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MRSAVVTTPGHTDVIEAPDPQVGPKDVLVKIRACGICGTDSFYISIGGLPPHRGRMPLGHEPAGEVVAVG SRVSGLAVGDHVVINPMAAPNGIIGNGGASGALADYLLIEEAVRGVSLEVIPEHIPFEVAALNEPMAVAR HAVNQCKPKPSDKVLIFGAGPIGLGAVLAFKSAGAAHVAVVDLIPSRLDKALQVGADAVINSAEEDLTRR LIDLHGPGQALFPGKAGTDIYLDAAGAPAAVNSALTNAKKGATIGIVAVHKKPVEVDLVTVMSHEITLVG SIGYPTEIFDVTKDIVADWQKYALIVDRTIAFDNVQDALAAAATPGTADKIVVTFP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3529 | - | - | 100% (336) | dehydrogenase |
| M. marinum M | MMAR_3328 | adhE2_1 | 2e-26 | 27.99% (343) | zinc-dependent alcohol dehydrogenase AdhE2_1 |
| M. marinum M | MMAR_2790 | - | 6e-25 | 30.87% (298) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 2e-19 | 28.61% (360) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_3479 | - | 1e-136 | 68.96% (335) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 1e-23 | 30.87% (298) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-16 | 27.33% (300) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0526c | - | 2e-25 | 26.20% (355) | hypothetical protein MAB_0526c |
| M. avium 104 | MAV_4173 | - | 1e-146 | 73.41% (331) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2914 | - | 6e-33 | 32.12% (330) | L-idonate 5-dehydrogenase |
| M. thermoresistible (build 8) | TH_4349 | - | 4e-22 | 31.39% (274) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 6e-24 | 31.33% (300) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | 5e-32 | 30.31% (353) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3479|M.gilvum_PYR-GCK ------MKSTIVTGPGS-TEVIDITRPQCGPDDVLVRMRACGICGSDAFY
MAV_4173|M.avium_104 ----------MVTSPDR-AEVIDVERPGVGPRDVLVRMRACGICGSDAFY
MMAR_3529|M.marinum_M ------MRSAVVTTPGH-TDVIEAPDPQVGPKDVLVKIRACGICGTDSFY
MSMEG_2914|M.smegmatis_MC2_155 ------MKAVVVHGAND-LRVEELPDPAPGTGEVLVAMEWGGICGSDISY
Rv1895|M.tuberculosis_H37Rv ------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH-
MUL_2962|M.ulcerans_Agy99 ------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH-
TH_4349|M.thermoresistible__bu ------MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHL
MLBr_01784|M.leprae_Br4923 --MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTY
MAB_0526c|M.abscessus_ATCC_199 ------MRASVLR-NGSMVYRDDVPSPTPGEGQVLVKVSACGICGSDLHF
Mvan_0788|M.vanbaalenii_PYR-1 ------MRAAVYYGPNK-LEVDDVAEPEPGPGTVKLKVGFNGICGTDLHE
Mb1557|M.bovis_AF2122/97 MSDGAVVRALVLEAPRR-LVVRQYRLPRIGDDDALVRVEACGLCGTDHEQ
. * . : : * * :*
Mflv_3479|M.gilvum_PYR-GCK ITIG-----------------GIPPRQGHTPLGHEPAGEVVEVGAAVTG-
MAV_4173|M.avium_104 ISIG-----------------GVPPRQGHTPLGHEPAGEVVEVGAEVTG-
MMAR_3529|M.marinum_M ISIG-----------------GLPPHRGRMPLGHEPAGEVVAVGSRVSG-
MSMEG_2914|M.smegmatis_MC2_155 WRHGS---------------TGTAVLKHPMVLGHEVAGHIAGVGAGVTG-
Rv1895|M.tuberculosis_H37Rv ---FY---------------EGEYPFTEPVALGHEAVGTIVEAGPQVRT-
MUL_2962|M.ulcerans_Agy99 ---FY---------------EGEYPLAEPVALGHEAVGTVVEKGPDVHT-
TH_4349|M.thermoresistible__bu MHDFE---------------PGMMPWQLPFTLGHENAGWVAAVGAGVGT-
MLBr_01784|M.leprae_Br4923 R-------------------EGGINDRYPFLLGHEAAGTVEVVGPGVTA-
MAB_0526c|M.abscessus_ATCC_199 AKHGARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRTQA-
Mvan_0788|M.vanbaalenii_PYR-1 YYAGPIFVP--------TEPHPLTGQQLPLTMGHEFSGTIAAVGDGVTG-
Mb1557|M.bovis_AF2122/97 YT-------------------GELAGGFAFVPGHETVGTIAAIGPRAEQR
*** . : * .
Mflv_3479|M.gilvum_PYR-GCK --VDVGDHVVINPMAAPSGIIGNGGATGALADY-----------------
MAV_4173|M.avium_104 --LAVGDHVVINPMAAPSGIIGNGGASGALADY-----------------
MMAR_3529|M.marinum_M --LAVGDHVVINPMAAPNGIIGNGGASGALADY-----------------
MSMEG_2914|M.smegmatis_MC2_155 --LREGDRVTIHPATESGGYFGSAAFDPHTDGG-----------------
Rv1895|M.tuberculosis_H37Rv --VGVGDLVMVSSVAGCGVCPGCETHDPVMCFS-------GPMIFGAG--
MUL_2962|M.ulcerans_Agy99 --VEVGDQVMVSSVAGCGACAGCATRDPAMCVS-------GPQIFGSG--
TH_4349|M.thermoresistible__bu --VTEGDAVAVYGPWGCGTCERCMGGAENYCENPA----GAPVLSGGAGL
MLBr_01784|M.leprae_Br4923 --VEPGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELT
MAB_0526c|M.abscessus_ATCC_199 --PASGTAVTSIPILLSAKGLEPIVYSNTTLGG-----------------
Mvan_0788|M.vanbaalenii_PYR-1 --WSEGDRVAVEPIYKCGHCGPCRAGNYNVCQQIG--------------F
Mb1557|M.bovis_AF2122/97 WGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHG---LADMYGFIPVDR
* *
Mflv_3479|M.gilvum_PYR-GCK --------LLIENAQRGKSLEVIPKHIPWEVAALNEPMAVARHGVNR--C
MAV_4173|M.avium_104 --------LLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNR--C
MMAR_3529|M.marinum_M --------LLIEEAVRGVSLEVIPEHIPFEVAALNEPMAVARHAVNQ--C
MSMEG_2914|M.smegmatis_MC2_155 --------FCGLKVVRAEQIRRLPDAVDTVRGALAEPLAVAMHAVNR--A
Rv1895|M.tuberculosis_H37Rv VLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR--A
MUL_2962|M.ulcerans_Agy99 ALGGAQADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR--A
TH_4349|M.thermoresistible__bu GMDGGMAEYLLVPAER-LVVKLPESMTPVTAAALTDAGLTPYHAIRRSWP
MLBr_01784|M.leprae_Br4923 PALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAIN-TA
MAB_0526c|M.abscessus_ATCC_199 --------YAEQMLLSAPLLLPIPNGLDPRHAALTEPMAVGLHAVNK--S
Mvan_0788|M.vanbaalenii_PYR-1 HGLMSDGGMAEYTVVPTSMLHKLPDNVSLELGALVEPMSVAYHAATLG--
Mb1557|M.bovis_AF2122/97 EPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVT-IP
* .
Mflv_3479|M.gilvum_PYR-GCK RPRPEHQVVVFGAGPIGLGATLAFKALGVRHVVVVDIVA---SRLAKALQ
MAV_4173|M.avium_104 QPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIP---GRLDKAVR
MMAR_3529|M.marinum_M KPKPSDKVLIFGAGPIGLGAVLAFKSAGAAHVAVVDLIP---SRLDKALQ
MSMEG_2914|M.smegmatis_MC2_155 GTVRGRDVLVNGAGPIGALVVAAAKYAGAASVVAADVVE---APLAIAKA
Rv1895|M.tuberculosis_H37Rv DISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVK---GRLQRAAT
MUL_2962|M.ulcerans_Agy99 DIPFGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQ---GRLQRAAE
TH_4349|M.thermoresistible__bu KLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRS---EALELARE
MLBr_01784|M.leprae_Br4923 AVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDD---TKLEWART
MAB_0526c|M.abscessus_ATCC_199 AIQPGTGAIVIGCGPVGIAVIAALHNLGIEPIVASDYSS---ARRDLAQR
Mvan_0788|M.vanbaalenii_PYR-1 DVSPGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSP---TRRAAIEV
Mb1557|M.bovis_AF2122/97 ETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQ
. : * * * : .
Mflv_3479|M.gilvum_PYR-GCK IGADAVIDSSEEDVVARLIELHGEGEAMWPGKAGTDIYLDAAG-AGAVVT
MAV_4173|M.avium_104 IGADAVVNSAEEDVAARLVELHGPGESMFPGKAGTDIYLDAAG-APAVVS
MMAR_3529|M.marinum_M VGADAVINSAEEDLTRRLIDLHGPGQALFPGKAGTDIYLDAAG-APAAVN
MSMEG_2914|M.smegmatis_MC2_155 MGADGVVNLAGGEQLP----------------SDVAVVFEASG-AVAALG
Rv1895|M.tuberculosis_H37Rv WGATPIPSP---AAETILAATRG---------RGADSVIDAVG-TDASMS
MUL_2962|M.ulcerans_Agy99 WGATAVASP---AAEAIVAATSG---------RGADSVIDAVD-TDASMT
TH_4349|M.thermoresistible__bu MGADHVVRSDEQAVEAIWELTGG---------RGADVLLDFVG-ADATIE
MLBr_01784|M.leprae_Br4923 FGATHTVNALELEVVKTIQDLTSG--------FGVDVVIDTVG-RPETWK
MAB_0526c|M.abscessus_ATCC_199 MGAHQVVDPKIEPTFHAWSRIG----------AGAPVIFEAVG-VPGILN
Mvan_0788|M.vanbaalenii_PYR-1 LGARTLDPTSADVPAFIADHTRG---------DGADAVFDAAG-VTPAVS
Mb1557|M.bovis_AF2122/97 FGADLAVDVAIDDPVAALTEQTG---------GLADVVVDVTAKAPAAFA
** . .:
Mflv_3479|M.gilvum_PYR-GCK -TALAAAKAGAILGVVG--VHKEPVPVDFAGIMSNEITIVGSMG---YPE
MAV_4173|M.avium_104 -TALAAAKKGATLGIVG--VHKEPVPVDLINVMSNEITIVGSMG---YPD
MMAR_3529|M.marinum_M -SALTNAKKGATIGIVA--VHKKPVEVDLVTVMSHEITLVGSIG---YPT
MSMEG_2914|M.smegmatis_MC2_155 GVLHAAARNGVVVQVGN--LPGQPTPASLGDLVSRELTWIGSFR---FVD
Rv1895|M.tuberculosis_H37Rv DALNAVRPGGTVSVVGV--HDLQPFPVPALTCLLRSITLRMTMA---PVQ
MUL_2962|M.ulcerans_Agy99 DALNAVRAGGTVSVVGV--HDLQPFPLPALTCLLRSITLRLTIA---PVQ
TH_4349|M.thermoresistible__bu LARAAARPLGDVTIVGI--AGGS----VPLSFFSQPYEVSIQTT---YWG
MLBr_01784|M.leprae_Br4923 QAFYARDLAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPE
MAB_0526c|M.abscessus_ATCC_199 EVLRDAPRSARVVVVGV---CMEPDAITPYFGIAKEVAVQFVLA---YEP
Mvan_0788|M.vanbaalenii_PYR-1 TALACVGSRKPMISVAI---YEKPLETPLLNLVMNESRIQGSLC---YTG
Mb1557|M.bovis_AF2122/97 QAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALG---VDA
. .
Mflv_3479|M.gilvum_PYR-GCK EIFQVTEDLVEN-WEKYALIVSHTIPFDKVHDALELADTP-GGAGKVVVT
MAV_4173|M.avium_104 EIFEVTGDLVRN-WEKYALIVSHTIPFDRVGEALELARTP-GAADKVVVT
MMAR_3529|M.marinum_M EIFDVTKDIVAD-WQKYALIVDRTIAFDNVQDALAAAATP-GTADKIVVT
MSMEG_2914|M.smegmatis_MC2_155 EITDAVAALNDG-LDVTPLIT-HRYPIDHAAEAIAVAADRNTGSGKVLIQ
Rv1895|M.tuberculosis_H37Rv RTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELRFCLR
MUL_2962|M.ulcerans_Agy99 RTWSELIPLLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGNDVKVLLK
TH_4349|M.thermoresistible__bu -TRPELVELLDLAARGLVHVESTTYPLDDALQAYRDLRAGRVRGRAVIVP
MLBr_01784|M.leprae_Br4923 RDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-
MAB_0526c|M.abscessus_ATCC_199 AEFSETLRRIAHGEIDVAPLVTGEVGLEDVGSAFADLGDPERHCKILVVP
Mvan_0788|M.vanbaalenii_PYR-1 ADFEAVIALMGQGKYDTTGWVTRIPIDDVVDEGFEALHAGTKMKVLVDPN
Mb1557|M.bovis_AF2122/97 TAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHGV
. . .
Mflv_3479|M.gilvum_PYR-GCK FD------------------------------------------
MAV_4173|M.avium_104 FC------------------------------------------
MMAR_3529|M.marinum_M FP------------------------------------------
MSMEG_2914|M.smegmatis_MC2_155 LNG-----------------------------------------
Rv1895|M.tuberculosis_H37Rv PDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN
MUL_2962|M.ulcerans_Agy99 V-------------------------------------------
TH_4349|M.thermoresistible__bu --------------------------------------------
MLBr_01784|M.leprae_Br4923 --------------------------------------------
MAB_0526c|M.abscessus_ATCC_199 --------------------------------------------
Mvan_0788|M.vanbaalenii_PYR-1 GA------------------------------------------
Mb1557|M.bovis_AF2122/97 LTP-----------------------------------------