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SAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYEYSMAATELTQLLGVTAAGVWQGSSATQYVAS HTPYLAWLTQQSATSAANAALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNEA DYVRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGSELSRMAADMSGFAAQAQATESGSALDSSN SVIDQLLNFFRDPLGTLRQIIEDFIRNPGAALATWLPFLLVLASMTYVLFAQVFWLFWAALLSAPLWLPL LILAAWQYLQPPAVDAAPADEIRPELGSTVNGQREHIEPLPAIALAPTATPVPTASASAPSAPAPAPAPT AAGAGFAPYLVGAIPDEPPAIQFGPTLNEGNKAQAPASGISAAAAAAASARSRARRKRGARVKDPAPQYM DMNVTVDADYGEPPGSAQRQSTASARGAGHLGLAGTSPKTTATAAGLVARGSAGSDTDVPETARIVPMIP TTWSTDSDEAID*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2254c | - | - | 100% (503) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | e-168 | 62.06% (506) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | e-167 | 61.24% (516) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 7e-98 | 43.85% (520) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-110 | 44.55% (532) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 7e-98 | 43.85% (520) | PPE family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 4e-71 | 36.09% (507) | PPE-family protein |
| M. marinum M | MMAR_0545 | - | 7e-94 | 42.10% (525) | PPE family protein, PPE4 |
| M. avium 104 | MAV_4867 | - | 1e-104 | 48.44% (512) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-113 | 45.28% (530) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-89 | 53.21% (327) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 5e-94 | 41.98% (524) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-114 | 46.63% (534) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_2254c|M.abscessus_ATCC_199 ----------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYE
MLBr_01991|M.leprae_Br4923 ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ
:* ****** :*. * *. .::.*. * ** :
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_2254c|M.abscessus_ATCC_199 YSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANA
MLBr_01991|M.leprae_Br4923 YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA
*: :*:**: :* . . *.* *. :.*:* .*: ** * * * *
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_2254c|M.abscessus_ATCC_199 ALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNE
MLBr_01991|M.leprae_Br4923 KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE
:: :* **: ***:***:.** *:. : .*:.***:*:*:***::.*
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGE-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-EAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-EAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-EAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVS-EAADAM
MAB_2254c|M.abscessus_ATCC_199 ADYVRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGSE--LSRMA
MLBr_01991|M.leprae_Br4923 ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPGSA-------
***.***:*** *. **. : :. : : .* :: **
Mb0294|M.bovis_AF2122/97 -------AASTVGAVNP---WQWLLA-LLQQLWNAYTGFYGWMLQLIWQF
Rv0286|M.tuberculosis_H37Rv -------AASTVGAVNP---WQWLLA-LLQQLWNAYTGFYGWMLQLIWQF
MMAR_0545|M.marinum_M DAAQAQSGAAAAGGSDP---WQLLWQ-LLQYLWNAYTGFNTWMFDLIWEF
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDP---WQLLWQ-LLQYLWNAYTGFNTWMFDLIWEF
MAV_4867|M.avium_104 ----ANNLAANAAQNSS---GDWWQN-FIQQLS---------------QF
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGA---AFDVSN-IIADIIRLYGEVLRFLFEPIFNF
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGS---ALDLSN-IIADLIRAYGELLRFLFEPIFDF
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGS---SLDLSS-IISDLLNQYLQGVPGGQ-AILDF
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGT---ALNLSD-LIANLLQYYQDYLDQLFGPIVDF
MAB_2254c|M.abscessus_ATCC_199 ADMSGFAAQAQATESGS---ALDSSNSVIDQLLN---------------F
MLBr_01991|M.leprae_Br4923 --------TQNVLQSVPDWIVQLLTD--------------------ILDF
. . *
Mb0294|M.bovis_AF2122/97 LQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQ--IFFNLVGWPTWG
Rv0286|M.tuberculosis_H37Rv LQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQ--IFFNLVGWPTWG
MMAR_0545|M.marinum_M LQDPIGNTIKIIIAFLTNPLQAIITYGPLLFALSYQ--IFFNLVGWPTWA
MUL_1208|M.ulcerans_Agy99 LQDPIGNTIKIIIAFLTNPLQAIITYGPLLFALSYQ--IFFNLVGWPTWA
MAV_4867|M.avium_104 FQN----IQKMLQDFWANLPAFLAANGPLLFFVAYQ--VFFNAVGWPTWG
Mflv_0325|M.gilvum_PYR-GCK LRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQ--AVSWVGASILYP
Mvan_0415|M.vanbaalenii_PYR-1 LRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQ--AVSWVGASILYP
MSMEG_0619|M.smegmatis_MC2_155 LKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQ--VFFNLVGWPTWG
TH_3569|M.thermoresistible__bu LRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQ--VFTNLVGWPTWA
MAB_2254c|M.abscessus_ATCC_199 FRDPLGTLRQIIEDFIRNPGAALATWLPFLLVLASMTYVLFAQVFWLFWA
MLBr_01991|M.leprae_Br4923 IADPYKYFLRFFQRLGFRP--AIAVVLAIIALQLYD---FLWYPYYASYG
: : :: : . : . .:: . :
Mb0294|M.bovis_AF2122/97 MILSSPFLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGS
Rv0286|M.tuberculosis_H37Rv MILSSPFLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGS
MMAR_0545|M.marinum_M LILSSPFLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKS
MUL_1208|M.ulcerans_Agy99 LILSSPFLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKS
MAV_4867|M.avium_104 AILTAPFLLPLLLGIGLSSLLAAPAEIAP--VAAPAAITPVLASNKPP-T
Mflv_0325|M.gilvum_PYR-GCK SLFLLPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPD
Mvan_0415|M.vanbaalenii_PYR-1 SLLLLPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRAD
MSMEG_0619|M.smegmatis_MC2_155 MIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRT
TH_3569|M.thermoresistible__bu MILASPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--
MAB_2254c|M.abscessus_ATCC_199 ALLSAPLWLPLLILAAWQYLQPPAVDAAP--ADEIRPELGSTVNGQREHI
MLBr_01991|M.leprae_Br4923 MLLL-PFFAPALSVLGTLSVLWNGQLSAG-----LPPNPAGSHPDNNAGP
:: *. .
Mb0294|M.bovis_AF2122/97 VWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSG
Rv0286|M.tuberculosis_H37Rv VWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSG
MMAR_0545|M.marinum_M VFPAASLASPGTGSAGAPASGAGAGAPGSAPPGPAAPAPASFLYAVGGSG
MUL_1208|M.ulcerans_Agy99 VFPAASLASPGTGSAGAPASGAGAGAPGTAPPGPGAPAPASFLYAVGGSG
MAV_4867|M.avium_104 LPAAVALAPSVATPAGAPASTVAAGSGAAAAPGP-AAAAGNFAYLVAFGG
Mflv_0325|M.gilvum_PYR-GCK QQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGR
Mvan_0415|M.vanbaalenii_PYR-1 QPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGR
MSMEG_0619|M.smegmatis_MC2_155 DQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANR
TH_3569|M.thermoresistible__bu -----------------VRAEPQNPLPLTXXX------------------
MAB_2254c|M.abscessus_ATCC_199 EPLPAIALAPTATPVPTASASAPSAPAPAPAPTAAGAGFAPYLVGAIPDE
MLBr_01991|M.leprae_Br4923 RIHVGVAPPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLS
.
Mb0294|M.bovis_AF2122/97 DWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----EL
Rv0286|M.tuberculosis_H37Rv DWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----EL
MMAR_0545|M.marinum_M DWGPSLGPTVGGRSGAKAPAATIPAAGAAAASRASARSRRRRRT----EM
MUL_1208|M.ulcerans_Agy99 DWGPSLGPTVGGRSGAKAPAVTIPAAGAAAASRASARSRRRRRT----EM
MAV_4867|M.avium_104 DPDTGVGPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRA----AL
Mflv_0325|M.gilvum_PYR-GCK DPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG
Mvan_0415|M.vanbaalenii_PYR-1 DPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG
MSMEG_0619|M.smegmatis_MC2_155 DPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 PPAIQFGPTLNEGNKAQAPASGISAAAAAAAS-ARSRARRKRGAR----V
MLBr_01991|M.leprae_Br4923 PPEVSSGPKAGTKS-PDTATNTIGITAAARTNSPSARAHRKRGNKTRGGA
Mb0294|M.bovis_AF2122/97 RDYGDEFLDMDS----DSGFGPSTGDHGAQASERGAGTLGFAGTATKERR
Rv0286|M.tuberculosis_H37Rv RDYGDEFLDMDS----DSGFGPSTGDHGAQASERGAGTLGFAGTATKERR
MMAR_0545|M.marinum_M RDYGDEFLDMDA----NGVTGPAATDDAARASERGAGQFGFAGTVSTEAV
MUL_1208|M.ulcerans_Agy99 RDYGDEFLDMDA----NGVTGPAATDDAARASERGAGQFGFAGTVSTEAV
MAV_4867|M.avium_104 HDYSDEFLDMDSGFGVPPDYGAEEELAAAVASGQGAGTLGFAGTQQRRKA
Mflv_0325|M.gilvum_PYR-GCK RGYADAYADYEEL---PDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD-
Mvan_0415|M.vanbaalenii_PYR-1 RAYADAYADYEPE---PDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA-
MSMEG_0619|M.smegmatis_MC2_155 RGYADAYMDYEE----PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD-
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 KDPAPQYMDMNVTVDADYGEPPGSAQRQSTASARGAGHLGLAGTSPKTTA
MLBr_01991|M.leprae_Br4923 RGYRYEFVEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTAS
Mb0294|M.bovis_AF2122/97 VRAVGLTALAGDEFGNGPR----MPMVPGTWEQGSNEPEAPDGSGRGGGD
Rv0286|M.tuberculosis_H37Rv VRAVGLTALAGDEFGNGPR----MPMVPGTWEQGSNEPEAPDGSGRGGGD
MMAR_0545|M.marinum_M LQAAGLTELAVDEFGNGPR----MPMVPGSWDS----PQE------GRED
MUL_1208|M.ulcerans_Agy99 LQAAGLTELAVDEFGNGPR----MPMVPGSWDS----PQE------GRED
MAV_4867|M.avium_104 FQAAGLTKLADDDFGGSPR----MPMVPGTWEQD---TQN------GAHP
Mflv_0325|M.gilvum_PYR-GCK EQAGGLTTLAGDSFGGGPR----EPMLPGTWDPD--ATDDRHTDGRDGHD
Mvan_0415|M.vanbaalenii_PYR-1 AQAGGLTTLPGDPFGGGPK----APMLPGTWDPD--TEPD------ERHN
MSMEG_0619|M.smegmatis_MC2_155 VTAAGLTTLTGDTFDDRPV----TPMLPGTWDGD--ENPA------PSPD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 TAAGLVARGSAGSDTDVPETARIVPMIPTTWSTD-------------SDE
MLBr_01991|M.leprae_Br4923 TPTGMAASTSSS-----------VPLLPTTWITG------------TSET
Mb0294|M.bovis_AF2122/97 GLPHDSK-
Rv0286|M.tuberculosis_H37Rv GLPHDSK-
MMAR_0545|M.marinum_M GLQSE---
MUL_1208|M.ulcerans_Agy99 GLQSE---
MAV_4867|M.avium_104 TEPGKGG-
Mflv_0325|M.gilvum_PYR-GCK GHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 HHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DPEGGPRR
TH_3569|M.thermoresistible__bu --------
MAB_2254c|M.abscessus_ATCC_199 AID-----
MLBr_01991|M.leprae_Br4923 AVHE----