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MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVGYERVITTLQTEEWLGPASTLMVEAVA PYVAWMRATAIQAEQAASQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQY AEMWAQDAMAMYGYAGSSATATKVTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPN TLLGLTSPLSSALTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPEAAEA AAAAPAAVGAAVGGTGPVSAGLGNAATIGKLSVPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAGAAGN LLGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1731c | PPE22 | - | 100% (385) | PPE family protein |
M. bovis AF2122 / 97 | Mb1817 | PPE26 | e-124 | 61.04% (403) | PPE family protein |
M. bovis AF2122 / 97 | Mb1836 | PPE31 | 9e-98 | 51.10% (409) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0325 | - | 3e-29 | 31.13% (363) | PPE protein |
M. tuberculosis H37Rv | Rv1705c | PPE22 | 0.0 | 99.74% (385) | PPE family protein |
M. leprae Br4923 | MLBr_01182 | - | 1e-50 | 34.36% (422) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_2230c | - | 6e-31 | 29.04% (396) | PPE family protein |
M. marinum M | MMAR_2516 | - | 1e-149 | 67.94% (393) | PPE family protein |
M. avium 104 | MAV_2924 | - | 1e-100 | 51.10% (409) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-34 | 30.70% (417) | PPE family protein |
M. thermoresistible (build 8) | TH_3113 | - | 7e-34 | 32.66% (395) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_1701 | - | 1e-150 | 67.68% (393) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 7e-35 | 31.16% (414) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE Mb1731c|M.bovis_AF2122/97 -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE Rv1705c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE MMAR_2516|M.marinum_M -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE MUL_1701|M.ulcerans_Agy99 -------------MDFGALPPEVNSGRMYTGPGSTPMVSAASAWNRLASE MAV_2924|M.avium_104 -------------MDYGAFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE * .** :* : ***. .: :*. * *: : Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG Mb1731c|M.bovis_AF2122/97 LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA Rv1705c|M.tuberculosis_H37Rv LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA MMAR_2516|M.marinum_M LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAEQAA MUL_1701|M.ulcerans_Agy99 LSFTADGYERVIKALSGEEWFGPASAMMLEAITPYVTWMRSTAVQAERAA MAV_2924|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA :* : : * .: ** *: : . . Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE Mb1731c|M.bovis_AF2122/97 SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE Rv1705c|M.tuberculosis_H37Rv SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE MMAR_2516|M.marinum_M KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE MUL_1701|M.ulcerans_Agy99 KQAEAAVAAFEAAFTGVVPPPLIASNRMQLMTLMARNIYGQYTAEIASLE MAV_2924|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE .:. *. :*:: . : *: * *. * : ** * Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI Mb1731c|M.bovis_AF2122/97 AQYAEMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLS Rv1705c|M.tuberculosis_H37Rv AQYAEMWAQDAMAMYGYAGSSATAT-KVTPFAPPPNTTSPS--AAATQLS MMAR_2516|M.marinum_M AQDAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSN MUL_1701|M.ulcerans_Agy99 AQYAEMWAQDARAMYTYAGSSASAT-KITAFTPPPETANPA--ASALQSN MAV_2924|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASAS-KVTPFQKAPQVTNPS--GQAAQSA MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE *: . * * * :* * . * .* Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL MAB_2230c|M.abscessus_ATCC_199 DMSGMAAQAQAAESGMALDDSESFFDKLMR----------QIQEFFSDPL TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL Mb1731c|M.bovis_AF2122/97 AVAKAAGTSAG---------------------------------AAQSAI Rv1705c|M.tuberculosis_H37Rv AVAKAAGTSAG---------------------------------AAQSAI MMAR_2516|M.marinum_M ATSTAAATAAG---------------------------------AAQSTL MUL_1701|M.ulcerans_Agy99 ATSTAAATAAG---------------------------------AAQSTL MAV_2924|M.avium_104 AVSTATANSTSTNTTKALQS---------------------LAQPASSST MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAA---------------------LDQAVNEGM Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF MAB_2230c|M.abscessus_ATCC_199 GTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPL TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP----------AYLFPVLV Mb1731c|M.bovis_AF2122/97 AELIAHLPNTLLGLTSPLSS---ALTAAATPG------------------ Rv1705c|M.tuberculosis_H37Rv AELIAHLPNTLLGLTSPLSS---ALTAAATPG------------------ MMAR_2516|M.marinum_M AGVISQLPNALTSLTSPIAS---ALTSAASPAT----------------- MUL_1701|M.ulcerans_Agy99 AGVISQLPNALTSLTSPIAS---ALTSAASPAT----------------- MAV_2924|M.avium_104 TATKAATTAASTTSTDPLSEIWFLLTGQTSLPT----------------- MLBr_01182|M.leprae_Br4923 EATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ----------------- . Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP MAB_2230c|M.abscessus_ATCC_199 WLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSPQ TH_3113|M.thermoresistible__bu YLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLA Mb1731c|M.bovis_AF2122/97 ---------------WLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNS Rv1705c|M.tuberculosis_H37Rv ---------------WLEWFINWYLPIS---QLFYNTVGLPYFAIGIGNS MMAR_2516|M.marinum_M ---------------WIDWLVNWYLPIS---QLFYNTVGLPYFAIGIGSS MUL_1701|M.ulcerans_Agy99 ---------------WIDWLVNWYLPIS---QLFYNTVGLPYFAIGIGSS MAV_2924|M.avium_104 ---------------NLGTLVNGYSPFA---GLFYNTEGLPYFSTGMANT MLBr_01182|M.leprae_Br4923 ---------------LWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNG Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGR Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGR MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANR MAB_2230c|M.abscessus_ATCC_199 QQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQED TH_3113|M.thermoresistible__bu GLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPAPTG---SAAPTTGT Mb1731c|M.bovis_AF2122/97 LITSWRALG-WIGPEAAEAAA------AAPAAVGAAVGGTGPVSAGLGNA Rv1705c|M.tuberculosis_H37Rv LITSWRALG-WIGPEAAEAAA------AAPAAVGAAVGGTGPVSAGLGNA MMAR_2516|M.marinum_M LITSERALG-LIGPEAEAAAAGAGAAEAAAGAAPAALGGAGPIGAGLGNA MUL_1701|M.ulcerans_Agy99 LITSERALG-LIGPEAEAAAAGAGAAEAAAGAAPAALGGAGPIGAGLGNA MAV_2924|M.avium_104 FTQIAKSVG-AIGGAAPAAAKALPGLGGLGGMLGGGAAAAHPVAA-LGGA MLBr_01182|M.leprae_Br4923 MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRA . . . . Mflv_0325|M.gilvum_PYR-GCK DPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG Mvan_0415|M.vanbaalenii_PYR-1 DPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG MSMEG_0619|M.smegmatis_MC2_155 DPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE MAB_2230c|M.abscessus_ATCC_199 PPAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPA TH_3113|M.thermoresistible__bu APGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPG-VARRSAGA Mb1731c|M.bovis_AF2122/97 ATIG-KLSVPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAG-AAGNLLG Rv1705c|M.tuberculosis_H37Rv ATIG-KLSLPPNWAGASPSLAPTVGSASAPLVSDIVEQPEAG-AAGNLLG MMAR_2516|M.marinum_M SALG-KLSVPPSWAGSGLDVPPSV-SAGGPLASDIVNPPEAS-APGSLLG MUL_1701|M.ulcerans_Agy99 SALG-KLSVPPSWPGSGLDVPPSV-SAGGPLASDIVNPPEAS-APGSLLG MAV_2924|M.avium_104 GSIGGKLSVPVAWSG--APATPALGHAIP--VSSISAAPEAAGGPGNLLG MLBr_01182|M.leprae_Br4923 ASIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPM . . Mflv_0325|M.gilvum_PYR-GCK RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQ Mvan_0415|M.vanbaalenii_PYR-1 RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQ MSMEG_0619|M.smegmatis_MC2_155 RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VT MAB_2230c|M.abscessus_ATCC_199 PQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTS TH_3113|M.thermoresistible__bu RRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPAS-MS Mb1731c|M.bovis_AF2122/97 G-MPLAG-SGTGTGGAGPRYGFRVTVMSRPPFAG---------------- Rv1705c|M.tuberculosis_H37Rv G-MPLAG-SGTGTGGAGPRYGFRVTVMSRPPFAG---------------- MMAR_2516|M.marinum_M G-MPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG---------------- MUL_1701|M.ulcerans_Agy99 G-MPLAGGPGGAAAGAGPRYGFRVTVMARPPFAG---------------- MAV_2924|M.avium_104 G-MPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG---------------- MLBr_01182|M.leprae_Br4923 APMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG---------------- . Mflv_0325|M.gilvum_PYR-GCK AGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK Mvan_0415|M.vanbaalenii_PYR-1 AGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS MSMEG_0619|M.smegmatis_MC2_155 AAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR MAB_2230c|M.abscessus_ATCC_199 AAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPG TH_3113|M.thermoresistible__bu AATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPA Mb1731c|M.bovis_AF2122/97 -------------------------------------------------- Rv1705c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2516|M.marinum_M -------------------------------------------------- MUL_1701|M.ulcerans_Agy99 -------------------------------------------------- MAV_2924|M.avium_104 -------------------------------------------------- MLBr_01182|M.leprae_Br4923 -------------------------------------------------- Mflv_0325|M.gilvum_PYR-GCK P----- Mvan_0415|M.vanbaalenii_PYR-1 Q----- MSMEG_0619|M.smegmatis_MC2_155 R----- MAB_2230c|M.abscessus_ATCC_199 ERGAST TH_3113|M.thermoresistible__bu EPN--- Mb1731c|M.bovis_AF2122/97 ------ Rv1705c|M.tuberculosis_H37Rv ------ MMAR_2516|M.marinum_M ------ MUL_1701|M.ulcerans_Agy99 ------ MAV_2924|M.avium_104 ------ MLBr_01182|M.leprae_Br4923 ------