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MDFIAMPPEMTSALIHSGPGPESLIEAADAWQRLGADLEESVRAHDPVLSALTDVWRGPSSAAMVGAISP YLTWLRATAQQCQQLAASAQVAAAAFSSTLATVVHPSEVRANRIALAQLLATNRLGRNLAAIAETEAQYE GMWVNNSAAMYRYEAASVQAVALPQFSSPLSTPDLTGSATRANVAAAAAAPVAAASPLDVLQSLTSIDPN SGWFGLANTYANQFVSSGFPVNLLSYLAQNTSAQALTSVAPDIAEGLSEGESALGESAATLSSAVEGVGA AAAPTAALGVGMPIGNLTAPPAAAGLLPAAQTPVQLASVASPLGTAESGFPMLPPLMPPPISAGSGWRKR KQQKYEDLEYGLELKGTFMPRPPSAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1235 | - | - | 100% (376) | PPE family protein, PPE14 |
| M. marinum M | MMAR_1513 | - | 1e-50 | 34.85% (396) | PPE family protein, PPE51 |
| M. marinum M | MMAR_2683 | - | 3e-49 | 34.66% (401) | PPE family protein, PPE31 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 7e-49 | 33.89% (419) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-27 | 30.00% (360) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 1e-48 | 34.23% (409) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-28 | 26.57% (429) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-28 | 30.19% (371) | PPE family protein |
| M. avium 104 | MAV_4274 | - | 1e-114 | 57.07% (382) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-28 | 38.39% (224) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 3e-27 | 38.62% (189) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2428 | - | 9e-50 | 34.60% (396) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-31 | 31.56% (358) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1235|M.marinum_M -------------MDFIAMPPEMTSALIHSGPGPESLIEAADAWQRLGAD
MAV_4274|M.avium_104 -------------MDLFA-PPEVTSTLIHTGPGAGSLIEAAAAWQRVAVE
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1807|M.tuberculosis_H37Rv -------------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MUL_2428|M.ulcerans_Agy99 -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
.** *: : *.*. .:: *. :* :. :
MMAR_1235|M.marinum_M LEESVRAHDPVLSALT-DVWRGPSSAAMVGAISPYLTWLRATAQQCQQLA
MAV_4274|M.avium_104 LENSVSSYASTLSSLI-ESWDGPSAMAMLQSVQPYLLWLRETAQQSAQLA
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1807|M.tuberculosis_H37Rv LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MUL_2428|M.ulcerans_Agy99 LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
:. . : : : * :: * *: : .
MMAR_1235|M.marinum_M ASAQVAAAAFSSTLATVVHPSEVRANRIALAQLLATNRLGRNLAAIAETE
MAV_4274|M.avium_104 NSAEAAATAFGTVRSTVVHPSVVSANRTRLAQLLATNRFGTNTAAIAETE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1807|M.tuberculosis_H37Rv AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MUL_2428|M.ulcerans_Agy99 IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
.** *: . : : *: *: :* :* * .** .*
MMAR_1235|M.marinum_M AQYEGMWVNNSAAMYRYEAASVQAVA-LPQFSSPLSTPDLTGSATRAN--
MAV_4274|M.avium_104 NEYQTMWANNSAALSRYQAASSQATSPLTQFNSPLAVTDPGGTANQQA--
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAG-ASAAATQLTPFTEPVQTTNASGLAAQS---
Rv1807|M.tuberculosis_H37Rv AQYAEMWSQDAMAMYGYAG-ASAAATQLTPFTEPVQTTNASGLAAQS---
MUL_2428|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYAT-TSAAAGMLTPFSSPNQATSPAGLAAQS---
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAA
:* ** : : : * : .
MMAR_1235|M.marinum_M ---VAAAAAAPVAAASPLDVLQSLTS-----------------------I
MAV_4274|M.avium_104 ---AVMKASVDSSGSSVGSVLNDLNMP--------------------GGF
Mb1836|M.bovis_AF2122/97 ---AAIAHATGASAGAQQTTLSQLIAA------IPSVLQGLSSSTAATSA
Rv1807|M.tuberculosis_H37Rv ---AAIAHATGASAGAQQTTLSQLIAA------IPSVLQGLSSSTAATFA
MUL_2428|M.ulcerans_Agy99 ---TAVTQAN--ATAAATDPITQLVSS------LTQSLG----AIQAIPS
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQT
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
MAB_4783|M.abscessus_ATCC_1997 -------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITDPV
MMAR_1235|M.marinum_M DPNSGWFGLANTYANQFVSSGFPVNLLSYLAQNTSAQALTSVAPDIAEGL
MAV_4274|M.avium_104 DPNAGWFNYFSTWGNQFISSGFPINLLGVWAQLATAQGVASVGGDIGSGL
Mb1836|M.bovis_AF2122/97 SGPSGLLGILGSGSSWLDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFL
Rv1807|M.tuberculosis_H37Rv SGPSGLLGIVGSGSSWLDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFL
MUL_2428|M.ulcerans_Agy99 ILPDDFT-ILDGVFSAYATVGVTQDIES------FCAGVIGAENNLG-LI
MLBr_01182|M.leprae_Br4923 AVPDSSSAAAPQLWGGFAQHLSPINDTLSMIN--NHAGMANAGLSLVNGM
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPAA
. :
MMAR_1235|M.marinum_M SEGESALGESAATLSSAVEGVG------A-AAAPTAALGVGMPIG-NLTA
MAV_4274|M.avium_104 SEG---LGATTASLANAIKGIG------AGAVAPSGAMGVGVSLG-KLTA
Mb1836|M.bovis_AF2122/97 GLLGGVAAADAAGDVLGEATSG------GLGGALVAPLGSAGGLGGTVAA
Rv1807|M.tuberculosis_H37Rv GLLGGVAAADAAGDVLGEATSG------GLGGALVAPLGSAGGLGGTVAA
MUL_2428|M.ulcerans_Agy99 GSSENPAEVTPSDFGLGSLIS----------STAPASAASGGGLGSAVAA
MLBr_01182|M.leprae_Br4923 GSAMKSLAPTTTKAAESAFKAM------GSAVQSTGRGLLGSSSGGHVTA
Mflv_0325|M.gilvum_PYR-GCK LATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPAT
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIA
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu LIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---------
MAB_4783|M.abscessus_ATCC_1997 GISIPLAITLASLSQMPEAPPV---------DAPAETVPARIDQPHAVAM
MMAR_1235|M.marinum_M PPAAAGLLPAAQTPVQLASVASPLGTAESGFPMLPPLMPPP-ISAGSG--
MAV_4274|M.avium_104 PPAVVGLLPGTQTGVQLASAASPLPAAESGFPLMPMMVPPPTTSAGTG--
Mb1836|M.bovis_AF2122/97 GLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTPMVAPPPAVAAGMP--
Rv1807|M.tuberculosis_H37Rv GLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTPMVAPPPAVAAGMP--
MUL_2428|M.ulcerans_Agy99 SVGRSGSIGQLSVPPSWSAPSARMVSALSPSGLTTIPGTEEAAAAGSP--
MLBr_01182|M.leprae_Br4923 QLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGG
Mflv_0325|M.gilvum_PYR-GCK MSAPPPPSGAPIAANTVSAGSPPAPG---APAAAAATFVPYVVAGRDPYE
Mvan_0415|M.vanbaalenii_PYR-1 VSAPPPPSSAAATVGTVATGTAPAPG---APAAATASFVPYAVAGRDPGT
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVA---APAPAAATFVPYAVANRDPGE
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
MAB_4783|M.abscessus_ATCC_1997 GGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGF
.
MMAR_1235|M.marinum_M ----WRKRKQQKYED----LEYGLELKGTFMPRPPSAG------------
MAV_4274|M.avium_104 ----WRKRKQQKYED----VAYGREVKGKVMPRNPSAG------------
Mb1836|M.bovis_AF2122/97 GMP-FGTMGGQGFGR----AVPQYGFRPNFVARPPAAG------------
Rv1807|M.tuberculosis_H37Rv GMP-FGTMGGQGFGR----AVPQYGFRPNFVARPPAAG------------
MUL_2428|M.ulcerans_Agy99 GFPGMVAPPATRASG----VLPRYGVRLTVMAHPPAAG------------
MLBr_01182|M.leprae_Br4923 GLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG------------
Mflv_0325|M.gilvum_PYR-GCK GFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYA
Mvan_0415|M.vanbaalenii_PYR-1 GFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYA
MSMEG_0619|M.smegmatis_MC2_155 GFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYR
MMAR_1235|M.marinum_M --------------------------------------------------
MAV_4274|M.avium_104 --------------------------------------------------
Mb1836|M.bovis_AF2122/97 --------------------------------------------------
Rv1807|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2428|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 DAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLT
MSMEG_0619|M.smegmatis_MC2_155 DAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 HEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLS
MMAR_1235|M.marinum_M ---------------------------------------------
MAV_4274|M.avium_104 ---------------------------------------------
Mb1836|M.bovis_AF2122/97 ---------------------------------------------
Rv1807|M.tuberculosis_H37Rv ---------------------------------------------
MUL_2428|M.ulcerans_Agy99 ---------------------------------------------
MLBr_01182|M.leprae_Br4923 ---------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 TLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TLDGDAEN--RTIPMLPGTWDVTDDDR------------------