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DLFAPPEVTSTLIHTGPGAGSLIEAAAAWQRVAVELENSVSSYASTLSSLIESWDGPSAMAMLQSVQPYL LWLRETAQQSAQLANSAEAAATAFGTVRSTVVHPSVVSANRTRLAQLLATNRFGTNTAAIAETENEYQTM WANNSAALSRYQAASSQATSPLTQFNSPLAVTDPGGTANQQAAVMKASVDSSGSSVGSVLNDLNMPGGFD PNAGWFNYFSTWGNQFISSGFPINLLGVWAQLATAQGVASVGGDIGSGLSEGLGATTASLANAIKGIGAG AVAPSGAMGVGVSLGKLTAPPAVVGLLPGTQTGVQLASAASPLPAAESGFPLMPMMVPPPTTSAGTGWRK RKQQKYEDVAYGREVKGKVMPRNPSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4274 | - | - | 100% (378) | PPE family protein |
| M. avium 104 | MAV_4273 | - | e-100 | 51.85% (378) | PPE family protein |
| M. avium 104 | MAV_2914 | - | 8e-47 | 35.03% (394) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 3e-44 | 32.72% (379) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-24 | 34.59% (185) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-44 | 33.33% (366) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-32 | 27.59% (424) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 1e-28 | 30.38% (372) | PPE family protein |
| M. marinum M | MMAR_1235 | - | 1e-114 | 57.07% (382) | PPE family protein, PPE14 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-28 | 35.16% (219) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-29 | 30.25% (400) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2427 | - | 2e-45 | 34.77% (394) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-27 | 29.70% (367) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4274|M.avium_104 -------------MDLFA-PPEVTSTLIHTGPGAGSLIEAAAAWQRVAVE
MMAR_1235|M.marinum_M -------------MDFIAMPPEMTSALIHSGPGPESLIEAADAWQRLGAD
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MUL_2427|M.ulcerans_Agy99 -------------MNYAFLPPEVNSARMYSGPGSASLLAAAASWDMVAIE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** * : *.*. .: *. :* :. :
MAV_4274|M.avium_104 LENSVSSYASTLSSLIES-WDGPSAMAMLQSVQPYLLWLRETAQQSAQLA
MMAR_1235|M.marinum_M LEESVRAHDPVLSALTDV-WRGPSSAAMVGAISPYLTWLRATAQQCQQLA
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MUL_2427|M.ulcerans_Agy99 LASAAEGYRSVISTLSGMYWWGPASAAMLAATGPFIGWLEITGALASETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:. . : : * .: *: *: . .
MAV_4274|M.avium_104 NSAEAAATAFGTVRSTVVHPSVVSANRTRLAQLLATNRFGTNTAAIAETE
MMAR_1235|M.marinum_M ASAQVAAAAFSSTLATVVHPSEVRANRIALAQLLATNRLGRNLAAIAETE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MUL_2427|M.ulcerans_Agy99 NQAAAAAAAYEQAYAMTVPPIVVAANRALLVALVASNIFGQNTAAIEATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
. .** *. . : : *: *: :* :* * .* *
MAV_4274|M.avium_104 NEYQTMWANNSAALSRYQAASSQATSPLTQFNSPLAVTDP-GGTANQQAA
MMAR_1235|M.marinum_M AQYEGMWVNNSAAMYRYEAASVQAVA-LPQFSSPLSTPDL-TGSATRANV
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPVQTTNA-SGLAAQSAA
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASAS-AVTPFSTPPQIANP-TAQGTQAAA
MUL_2427|M.ulcerans_Agy99 AEYAEMWAQDAGAMYDYAATSAMAT-ALVPFSAPGQDTNP-AGLAAQSAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNE-VGLAQEVVE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
:* ** : : .: * . : . . .
MAV_4274|M.avium_104 VMKASVDSSGSSVGSVLNDLNMPGGFDPNAGWFN----------------
MMAR_1235|M.marinum_M AAAAAAPVAAASPLDVLQSLTS---IDPNSGWFG----------------
Mb1836|M.bovis_AF2122/97 IAHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAATSASGPSGLLGILG
Rv1789|M.tuberculosis_H37Rv VATA----AGTAQSTLTEMITGLPNALQSLTSPLLQSSNGPLSWLWQILF
MUL_2427|M.ulcerans_Agy99 VSQAAGNAPASAQSVWSQLTSLVPDALPSLSN------------WPNILP
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQ
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
MAV_4274|M.avium_104 ----------YFSTWGNQFISSGFPINLLGVW------------------
MMAR_1235|M.marinum_M ----------LANTYANQFVSSGFPVNLLSYL------------------
Mb1836|M.bovis_AF2122/97 SGS--SWLDKLWALLD---PNSNFWNTIASSG------------------
Rv1789|M.tuberculosis_H37Rv GTP--NFPTSISALLTDLQPYASFFYNTEGLP------------------
MUL_2427|M.ulcerans_Agy99 DDF--SMLDGIFAMYA----TVGVTQDVESFC------------------
MLBr_01182|M.leprae_Br4923 TAVPDSSSAAAPQLWGGFAQHLSPINDTLSMI------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
MAV_4274|M.avium_104 --AQLATAQG-----------VASVGGDIGSGLSEG---LGATTASLANA
MMAR_1235|M.marinum_M --AQNTSAQA-----------LTSVAPDIAEGLSEGESALGESAATLSSA
Mb1836|M.bovis_AF2122/97 --LFLPSN-----TIAPFLGLLGGVAAADAAGDVLGEATSGGLGGALVAP
Rv1789|M.tuberculosis_H37Rv --YFSIGMGNNFIQSAKTLGLIG--SAAPAAVAAAGDAAKGLPG--LGGM
MUL_2427|M.ulcerans_Agy99 --AGIIGAG-------NNLGLLG---AASENSAEVTPGALGLGAMFSSAE
MLBr_01182|M.leprae_Br4923 --NNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGR
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHAVAMG
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
MAV_4274|M.avium_104 IKGIGAGAVAPSGAMGVGVSLGKLTAPPAVVGLLPGTQTGVQLASAASPL
MMAR_1235|M.marinum_M VEGVGA-AAAPTAALGVGMPIGNLTAPPAAAGLLPAAQTPVQLASVASPL
Mb1836|M.bovis_AF2122/97 LGSAGGLGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALG-----
Rv1789|M.tuberculosis_H37Rv LG-----GGPVAAGLGNAASVGKLSVPPVWSGPLPGSVTPGAAPL-----
MUL_2427|M.ulcerans_Agy99 RSAVGGATNAVTVSMSRAGSIGQLSVPPSWAAPSSGSASALSVSG-----
MLBr_01182|M.leprae_Br4923 GLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVA
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
.
MAV_4274|M.avium_104 PAAESGFPLMPMMVPPPTTSAGTGWRKRKQQKYEDVAYGREVKGKVMPRN
MMAR_1235|M.marinum_M GTAESGFPMLPPLMPPP-ISAGSGWRKRKQQKYEDLEYGLELKGTFMPRP
Mb1836|M.bovis_AF2122/97 GTPMVAP---PPAVAAG--MPGMPFGTMGGQGFGRAVPQYGFRPNFVARP
Rv1789|M.tuberculosis_H37Rv PVSTVSA---APEAAPGSLLGGLPLAGAGGAGAG---PRYGFRPTVMARP
MUL_2427|M.ulcerans_Agy99 LTTIPGT---EVAEQGAPGMPGMPVG--TGKRATSVILRYGVRLTVMARP
MLBr_01182|M.leprae_Br4923 VATESES---APLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRN
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRG
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
.
MAV_4274|M.avium_104 PSAG----------------------------------------------
MMAR_1235|M.marinum_M PSAG----------------------------------------------
Mb1836|M.bovis_AF2122/97 PAAG----------------------------------------------
Rv1789|M.tuberculosis_H37Rv PFAG----------------------------------------------
MUL_2427|M.ulcerans_Agy99 PAAG----------------------------------------------
MLBr_01182|M.leprae_Br4923 PAAG----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGG
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGG
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAG
MAB_4783|M.abscessus_ATCC_1997 YRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATG
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---SAAG
MAV_4274|M.avium_104 -----------------------------------------------
MMAR_1235|M.marinum_M -----------------------------------------------
Mb1836|M.bovis_AF2122/97 -----------------------------------------------
Rv1789|M.tuberculosis_H37Rv -----------------------------------------------
MUL_2427|M.ulcerans_Agy99 -----------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 LSTLDGDAEN--RTIPMLPGTWDVTDDDR------------------
TH_3113|M.thermoresistible__bu IRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN---