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LDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGAASLSMVAAAT PYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQY AEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVVAQVAAVAAMPGLLQRLSSAASVSWSNPNDW WLVRLLGSITPTERTTIVRLLGQSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRA VSASLARANKIGALSVPPSWVKTTALTEPGAHAVSANPTVGSSHGPHGLLRGLPLGSRITRRSGAFAHRY GFRHSVVARPPSAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1815 | PPE25 | - | 100% (364) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1818 | PPE27 | e-167 | 83.33% (366) | PPE family protein |
| M. bovis AF2122 / 97 | Mb2916c | PPE45 | e-103 | 51.47% (408) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-30 | 37.50% (192) | PPE protein |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | 0.0 | 99.45% (365) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-39 | 48.09% (183) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 4e-28 | 37.72% (167) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 1e-105 | 53.30% (424) | PPE family protein, PPE25 |
| M. avium 104 | MAV_2928 | - | 1e-105 | 52.38% (420) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-31 | 37.19% (199) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-30 | 35.94% (217) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 1e-105 | 54.09% (416) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-33 | 39.02% (205) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1815|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
Rv1787|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVE
MMAR_2669|M.marinum_M ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MUL_3089|M.ulcerans_Agy99 ------------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAE
MAV_2928|M.avium_104 ------------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :* : ***...: :*. * :. .
Mb1815|M.bovis_AF2122/97 LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
Rv1787|M.tuberculosis_H37Rv LGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAG
MMAR_2669|M.marinum_M LSSAASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MUL_3089|M.ulcerans_Agy99 LSSAASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAA
MAV_2928|M.avium_104 LGIAASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : * .: ** ** : .
Mb1815|M.bovis_AF2122/97 MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
Rv1787|M.tuberculosis_H37Rv MQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAE
MMAR_2669|M.marinum_M SQARAAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATE
MUL_3089|M.ulcerans_Agy99 SQARAAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATE
MAV_2928|M.avium_104 SQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .** *. :*:. . : *:. *: :*::* *: .* *
Mb1815|M.bovis_AF2122/97 AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPP------KTTN---SA
Rv1787|M.tuberculosis_H37Rv AQYAEMWAQDAVAMYGYAAASASAS-RLIPFAAPP------KTTN---SA
MMAR_2669|M.marinum_M AQYMEMWAQDAAAMYSYAGSSALAT-ELPRFAPPP------DTTSVNAAG
MUL_3089|M.ulcerans_Agy99 AQYMEMWAQDAAAMYSYAGSSAPAT-ELPRFAPPP------DTTSVNAAG
MAV_2928|M.avium_104 AQYMEMWAQDAAAMYGYAAASQTAS-TLSPFAAPP------NTTAPEGES
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPP------LGVN--EVG
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * *.:* * * ...*
Mb1815|M.bovis_AF2122/97 GVVAQVAAVAAMPG--------------------------LLQRLSS---
Rv1787|M.tuberculosis_H37Rv GVVAQVAAVAAMPG--------------------------LLQRLSS---
MMAR_2669|M.marinum_M GQSAVVAQAAATPAGDSAQTITATIPQLLSSAGVPGLQQLSLSSVSS---
MUL_3089|M.ulcerans_Agy99 GQSAVVAQAAATPAGDSAQTITATIPQLLSSAGVPGLQQRSLSSVSS---
MAV_2928|M.avium_104 DQAAAVSQAMAQPAGSTAQTAANTSSQLATPQ---ALSAGTSQAATQ---
MLBr_01182|M.leprae_Br4923 LAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQ---
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Mb1815|M.bovis_AF2122/97 -----------------------AASVSWSNPNDWWLVR-----LLGS--
Rv1787|M.tuberculosis_H37Rv -----------------------AASVSWSNPNDWWLVR-----LLGS--
MMAR_2669|M.marinum_M -----------------------MSPSAASSPTVWQIIQTQVQNFLTYGL
MUL_3089|M.ulcerans_Agy99 -----------------------MSPSAASSPTVWQIIQTQVQNFLTYGL
MAV_2928|M.avium_104 -----------------------ASSSSASQTGPFTWLTSALQNLQQSGL
MLBr_01182|M.leprae_Br4923 -----------------------QVNVDVATPQTAVPDSSSAAAPQLWGG
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Mb1815|M.bovis_AF2122/97 ---------ITPTERTTIVRLLG-QSYFATGMA-----------------
Rv1787|M.tuberculosis_H37Rv ---------ITPTERTTIVRLLG-QSYFATGMA-----------------
MMAR_2669|M.marinum_M PTPDNNYAGLYPGMYNALRQTLQ--AYFGVGIG-----------------
MUL_3089|M.ulcerans_Agy99 PTPDNNYAGLYPGMYNALRQTLQ--AYFGVGIG-----------------
MAV_2928|M.avium_104 PTPTNNYLGLSPTFYTVMLKQTSGLGYFSNGIT-----------------
MLBr_01182|M.leprae_Br4923 FAQHLSPINDTLSMINNHAGMANAGLSLVNGMG-----------------
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
.
Mb1815|M.bovis_AF2122/97 ---------------QFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLG
Rv1787|M.tuberculosis_H37Rv ---------------QFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLG
MMAR_2669|M.marinum_M ---------------NSGWSIAQQLTFGPGGTTAGAGGAWYPTPEFAALG
MUL_3089|M.ulcerans_Agy99 ---------------NFGWSIAQQLTLGPGGTTAGAGGAWYPTPEFAALG
MAV_2928|M.avium_104 ---------------AFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLG
MLBr_01182|M.leprae_Br4923 ---------------SAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGS
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
. .
Mb1815|M.bovis_AF2122/97 ASRA-------------------VSASLARANKIGALSVPPSWVKTTALT
Rv1787|M.tuberculosis_H37Rv ASRA-------------------VSASLARANKIGALSVPPSWVKTTALT
MMAR_2669|M.marinum_M ADTW----------------HWHPMASFASSSKVGGLSVPASWGTAPGAV
MUL_3089|M.ulcerans_Agy99 ADTW----------------HWHPMASFASSSKVGGLSVPASWGTTPGAV
MAV_2928|M.avium_104 LGNLGSVG-----------GASHVSAISAGAGRAGALSVPQQWATLTSAV
MLBr_01182|M.leprae_Br4923 SSGG------------------HVTAQLGRAASIGSLRVPQTWTTASQPV
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
. .
Mb1815|M.bovis_AF2122/97 E-PGAHAV-----------------------------SANPTVGSS----
Rv1787|M.tuberculosis_H37Rv ESPVAHAV-----------------------------SANPTVGSS----
MMAR_2669|M.marinum_M EQASTKLV-----------------------------STNFTTSPGEANP
MUL_3089|M.ulcerans_Agy99 EQASTKLV-----------------------------STNFTTSPGEANP
MAV_2928|M.avium_104 SPAVSEEG-----------------------------SAVQAAAGG--AP
MLBr_01182|M.leprae_Br4923 TAATRALS-----------------------------PARVAVATESESA
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
Mb1815|M.bovis_AF2122/97 -HGPHGLLRGLPLGSRITRRSGA-FAHRYGFRHSVVARPPSAG-------
Rv1787|M.tuberculosis_H37Rv -HGPHGLLRGLPLGSRITRRSGA-FAHRYGFRHSVVARPPSAG-------
MMAR_2669|M.marinum_M ANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG-------
MUL_3089|M.ulcerans_Agy99 ANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG-------
MAV_2928|M.avium_104 GGAANGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG-------
MLBr_01182|M.leprae_Br4923 PLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
.
Mb1815|M.bovis_AF2122/97 ---------------
Rv1787|M.tuberculosis_H37Rv ---------------
MMAR_2669|M.marinum_M ---------------
MUL_3089|M.ulcerans_Agy99 ---------------
MAV_2928|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------