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VFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAELSSAASGYSSVIAELTSSPWLGPASRSMMSAV APYVTWLSAAAAQTETAASQARAAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATEAQ YMEMWAQDAAAMYSYAGSSALATELPRFAPPPDTTSVNAAGGQSAVVAQAAATPAGDSAQTITATIPQLL SSAGVPGLQQLSLSSVSSMSPSAASSPTVWQIIQTQVQNFLTYGLPTPDNNYAGLYPGMYNALRQTLQAY FGVGIGNSGWSIAQQLTFGPGGTTAGAGGAWYPTPEFAALGADTWHWHPMASFASSSKVGGLSVPASWGT APGAVEQASTKLVSTNFTTSPGEANPANGLNAALRGFPVGSRGAQRTGNLGVRYGFRYPVLTRPPSAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2669 | - | - | 100% (418) | PPE family protein, PPE25 |
| M. marinum M | MMAR_1905 | - | 2e-79 | 44.05% (420) | PPE family protein |
| M. marinum M | MMAR_1095 | - | 2e-78 | 43.06% (418) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1815 | PPE25 | 1e-105 | 53.30% (424) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-32 | 39.90% (198) | PPE protein |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | 1e-106 | 54.09% (416) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-47 | 33.49% (439) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 6e-32 | 41.07% (168) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 1e-122 | 57.61% (427) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-36 | 41.33% (225) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 6e-33 | 37.74% (212) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 0.0 | 98.33% (418) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-36 | 40.74% (216) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1815|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
Rv1787|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
MMAR_2669|M.marinum_M ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MUL_3089|M.ulcerans_Agy99 ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
: * .** :* : ***...:::*. * :. .
Mb1815|M.bovis_AF2122/97 LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
Rv1787|M.tuberculosis_H37Rv LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
MMAR_2669|M.marinum_M LSSAASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MUL_3089|M.ulcerans_Agy99 LSSAASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
:* : : * :: :** ** : .
Mb1815|M.bovis_AF2122/97 MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
Rv1787|M.tuberculosis_H37Rv MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
MMAR_2669|M.marinum_M SQARAAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATE
MUL_3089|M.ulcerans_Agy99 SQARAAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
: .** *: :*:. . : *:. *: :*::* *: .* *
Mb1815|M.bovis_AF2122/97 AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTN---SAGVVAQV
Rv1787|M.tuberculosis_H37Rv AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTN---SAGVVAQV
MMAR_2669|M.marinum_M AQYMEMWAQDAAAMYSYAGSSALAT-ELPRFAPPPDTTSVNAAGGQSAVV
MUL_3089|M.ulcerans_Agy99 AQYMEMWAQDAAAMYSYAGSSAPAT-ELPRFAPPPDTTSVNAAGGQSAVV
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN--EVGLAQEVV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
*:* .** * *.:* * * :..*
Mb1815|M.bovis_AF2122/97 AAVAAMPG--------------------------LLQRLSSAASVSWSNP
Rv1787|M.tuberculosis_H37Rv AAVAAMPG--------------------------LLQRLSSAASVSWSNP
MMAR_2669|M.marinum_M AQAAATPAGDSAQTITATIPQLLSSAGVPGLQQLSLSSVSSMSPSAASSP
MUL_3089|M.ulcerans_Agy99 AQAAATPAGDSAQTITATIPQLLSSAGVPGLQQRSLSSVSSMSPSAASSP
MAV_2928|M.avium_104 SQAMAQPAGSTAQTAANTSSQLATPQ---ALSAGTSQAATQASSSSASQT
MLBr_01182|M.leprae_Br4923 EEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPL
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPI
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAGEMV
Mb1815|M.bovis_AF2122/97 NDWWLVR-----LLGS-----------ITPTERTTIVRLLG-QSYFATGM
Rv1787|M.tuberculosis_H37Rv NDWWLVR-----LLGS-----------ITPTERTTIVRLLG-QSYFATGM
MMAR_2669|M.marinum_M TVWQIIQTQVQNFLTYGLPTPDNNYAGLYPGMYNALRQTLQ--AYFGVGI
MUL_3089|M.ulcerans_Agy99 TVWQIIQTQVQNFLTYGLPTPDNNYAGLYPGMYNALRQTLQ--AYFGVGI
MAV_2928|M.avium_104 GPFTWLTSALQNLQQSGLPTPTNNYLGLSPTFYTVMLKQTSGLGYFSNGI
MLBr_01182|M.leprae_Br4923 QTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGM
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPL
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
TH_3569|M.thermoresistible__bu GNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPV
MAB_0809c|M.abscessus_ATCC_199 EHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPA
:
Mb1815|M.bovis_AF2122/97 AQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRA--------VS
Rv1787|M.tuberculosis_H37Rv AQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRA--------VS
MMAR_2669|M.marinum_M GNSGWSIAQQLTFGPGGTTAGAGGAWYPTPEFAALGADTW-----HWHPM
MUL_3089|M.ulcerans_Agy99 GNFGWSIAQQLTLGPGGTTAGAGGAWYPTPEFAALGADTW-----HWHPM
MAV_2928|M.avium_104 TAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLGLGNLGSVGGASHVS
MLBr_01182|M.leprae_Br4923 GSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGG-------HVT
Mflv_0325|M.gilvum_PYR-GCK LATTLAIV----AGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQS
Mvan_0415|M.vanbaalenii_PYR-1 VATTLAIV----LGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPS
MSMEG_0619|M.smegmatis_MC2_155 LIPALAAL----GITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQP
TH_3569|M.thermoresistible__bu LIPLAITL----GVAGLVMIADQAQP-----PAEEAAPEEDVAAP-----
MAB_0809c|M.abscessus_ATCC_199 LALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAPS
Mb1815|M.bovis_AF2122/97 ASLARANKIGALSVPPSWVKTTALTE-PGAHAVSANPTVGSS-----HGP
Rv1787|M.tuberculosis_H37Rv ASLARANKIGALSVPPSWVKTTALTESPVAHAVSANPTVGSS-----HGP
MMAR_2669|M.marinum_M ASFASSSKVGGLSVPASWGTAPGAVEQASTKLVSTNFTTSPGEANPANGL
MUL_3089|M.ulcerans_Agy99 ASFASSSKVGGLSVPASWGTTPGAVEQASTKLVSTNFTTSPGEANPANGL
MAV_2928|M.avium_104 AISAGAGRAGALSVPQQWATLTSAVSPAVSEEGSAVQAAAGG--APGGAA
MLBr_01182|M.leprae_Br4923 AQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLG
Mflv_0325|M.gilvum_PYR-GCK FPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPY
Mvan_0415|M.vanbaalenii_PYR-1 PAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPG
MSMEG_0619|M.smegmatis_MC2_155 LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPG
TH_3569|M.thermoresistible__bu --------------VRAEPQNPLPLTXXX---------------------
MAB_0809c|M.abscessus_ATCC_199 PPASAAAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLG
.
Mb1815|M.bovis_AF2122/97 HGLLRGLPLGSRITRRSGA-FAHRYGFRHSVVARPPSAG-----------
Rv1787|M.tuberculosis_H37Rv HGLLRGLPLGSRITRRSGA-FAHRYGFRHSVVARPPSAG-----------
MMAR_2669|M.marinum_M NAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG-----------
MUL_3089|M.ulcerans_Agy99 NAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG-----------
MAV_2928|M.avium_104 NGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG-----------
MLBr_01182|M.leprae_Br4923 GGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-----------
Mflv_0325|M.gilvum_PYR-GCK EGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGY
Mvan_0415|M.vanbaalenii_PYR-1 TGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAY
MSMEG_0619|M.smegmatis_MC2_155 EGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 TGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRG-
Mb1815|M.bovis_AF2122/97 --------------------------------------------------
Rv1787|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2669|M.marinum_M --------------------------------------------------
MUL_3089|M.ulcerans_Agy99 --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 ADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGLT
MSMEG_0619|M.smegmatis_MC2_155 ADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 ----IEYMDMNATARCEEPAPDTTASHRGAGTMGFAGTVIKTGATASGLA
Mb1815|M.bovis_AF2122/97 ----------------------------------------------
Rv1787|M.tuberculosis_H37Rv ----------------------------------------------
MMAR_2669|M.marinum_M ----------------------------------------------
MUL_3089|M.ulcerans_Agy99 ----------------------------------------------
MAV_2928|M.avium_104 ----------------------------------------------
MLBr_01182|M.leprae_Br4923 ----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TLA-GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TLP-GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 TLT-GDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ----------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 MLSRDDDLFEGVRAPMVPNTWDPEHGRQD-----------------