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FDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAELSSAASGYSLVIAELTSSPWLGPASRSMMSAVA PYVTWLSAAAAQTETAASQARAAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATEAQY MEMWAQDAAAMYSYAGSSAPATELPRFAPPPDTTSVNAAGGQSAVVAQAAATPAGDSAQTITATIPQLLS SAGVPGLQQRSLSSVSSMSPSAASSPTVWQIIQTQVQNFLTYGLPTPDNNYAGLYPGMYNALRQTLQAYF GVGIGNFGWSIAQQLTLGPGGTTAGAGGAWYPTPEFAALGADTWHWHPMASFASSSKVGGLSVPASWGTT PGAVEQASTKLVSTNFTTSPGEANPANGLNAALRGFPVGSRGAQRTGNLGVRYGFRYPVLTRPPSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3089 | - | - | 100% (418) | PPE family protein |
| M. ulcerans Agy99 | MUL_2129 | - | 5e-78 | 42.00% (431) | PPE family protein |
| M. ulcerans Agy99 | MUL_1701 | - | 6e-77 | 42.52% (421) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1815 | PPE25 | 1e-105 | 54.09% (416) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 7e-32 | 39.39% (198) | PPE protein |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | 1e-106 | 54.09% (416) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 5e-46 | 33.03% (439) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 5e-32 | 36.15% (213) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 0.0 | 98.33% (418) | PPE family protein, PPE25 |
| M. avium 104 | MAV_2928 | - | 1e-122 | 57.38% (427) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-35 | 41.26% (223) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-32 | 38.21% (212) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 40.28% (216) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_2254c|M.abscessus_ATCC_199 ----------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYE
MUL_3089|M.ulcerans_Agy99 ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MMAR_2669|M.marinum_M ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
Mb1815|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
Rv1787|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: *:.** :* : ***...:::*. * :: *
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_2254c|M.abscessus_ATCC_199 YSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANA
MUL_3089|M.ulcerans_Agy99 LSSAASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MMAR_2669|M.marinum_M LSSAASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
Mb1815|M.bovis_AF2122/97 LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
Rv1787|M.tuberculosis_H37Rv LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
** : : * :: :** **: :* .
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_2254c|M.abscessus_ATCC_199 ALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNE
MUL_3089|M.ulcerans_Agy99 SQARAAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATE
MMAR_2669|M.marinum_M SQARAAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATE
Mb1815|M.bovis_AF2122/97 MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
Rv1787|M.tuberculosis_H37Rv MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.:* *: :*:. . : *:. *: :*::* *: .** *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MAB_2254c|M.abscessus_ATCC_199 ADYVRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGS-ELSRMAA
MUL_3089|M.ulcerans_Agy99 AQYMEMWAQDAAAMYSYAGSSAPAT-ELPRFAPPPDTTSVNAAGGQSAVV
MMAR_2669|M.marinum_M AQYMEMWAQDAAAMYSYAGSSALAT-ELPRFAPPPDTTSVNAAGGQSAVV
Mb1815|M.bovis_AF2122/97 AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTNSAGVVAQVAAV
Rv1787|M.tuberculosis_H37Rv AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTNSAGVVAQVAAV
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:* .** * *.:* * . * :..*
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MAB_2254c|M.abscessus_ATCC_199 DMSGFAAQAQATESGSALDSSNSVIDQL--------------LNFFRDPL
MUL_3089|M.ulcerans_Agy99 AQAAATPAGDSAQTIT-----ATIPQLLSSA---------GVPGLQQRSL
MMAR_2669|M.marinum_M AQAAATPAGDSAQTIT-----ATIPQLLSSA---------GVPGLQQLSL
Mb1815|M.bovis_AF2122/97 A---------------------AMPGLLQR----------------LSSA
Rv1787|M.tuberculosis_H37Rv A---------------------AMPGLLQR----------------LSSA
MAV_2928|M.avium_104 SQAMAQPAGSTAQTAANTSSQLATPQALSAG---------TSQAATQASS
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS-------QAALDQA---------VNEGMEATVV
:
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQ--VFFNLVGWPTWGMIFAS
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQ--VFTNLVGWPTWAMILAS
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQ--AVSWVGASILYPSLFLL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQ--AVSWVGASILYPSLLLL
MAB_2254c|M.abscessus_ATCC_199 GTLRQIIEDFIRNPGAALATWLPFLLVLASMTYVLFAQVFWLFWAALLSA
MUL_3089|M.ulcerans_Agy99 SSVSSMSPSAASSPTVWQIIQTQVQNFLTYGL-PTPDNNYAGLYPGMYNA
MMAR_2669|M.marinum_M SSVSSMSPSAASSPTVWQIIQTQVQNFLTYGL-PTPDNNYAGLYPGMYNA
Mb1815|M.bovis_AF2122/97 ASVS------WSNPNDWWLVR--LLGS---------------ITPTERTT
Rv1787|M.tuberculosis_H37Rv ASVS------WSNPNDWWLVR--LLGS---------------ITPTERTT
MAV_2928|M.avium_104 SSAS------QTGPFTWLTSA--LQNLQQSGL-PTPTNNYLGLSPTFYTV
MLBr_01182|M.leprae_Br4923 PQVDQQVNVDVATPQTAVPDSSSAAAPQLWGG-FAQHLSPINDTLSMINN
*
MSMEG_0619|M.smegmatis_MC2_155 PFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLA
TH_3569|M.thermoresistible__bu PVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP-------
Mflv_0325|M.gilvum_PYR-GCK PLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFP
Mvan_0415|M.vanbaalenii_PYR-1 PLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPA
MAB_2254c|M.abscessus_ATCC_199 PLWLPLLILAAWQYLQPPAVDAAP--ADEIRPELGSTVNGQREHIEPLPA
MUL_3089|M.ulcerans_Agy99 LRQTLQ--AYFGVGIGNFGWSIAQQLTLGPGGTTAGAGGAWYPTPEFAAL
MMAR_2669|M.marinum_M LRQTLQ--AYFGVGIGNSGWSIAQQLTFGPGGTTAGAGGAWYPTPEFAAL
Mb1815|M.bovis_AF2122/97 IVRLLG-QSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGL
Rv1787|M.tuberculosis_H37Rv IVRLLG-QSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGL
MAV_2928|M.avium_104 MLKQTSGLGYFSNGITAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASL
MLBr_01182|M.leprae_Br4923 HAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLG
MSMEG_0619|M.smegmatis_MC2_155 VGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEG
TH_3569|M.thermoresistible__bu ------------VRAEPQNPLPLTXXX-----------------------
Mflv_0325|M.gilvum_PYR-GCK ATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEG
Mvan_0415|M.vanbaalenii_PYR-1 IAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTG
MAB_2254c|M.abscessus_ATCC_199 IALAPTATPVPTASASAPSAPAPAPAPTAAGAGFAPYLVGAIPDEPPAIQ
MUL_3089|M.ulcerans_Agy99 GADT-----WHWHPMASFASSSKVGGLSVPASWGTTPGAVEQASTKLVST
MMAR_2669|M.marinum_M GADT-----WHWHPMASFASSSKVGGLSVPASWGTAPGAVEQASTKLVST
Mb1815|M.bovis_AF2122/97 GAS--------RAVSASLARANKIGALSVPPSWVKTT-ALTE-PGAHAVS
Rv1787|M.tuberculosis_H37Rv GAS--------RAVSASLARANKIGALSVPPSWVKTT-ALTESPVAHAVS
MAV_2928|M.avium_104 GLGNLGSVGGASHVSAISAGAGRAGALSVPQQWATLTSAVSPAVSEEGSA
MLBr_01182|M.leprae_Br4923 SSSG-------GHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPA
MSMEG_0619|M.smegmatis_MC2_155 FTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYAD
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK FSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYAD
Mvan_0415|M.vanbaalenii_PYR-1 FSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYAD
MAB_2254c|M.abscessus_ATCC_199 FGPTLNEGNKAQAPASGISAAAA-AAASARSRARRKRGARVKDPAPQYMD
MUL_3089|M.ulcerans_Agy99 NFTTSPGEANPANGLNAALRGFPVGSRGAQR-------------------
MMAR_2669|M.marinum_M NFTTSPGEANPANGLNAALRGFPVGSRGAQR-------------------
Mb1815|M.bovis_AF2122/97 ANPTVGS--SHG--PHGLLRGLPLGSRITRR-------------------
Rv1787|M.tuberculosis_H37Rv ANPTVGS--SHG--PHGLLRGLPLGSRITRR-------------------
MAV_2928|M.avium_104 VQAAAGG--APGGAANGLLRGMPVGALGRRG-------------------
MLBr_01182|M.leprae_Br4923 RVAVATESESAPLLGGGLPMAPMVPGGGSGT-------------------
MSMEG_0619|M.smegmatis_MC2_155 AYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTT-
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLTT-
Mvan_0415|M.vanbaalenii_PYR-1 AYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLTT-
MAB_2254c|M.abscessus_ATCC_199 MNVTVDADYGEPPGSAQR-QSTASARGAGHLGLAGTSPKTTATAAGLVAR
MUL_3089|M.ulcerans_Agy99 ----------------------TGN-LGVRYGFRYPVLTRPPSAG-----
MMAR_2669|M.marinum_M ----------------------TGN-LGVRYGFRYPVLTRPPSAG-----
Mb1815|M.bovis_AF2122/97 ----------------------SGA-FAHRYGFRHSVVARPPSAG-----
Rv1787|M.tuberculosis_H37Rv ----------------------SGA-FAHRYGFRHSVVARPPSAG-----
MAV_2928|M.avium_104 ----------------------AAAGYVNKYGFRYSVLTRPPSAG-----
MLBr_01182|M.leprae_Br4923 ----------------------GGVNTALRLQPRAFVMPRNPAAG-----
MSMEG_0619|M.smegmatis_MC2_155 ----LTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ----LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ----LPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_2254c|M.abscessus_ATCC_199 GSAGSDTDVPETARIVPMIPTTWSTDSDEAID----------------
MUL_3089|M.ulcerans_Agy99 ------------------------------------------------
MMAR_2669|M.marinum_M ------------------------------------------------
Mb1815|M.bovis_AF2122/97 ------------------------------------------------
Rv1787|M.tuberculosis_H37Rv ------------------------------------------------
MAV_2928|M.avium_104 ------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------------------------------------