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YAGPGSGPLMAAAAAWDEVAAELGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEE TASQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQYMEMWAQDAAAMYGYA AASQTASTLSPFAAPPNTTAPEGESDQAAAVAQAAAEPAGNSAQTAAQASSQLATSQAVTTGSQAVAQAS TTTASQPGPFTWLTSALQNLQQSGLPTPTNNWLGLNPSFYTVMLKQNTGLAYFSNGITSFWSSIAQQLVS GPGGSTAGAGGAWYPTPQFASLGLGNLGSVGGASHVSAISAGAGRVGALSVPQQWATLTSAVSPAVSEEG SAVQAAAGGAPGGAANGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2925 | - | - | 100% (405) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 0.0 | 93.10% (406) | PPE family protein |
| M. avium 104 | MAV_2926 | - | 6e-81 | 44.99% (409) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1815 | PPE25 | 3e-99 | 51.23% (406) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 6e-33 | 29.68% (401) | PPE protein |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | 3e-99 | 51.48% (406) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-44 | 33.97% (421) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 3e-29 | 35.35% (198) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 1e-117 | 57.28% (412) | PPE family protein, PPE25 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-30 | 38.68% (212) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-30 | 38.38% (198) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 1e-116 | 57.04% (412) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 7e-35 | 31.40% (414) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mb1815|M.bovis_AF2122/97 ---------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLA
Rv1787|M.tuberculosis_H37Rv ---------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLA
MMAR_2669|M.marinum_M --------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAELSSA
MUL_3089|M.ulcerans_Agy99 --------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAELSSA
MAV_2925|M.avium_104 -----------------------MYAGPGSGPLMAAAAAWDEVAAELGIA
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
TH_3569|M.thermoresistible__bu -----MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAEYASA
MAB_2254c|M.abscessus_ATCC_199 ------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYEYSMA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
: *.*. .:: **. * .: .
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLS-QNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLS-QMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
Mb1815|M.bovis_AF2122/97 ATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAA
Rv1787|M.tuberculosis_H37Rv ATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAA
MMAR_2669|M.marinum_M ASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAASQAR
MUL_3089|M.ulcerans_Agy99 ASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAASQAR
MAV_2925|M.avium_104 ASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETASQGR
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
TH_3569|M.thermoresistible__bu AAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATAGRHE
MAB_2254c|M.abscessus_ATCC_199 ATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANAALHE
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
* : : * :: * ** : : .
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADYI
Mb1815|M.bovis_AF2122/97 AAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYA
Rv1787|M.tuberculosis_H37Rv AAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYA
MMAR_2669|M.marinum_M AAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATEAQYM
MUL_3089|M.ulcerans_Agy99 AAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATEAQYM
MAV_2925|M.avium_104 AAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQYM
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
TH_3569|M.thermoresistible__bu TAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNEADYV
MAB_2254c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNEADYV
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
. * :: * . : *: * :*::* * .** **:*
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEPVAPP-KPIAVPPGSEAAFAGAMSGA
Mvan_0077|M.vanbaalenii_PYR-1 RMWNQAAAVMTGYETETILNSTFEPVAPP-KPITVFGSTQAAMATAIGSA
Mb1815|M.bovis_AF2122/97 EMWAQDAVAMYGYAAASASASRLIPFAAPPKTTN------SAGVVAQVAA
Rv1787|M.tuberculosis_H37Rv EMWAQDAVAMYGYAAASASASRLIPFAAPPKTTN------SAGVVAQVAA
MMAR_2669|M.marinum_M EMWAQDAAAMYSYAGSSALATELPRFAPPPDTTSVNAAGGQSAVVAQAAA
MUL_3089|M.ulcerans_Agy99 EMWAQDAAAMYSYAGSSAPATELPRFAPPPDTTSVNAAGGQSAVVAQAAA
MAV_2925|M.avium_104 EMWAQDAAAMYGYAAASQTASTLSPFAAPPNTTAPEGESDQAAAVAQAAA
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
TH_3569|M.thermoresistible__bu RMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMATTQQ
MAB_2254c|M.abscessus_ATCC_199 RMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGS-ELSRMAADMSG
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVEE
.** * *. * * ..
Mflv_0768|M.gilvum_PYR-GCK VPGAGEAVMRNAIISKVS----------------STAKLDTANQIAGRAE
Mvan_0077|M.vanbaalenii_PYR-1 APGIASAAARNATFTKVS----------------VVGKLDEVNQKAGHAE
Mb1815|M.bovis_AF2122/97 VAA-----------------------------------MPGLLQR-----
Rv1787|M.tuberculosis_H37Rv VAA-----------------------------------MPGLLQR-----
MMAR_2669|M.marinum_M TPAGDSAQTITATIPQLL----------------SSAGVPGLQQLS---L
MUL_3089|M.ulcerans_Agy99 TPAGDSAQTITATIPQLL----------------SSAGVPGLQQRS---L
MAV_2925|M.avium_104 EPAGNSAQTAAQASSQLA----------------TSQAVTTGSQ------
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLG
TH_3569|M.thermoresistible__bu IGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLF
MAB_2254c|M.abscessus_ATCC_199 FAAQAQATESGSALDSSNSVIDQL--------------LNFFRDPLGTLR
MLBr_01182|M.leprae_Br4923 VVEEVVEAEQAISQAALD------------------QAVNEGMEAT----
: :
Mflv_0768|M.gilvum_PYR-GCK GTLRGVVDRAGSHAEKSQ-GLEQAPQQGMQMGMQMASQLGSTLGQMPQQM
Mvan_0077|M.vanbaalenii_PYR-1 GLLQQAADSGRSQAEQGQ-LLQQAPQQGMQMGMQMASQLGSTLGQLPQQM
Mb1815|M.bovis_AF2122/97 --LSSAASVSWSNPNDWW-LVR-----LLGSITPTERTTIVRLLG-----
Rv1787|M.tuberculosis_H37Rv --LSSAASVSWSNPNDWW-LVR-----LLGSITPTERTTIVRLLG-----
MMAR_2669|M.marinum_M SSVSSMSPSAASSPTVWQ-IIQTQVQNFLTYGLPTPDNNYAGLYPGMYNA
MUL_3089|M.ulcerans_Agy99 SSVSSMSPSAASSPTVWQ-IIQTQVQNFLTYGLPTPDNNYAGLYPGMYNA
MAV_2925|M.avium_104 -AVAQASTTTASQPGPFT-WLTSALQNLQQSGLPTPTNNWLGLNPSFYTV
MSMEG_0619|M.smegmatis_MC2_155 RLLTDFMTNPAGALATWWPFLFGVAYQ--VFFNLVGWPTWGMIFASPFLI
TH_3569|M.thermoresistible__bu QLIDDFLTNPAGALVTWWPLLFAVAYQ--VFTNLVGWPTWAMILASPVLI
MAB_2254c|M.abscessus_ATCC_199 QIIEDFIRNPGAALATWLPFLLVLASMTYVLFAQVFWLFWAALLSAPLWL
MLBr_01182|M.leprae_Br4923 -VVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMI
: : :
Mflv_0768|M.gilvum_PYR-GCK MQGVTQPFQQLTQPLQQMSSLFGGM--MNGDKGAQIGMVGATPFSNHPAI
Mvan_0077|M.vanbaalenii_PYR-1 MQGVTQPFQQLTQPLQQMSSLFGQMGGLGGDRGAQIGMLGATPFSNHPAI
Mb1815|M.bovis_AF2122/97 -------QSYFATGMAQFFASIAQQLTFGPG-GTTAGSGGAWYPTPQFAG
Rv1787|M.tuberculosis_H37Rv -------QSYFATGMAQFFASIAQQLTFGPG-GTTAGSGGAWYPTPQFAG
MMAR_2669|M.marinum_M LR--QTLQAYFGVGIGNSGWSIAQQLTFGPG-GTTAGAGGAWYPTPEFAA
MUL_3089|M.ulcerans_Agy99 LR--QTLQAYFGVGIGNFGWSIAQQLTLGPG-GTTAGAGGAWYPTPEFAA
MAV_2925|M.avium_104 MLKQNTGLAYFSNGITSFWSSIAQQLVSGPG-GSTAGAGGAWYPTPQFAS
MSMEG_0619|M.smegmatis_MC2_155 PALAALGITGLVLLIDHVLNNPVDVPAEDEAP--QEVAAAPRTDQPLAVG
TH_3569|M.thermoresistible__bu PLAITLGVAGLVMIADQAQP-----PAEEAAP--EEDVAAP---------
MAB_2254c|M.abscessus_ATCC_199 PLLILAAWQYLQPPAVDAAPADEIRPELGSTVNGQREHIEPLPAIALAPT
MLBr_01182|M.leprae_Br4923 NNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGL
: .
Mflv_0768|M.gilvum_PYR-GCK GGTGPATG--SGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-SPVAVG
Mvan_0077|M.vanbaalenii_PYR-1 GGSGAATG--AGLVRAASLPGAGGTAARTPLMSNLVGSGLQPTVSAVAVG
Mb1815|M.bovis_AF2122/97 LGASRA--------VSASLARANKIGALSVPPSWVKTTALTE-PGAHAVS
Rv1787|M.tuberculosis_H37Rv LGASRA--------VSASLARANKIGALSVPPSWVKTTALTESPVAHAVS
MMAR_2669|M.marinum_M LGADTW-----HWHPMASFASSSKVGGLSVPASWGTAPGAVEQASTKLVS
MUL_3089|M.ulcerans_Agy99 LGADTW-----HWHPMASFASSSKVGGLSVPASWGTTPGAVEQASTKLVS
MAV_2925|M.avium_104 LGLGNLGSVGGASHVSAISAGAGRVGALSVPQQWATLTSAVSPAVSEEGS
MSMEG_0619|M.smegmatis_MC2_155 ISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFT
TH_3569|M.thermoresistible__bu ----------VRAEPQNPLPLTXXX-------------------------
MAB_2254c|M.abscessus_ATCC_199 ATPVP---TASASAPSAPAPAPAPTAAGAGFAPYLVG-AIPDEPPAIQFG
MLBr_01182|M.leprae_Br4923 LGSSSG------GHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSP
Mflv_0768|M.gilvum_PYR-GCK AGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSG--------------
Mvan_0077|M.vanbaalenii_PYR-1 AGAGAGAGAGLAPVGAGSGMGGGGPMGMLGQRGKSG--------------
Mb1815|M.bovis_AF2122/97 ANPTVGSS------HGPHGLLRGLPLGSRITRRSGA--------------
Rv1787|M.tuberculosis_H37Rv ANPTVGSS------HGPHGLLRGLPLGSRITRRSGA--------------
MMAR_2669|M.marinum_M TNFTTSPGE-ANPANGLNAALRGFPVGSRGAQRTGN--------------
MUL_3089|M.ulcerans_Agy99 TNFTTSPGE-ANPANGLNAALRGFPVGSRGAQRTGN--------------
MAV_2925|M.avium_104 AVQAAAGG---APGGAANGLLRGMPVGALGRRGAAAG-------------
MSMEG_0619|M.smegmatis_MC2_155 PTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 PTLNEGNKAQAPASGISAAAA-AAASARSRARRKRGARVKDPAPQYMDMN
MLBr_01182|M.leprae_Br4923 ARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVN--------------
Mflv_0768|M.gilvum_PYR-GCK ------------------------GNKPGLNAPAPLDHDLGEDEDEEW--
Mvan_0077|M.vanbaalenii_PYR-1 ------------------------GNKPGLNAPAPLEHDLSEDDDDDW--
Mb1815|M.bovis_AF2122/97 -----------------------FAHRYGFRHSVVARPPSAG--------
Rv1787|M.tuberculosis_H37Rv -----------------------FAHRYGFRHSVVARPPSAG--------
MMAR_2669|M.marinum_M -----------------------LGVRYGFRYPVLTRPPSAG--------
MUL_3089|M.ulcerans_Agy99 -----------------------LGVRYGFRYPVLTRPPSAG--------
MAV_2925|M.avium_104 -----------------------YVNKYGFRYSVLTRPPSAG--------
MSMEG_0619|M.smegmatis_MC2_155 MDYEEPDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTT----
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 VTVDADYGEPPGSAQRQSTASARGAGHLGLAGTSPKTTATAAGLVARGSA
MLBr_01182|M.leprae_Br4923 -----------------------TALRLQPRAFVMPRNPAAG--------
Mflv_0768|M.gilvum_PYR-GCK ---------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 ---------------------------------------
Mb1815|M.bovis_AF2122/97 ---------------------------------------
Rv1787|M.tuberculosis_H37Rv ---------------------------------------
MMAR_2669|M.marinum_M ---------------------------------------
MUL_3089|M.ulcerans_Agy99 ---------------------------------------
MAV_2925|M.avium_104 ---------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 -LTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------
MAB_2254c|M.abscessus_ATCC_199 GSDTDVPETARIVPMIPTTWSTDSDEAID----------
MLBr_01182|M.leprae_Br4923 ---------------------------------------