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PDKTYQPTIAGLRAFVAVAEKRQFSGAATALGVSQSTLSQALAALEAGLGTQLVERSTRRVFLTPQGAEL LPHAQAVVEAADAFTAAAAGSADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRPGLTLRVTEDQTERLLA VLREGALDAALIALPAETAGVTAIPIYDEDFVLALPPGHPLAGKRRVPATALADLPLLLLDEGHCLRDQA LDVCHKAGVRAELANTRAASLATAVQCVTGGLGVTLIPQSAVPVEASRSRLGLAQFAAPRPGRRIGLVFR SSSGRDDSYRELAGLIGELISSQHQVRLVK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2838 | - | - | 100% (311) | hydrogen peroxide-inducible genes activator |
| M. avium 104 | MAV_4979 | - | 7e-28 | 32.01% (278) | transcriptional regulator, LysR family protein, putative |
| M. avium 104 | MAV_1538 | - | 7e-23 | 29.49% (234) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 2e-21 | 30.23% (215) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3565 | - | 6e-25 | 33.20% (241) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 2e-21 | 30.23% (215) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-138 | 79.35% (310) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4409 | - | 1e-104 | 62.54% (307) | hydrogen peroxide-inducible genes activator |
| M. marinum M | MMAR_2756 | oxyR | 1e-131 | 76.45% (310) | hydrogen peroxide-inducible genes activator, OxyR |
| M. smegmatis MC2 155 | MSMEG_5654 | - | 7e-28 | 32.78% (241) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 1e-12 | 25.30% (249) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 1e-129 | 75.65% (308) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 3e-27 | 33.61% (241) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2838|M.avium_104 --------MPDKTYQPTIAGLRAFVAVAEKRQFSGAATALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MAB_4409|M.abscessus_ATCC_1997 --------MSDRSYQPTVVGLRAFVAIARKRHFGSAAGELGVSQPSLSQA
Mflv_3565|M.gilvum_PYR-GCK ---------------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQ
Mvan_3362|M.vanbaalenii_PYR-1 ---------------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQ
MSMEG_5654|M.smegmatis_MC2_155 -----------------MRHLRCFVVLAEELHFGRAAQRLHVAQPALSQL
Mb2303c|M.bovis_AF2122/97 --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
Rv2282c|M.tuberculosis_H37Rv --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
: : ::.:.. : ** : * ::*
MAV_2838|M.avium_104 LAALEAGLGTQLVERSTRRVFLTPQGAELLPHAQAVVEAADAFTAAAAGS
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MAB_4409|M.abscessus_ATCC_1997 LSMLEEGLGVRLVERNTRKVLLTPEGDALLEKAISALNAVDEFTSAASGV
Mflv_3565|M.gilvum_PYR-GCK IRRLERSVGQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDV
Mvan_3362|M.vanbaalenii_PYR-1 IRRLERQVGQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQAAVDDV
MSMEG_5654|M.smegmatis_MC2_155 IQRVERELGAQLFLRTRRTVSLTEAGQTLLPEARRILRDADRVTQAVRAV
Mb2303c|M.bovis_AF2122/97 LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
Rv2282c|M.tuberculosis_H37Rv LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. * * * :* * : . :
MAV_2838|M.avium_104 ADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRPG-----LTLRVTEDQTE
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPT-----LTLRVVEDQTE
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPT-----LTVRVIEDQTE
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPT-----LTVRVIEDQTE
MAB_4409|M.abscessus_ATCC_1997 RDPFAQTLRLGLIPTVAPYVLPMVLSGLSREFPE-----MSLRVTEDQTH
Mflv_3565|M.gilvum_PYR-GCK AGLLRGSVAIGTVTLHPMNVA-HLIAEFHADHPD-----VEITLGTATSD
Mvan_3362|M.vanbaalenii_PYR-1 ANLVRGAVAIGTVTLHPVDVA-RLMADFHAEHPG-----VEITLGTDTSD
MSMEG_5654|M.smegmatis_MC2_155 HRGETGSVTIGFVGSAADDVLPRLVAAHRRHHPG-----VSIRLEEGTTA
Mb2303c|M.bovis_AF2122/97 RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
Rv2282c|M.tuberculosis_H37Rv RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPS-----TSFTLRQLYPD
. . : . : .
MAV_2838|M.avium_104 RLLAVLREGALDAALIALPAET--AGVTAIPIYDEDFVLALPPGHPLAGK
MLBr_02041|M.leprae_Br4923 HLLTALREGALDAAMIALPVET--AGIAEIPIYDEDFVLALPPGHPLSGK
MMAR_2756|M.marinum_M RLLTALREGSLDTALIALPADY--GGLTEIPIYEEDFVLALPPGHPMADR
MUL_2998|M.ulcerans_Agy99 RLLTALREGSLDTALIALPADY--GGLTEIPIYEEDFVLALPPGHPMADR
MAB_4409|M.abscessus_ATCC_1997 RLLRSLSDGTLDVAVMALPVQT--QGMAEIPMYREDFVLALPSGHPLAGS
Mflv_3565|M.gilvum_PYR-GCK VLIAELGDGRLDLAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHR
Mvan_3362|M.vanbaalenii_PYR-1 VLLAKLEDGRLDAAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLARR
MSMEG_5654|M.smegmatis_MC2_155 QQLEWLRDQRITVGLGRTPIDD--PAVSTVVLARESLVLAVPDSHALSGA
Mb2303c|M.bovis_AF2122/97 HAIAAVRDGIADLGFIENPCPP--TGLGSVVVARDELVVVVPPGHKWARR
Rv2282c|M.tuberculosis_H37Rv HAIAAVRDGIADLGFIENPCPP--TGLGSVVVARDELVVVVPPGHKWARR
TH_3504|M.thermoresistible__bu ALTDAVFDGTVQLGLRRGVVPT--PELATAVIGYHRVRVAFVDSHPLAAR
: : .. : : . . .. * :
MAV_2838|M.avium_104 -RRVPATALADLPLLLLD--EGHCLRDQALDVCHK---AGVRAELANTRA
MLBr_02041|M.leprae_Br4923 -RRVPTTALAQLPLLLLD--EGHCLRDQTLDICRK---SGVQAELANTRA
MMAR_2756|M.marinum_M -HGVPVAALSELPLLLLD--EGHCLRDQALDVCQN---AGVRAELADTRA
MUL_2998|M.ulcerans_Agy99 -HGVPVAALSELPLLLLD--EGHCLRDQALDVCQN---AGVRAEHADTRA
MAB_4409|M.abscessus_ATCC_1997 -KNVEPADLADMPLLLLD--EGHCLRDQALEVCQL---AGVRPDLGHTRA
Mflv_3565|M.gilvum_PYR-GCK -RSLSLEQLSRHPLISLP--AGTGLRTRLDTACAA---AGLRPRIAFEAT
Mvan_3362|M.vanbaalenii_PYR-1 -KSLSLKQLCEYPVISLP--AGTGLRSRLDDACAA---AGLRPRIAFEAT
MSMEG_5654|M.smegmatis_MC2_155 -ESAELAGLAEEPFIMFPRHLGPGLYDIIHSACAA---AGFTPSVVYETV
Mb2303c|M.bovis_AF2122/97 SRVVSARELAQTPLVTRE--PNSGIRDSLTAALRDTLGEDMQQAPPVLEL
Rv2282c|M.tuberculosis_H37Rv SRVVSARELAQTPLVTRE--PNSGIRDSLTAALRDTLGEDMQQAPPVLEL
TH_3504|M.thermoresistible__bu -ESVDITELAREQVALWAPPGTSYYSDFLMGACRR---AGFEPDYVVSRV
. *. . ..
MAV_2838|M.avium_104 ASLATAVQCVTGGLGVTLIPQSAVPVEASRSRLGLAQFAAPRPGRRIGLV
MLBr_02041|M.leprae_Br4923 ASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLA
MMAR_2756|M.marinum_M ASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRIGLV
MUL_2998|M.ulcerans_Agy99 DSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGLV
MAB_4409|M.abscessus_ATCC_1997 ASLATAVQCVEGGLGVTLIPGTAVTAETASGGLATATFAAPVPGRRIGLV
Mflv_3565|M.gilvum_PYR-GCK S-PAELAELARHGLGVAILPQSMAR---GGSGLHALRLAPELRG-RLVWA
Mvan_3362|M.vanbaalenii_PYR-1 S-PLELADLARHGLGVAILPRSMAR---GSAGLHPLRLSPELRG-RLVWA
MSMEG_5654|M.smegmatis_MC2_155 R-MQTIVGLVSGGLGVALVPESVRNL--GRKGVRYVHLADAPPAIELSMM
Mb2303c|M.bovis_AF2122/97 SSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAI
Rv2282c|M.tuberculosis_H37Rv SSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAI
TH_3504|M.thermoresistible__bu QGAATVAAPLTTG-GIAFVTAAAGPT--MNGRVQVVDLTP-PLLVPVQAL
* * : :. : :. :
MAV_2838|M.avium_104 FRSSSGRDDSYRELAGLIGELISSQHQVRLVK---
MLBr_02041|M.leprae_Br4923 FRSASGRSASYRQIAKIIGELISTEHHVRLVA---
MMAR_2756|M.marinum_M YRASSGRDEAYRQLAAIMGESISNEQQVRLVN---
MUL_2998|M.ulcerans_Agy99 YRASSGRDEAYRQLAAIMGESISNEQQVRLVN---
MAB_4409|M.abscessus_ATCC_1997 YRAISAREDAYRRLAELLTRLVSAVHPVTADAA--
Mflv_3565|M.gilvum_PYR-GCK WRADGANPAARVLGERARAMAVSPGSGAPAVVPGA
Mvan_3362|M.vanbaalenii_PYR-1 WRTDISGPAARLLNARARAMIAATG--TPAVIPGA
MSMEG_5654|M.smegmatis_MC2_155 WRNDCESPHLQPLRKTARHL---------------
Mb2303c|M.bovis_AF2122/97 WVG--GRTPPAGAIRDLLSHITSRST---------
Rv2282c|M.tuberculosis_H37Rv WVG--GRTPPAGAIRDLLSHITSRST---------
TH_3504|M.thermoresistible__bu WQRHTLSAIRDRILEGLG-----------------
: