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M. bovis AF2122 / 97 Mb1731c (PPE22)

annotation: PPE family protein
coordinates: 1916838 - 1917995
length: 385

MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVGYERVITTLQTEEWLGPASTLMVEAVA
PYVAWMRATAIQAEQAASQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQY
AEMWAQDAMAMYGYAGSSATATKVTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPN
TLLGLTSPLSSALTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPEAAEA
AAAAPAAVGAAVGGTGPVSAGLGNAATIGKLSVPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAGAAGN
LLGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1731cPPE22-100% (385)PPE family protein
M. bovis AF2122 / 97Mb1817PPE26e-12461.04% (403) PPE family protein
M. bovis AF2122 / 97Mb1836PPE319e-9851.10% (409) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0325-3e-2931.13% (363) PPE protein
M. tuberculosis H37RvRv1705cPPE220.099.74% (385) PPE family protein
M. leprae Br4923MLBr_01182-1e-5034.36% (422) PPE-family protein
M. abscessus ATCC 19977MAB_2230c-6e-3129.04% (396) PPE family protein
M. marinum MMMAR_2516-1e-14967.94% (393) PPE family protein
M. avium 104MAV_2924-1e-10051.10% (409) PPE family protein
M. smegmatis MC2 155MSMEG_0619-2e-3430.70% (417) PPE family protein
M. thermoresistible (build 8)TH_3113-7e-3432.66% (395) PUTATIVE PPE protein
M. ulcerans Agy99MUL_1701-1e-15067.68% (393) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-7e-3531.16% (414) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2230c|M.abscessus_ATCC_199      ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
TH_3113|M.thermoresistible__bu      ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Mb1731c|M.bovis_AF2122/97           -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE
Rv1705c|M.tuberculosis_H37Rv        -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE
MMAR_2516|M.marinum_M               -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MUL_1701|M.ulcerans_Agy99           -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE
MAV_2924|M.avium_104                -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MLBr_01182|M.leprae_Br4923          ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
                                                     * .** :*  :  ***. .: :*.  *  *: :

Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2230c|M.abscessus_ATCC_199      YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu      YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Mb1731c|M.bovis_AF2122/97           LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA
Rv1705c|M.tuberculosis_H37Rv        LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA
MMAR_2516|M.marinum_M               LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAEQAA
MUL_1701|M.ulcerans_Agy99           LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAA
MAV_2924|M.avium_104                LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MLBr_01182|M.leprae_Br4923          LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
                                       :*      :       : * .:        **  *:   :  .   .

Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199      VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu      AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Mb1731c|M.bovis_AF2122/97           SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE
Rv1705c|M.tuberculosis_H37Rv        SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE
MMAR_2516|M.marinum_M               KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MUL_1701|M.ulcerans_Agy99           KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE
MAV_2924|M.avium_104                SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MLBr_01182|M.leprae_Br4923          TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
                                        .:. *. :*::   .   :  *:     *   *. *  :  **  *

Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_2230c|M.abscessus_ATCC_199      ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA
TH_3113|M.thermoresistible__bu      ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Mb1731c|M.bovis_AF2122/97           AQYAEMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLS
Rv1705c|M.tuberculosis_H37Rv        AQYAEMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLS
MMAR_2516|M.marinum_M               AQDAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSN
MUL_1701|M.ulcerans_Agy99           AQYAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSN
MAV_2924|M.avium_104                AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPS--GQAAQSA
MLBr_01182|M.leprae_Br4923          AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
                                    *:  . * * * :*  * .    *         .*               

Mflv_0325|M.gilvum_PYR-GCK          DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1       DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155      SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_2230c|M.abscessus_ATCC_199      DMSGMAAQAQAAESGMALDDSESFFDKLMR----------QIQEFFSDPL
TH_3113|M.thermoresistible__bu      TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL
Mb1731c|M.bovis_AF2122/97           AVAKAAGTSAG---------------------------------AAQSAI
Rv1705c|M.tuberculosis_H37Rv        AVAKAAGTSAG---------------------------------AAQSAI
MMAR_2516|M.marinum_M               ATSTAAATAAG---------------------------------AAQSTL
MUL_1701|M.ulcerans_Agy99           ATSTAAATAAG---------------------------------AAQSTL
MAV_2924|M.avium_104                AVSTATANSTSTNTTKALQS---------------------LAQPASSST
MLBr_01182|M.leprae_Br4923          VVEEVVEEVVEAEQAISQAA---------------------LDQAVNEGM
                                                                                      

Mflv_0325|M.gilvum_PYR-GCK          GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1       GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155      GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_2230c|M.abscessus_ATCC_199      GTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPL
TH_3113|M.thermoresistible__bu      GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP----------AYLFPVLV
Mb1731c|M.bovis_AF2122/97           AELIAHLPNTLLGLTSPLSS---ALTAAATPG------------------
Rv1705c|M.tuberculosis_H37Rv        AELIAHLPNTLLGLTSPLSS---ALTAAATPG------------------
MMAR_2516|M.marinum_M               AGVISQLPNALTSLTSPIAS---ALTSAASPAT-----------------
MUL_1701|M.ulcerans_Agy99           AGVISQLPNALTSLTSPIAS---ALTSAASPAT-----------------
MAV_2924|M.avium_104                TATKAATTAASTTSTDPLSEIWFLLTGQTSLPT-----------------
MLBr_01182|M.leprae_Br4923          EATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ-----------------
                                                    .                                 

Mflv_0325|M.gilvum_PYR-GCK          LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1       LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155      LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_2230c|M.abscessus_ATCC_199      WLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSPQ
TH_3113|M.thermoresistible__bu      YLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLA
Mb1731c|M.bovis_AF2122/97           ---------------WLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNS
Rv1705c|M.tuberculosis_H37Rv        ---------------WLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNS
MMAR_2516|M.marinum_M               ---------------WIDWLVNWYLPIS---QLFYNTVGLPYFAIGIGSS
MUL_1701|M.ulcerans_Agy99           ---------------WIDWLVNWYLPIS---QLFYNTVGLPYFAIGIGSS
MAV_2924|M.avium_104                ---------------NLGTLVNGYSPFA---GLFYNTEGLPYFSTGMANT
MLBr_01182|M.leprae_Br4923          ---------------LWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNG
                                                                                      

Mflv_0325|M.gilvum_PYR-GCK          SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGR
Mvan_0415|M.vanbaalenii_PYR-1       SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGR
MSMEG_0619|M.smegmatis_MC2_155      -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANR
MAB_2230c|M.abscessus_ATCC_199      QQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQED
TH_3113|M.thermoresistible__bu      GLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTG---SAAPTTGT
Mb1731c|M.bovis_AF2122/97           LITSWRALG-WIGPEAAEAAA------AAPAAVGAAVGGTGPVSAGLGNA
Rv1705c|M.tuberculosis_H37Rv        LITSWRALG-WIGPEAAEAAA------AAPAAVGAAVGGTGPVSAGLGNA
MMAR_2516|M.marinum_M               LITSERALG-LIGPEAEAAAAGAGAAEAAAGAAPAALGGAGPIGAGLGNA
MUL_1701|M.ulcerans_Agy99           LITSERALG-LIGPEAEAAAAGAGAAEAAAGAAPAALGGAGPIGAGLGNA
MAV_2924|M.avium_104                FTQIAKSVG-AIGGAAPAAAKALPGLGGLGGMLGGGAAAAHPVAA-LGGA
MLBr_01182|M.leprae_Br4923          MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRA
                                          .        .              .    .              

Mflv_0325|M.gilvum_PYR-GCK          DPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG
Mvan_0415|M.vanbaalenii_PYR-1       DPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG
MSMEG_0619|M.smegmatis_MC2_155      DPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE
MAB_2230c|M.abscessus_ATCC_199      PPAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPA
TH_3113|M.thermoresistible__bu      APGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG-VARRSAGA
Mb1731c|M.bovis_AF2122/97           ATIG-KLSVPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAG-AAGNLLG
Rv1705c|M.tuberculosis_H37Rv        ATIG-KLSLPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAG-AAGNLLG
MMAR_2516|M.marinum_M               SALG-KLSVPPSWAGSGLDVPPSV-SAGGPLASDIVNPPEAS-APGSLLG
MUL_1701|M.ulcerans_Agy99           SALG-KLSVPPSWPGSGLDVPPSV-SAGGPLASDIVNPPEAS-APGSLLG
MAV_2924|M.avium_104                GSIGGKLSVPVAWSG--APATPALGHAIP--VSSISAAPEAAGGPGNLLG
MLBr_01182|M.leprae_Br4923          ASIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPM
                                     .           .                                    

Mflv_0325|M.gilvum_PYR-GCK          RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQ
Mvan_0415|M.vanbaalenii_PYR-1       RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQ
MSMEG_0619|M.smegmatis_MC2_155      RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VT
MAB_2230c|M.abscessus_ATCC_199      PQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTS
TH_3113|M.thermoresistible__bu      RRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS-MS
Mb1731c|M.bovis_AF2122/97           G-MPLAG-SGTGTGGAGPRYGFRVTVMSRPPFAG----------------
Rv1705c|M.tuberculosis_H37Rv        G-MPLAG-SGTGTGGAGPRYGFRVTVMSRPPFAG----------------
MMAR_2516|M.marinum_M               G-MPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG----------------
MUL_1701|M.ulcerans_Agy99           G-MPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG----------------
MAV_2924|M.avium_104                G-MPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG----------------
MLBr_01182|M.leprae_Br4923          APMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG----------------
                                                                     .                

Mflv_0325|M.gilvum_PYR-GCK          AGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1       AGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155      AAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_2230c|M.abscessus_ATCC_199      AAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPG
TH_3113|M.thermoresistible__bu      AATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPA
Mb1731c|M.bovis_AF2122/97           --------------------------------------------------
Rv1705c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2516|M.marinum_M               --------------------------------------------------
MUL_1701|M.ulcerans_Agy99           --------------------------------------------------
MAV_2924|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_0325|M.gilvum_PYR-GCK          P-----
Mvan_0415|M.vanbaalenii_PYR-1       Q-----
MSMEG_0619|M.smegmatis_MC2_155      R-----
MAB_2230c|M.abscessus_ATCC_199      ERGAST
TH_3113|M.thermoresistible__bu      EPN---
Mb1731c|M.bovis_AF2122/97           ------
Rv1705c|M.tuberculosis_H37Rv        ------
MMAR_2516|M.marinum_M               ------
MUL_1701|M.ulcerans_Agy99           ------
MAV_2924|M.avium_104                ------
MLBr_01182|M.leprae_Br4923          ------