerans_Agy99 ---MAEALDFYARG---LIHPTVEGAALEDINHVFERMERGQIDGRVVID
MAV_2804|M.avium_104 ---WPELIPLLQSGRLDVDGIFTTTMPLDEAAIGYATAGSRSGDDVKILL
MSMEG_3265|M.smegmatis_MC2_155 PYCWPAAIKMIESGALPMDEICTHQFPLTEFQKGLDLVASGKESVKVSLI
Mvan_2879|M.vanbaalenii_PYR-1 VLSRALAFLEEYQHRLPFDRLAAARYSLDDINEAFAAAEDKRDVRASIVP
. . : :
MLBr_01784|M.leprae_Br4923 -------------------------------
TH_4627|M.thermoresistible__bu K------------------------------
MAB_2041c|M.abscessus_ATCC_199 NVFLPTP------------------------
MMAR_3163|M.marinum_M NVFVPTPSQHAELQQRKVTRDENGTRTDARP
Mflv_4626|M.gilvum_PYR-GCK NVFVPIA------------------------
Mb1557|M.bovis_AF2122/97 GVLTP--------------------------
Rv1530|M.tuberculosis_H37Rv GVLTP--------------------------
MUL_0495|M.ulcerans_Agy99 YR-----------------------------
MAV_2804|M.avium_104 KP-----------------------------
MSMEG_3265|M.smegmatis_MC2_155 PA-----------------------------
Mvan_2879|M.vanbaalenii_PYR-1 -------------------------------