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KDLCSSGMDVVQAGRVELRHLRAFEAVARLESFTLAAQELSITQPALSRTIKQLEDALEASLLDRTSRHV ATTPAGRVFLGHVERILTELGRGVDAVRQQASIRLGFSWLLPDPWAQDTVARFERTTRTTVSLIRTDDAL GAVQQGRVDIALVRGHVTSTAVRIVHLFDEPRVAVCSVHSPLAKRAKLDWAEVPRWPLVINTASGTTGPW SWPAGDGPETIVETTNFDEWIESVAADRGIGVIPDVAIRRNVHPGVRFVALRDAPDIPVALAFVKRASGP VLRRFIEAAVDAAANQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2789 | - | - | 100% (297) | transcriptional regulator, LysR family protein |
| M. avium 104 | MAV_2838 | - | 6e-12 | 28.80% (191) | hydrogen peroxide-inducible genes activator |
| M. avium 104 | MAV_3102 | - | 1e-09 | 29.90% (194) | LysR substrate binding domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 3e-07 | 27.75% (191) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1356 | - | 2e-20 | 31.82% (286) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 3e-07 | 27.75% (191) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 6e-10 | 25.13% (191) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0993c | - | 5e-16 | 29.57% (186) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 7e-11 | 28.87% (194) | hydrogen peroxide-inducible genes activator, OxyR |
| M. smegmatis MC2 155 | MSMEG_0471 | - | 6e-23 | 28.95% (266) | transcriptional regulator LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-15 | 29.18% (281) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 5e-11 | 28.87% (194) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_4518 | - | 2e-16 | 31.29% (278) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2756|M.marinum_M -----------MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANA
MUL_2998|M.ulcerans_Agy99 ----------------MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANA
MLBr_02041|M.leprae_Br4923 -------------------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASF
Mb2303c|M.bovis_AF2122/97 -------------------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARE
Rv2282c|M.tuberculosis_H37Rv -------------------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARE
Mflv_1356|M.gilvum_PYR-GCK MVSAVTGRPTNDPPHTWRHRTIKEPPMELRHLRYFLAVAETCHFGQAAEQ
MAV_2789|M.avium_104 ----------MKDLCSSGMDVVQAGRVELRHLRAFEAVARLESFTLAAQE
MSMEG_0471|M.smegmatis_MC2_155 ------------------------MEWTLRELRVFVTAADTGSFTDAAAQ
Mvan_4518|M.vanbaalenii_PYR-1 --------------------------MTLRQLRYFAVLGHELNYRRAAEK
TH_3504|M.thermoresistible__bu ---------------------VPSPKIDLRRLAQFVAVAELGSFTRAAAT
MAB_0993c|M.abscessus_ATCC_199 ------------------MAETAPLDLDLRLVRYFTVVAEQRHFGRASTE
: . * . *:
MMAR_2756|M.marinum_M LGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEA
MUL_2998|M.ulcerans_Agy99 LGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEA
MLBr_02041|M.leprae_Br4923 LGVRQSTLSQALAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEA
Mb2303c|M.bovis_AF2122/97 LGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEV
Rv2282c|M.tuberculosis_H37Rv LGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEV
Mflv_1356|M.gilvum_PYR-GCK LHIAQPALSYAIRQLENSLDATLFTRTTRHVALTPAGEFLRVEATRILNG
MAV_2789|M.avium_104 LSITQPALSRTIKQLEDALEASLLDRTSRHVATTPAGRVFLGHVERILTE
MSMEG_0471|M.smegmatis_MC2_155 LHVSQAAVSRTIAGLEKIVGDRLLRRVPRGCELTAAGQQILPLARRVLAE
Mvan_4518|M.vanbaalenii_PYR-1 LFITQPALSTAIKQLEHQFGVVLFHRNTREVALTDLGAAWLPQVQQALSG
TH_3504|M.thermoresistible__bu LHLSQQALSSAVRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAA
MAB_0993c|M.abscessus_ATCC_199 LRVAQPSLSRQISRLEQQLGVRLLDRTPQGTTLTEAGEVFLPKAKTLLRS
* : * ::* : :* . * * : * * :
MMAR_2756|M.marinum_M VEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGL-----TRRLPT
MUL_2998|M.ulcerans_Agy99 VEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGL-----TRRLPT
MLBr_02041|M.leprae_Br4923 MDAFTAAAAGESDPLRGGMRLGLIPTVAPYVLPTMLTGL-----THRLPT
Mb2303c|M.bovis_AF2122/97 ADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTV
Rv2282c|M.tuberculosis_H37Rv ADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTV
Mflv_1356|M.gilvum_PYR-GCK VDAAQRGVRRIAAGRSGLLRLGLTGTAAFSHLPKIARIVR-----QELPA
MAV_2789|M.avium_104 LGRGVDAVRQQAS-----IRLGFSWLLPDPWAQDTVARF------ERTTR
MSMEG_0471|M.smegmatis_MC2_155 AESFTEFLHSRHG----VLRLGYAWAAVGRHTARLQRDWA-----QRQAD
Mvan_4518|M.vanbaalenii_PYR-1 VDAVVDNLIMLSGTRRGVLRVGYLIGTGADLLFRLVRHFE-----AAYPD
TH_3504|M.thermoresistible__bu ARTVAEHVRQTEAAAQAHYVIGHTPALSGAEAYALIEPAV-----TAYPS
MAB_0993c|M.abscessus_ATCC_199 ADQAAAHAR--AAAQPSHLTVGYSMGIIVTPAVLQMRQKH--------PD
. .
MMAR_2756|M.marinum_M LTVRVIEDQ-TERLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLA
MUL_2998|M.ulcerans_Agy99 LTVRVIEDQ-TERLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLA
MLBr_02041|M.leprae_Br4923 LTLRVVEDQ-TEHLLTALREGALDAAMIALPVETAGIAEIPIYDEDFVLA
Mb2303c|M.bovis_AF2122/97 PEVILTATN-SEHAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVV
Rv2282c|M.tuberculosis_H37Rv PEVILTATN-SEHAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVV
Mflv_1356|M.gilvum_PYR-GCK VALDIHADLLTPDQCEGLRTGALDVGVLRPPAVGGDVATRTIAAEPLVLA
MAV_2789|M.avium_104 TTVSLIRTD---DALGAVQQGRVDIALVRGHVTSTAVRIVHLFDEPRVAV
MSMEG_0471|M.smegmatis_MC2_155 IELELVRHN---SPTAGLAEGLCDVAVIRRPTDEKRFASVIVGLERRLVA
Mvan_4518|M.vanbaalenii_PYR-1 VTVEPIEFD-FADPTAGLADGTTEVAIIRPPVDLPEHRMLILDSESWVAC
TH_3504|M.thermoresistible__bu TSFTLRQLY-PDALTDAVFDGTVQLGLRRGVVPTPELATAVIGYHRVRVA
MAB_0993c|M.abscessus_ATCC_199 ADIRATHLK-WDEARAALLDHRVDAVVARLPFSTDQLHVTILYDEPRVVL
. .: : . : .
MMAR_2756|M.marinum_M LPPG-HPMADR-HGVPVAALSELPLLLLDEGHCLRDQALDVCQN---AGV
MUL_2998|M.ulcerans_Agy99 LPPG-HPMADR-HGVPVAALSELPLLLLDEGHCLRDQALDVCQN---AGV
MLBr_02041|M.leprae_Br4923 LPPG-HPLSGK-RRVPTTALAQLPLLLLDEGHCLRDQTLDICRK---SGV
Mb2303c|M.bovis_AF2122/97 VPPG-HKWARRSRVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDM
Rv2282c|M.tuberculosis_H37Rv VPPG-HKWARRSRVVSARELAQTPLVTREPNSGIRDSLTAALRDTLGEDM
Mflv_1356|M.gilvum_PYR-GCK VSAD-HRLAAEPVVSLADLRSEPFIGYTGQDSAVNDAVTRSCRA----AG
MAV_2789|M.avium_104 CSVH-SPLAKRAKLDWAEVPRWPLVINTASG--TTGPWSWPAGD------
MSMEG_0471|M.smegmatis_MC2_155 FASDDEQWSGRRQLSMAEIADRTVIIDPRIGTTSSELWEGSGHVP-----
Mvan_4518|M.vanbaalenii_PYR-1 LPRD-HRLAERREVEIAELLDDPIVCAPLTAGTWRDYWLAMDVR----GN
TH_3504|M.thermoresistible__bu FVDS-HPLAARESVDITELAREQVALWAPPGTSYYSDFLMGACRR---AG
MAB_0993c|M.abscessus_ATCC_199 LPSD-HPLAQHDSLTLADIANEPMPRIRNADPSWSAYWRVEPRP----DG
: . .
MMAR_2756|M.marinum_M RAELADTRAASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAP
MUL_2998|M.ulcerans_Agy99 RAEHADTRADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAP
MLBr_02041|M.leprae_Br4923 QAELANTRAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAP
Mb2303c|M.bovis_AF2122/97 QQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPAL
Rv2282c|M.tuberculosis_H37Rv QQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPAL
Mflv_1356|M.gilvum_PYR-GCK FVPHREHSAPGTAVLLALVAADLGVSVVPASVRALPLHG--VVFRDLVDG
MAV_2789|M.avium_104 -GPETIVETTNFDEWIESVAADRGIGVIPDVAIRRNVHPG-VRFVALRDA
MSMEG_0471|M.smegmatis_MC2_155 ----QFIVSTDVDTWLDAIAAGRGVGTTAEATAHHHPRHG-VTYRPIKDG
Mvan_4518|M.vanbaalenii_PYR-1 RPPTIAAVAATYEAETTAIARGLGISFTTSSVARFYDRPG-IVYVPICDR
TH_3504|M.thermoresistible__bu FEPDYVVSRVQGAATVAAPLTTGGIAFVTAAAG--PTMNGRVQVVDL-TP
MAB_0993c|M.abscessus_ATCC_199 SLAPDGPVIDAIEDKFEVIASGQAISLSAGAHGSTMRPDIVAVPLEGVEP
. .
MMAR_2756|M.marinum_M TPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN-
MUL_2998|M.ulcerans_Agy99 TPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN-
MLBr_02041|M.leprae_Br4923 CPGRRIGLAFRSASGRSASYRQIAKIIGELISTEHHVRLVA-
Mb2303c|M.bovis_AF2122/97 NLRRQLRAIWVG--GRTPPAGAIRDLLSHITSRST-------
Rv2282c|M.tuberculosis_H37Rv NLRRQLRAIWVG--GRTPPAGAIRDLLSHITSRST-------
Mflv_1356|M.gilvum_PYR-GCK G-TVDLALAWRDGVDNPVVDAVVAVLAGALTSLDHPALQEQS
MAV_2789|M.avium_104 P-DIPVALAFVKRASGPVLRRFIEAAVDAAANQ---------
MSMEG_0471|M.smegmatis_MC2_155 P-RIAVRLAWWRDHRPRGLDELVDAVTRLYST----------
Mvan_4518|M.vanbaalenii_PYR-1 P-PSHTALAWNPADLTPQADALVRHVQSQWSFGDGDNADHG-
TH_3504|M.thermoresistible__bu PLLVPVQALWQRHTLSAIRDRILEGLG---------------
MAB_0993c|M.abscessus_ATCC_199 S---HVAIATRADDRGRLVAAFRKVAQAVLTGPG--------