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VTSPDRAEVIDVERPGVGPRDVLVRMRACGICGSDAFYISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTG LAVGDHVVINPMAAPSGIIGNGGASGALADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNR CQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRIGADAVVNSAEEDVAARLVELH GPGESMFPGKAGTDIYLDAAGAPAVVSTALAAAKKGATLGIVGVHKEPVPVDLINVMSNEITIVGSMGYP DEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALELARTPGAADKVVVTFC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4173 | - | - | 100% (332) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. avium 104 | MAV_0537 | - | 1e-24 | 27.65% (340) | zinc-binding dehydrogenase |
| M. avium 104 | MAV_2804 | - | 8e-22 | 30.55% (275) | zinc-binding dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 5e-20 | 25.46% (377) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3479 | - | 1e-158 | 81.57% (331) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 3e-22 | 31.41% (277) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 5e-17 | 27.37% (285) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0526c | - | 2e-26 | 28.24% (340) | hypothetical protein MAB_0526c |
| M. marinum M | MMAR_3529 | - | 1e-145 | 73.41% (331) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2914 | - | 2e-33 | 33.02% (321) | L-idonate 5-dehydrogenase |
| M. thermoresistible (build 8) | TH_4349 | - | 1e-21 | 30.99% (284) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 2e-22 | 30.74% (296) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | 1e-31 | 31.70% (306) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4173|M.avium_104 --------MVTS-PDRAEVIDVERPGVGPRDVLVRMRACGICGSDAFYIS
Mflv_3479|M.gilvum_PYR-GCK ----MKSTIVTG-PGSTEVIDITRPQCGPDDVLVRMRACGICGSDAFYIT
MMAR_3529|M.marinum_M ----MRSAVVTT-PGHTDVIEAPDPQVGPKDVLVKIRACGICGTDSFYIS
MSMEG_2914|M.smegmatis_MC2_155 ----MKAVVVHG-ANDLRVEELPDPAPGTGEVLVAMEWGGICGSDISYWR
Mb3753|M.bovis_AF2122/97 ----MKAVTCTN-AKLEVVD-RPSPAPAKGQLLLDVLRCGICGSDLHARL
MAB_0526c|M.abscessus_ATCC_199 ----MRASVLRN-GSMVYRDDVPSPTPGEGQVLVKVSACGICGSDLHFAK
Rv1895|M.tuberculosis_H37Rv ----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH---
MUL_2962|M.ulcerans_Agy99 ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH---
TH_4349|M.thermoresistible__bu ----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHLMH
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
Mvan_0788|M.vanbaalenii_PYR-1 ----MRAAVYYG-PNKLEVDDVAEPEPGPGTVKLKVGFNGICGTDLHEYY
. . : : * * :*
MAV_4173|M.avium_104 IG-----------------GVPPRQGHTPLGHEPAGEVVEVGAEVTGLAV
Mflv_3479|M.gilvum_PYR-GCK IG-----------------GIPPRQGHTPLGHEPAGEVVEVGAAVTGVDV
MMAR_3529|M.marinum_M IG-----------------GLPPHRGRMPLGHEPAGEVVAVGSRVSGLAV
MSMEG_2914|M.smegmatis_MC2_155 HGS---------------TGTAVLKHPMVLGHEVAGHIAGVGAGVTGLRE
Mb3753|M.bovis_AF2122/97 HCD---ELADVMAES-GYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPR
MAB_0526c|M.abscessus_ATCC_199 HGARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRT-QAPA
Rv1895|M.tuberculosis_H37Rv -FYEG---------------EYPFTEPVALGHEAVGTIVEAGPQVRTVGV
MUL_2962|M.ulcerans_Agy99 -FYEG---------------EYPLAEPVALGHEAVGTVVEKGPDVHTVEV
TH_4349|M.thermoresistible__bu DFEPG---------------MMPWQLPFTLGHENAGWVAAVGAGVGTVTE
MLBr_01784|M.leprae_Br4923 GG-------------------INDRYPFLLGHEAAGTVEVVGPGVTAVEP
Mvan_0788|M.vanbaalenii_PYR-1 AGPIFVPTEP--------HPLTGQQLPLTMGHEFSGTIAAVGDGVTGWSE
:*** . : * .
MAV_4173|M.avium_104 -GDHVVINPMAAP-SGIIGNGG----------------------ASGALA
Mflv_3479|M.gilvum_PYR-GCK -GDHVVINPMAAP-SGIIGNGG----------------------ATGALA
MMAR_3529|M.marinum_M -GDHVVINPMAAP-NGIIGNGG----------------------ASGALA
MSMEG_2914|M.smegmatis_MC2_155 -GDRVTIHPATES-GGYFGSAA----------------------FDPHTD
Mb3753|M.bovis_AF2122/97 RGTPVVAMPLLRRGNKEVHGIG----------------------LSTMAP
MAB_0526c|M.abscessus_ATCC_199 SGTAVTSIPILLS-AKGLEPIV----------------------YSNTTL
Rv1895|M.tuberculosis_H37Rv GDLVMVSSVAGCGVCPGCETHDPVMCFS------GPMIFGAG--VLGGAQ
MUL_2962|M.ulcerans_Agy99 GDQVMVSSVAGCGACAGCATRDPAMCVS------GPQIFGSG--ALGGAQ
TH_4349|M.thermoresistible__bu GDAVAVYGPWGCGTCERCMGGAENYCENPA---GAPVLSGGAGLGMDGGM
MLBr_01784|M.leprae_Br4923 GDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALGI
Mvan_0788|M.vanbaalenii_PYR-1 GDRVAVEPIYKCGHCGPCRAGNYNVCQQIG-------------FHGLMSD
.
MAV_4173|M.avium_104 DYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNR--CQPRPTD
Mflv_3479|M.gilvum_PYR-GCK DYLLIENAQRGKSLEVIPKHIPWEVAALNEPMAVARHGVNR--CRPRPEH
MMAR_3529|M.marinum_M DYLLIEEAVRGVSLEVIPEHIPFEVAALNEPMAVARHAVNQ--CKPKPSD
MSMEG_2914|M.smegmatis_MC2_155 GGFCGLKVVRAEQIRRLPDAVDTVRGALAEPLAVAMHAVNR--AGTVRGR
Mb3753|M.bovis_AF2122/97 GAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRR--GEVGKGD
MAB_0526c|M.abscessus_ATCC_199 GGYAEQMLLSAPLLLPIPNGLDPRHAALTEPMAVGLHAVNK--SAIQPGT
Rv1895|M.tuberculosis_H37Rv ADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR--ADISFGS
MUL_2962|M.ulcerans_Agy99 ADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR--ADIPFGA
TH_4349|M.thermoresistible__bu AEYLLVPAER-LVVKLPESMTPVTAAALTDAGLTPYHAIRRSWPKLTPTS
MLBr_01784|M.leprae_Br4923 GAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDD
Mvan_0788|M.vanbaalenii_PYR-1 GGMAEYTVVPTSMLHKLPDNVSLELGALVEPMSVAYHAATLG--DVSPGD
* .
MAV_4173|M.avium_104 KVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRIGADAVVNS
Mflv_3479|M.gilvum_PYR-GCK QVVVFGAGPIGLGATLAFKALGVRHVVVVDIVASRLAKALQIGADAVIDS
MMAR_3529|M.marinum_M KVLIFGAGPIGLGAVLAFKSAGAAHVAVVDLIPSRLDKALQVGADAVINS
MSMEG_2914|M.smegmatis_MC2_155 DVLVNGAGPIGALVVAAAKYAGAASVVAADVVEAPLAIAKAMGADGVVNL
Mb3753|M.bovis_AF2122/97 VAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDP
MAB_0526c|M.abscessus_ATCC_199 GAIVIGCGPVGIAVIAALHNLGIEPIVASDYSSARRDLAQRMGAHQVVDP
Rv1895|M.tuberculosis_H37Rv AVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSP
MUL_2962|M.ulcerans_Agy99 TVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWGATAVASP
TH_4349|M.thermoresistible__bu TAVVIGVGGLGHVAVQLVKATTAARLIAVDNRSEALELAREMGADHVVRS
MLBr_01784|M.leprae_Br4923 TVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNA
Mvan_0788|M.vanbaalenii_PYR-1 TAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRAAIEVLGARTLDPT
. : * * :* : . : **
MAV_4173|M.avium_104 AEEDVAARLVELHGP----------------------------------G
Mflv_3479|M.gilvum_PYR-GCK SEEDVVARLIELHGE----------------------------------G
MMAR_3529|M.marinum_M AEEDLTRRLIDLHGP----------------------------------G
MSMEG_2914|M.smegmatis_MC2_155 AGGEQLP-------------------------------------------
Mb3753|M.bovis_AF2122/97 VQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLPWWHLWRAA
MAB_0526c|M.abscessus_ATCC_199 KIEPTFHAWSRIGAG-----------------------------------
Rv1895|M.tuberculosis_H37Rv ---AAETILAATRGR-----------------------------------
MUL_2962|M.ulcerans_Agy99 ---AAEAIVAATSGR-----------------------------------
TH_4349|M.thermoresistible__bu DEQAVEAIWELTGGR-----------------------------------
MLBr_01784|M.leprae_Br4923 LELEVVKTIQDLTSG-----------------------------------
Mvan_0788|M.vanbaalenii_PYR-1 SADVPAFIADHTRGD-----------------------------------
MAV_4173|M.avium_104 ESMFPGKAGTDIYLDAAGAPAVVS-TALAAAKKGATLGIVG-VHKEPVPV
Mflv_3479|M.gilvum_PYR-GCK EAMWPGKAGTDIYLDAAGAGAVVT-TALAAAKAGAILGVVG-VHKEPVPV
MMAR_3529|M.marinum_M QALFPGKAGTDIYLDAAGAPAAVN-SALTNAKKGATIGIVA-VHKKPVEV
MSMEG_2914|M.smegmatis_MC2_155 -------SDVAVVFEASGAVAALGGVLHAAARNGVVVQVGN-LPGQPTPA
Mb3753|M.bovis_AF2122/97 EAAGAATPKRPVIFECVGVPGIID-GIIASAPLFSRVVVVG-VCMGSDHI
MAB_0526c|M.abscessus_ATCC_199 ---------APVIFEAVGVPGILN-EVLRDAPRSARVVVVG-VCMEPDAI
Rv1895|M.tuberculosis_H37Rv --------GADSVIDAVGTDASMSDALNAVRPGGTVSVVGV-HDLQPFPV
MUL_2962|M.ulcerans_Agy99 --------GADSVIDAVDTDASMTDALNAVRAGGTVSVVGV-HDLQPFPL
TH_4349|M.thermoresistible__bu --------GADVLLDFVGADATIELARAAARPLGDVTIVGI-AGGS----
MLBr_01784|M.leprae_Br4923 -------FGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDM
Mvan_0788|M.vanbaalenii_PYR-1 --------GADAVFDAAGVTPAVSTALACVGSRKPMISVAI--YEKPLET
:: . :
MAV_4173|M.avium_104 DLINVMSNEITIV---GSMGYP-DEIFEVTGDLVRNWEKYALIVSHTIPF
Mflv_3479|M.gilvum_PYR-GCK DFAGIMSNEITIV---GSMGYP-EEIFQVTEDLVENWEKYALIVSHTIPF
MMAR_3529|M.marinum_M DLVTVMSHEITLV---GSIGYP-TEIFDVTKDIVADWQKYALIVDRTIAF
MSMEG_2914|M.smegmatis_MC2_155 SLGDLVSRELTWI---GSFRFV-DEITDAVAALNDGLDVTPLIT-HRYPI
Mb3753|M.bovis_AF2122/97 RPAMAINKEINLR---FVLGYTPLEFRDTLHMLADGKVNAAPLITGTVGL
MAB_0526c|M.abscessus_ATCC_199 TPYFGIAKEVAVQ---FVLAYEPAEFSETLRRIAHGEIDVAPLVTGEVGL
Rv1895|M.tuberculosis_H37Rv PALTCLLRSITLR---MTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPL
MUL_2962|M.ulcerans_Agy99 PALTCLLRSITLR---LTIAPVQRTWSELIPLLESGRLDVDGIFTTSLPL
TH_4349|M.thermoresistible__bu VPLSFFSQPYEVS---IQTTYWG-TRPELVELLDLAARGLVHVESTTYPL
MLBr_01784|M.leprae_Br4923 PLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGL
Mvan_0788|M.vanbaalenii_PYR-1 PLLNLVMNESRIQG---SLCYTGADFEAVIALMGQGKYDTTGWVTRIPID
. .
MAV_4173|M.avium_104 DRVGEALELARTP-GAADKVVVTFC-------------------------
Mflv_3479|M.gilvum_PYR-GCK DKVHDALELADTP-GGAGKVVVTFD-------------------------
MMAR_3529|M.marinum_M DNVQDALAAAATP-GTADKIVVTFP-------------------------
MSMEG_2914|M.smegmatis_MC2_155 DHAAEAIAVAADRNTGSGKVLIQLNG------------------------
Mb3753|M.bovis_AF2122/97 PGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE--------------
MAB_0526c|M.abscessus_ATCC_199 EDVGSAFADLGDPERHCKILVVP---------------------------
Rv1895|M.tuberculosis_H37Rv DEAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVAD
MUL_2962|M.ulcerans_Agy99 DEAAKGYSIAGSRSGNDVKVLLKV--------------------------
TH_4349|M.thermoresistible__bu DDALQAYRDLRAGRVRGRAVIVP---------------------------
MLBr_01784|M.leprae_Br4923 GDVEEAFHKIHGGKVLRSVVML----------------------------
Mvan_0788|M.vanbaalenii_PYR-1 DVVDEGFEALHAGTKMKVLVDPNGA-------------------------
. . .
MAV_4173|M.avium_104 -----------------
Mflv_3479|M.gilvum_PYR-GCK -----------------
MMAR_3529|M.marinum_M -----------------
MSMEG_2914|M.smegmatis_MC2_155 -----------------
Mb3753|M.bovis_AF2122/97 -----------------
MAB_0526c|M.abscessus_ATCC_199 -----------------
Rv1895|M.tuberculosis_H37Rv LQLEGAADGVDGPSMLN
MUL_2962|M.ulcerans_Agy99 -----------------
TH_4349|M.thermoresistible__bu -----------------
MLBr_01784|M.leprae_Br4923 -----------------
Mvan_0788|M.vanbaalenii_PYR-1 -----------------