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MLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAELNAAALSYDKVVTALASEEWLGSASASMASAV APYVGWMSTTAAQAEEAASQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLEAQ YGEYWAQDAAAMYSYAGQSASASKVTPFQKAPQVTNPSGQAAQSAAVSTATANSTSTNTTKALQSLAQPA SSSTTATKAATTAASTTSTDPLSEIWFLLTGQTTLPTSLGSAVNGYSPFASLFYNTEGLPYFSTGMANTF TQIAKSVGAIGGAAPAAAKALPGLGGLGGMLGGGAAAAHPVAALGGAGSIGGKLSVPVAWSGAPATPALG HAIPVSSISAAPEAAGGPGNLLGGMPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2926 | - | - | 100% (407) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 0.0 | 98.27% (405) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 7e-87 | 45.65% (425) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 1e-126 | 59.12% (411) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 4e-27 | 28.40% (412) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-126 | 59.12% (411) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-45 | 34.35% (428) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 3e-31 | 31.17% (401) | PPE family protein |
| M. marinum M | MMAR_2671 | - | 1e-112 | 53.49% (415) | PPE family protein, PPE26 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-32 | 30.86% (405) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 6e-36 | 31.65% (417) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3087 | - | 1e-110 | 52.78% (413) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 6e-30 | 41.71% (187) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1817|M.bovis_AF2122/97 ---------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAELSSA
Rv1789|M.tuberculosis_H37Rv ---------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAELSSA
MAV_2926|M.avium_104 -------MMLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAELNAA
MMAR_2671|M.marinum_M -------MAMDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAELNST
MUL_3087|M.ulcerans_Agy99 ---------MDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAELNST
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
Mvan_0415|M.vanbaalenii_PYR-1 ------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEYAAA
MAB_4783|M.abscessus_ATCC_1997 ------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTEYSSA
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
.** : : *.*. .: ** * :: . :
Mb1817|M.bovis_AF2122/97 ATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAATQAR
Rv1789|M.tuberculosis_H37Rv ATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAATQAR
MAV_2926|M.avium_104 ALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAASQAR
MMAR_2671|M.marinum_M AQGYLTVITQLSSEEWMGPASATMAQAVEPYMTWMSVTAGQAEHAATQAQ
MUL_3087|M.ulcerans_Agy99 AQGYLTVITQLSSEEWMGPASATMAQAVEPFMTWMSVTAGQAEHAATQAQ
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
Mvan_0415|M.vanbaalenii_PYR-1 AAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAAAQHE
MAB_4783|M.abscessus_ATCC_1997 ANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVAAQTE
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQN-WQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
* : : * .: * *: : . . *
Mb1817|M.bovis_AF2122/97 AAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAEAQYG
Rv1789|M.tuberculosis_H37Rv AAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAEAQYG
MAV_2926|M.avium_104 AAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLEAQYG
MMAR_2671|M.marinum_M SAAAAFETAFAAVVPPPLIATNRAELTQALQTNMFGLNNGVIAQLEAQYA
MUL_3087|M.ulcerans_Agy99 SAAAAFETAFAAVVPPPLIATNLAELTQALQTNMFGLNNGVIAQLEAQYA
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTEADYV
MAB_4783|M.abscessus_ATCC_1997 TAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNEADYI
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYA
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
* : * : : * :*.:* * ** **:*
Mb1817|M.bovis_AF2122/97 EMWAQDSAAMYAYAGSSASASAVTP-FSTPPQIANPTAQGTQAAAVATAA
Rv1789|M.tuberculosis_H37Rv EMWAQDSAAMYAYAGSSASASAVTP-FSTPPQIANPTAQGTQAAAVATAA
MAV_2926|M.avium_104 EYWAQDAAAMYSYAGQSASASKVTP-FQKAPQVTNPSGQAAQSAAVSTAT
MMAR_2671|M.marinum_M EMWAQDASAMYNYAASSALATKIES-FTEAPTIANPAASTTQGAAVSAAQ
MUL_3087|M.ulcerans_Agy99 EMWAQDASAMYNYAASSALATKIES-FTEAPTIASPAASTTQGAAVSAAQ
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATK-AFTAPPLGVNEVGLAQEVVEEVVE
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
Mvan_0415|M.vanbaalenii_PYR-1 RMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAADVTA
MAB_4783|M.abscessus_ATCC_1997 RMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART------
TH_3113|M.thermoresistible__bu RMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAITGAH
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMSGAV
. * * ::.* * * :
Mb1817|M.bovis_AF2122/97 GTAQST--------LTEMITGL-----PNALQSLTSPLLQSSNGPLSWLW
Rv1789|M.tuberculosis_H37Rv GTAQST--------LTEMITGL-----PNALQSLTSPLLQSSNGPLSWLW
MAV_2926|M.avium_104 ANSTSTNTTKALQSLAQPASSS-----TTATKAATTAASTTSTDPLSEIW
MMAR_2671|M.marinum_M ATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLG-ASNPILTEIW
MUL_3087|M.ulcerans_Agy99 ATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLG-ASNPILTEIW
MLBr_01182|M.leprae_Br4923 EVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVP
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPLGNLG
Mvan_0415|M.vanbaalenii_PYR-1 FAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTI
MAB_4783|M.abscessus_ATCC_1997 -AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPVGTIV
TH_3113|M.thermoresistible__bu VTAELRAAESRTLLDEINELIDRLFAP-LFPPGFADALPDGL---LGTLL
Mflv_0768|M.gilvum_PYR-GCK PGAGEAVMRNAIISKVSSTAKLDT---ANQIAGRAEGTLRGVVDRAGSHA
Mb1817|M.bovis_AF2122/97 QILFGTP-NFPTSISALLTDLQPYASFFYN--------------------
Rv1789|M.tuberculosis_H37Rv QILFGTP-NFPTSISALLTDLQPYASFFYN--------------------
MAV_2926|M.avium_104 FLLTGQT-TLPTSLGSAVNGYSPFASLFYN--------------------
MMAR_2671|M.marinum_M FLLTGQT-VLPNNLGTFMQGYSNYASFFYN--------------------
MUL_3087|M.ulcerans_Agy99 FLLTGQT-VLPNNLGTFMQGYSNYASFFYN--------------------
MLBr_01182|M.leprae_Br4923 DSSSAAAPQLWGGFAQHLSPINDTLSMINN--------------------
MSMEG_0619|M.smegmatis_MC2_155 RLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPA
Mvan_0415|M.vanbaalenii_PYR-1 KLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLLLLPL
MAB_4783|M.abscessus_ATCC_1997 RIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAIMGPA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGVVHTT
Mflv_0768|M.gilvum_PYR-GCK EKSQGLEQAPQQGMQMGMQMASQLGSTLG---------------------
:
Mb1817|M.bovis_AF2122/97 ------------------------TEGLPYFSIGMGN-------------
Rv1789|M.tuberculosis_H37Rv ------------------------TEGLPYFSIGMGN-------------
MAV_2926|M.avium_104 ------------------------TEGLPYFSTGMAN-------------
MMAR_2671|M.marinum_M ------------------------TEGLPYFSVGMGN-------------
MUL_3087|M.ulcerans_Agy99 ------------------------TEGLPYFSVGMGN-------------
MLBr_01182|M.leprae_Br4923 ------------------------HAGMANAGLSLVN-------------
MSMEG_0619|M.smegmatis_MC2_155 LAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP-LAV
Mvan_0415|M.vanbaalenii_PYR-1 VATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQPSPAI
MAB_4783|M.abscessus_ATCC_1997 AGISIPLAITLAS---LSQMPEAPPVDAPAETVPARI------DQP-HAV
TH_3113|M.thermoresistible__bu VAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSG-----LAGLAGLT
Mflv_0768|M.gilvum_PYR-GCK --------------------------QMPQQMMQGVT------------Q
.
Mb1817|M.bovis_AF2122/97 NFIQAAKTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLG--GGPVAAG---
Rv1789|M.tuberculosis_H37Rv NFIQSAKTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLG--GGPVAAG---
MAV_2926|M.avium_104 TFTQIAKSVGAIGGAAPAAAKAL----PGLGGLGGMLG--GGAAAAHPVA
MMAR_2671|M.marinum_M FGVQMAKTLGLITQPAAAAAAALP-KVPGLGGALGAIGSAGSQVAAG---
MUL_3087|M.ulcerans_Agy99 FGVQMAKTLGLITQPAAAAAAALP-KVPGLGGALGAIGSAGSQVAAG---
MLBr_01182|M.leprae_Br4923 GMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQ---
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVAAPAP----AAATFVPYAVANRDP
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGAPAA----ATASFVPYAVAGRDP
MAB_4783|M.abscessus_ATCC_1997 AMGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPP
Mflv_0768|M.gilvum_PYR-GCK PFQQLTQPLQQMSSLFGGMMNGDKGAQIGMVG---ATPFSNHPAIGG---
Mb1817|M.bovis_AF2122/97 -LGNAASVG-KLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGS
Rv1789|M.tuberculosis_H37Rv -LGNAASVG-KLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGS
MAV_2926|M.avium_104 ALGGAGSIGGKLSVPVAWSG-APATPALGHA-IPVSSISAAPEAAGGPGN
MMAR_2671|M.marinum_M -LGSGAHVG-HLAVPASWPG-ASVAEAVRPTVQAVSEPITSPEAA----N
MUL_3087|M.ulcerans_Agy99 -LGSGAHVG-HLAVPASWPG-ASVAEAVRPTVQAVSEPITSPEAA----N
MLBr_01182|M.leprae_Br4923 -LGRAASIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESES---AP
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRG
TH_3113|M.thermoresistible__bu PAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPA
Mflv_0768|M.gilvum_PYR-GCK -TGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPTSPVAVGAGAG
* .
Mb1817|M.bovis_AF2122/97 LLGG-------------LPLAGAGGAG---AGPRYGFRPTVMARPPFAG-
Rv1789|M.tuberculosis_H37Rv LLGG-------------LPLAGAGGAG---AGPRYGFRPTVMARPPFAG-
MAV_2926|M.avium_104 LLGG-------------MPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG-
MMAR_2671|M.marinum_M VIGG-------------MPVGATGAGRGVGSGPRYGFKPTVMARPLPAG-
MUL_3087|M.ulcerans_Agy99 VIGG-------------MPVGATGAGRGVGSGPRYGFKPTVMARPLPAG-
MLBr_01182|M.leprae_Br4923 LLGGGLPMA-------PMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYE-EPDEDPAPQPEPRVRASE-RGSDAMGFTGTVTR-HDVTAA
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATE-RGAGPMGFAGTVSR-DAAQAG
MAB_4783|M.abscessus_ATCC_1997 YRHEYATMD---DHTPTGPQDPVTAVASGTGAGRLGFAGVHTATTAVEAT
TH_3113|M.thermoresistible__bu GSAAAAAAA---RESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAA
Mflv_0768|M.gilvum_PYR-GCK PGAG-------------VGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPG
Mb1817|M.bovis_AF2122/97 -----------------------------------------------
Rv1789|M.tuberculosis_H37Rv -----------------------------------------------
MAV_2926|M.avium_104 -----------------------------------------------
MMAR_2671|M.marinum_M -----------------------------------------------
MUL_3087|M.ulcerans_Agy99 -----------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 GLTTLTGDT-----FDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR
Mvan_0415|M.vanbaalenii_PYR-1 GLTTLPGDP-----FGGGPKAPMLPGTWDPDTEPDERHNHHDGKDSQ
MAB_4783|M.abscessus_ATCC_1997 GLSTLDGD-------AENRTIPMLPGTWDVTDDDR------------
TH_3113|M.thermoresistible__bu GIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN--
Mflv_0768|M.gilvum_PYR-GCK -------------------LNAPAPLDHDLGEDEDEEW---------