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RTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGSDLHFYEADFPMPDPIALGHEAIGTVVEAGPQ VRNVKVGDQVMVSSVAGCGSCAGCATRDPVLCHSGFQIFGGGVLGGAQADLLAVPAADFQLLKIPEGIST EQALLLTDNLATGWAAAQRADIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARWGA TPLKAPALEAILAATGGRGADAVIDAVATDASLTEALNAVRPGGTVSVVGVHDMNPFPLNALGCLIRSIT LRMTTAPVQRTWPELIPLLQSGRLDVDGIFTTTMPLDEAAIGYATAGSRSGDDVKILLKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2804 | - | - | 100% (341) | zinc-binding dehydrogenase |
| M. avium 104 | MAV_4101 | - | 2e-54 | 37.47% (395) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. avium 104 | MAV_5022 | - | 7e-34 | 33.02% (321) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1929 | - | 1e-107 | 83.26% (233) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4517 | - | 1e-132 | 69.21% (341) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 1e-156 | 78.30% (341) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 4e-27 | 35.94% (256) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 1e-33 | 33.43% (356) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_2790 | - | 1e-157 | 80.00% (340) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0671 | - | 2e-52 | 36.65% (382) | S-(hydroxymethyl)glutathione dehydrogenase |
| M. thermoresistible (build 8) | TH_4349 | - | 6e-34 | 34.15% (325) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 1e-157 | 80.00% (340) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1841 | - | 1e-133 | 69.79% (341) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4517|M.gilvum_PYR-GCK ----------MRTVVVDSQRSIRVDTRPDPRLPGPDGVIVDVTASAICGS
Mvan_1841|M.vanbaalenii_PYR-1 ----------MRAVVIDSERRIRVETRPDPQLPGPDGAIVEVTATAICGS
MMAR_2790|M.marinum_M ----------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGS
MUL_2962|M.ulcerans_Agy99 ----------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGS
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv ----------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGS
MAV_2804|M.avium_104 ----------MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGS
MSMEG_0671|M.smegmatis_MC2_155 ----------MRAMVYRGPYKIRLEDKPIPAIEHPNDAIVRVTKAAICGS
TH_4349|M.thermoresistible__bu ----------MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHS
MLBr_01784|M.leprae_Br4923 ------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHT
MAB_0983c|M.abscessus_ATCC_199 MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCHS
Mflv_4517|M.gilvum_PYR-GCK DLHFLDGHYP---IDQP-VPIGHEAVGVVVETGSDVTRFTNGDRVLVSSV
Mvan_1841|M.vanbaalenii_PYR-1 DLHFLEGHYP---IDQP-VSIGHEAVGVVVETGTTVAGFKVGDRVLVSSV
MMAR_2790|M.marinum_M DLHFYEGEYP---LAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSV
MUL_2962|M.ulcerans_Agy99 DLHFYEGEYP---LAEP-VALGHEAVGTVVEKGPDVHTVEVGDQVMVSSV
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv DLHFYEGEYP---FTEP-VALGHEAVGTIVEAGPQVRTVGVGDLVMVSSV
MAV_2804|M.avium_104 DLHFYEADFP---MPDP-IALGHEAIGTVVEAGPQVRNVKVGDQVMVSSV
MSMEG_0671|M.smegmatis_MC2_155 DLHLYHGMMP---DTRVGTTFGHEFIGVVEKVGPSVQNLSVGDRVMVPFN
TH_4349|M.thermoresistible__bu DLHLMHDFEPGMMPWQLPFTLGHENAGWVAAVGAGVGTVTEGDAVAVYGP
MLBr_01784|M.leprae_Br4923 DLTYREGGIN----DRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWR
MAB_0983c|M.abscessus_ATCC_199 DLSVVDGNRI----RPVPMALGHEAAGVIAAVGPGVRDVSPGDHVVLVYV
Mflv_4517|M.gilvum_PYR-GCK TGCGRC--------AGCLTLDPVKCVHGPQIFG----------TGLLGGA
Mvan_1841|M.vanbaalenii_PYR-1 AGCGRC--------AGCRTQDPVKCVQGPQIFG----------SGLLGGA
MMAR_2790|M.marinum_M AGCGAC--------AGCATRDPAMCVSGPQIFG----------SGALGGA
MUL_2962|M.ulcerans_Agy99 AGCGAC--------AGCATRDPAMCVSGPQIFG----------SGALGGA
Mb1929|M.bovis_AF2122/97 -----------------------------MIFG----------AGVLGGA
Rv1895|M.tuberculosis_H37Rv AGCGVC--------PGCETHDPVMCFSGPMIFG----------AGVLGGA
MAV_2804|M.avium_104 AGCGSC--------AGCATRDPVLCHSGFQIFG----------GGVLGGA
MSMEG_0671|M.smegmatis_MC2_155 IFCGSCYFCARGLYSNCHNVNPNATAVG-GIYGY------SHTCGGYDGG
TH_4349|M.thermoresistible__bu WGCGTCERCMGGAENYCENPAGAPVLSGGAGLG-------------MDGG
MLBr_01784|M.leprae_Br4923 AVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG---------TELTPALGI
MAB_0983c|M.abscessus_ATCC_199 PSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLDGTEVRHHLGV
*
Mflv_4517|M.gilvum_PYR-GCK QSDLLAVPAADFQLLAVPDGIGTEEALLLTDNLPTGWAAAKR--ADIPVG
Mvan_1841|M.vanbaalenii_PYR-1 QADLMAVPAADFQLLAIPDGIDTEQALLLTDNLATGWAAAKR--ADIPVG
MMAR_2790|M.marinum_M QADLLAVPAADFQVLKIPAAITTEQALLLTDNLATGWAAARR--ADILFG
MUL_2962|M.ulcerans_Agy99 QADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR--ADIPFG
Mb1929|M.bovis_AF2122/97 QADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR--ADISFG
Rv1895|M.tuberculosis_H37Rv QADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR--ADISFG
MAV_2804|M.avium_104 QADLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQR--ADIPFG
MSMEG_0671|M.smegmatis_MC2_155 QAEFVRVPFADVGPSIIPDRLDDEDALLLTDALATGYFGAQL--GNIAEG
TH_4349|M.thermoresistible__bu MAEYLLVP-AERLVVKLPESMTPVTAAALTDAGLTPYHAIRRSWPKLTPT
MLBr_01784|M.leprae_Br4923 GAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAIN-TAAVSRD
MAB_0983c|M.abscessus_ATCC_199 SGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAVTH-TASVRPG
. . : * : : . :
Mflv_4517|M.gilvum_PYR-GCK GTVAVIGAGAVGQCALRSALALGAARVFAVDPVVARRERAAAAG-ATPMD
Mvan_1841|M.vanbaalenii_PYR-1 GTVAVIGAGAVGQCALRSAYALGAATVFAVDPVAARRDRAAAAG-ARAVP
MMAR_2790|M.marinum_M ATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRASEWG-ATAVA
MUL_2962|M.ulcerans_Agy99 ATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWG-ATAVA
Mb1929|M.bovis_AF2122/97 SAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWG-ATPIP
Rv1895|M.tuberculosis_H37Rv SAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWG-ATPIP
MAV_2804|M.avium_104 GTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARWG-ATPLK
MSMEG_0671|M.smegmatis_MC2_155 DTVVVFGAGPVGLFAAKSAWLMGAGRVIVIDHLEYRLEKARTFAHAETIN
TH_4349|M.thermoresistible__bu STAVVIGVGGLGHVAVQLVKATTAARLIAVDNRSEALELAREMG-ADHVV
MLBr_01784|M.leprae_Br4923 DTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFG-ATHTV
MAB_0983c|M.abscessus_ATCC_199 DSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALELG-ATSAC
:..*:* * :* . . * ::.:* * . *
Mflv_4517|M.gilvum_PYR-GCK SPAAQTILE----ATDGLGADSVIDAVGTDAS------------------
Mvan_1841|M.vanbaalenii_PYR-1 APAAAAILE----ATGGLGVDSVIDAVGTDTS------------------
MMAR_2790|M.marinum_M SPAAEAIVA----ATGGRGADSVIDAVGTDAS------------------
MUL_2962|M.ulcerans_Agy99 SPAAEAIVA----ATSGRGADSVIDAVDTDAS------------------
Mb1929|M.bovis_AF2122/97 SPAAETILA----ATRGRGADSVIDAVGTDAS------------------
Rv1895|M.tuberculosis_H37Rv SPAAETILA----ATRGRGADSVIDAVGTDAS------------------
MAV_2804|M.avium_104 APALEAILA----ATGGRGADAVIDAVATDAS------------------
MSMEG_0671|M.smegmatis_MC2_155 FVDCDDIVVKMKRTTDHLGADVAIDAAGAEADGNFLQHVTATKLKLQGGS
TH_4349|M.thermoresistible__bu RSDEQAVEA-IWELTGGRGADVLLDFVGADAT------------------
MLBr_01784|M.leprae_Br4923 NALELEVVKTIQDLTSGFGVDVVIDTVGRPET------------------
MAB_0983c|M.abscessus_ATCC_199 APDEAPG-----------GHDWVFEVVGSAAV------------------
* * :: .
Mflv_4517|M.gilvum_PYR-GCK ---IDDALAGVRTGGTVSVVGVHDLTP-YPLPALVCLLRSLTLR---MTT
Mvan_1841|M.vanbaalenii_PYR-1 ---LDDALACVRTGGTVSIVGVHDLQP-YPLPALVCLLRSLTIR---LTT
MMAR_2790|M.marinum_M ---MTDALNAVRAGGTVSVVGVHDLQP-FPLPALTCLLRSITLR---LTI
MUL_2962|M.ulcerans_Agy99 ---MTDALNAVRAGGTVSVVGVHDLQP-FPLPALTCLLRSITLR---LTI
Mb1929|M.bovis_AF2122/97 ---MSDALNAVRPGGTVSVVGVHDLQP-FPLPALTCLLRSITLR---MTM
Rv1895|M.tuberculosis_H37Rv ---MSDALNAVRPGGTVSVVGVHDLQP-FPVPALTCLLRSITLR---MTM
MAV_2804|M.avium_104 ---LTEALNAVRPGGTVSVVGVHDMNP-FPLNALGCLIRSITLR---MTT
MSMEG_0671|M.smegmatis_MC2_155 PIALNWAIDSVRKGGTVSVVGAYGPMF-SAVKFGDAFNKGLTLR---MNQ
TH_4349|M.thermoresistible__bu ---IELARAAARPLGDVTIVGIAGGS-----VPLSFFSQPYEVS---IQT
MLBr_01784|M.leprae_Br4923 ---WKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGD
MAB_0983c|M.abscessus_ATCC_199 ---LEQAYALTGRGGGTVSVGLPHPDARISLPALNIVAEGRSILGSYMGS
* * . ** . . :
Mflv_4517|M.gilvum_PYR-GCK APVQQTWAELVPLLQAGRLSVDGIFTDAMPLAEAEAAYAAAFSRSGEHLK
Mvan_1841|M.vanbaalenii_PYR-1 APVQQTWPELIPLLQAGRLSVDGIFTGALPLDDAERAYAAAFSRSAEHLK
MMAR_2790|M.marinum_M APVQRTWSELIPLLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGNDVK
MUL_2962|M.ulcerans_Agy99 APVQRTWSELIPLLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGNDVK
Mb1929|M.bovis_AF2122/97 APVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELK
Rv1895|M.tuberculosis_H37Rv APVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELR
MAV_2804|M.avium_104 APVQRTWPELIPLLQSGRLDVDGIFTTTMPLDEAAIGYATAGSRSGDDVK
MSMEG_0671|M.smegmatis_MC2_155 CPVKREWPRLLSHIKNGYLKPNDIVTHRIPLEHIAEGYHIFSAKLDDCIK
TH_4349|M.thermoresistible__bu TYWG-TRPELVELLDLAARGLVHVESTTYPLDDALQAYRDLRAGRVRGRA
MLBr_01784|M.leprae_Br4923 CLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSV
MAB_0983c|M.abscessus_ATCC_199 AQPQQDIPAMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQI
. :: . . : * . .
Mflv_4517|M.gilvum_PYR-GCK VHLVP-------------------------------------------
Mvan_1841|M.vanbaalenii_PYR-1 VQLIP-------------------------------------------
MMAR_2790|M.marinum_M VLLKV-------------------------------------------
MUL_2962|M.ulcerans_Agy99 VLLKV-------------------------------------------
Mb1929|M.bovis_AF2122/97 VLLTP-------------------------------------------
Rv1895|M.tuberculosis_H37Rv FCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN
MAV_2804|M.avium_104 ILLKP-------------------------------------------
MSMEG_0671|M.smegmatis_MC2_155 PIIVPTAS----------------------------------------
TH_4349|M.thermoresistible__bu VIVP--------------------------------------------
MLBr_01784|M.leprae_Br4923 VML---------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 LRPGVSA-----------------------------------------