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MVSAVTGRPTNDPPHTWRHRTIKEPPMELRHLRYFLAVAETCHFGQAAEQLHIAQPALSYAIRQLENSLD ATLFTRTTRHVALTPAGEFLRVEATRILNGVDAAQRGVRRIAAGRSGLLRLGLTGTAAFSHLPKIARIVR QELPAVALDIHADLLTPDQCEGLRTGALDVGVLRPPAVGGDVATRTIAAEPLVLAVSADHRLAAEPVVSL ADLRSEPFIGYTGQDSAVNDAVTRSCRAAGFVPHREHSAPGTAVLLALVAADLGVSVVPASVRALPLHGV VFRDLVDGGTVDLALAWRDGVDNPVVDAVVAVLAGALTSLDHPALQEQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1356 | - | - | 100% (329) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1346 | - | 9e-53 | 41.72% (290) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3565 | - | 5e-20 | 32.52% (286) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 6e-17 | 30.14% (292) | oxidative stress response regulatory protein OXYS |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 6e-17 | 30.14% (292) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 5e-19 | 30.40% (250) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4795c | - | 2e-28 | 32.11% (299) | LysR family transcriptional regulator |
| M. marinum M | MMAR_4157 | - | 6e-22 | 30.20% (245) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_1538 | - | 7e-28 | 29.55% (291) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_1909 | - | 1e-126 | 75.24% (307) | putative HTH-type transcriptional regulator YnfL |
| M. thermoresistible (build 8) | TH_3504 | - | 3e-19 | 27.15% (291) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4020 | - | 4e-22 | 30.20% (245) | LuxR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 2e-42 | 37.94% (282) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1356|M.gilvum_PYR-GCK MVSAVTGRPTNDPPHTWRHRTIKEPPMELRHLRYFLAVAETCHFGQAAEQ
MSMEG_1909|M.smegmatis_MC2_155 --------------------------MELRHLRYFAAVADTCHFGQAAEQ
Mvan_1027|M.vanbaalenii_PYR-1 -------------------------MFSLARLSCFVAVAEELHFGRAAER
MAB_4795c|M.abscessus_ATCC_199 --------------MPEHSAGIWDDPVDLRRLQQFLSVAEHSGFTRAAQQ
TH_3504|M.thermoresistible__bu ---------------------VPSPKIDLRRLAQFVAVAELGSFTRAAAT
MMAR_4157|M.marinum_M --------------------------MELYQLRYFQAVAECGTLRGASEQ
MUL_4020|M.ulcerans_Agy99 --------------------------MELYQLRYFQAVAECGTLRGASEQ
Mb0121|M.bovis_AF2122/97 --------------------------MLFRQLEYFVAVAQERHFARAAEK
Rv0117|M.tuberculosis_H37Rv --------------------------MLFRQLEYFVAVAQERHFARAAEK
MAV_1538|M.avium_104 --------------------------MAVGDYEWFITLAELQHVTAAAEQ
MLBr_02041|M.leprae_Br4923 -------------------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASF
. * ::.: . *:
Mflv_1356|M.gilvum_PYR-GCK LHIAQPALSYAIRQLENSLDATLFTRTTRHVALTPAGEFLRVEATRILNG
MSMEG_1909|M.smegmatis_MC2_155 LHVAQPALSYAIRQLETELDVTLFYRTTRQVSLTPAGEFLRAEAARILAG
Mvan_1027|M.vanbaalenii_PYR-1 LHMTQPPLSRQVQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQL
MAB_4795c|M.abscessus_ATCC_199 LRLTQQAISQSVTNLEKQVGAKLFDRSGRHIALTPAGEVLRDGSVVLLAA
TH_3504|M.thermoresistible__bu LHLSQQALSSAVRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAA
MMAR_4157|M.marinum_M LLVSQSAVSRAITLLEAEIGVQLFTRRGRTNELNRYGQALLVGSRLAQRS
MUL_4020|M.ulcerans_Agy99 LLVSQSAVSRAITLLEAEIGVQLFTRRGRTNELNRYGQALLVGSRLAQRS
Mb0121|M.bovis_AF2122/97 CYVSQPALSSAIAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAE
Rv0117|M.tuberculosis_H37Rv CYVSQPALSSAIAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAE
MAV_1538|M.avium_104 LHVAQPTLTRMLARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLE
MLBr_02041|M.leprae_Br4923 LGVRQSTLSQALAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEA
: * .:: : ** :.. *: * :. * : .
Mflv_1356|M.gilvum_PYR-GCK VDAAQRGVRRIAAGRSGLLRLGLTGTAAFSHLPKIARIVRQELPAVALDI
MSMEG_1909|M.smegmatis_MC2_155 VDDAERGVRRIARGRGGLLRLGLTGTAAFSHLPRIARIVKREMPDVALEI
Mvan_1027|M.vanbaalenii_PYR-1 AEGAAQTVKRIPAGDLGTVVVGFTAASAHAVLPRLLERARERLPDVKLDL
MAB_4795c|M.abscessus_ATCC_199 AQTLVRQVQNTAAEQPRPFVVAHTPAITAEEVHQLLVPVRSALPNVSVTA
TH_3504|M.thermoresistible__bu ARTVAEHVRQTEAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTL
MMAR_4157|M.marinum_M VSSAIDNVRELAGVSGGTVALGFLHSLGMQTVPHLIRLHHSRFPQARFEL
MUL_4020|M.ulcerans_Agy99 VSSAIDNVRELAGVSGGTVALGFLHSLGMQTVPHLIRLHHSRFPQARFEL
Mb0121|M.bovis_AF2122/97 HAAFKAEVDAVRSGITGTLRLGTVPTASTTAS-LVLSAFCSAHPLAKVQV
Rv0117|M.tuberculosis_H37Rv HAAFKAEVDAVRSGITGTLRLGTVPTASTTAS-LVLSAFCSAHPLAKVQV
MAV_1538|M.avium_104 LDSARRAIADLADPAVGEIRLAYLSSFGSTVVPRLIARFKESSPRVTFTL
MLBr_02041|M.leprae_Br4923 MDAFTAAAAGESDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRV
:. : : * .
Mflv_1356|M.gilvum_PYR-GCK HADLLTPDQCEGLRTGALDVGVLRPPAVG--GDVATRTIAAEPLVLAVSA
MSMEG_1909|M.smegmatis_MC2_155 HADMLTPVQCDSLRSGALDLGVLRPPAVG--DGVELTVIDAESLVLAVSA
Mvan_1027|M.vanbaalenii_PYR-1 R-EMVTAAQIEGLMTGELDLGMARPPLKR--PGLVSRPLLHEQLLAALPE
MAB_4795c|M.abscessus_ATCC_199 L-QVFPNALEPAVIGGSADIALRRGIATP--KNLASRVIGYHALRVAVPR
TH_3504|M.thermoresistible__bu R-QLYPDALTDAVFDGTVQLGLRRGVVPT--PELATAVIGYHRVRVAFVD
MMAR_4157|M.marinum_M H-QRSGQGVLSDLVSGVTDVSLSFPAAFEGYGEIAWQTLFTQQLYAVVST
MUL_4020|M.ulcerans_Agy99 H-QRSGQGVLSDLVSGVTDVSLSFPAAFEGYGEIAWQTLFTQQLYAVVST
Mb0121|M.bovis_AF2122/97 CSRLAATELYRRLREFELDAVIVHPETQD--SDDVDLVPLYEEQYVLLSP
Rv0117|M.tuberculosis_H37Rv CSRLAATELYRRLREFELDAVIVHPETQD--SDDVDLVPLYEEQYVLLSP
MAV_1538|M.avium_104 E-EGAAESIADRVRSGGVDIGVVSPRPVER--TLAWRSLFRQRLGVAVPD
MLBr_02041|M.leprae_Br4923 V-EDQTEHLLTALREGALDAAMIALPVET--AGIAEIPIYDEDFVLALPP
: : : . .
Mflv_1356|M.gilvum_PYR-GCK DHRLAAEP-VVSLADLRSEPFIGYTGQDS-AVNDAVTRSCRAAGFVPHRE
MSMEG_1909|M.smegmatis_MC2_155 DHRLAAEP-VVSMADLRAEPFVGYASRDS-AVNDAVLRSCRSAGFVPDRA
Mvan_1027|M.vanbaalenii_PYR-1 GHPLADMTRELTLIDLDGQDFVMYSPVQARYFNELLISTFTIAGTTPRYV
MAB_4795c|M.abscessus_ATCC_199 EHLLAERD-SVALRDLRNERIIVWAPPGVSHYTDFILSTCRSAGFEPAFV
TH_3504|M.thermoresistible__bu SHPLAARE-SVDITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDYV
MMAR_4157|M.marinum_M DHPLAGRR-LIRFPELAAYPFVVLDRDHT--LRRIVDAACARHGIDPTLA
MUL_4020|M.ulcerans_Agy99 DHPLAGRR-LIRFPELAAYPFVVLDRDHT--LRRIVDAACARHGIDPTPA
Mb0121|M.bovis_AF2122/97 ADMLPPGTSTLVWRDAAQLPLALLTADMR--DRQVIDAAFADHAVSAIPQ
Rv0117|M.tuberculosis_H37Rv ADMLPPGTSTLVWRDAAQLPLALLTADMR--DRQVIDAAFADHAVSAIPQ
MAV_1538|M.avium_104 GHRFARGA-AVSMVDLADEPFVTMHPGFG--MRRLLDELCAAAQFRPRVA
MLBr_02041|M.leprae_Br4923 GHPLSGKR-RVPTTALAQLPLLLLDEGHC--LRDQTLDICRKSGVQAELA
. :. : . .
Mflv_1356|M.gilvum_PYR-GCK HS-APGTAVLLALVAADLGVSVVPASVRALPLHGVVFRDL--VDGGTVD-
MSMEG_1909|M.smegmatis_MC2_155 HT-APGTAVLLALVAADLGVAVVPESVRALPLDGVVFRDL--LDGGTVE-
Mvan_1027|M.vanbaalenii_PYR-1 QY-VTQVHTMLVLVRSGIGIALVPASAATLHPEGVVFRTIGAFRERPVE-
MAB_4795c|M.abscessus_ATCC_199 IN-HVQGTPPVTAVLDNDGVAFVTAPTGPCLAGQVVVIDI--VDPPQAP-
TH_3504|M.thermoresistible__bu VS-RVQGAATVAAPLTTGGIAFVTAAAGPTMNGRVQVVDL--TPPLLVP-
MMAR_4157|M.marinum_M FE-GTDVGTLRGLIGANLGVGVLPQATARPADIIEIAIDD---AQLVRP-
MUL_4020|M.ulcerans_Agy99 FE-GTDVGTLRGLIGANLGVGVLPQATARPADIIEIAIDD---AQLVRP-
Mb0121|M.bovis_AF2122/97 VE-TDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDP-
Rv0117|M.tuberculosis_H37Rv VE-TDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDP-
MAV_1538|M.avium_104 LQ-APNLTTAASLVAAGLGISLVPIDGSSYPSG--VSVKPLADADAYRD-
MLBr_02041|M.leprae_Br4923 NTRAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRR
.:.
Mflv_1356|M.gilvum_PYR-GCK LALAWRDGVD-----NPVVDAVVAVLAGALTSLDHPALQEQS-----
MSMEG_1909|M.smegmatis_MC2_155 LALAWRRAADRDSHANPLVGSVVDILAPAPSRESVPSLEERL-----
Mvan_1027|M.vanbaalenii_PYR-1 LDAVWRGDSTN--------PALLRVLKDVLPQQEWTT----------
MAB_4795c|M.abscessus_ATCC_199 IQAIWLPHTQS---------AIRDALTSG------------------
TH_3504|M.thermoresistible__bu VQALWQRHTLS---------AIRDRILEGLG----------------
MMAR_4157|M.marinum_M IAIGWIADRCLP----SSAVAFRETALGCYGHRVSAAGV--------
MUL_4020|M.ulcerans_Agy99 IAIGWIADRCLP----SSAVAFRETAFGCYGHRDSAAGV--------
Mb0121|M.bovis_AF2122/97 VLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv VLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
MAV_1538|M.avium_104 VGMIWDSGRPLP-------RSARDFIAGAAAVGHGGW----------
MLBr_02041|M.leprae_Br4923 IGLAFRSASGRS----ASYRQIAKIIGELISTEHHVRLVA-------
: