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MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAFVPGHETVGTI AAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQY LAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMV TGLGPRDADRLALAAQFGADLAVDVAIDDPVAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVV VAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLAT MAGERDGVPPIHGVLTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1530 | adh | - | 100% (367) | Probable alcohol dehydrogenase adh |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 2e-19 | 29.45% (343) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. tuberculosis H37Rv | Rv1895 | - | 3e-17 | 30.96% (281) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 0.0 | 100.00% (367) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_4626 | - | 1e-127 | 63.06% (360) | alcohol dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 8e-18 | 29.70% (266) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2041c | - | 1e-123 | 61.14% (350) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_3163 | - | 1e-121 | 58.52% (364) | Zn-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_2804 | - | 3e-21 | 32.75% (284) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2882 | - | 2e-31 | 31.32% (348) | 5-exo-alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 5e-21 | 31.95% (266) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 1e-27 | 32.80% (314) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_2879 | - | 1e-26 | 29.94% (354) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 ------------MSQTVRGVISRKKDEPVELVDIVIPDP-GPGEAVVDVT
TH_4627|M.thermoresistible__bu ------------MSQSVRGVIARKKDEPVEVVDIVIPDP-GPGEVVVKVT
Rv1530|M.tuberculosis_H37Rv ----------MSDGAVVRALVLEAP-RRLVVRQYRLPRI-GDDDALVRVE
Mb1557|M.bovis_AF2122/97 ----------MSDGAVVRALVLEAP-RRLVVRQYRLPRI-GDDDALVRVE
MAB_2041c|M.abscessus_ATCC_199 --------------MIAEAMVLTGP-RSLQRRQMIIPDV-GDRGAILRVE
MMAR_3163|M.marinum_M --------------MIAEAMVLTGP-RNLERRQMTIPDV-GDRGAILRVE
Mflv_4626|M.gilvum_PYR-GCK --------------MNADALVLTKP-RTLERRHLPVPRI-DDESGLLRIE
MSMEG_2882|M.smegmatis_MC2_155 ---------MTLASGTGRIARFDEPGKPFEIQTVPVPQV-GPGEILIRVT
Mvan_2879|M.vanbaalenii_PYR-1 ---------MSRAPFTGRIARFDEPGKPFDIETVTLPEV-GPGEILIKVT
MUL_0495|M.ulcerans_Agy99 MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPTP-GYGEALVKLE
MAV_2804|M.avium_104 ----------------MRTVVVDGP-RSIRVDTRPDPVLPGPDGAIVEVS
. . * . :: :
MLBr_01784|M.leprae_Br4923 ACGVCHTDLTYREGGINDR-----YPFLLGHEAAGTVEVVGPGVT-----
TH_4627|M.thermoresistible__bu ACGVCHTDLHYREGGINDE-----FPFLLGHEAAGTVESVGSGVT-----
Rv1530|M.tuberculosis_H37Rv ACGLCGTDHEQYTGELAGG-----FAFVPGHETVGTIAAIGPRAEQRWG-
Mb1557|M.bovis_AF2122/97 ACGLCGTDHEQYTGELAGG-----FAFVPGHETVGTIAAIGPRAEQRWG-
MAB_2041c|M.abscessus_ATCC_199 ACGLCGTDHEQFTGHLPAG-----FSFVPGHEIVGIVEHVGAAAGQRWG-
MMAR_3163|M.marinum_M ACGLCGTDHEQFTGHLPAG-----FSFVPGHEIVGIVEHVGNAASERWC-
Mflv_4626|M.gilvum_PYR-GCK ACGLCGTDHEQFSGHLPTG-----FAFIPGHEIIGVIEGIGDAARERWG-
MSMEG_2882|M.smegmatis_MC2_155 RANICGSDVHAWHGTFATRGLGGQLPTVLGHEMVGVVAVLGDDVHSDSDG
Mvan_2879|M.vanbaalenii_PYR-1 RANICGSDVHAWHGTFATRGLGGQLPTVLGHEMVGAVEELGAGVTADSNG
MUL_0495|M.ulcerans_Agy99 TSGVCHTDLHAAHGDWPVKP---APPFVPGHEGCGTVVALGDGVTD----
MAV_2804|M.avium_104 AAGICGSDLHFYEADFPMP-----DPIALGHEAIGTVVEAGPQVRN----
..:* :* . . *** * : * .
MLBr_01784|M.leprae_Br4923 -AVEPGDFVILNWRA-VCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTEL
TH_4627|M.thermoresistible__bu -NVEPGDFVVLNWRA-VCGQCRACKRGRPHLCFDTFNATQKMTLGDGTEL
Rv1530|M.tuberculosis_H37Rv --VSAGDRVAVEVFQ-SCRQCANCRGGEYRRCVR--HGLADMYGFIPVDR
Mb1557|M.bovis_AF2122/97 --VSAGDRVAVEVFQ-SCRQCANCRGGEYRRCVR--HGLADMYGFIPVDR
MAB_2041c|M.abscessus_ATCC_199 --VQAGQRVAVEVFR-SCRDCPECRRGEYRRCAV--NGIATMFGFVDVEI
MMAR_3163|M.marinum_M --VRAGQRVAVEVFR-SCRDCPECRRGEYRRCAV--NGIATMFGFVDVEI
Mflv_4626|M.gilvum_PYR-GCK --VSVGQRVAVEVFR-SCRECDSCGRGEYRRCSS--NGLATMFGFVDVNI
MSMEG_2882|M.smegmatis_MC2_155 RPLEVGTRVVFPYFF-CCHTCRNCLAGRRNACVN--LKMAMLG---RADE
Mvan_2879|M.vanbaalenii_PYR-1 KPLELGTRVVFPYFF-CCHTCRNCLAGRRNACLN--LKMAMLG---RADE
MUL_0495|M.ulcerans_Agy99 --LKVGDKVGNAWLWSACGSCEQCRTGWETLCEN-------------QRN
MAV_2804|M.avium_104 --VKVGDQVMVSSVA-GCGSCAGCATRDPVLCHSG----------FQIFG
: * * * * * *
MLBr_01784|M.leprae_Br4923 TPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTA
TH_4627|M.thermoresistible__bu TPALGIGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAINTG
Rv1530|M.tuberculosis_H37Rv EPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNP-LGAGIRWGVTIP
Mb1557|M.bovis_AF2122/97 EPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNP-LGAGIRWGVTIP
MAB_2041c|M.abscessus_ATCC_199 GAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP-LGAGIQWGATLP
MMAR_3163|M.marinum_M GAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP-LGAGIQWGKTLP
Mflv_4626|M.gilvum_PYR-GCK PPGLWGGYATHLHLPFDSMPLPVPDGLDPIVATLFNP-LGAGIKWAAMLP
MSMEG_2882|M.smegmatis_MC2_155 PPHFVGGYADYFLLPAKAVVYTVPDSVSDEIAAGANC-ALSQVMYGLERV
Mvan_2879|M.vanbaalenii_PYR-1 PPYFVGGYADYFVLPAGAVVYTVPDAVSDDIAAGANC-ALSQVMYGLERV
MUL_0495|M.ulcerans_Agy99 GGYTVNGSFGTYMLVNADYAARIPDGADPLEVAPILC-AGVTVYKGLKVT
MAV_2804|M.avium_104 GGVLGGAQADLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQRA
. : .
MLBr_01784|M.leprae_Br4923 AVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDD---TKLEWART
TH_4627|M.thermoresistible__bu AVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDA---KKLDWARE
Rv1530|M.tuberculosis_H37Rv ETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQ
Mb1557|M.bovis_AF2122/97 ETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQ
MAB_2041c|M.abscessus_ATCC_199 DTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARS
MMAR_3163|M.marinum_M DTKAGGIVAILGPGIRGICAAVAAKEAGAAFVAMTGIGPRDDQRLAIARS
Mflv_4626|M.gilvum_PYR-GCK ETSPGDVVAVLGPGIRGICAAVAAKEAGAAFVAMTGVGPRDRTRLAAAHQ
MSMEG_2882|M.smegmatis_MC2_155 DLQLGETVVVQGAGALGLYAVAVAKARGAKTVIAIDGVP---ERLELAKA
Mvan_2879|M.vanbaalenii_PYR-1 DQQLGEYVVVQGAGALGLYAVAVAKARGAAKVIAIDGVP---ERLELATA
MUL_0495|M.ulcerans_Agy99 DTRPGQWVAISGIGGLGHVAVQYARAMGLR-VVAIDIDD---DKLALAAR
MAV_2804|M.avium_104 DIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDG---RLARAAR
. *.: * * * * * * : . :* *
MLBr_01784|M.leprae_Br4923 FGATHTVNALE---LEVVKTIQDLTSGFGVDVVIDTVG-RPETWKQAFYA
TH_4627|M.thermoresistible__bu FGATHTIDASS---TDVVEAIQELTDGFGADVVVDAVG-RPETWEQAFYA
Rv1530|M.tuberculosis_H37Rv FGADLAVDVAI---DDPVAALTEQTG-GLADVVVDVTAKAPAAFAQAIAL
Mb1557|M.bovis_AF2122/97 FGADLAVDVAI---DDPVAALTEQTG-GLADVVVDVTAKAPAAFAQAIAL
MAB_2041c|M.abscessus_ATCC_199 FGVDLPIDVSQ---DDAATALQRETGGRLADVVVDVTAKAPSAFADAVGL
MMAR_3163|M.marinum_M FGVDLPIDVSQ---DDAVTALQRETGGQLADVVIDVTAKAPSAFADAVAL
Mflv_4626|M.gilvum_PYR-GCK FGVDLTIDVTE---DDPAQALQMATG-RLADVVVDVTAKAPAAFADAVAL
MSMEG_2882|M.smegmatis_MC2_155 FGADEVIDITATTDKDRVKIVRRLTDRQGADVVVEVVG-HPSAIDEGLKL
Mvan_2879|M.vanbaalenii_PYR-1 FGADAVIDITATTDKDRAKIVRSLTDGQGADVVVEVVG-HPSAIDEGLKL
MUL_0495|M.ulcerans_Agy99 LGAELVVNART---SDVVAQVQEATG---GVHGVLVTAVHPQAFGQAIGL
MAV_2804|M.avium_104 WGATPLKAPAL-------EAILAATGGRGADAVIDAVA-TDASLTEALNA
*. : *. : ... : :..
MLBr_01784|M.leprae_Br4923 RDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTL
TH_4627|M.thermoresistible__bu RDLAGTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYGDCLPERDFPTL
Rv1530|M.tuberculosis_H37Rv ARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALD
Mb1557|M.bovis_AF2122/97 ARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALD
MAB_2041c|M.abscessus_ATCC_199 ARPGGTIVVAGTRGGG-GAPRFEPDLLVYKELHVVGALGVEYPAYRAALE
MMAR_3163|M.marinum_M ARPGGRVVVAGTRGGG-GAPGFEPDTLVYKELHIAGALGVEYPAYRAALE
Mflv_4626|M.gilvum_PYR-GCK AQPGGRVVVAGTRGGG-GAPGFEPDLLVFKELRIFGSLGVDYPAYQSAIE
MSMEG_2882|M.smegmatis_MC2_155 LGQFGRYVEIGNINIG-KTFEFDPSRFVFANKTMVGVSLYDPAVLSRALT
Mvan_2879|M.vanbaalenii_PYR-1 LGQFGRYVEIGNINIG-RTFEFDPSRFVFANKTMVGVSLYDPSVLSRALA
MUL_0495|M.ulcerans_Agy99 ARRGGTIVFNGLPPGDFPAPIF---VIVLKGLTIRGSIVGTRQDMAEALD
MAV_2804|M.avium_104 VRPGGTVSVVGVHDMN----PFPLNALGCLIRSITLRMTTAPVQRTWPEL
* * . . .
MLBr_01784|M.leprae_Br4923 VDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGK-----VLRSVVML--
TH_4627|M.thermoresistible__bu INLYLQGRLPLEKFVTERIALDEVEGAFEKMQRGE-----VLRSVVVLK-
Rv1530|M.tuberculosis_H37Rv LLVSG--RYPFASLPRRCVRLEGAEDLLATMAGER-DGVPPIHGVLTP--
Mb1557|M.bovis_AF2122/97 LLVSG--RYPFASLPRRCVRLEGAEDLLATMAGER-DGVPPIHGVLTP--
MAB_2041c|M.abscessus_ATCC_199 ILAMG--RWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP
MMAR_3163|M.marinum_M ILATR--RWPFDRITRESTGFAGLAPLLSSLADENAKSSAALHNVFVPTP
Mflv_4626|M.gilvum_PYR-GCK LLVSR--RWPFEELHREITGFAGLPRLLDLLAGNEPDRVPALHNVFVPIA
MSMEG_2882|M.smegmatis_MC2_155 FLAEYQDRLPFDRLAAACYRLEDINDAFSAAENKR-----DVRASIVP--
Mvan_2879|M.vanbaalenii_PYR-1 FLEEYQHRLPFDRLAAARYSLDDINEAFAAAEDKR-----DVRASIVP--
MUL_0495|M.ulcerans_Agy99 FYARG-----LIHPTVEGAALEDINHVFERMERGQ------IDGRVVIDY
MAV_2804|M.avium_104 IPLLQSGRLDVDGIFTTTMPLDEAAIGYATAGSRS---GDDVKILLKP--
. . : : .
MLBr_01784|M.leprae_Br4923 ------------------------
TH_4627|M.thermoresistible__bu ------------------------
Rv1530|M.tuberculosis_H37Rv ------------------------
Mb1557|M.bovis_AF2122/97 ------------------------
MAB_2041c|M.abscessus_ATCC_199 ------------------------
MMAR_3163|M.marinum_M SQHAELQQRKVTRDENGTRTDARP
Mflv_4626|M.gilvum_PYR-GCK ------------------------
MSMEG_2882|M.smegmatis_MC2_155 ------------------------
Mvan_2879|M.vanbaalenii_PYR-1 ------------------------
MUL_0495|M.ulcerans_Agy99 R-----------------------
MAV_2804|M.avium_104 ------------------------