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MSEASIVRRASYGPSSPAVGARGANTRGRIAEVSLELFGRVGYFDTSVDAIAKAAGVSRATLYQYFKGKD EIFLELLNECGSALFRVARRIGPLGPDEVGFDNLNWWLGEWSWVFDKYSTMFVQWTAIASSDTKVRPEIT RFVRGYNHRLAERLAGSGLNGLDPEVAAMAMTALVHRINLFVHTDRAYGRSAKDAVDTLSVFLQLMLFPD TPRSVLRSLSLHASTDPAADIDALKAPPAPDIAGLSISERTTSLSKRAVTTVNALADAGAAQFRARGYRS TSVDDIVEAANVARGTFYKYFSDKQDLLAAVAAEIYGAGTAFAHRIADVDPVAKKSTLRHWLRTYVEFYD RYSGCIEAWVEGATDDPTIVSIGENGQVQMDIGAARMLIRGPGRYPFDPVVSALILRALVTRVPQAALDL PEPIDADELVDVLMTCINRGFFGRAK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2650 | - | - | 100% (446) | putative transcriptional regulator |
| M. avium 104 | MAV_1948 | - | 0.0 | 85.39% (445) | putative transcriptional regulator |
| M. avium 104 | MAV_2588 | - | 2e-47 | 31.05% (438) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0710c | - | 9e-09 | 44.07% (59) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 2e-12 | 27.65% (293) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0691c | - | 9e-09 | 44.07% (59) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 7e-06 | 27.14% (210) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4046c | - | 4e-10 | 23.78% (328) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4325 | - | 3e-08 | 24.65% (288) | TetR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 3e-10 | 25.30% (328) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4015 | - | 1e-10 | 26.26% (198) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0135 | - | 4e-09 | 25.35% (288) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 8e-12 | 26.09% (299) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4325|M.marinum_M --------------------------------------------------
MUL_0135|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2650|M.avium_104 --------------------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
TH_4015|M.thermoresistible__bu -------------------------------------------------V
MAB_4046c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4325|M.marinum_M ---------------MADH-------RDQAGTDDSGTRRTEILQTAAALI
MUL_0135|M.ulcerans_Agy99 ---------------MADH-------RDQAGTDDSGTRRTEILQTAAALI
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
Mb0710c|M.bovis_AF2122/97 ------------------------MPHESRVGRRRSTTPHHISDVAIELF
Rv0691c|M.tuberculosis_H37Rv ------------------------MPHESRVGRRRSTTPHHISDVAIELF
MAV_2650|M.avium_104 ------------MSEASIVRRASYGPSSPAVGARGANTRGRIAEVSLELF
MLBr_01070|M.leprae_Br4923 ---------MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLL
TH_4015|M.thermoresistible__bu VPRRRVDNGSNEQGVASDATGGDRMNRPLPPTARGRRSRRALLDAAKEVF
MAB_4046c|M.abscessus_ATCC_199 --------------MEQLVAQEPPRRGRPPVSGLADRRRQQIVDAAFAAF
: .: :
MMAR_4325|M.marinum_M ASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQIG
MUL_0135|M.ulcerans_Agy99 ASSGLR-TSLQEIADAAGILPGSLYHHFESKEAILIELIRRYQDDLHQIG
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
Mb0710c|M.bovis_AF2122/97 AAHGFTDVSVDDIARAAGIARRTLFRYYASKNAIPWGDFSTHLAQLQGLL
Rv0691c|M.tuberculosis_H37Rv AAHGFTDVSVDDIARAAGIARRTLFRYYASKNAIPWGDFSTHLAQLQGLL
MAV_2650|M.avium_104 GRVGYFDTSVDAIAKAAGVSRATLYQYFKGKDEIFLELLNECGSALFRVA
MLBr_01070|M.leprae_Br4923 AERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAV
TH_4015|M.thermoresistible__bu ARDGFADARITDIADAAGTAHGSFYRYFDSKEEIFIELLRELVEELRQPV
MAB_4046c|M.abscessus_ATCC_199 TENGYEQTSMSDIATRAGMGQGTVYRYVESKREVLDLVFDYGVERLVDTL
: :* .* :.: : .* : .
MMAR_4325|M.marinum_M QSWQAKLDQPD---------------SRTVAEKITQLGAAIANCAVAHRA
MUL_0135|M.ulcerans_Agy99 QSWQAKLDQPD---------------SRTVAEKITQLGAAIANCAVAHRA
Mflv_0186|M.gilvum_PYR-GCK AGID----------------------GDDPEVVLDRLVSALIDIALANRS
Mvan_0719|M.vanbaalenii_PYR-1 AGIE----------------------GDDPQVVLDRLVSALTDTALANRG
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPEN---------------SEDAREQLRLLAAALTDTSLANRE
Mb0710c|M.bovis_AF2122/97 DNID----------------------------SRIQLRDALRAALLAFN-
Rv0691c|M.tuberculosis_H37Rv DNID----------------------------SRIQLRDALRAALLAFN-
MAV_2650|M.avium_104 RRIGPLGPDEVGFDNLNWWLGEWSWVFDKYSTMFVQWTAIASSDTKVRPE
MLBr_01070|M.leprae_Br4923 EALA---------------------------------EQLPADPAAVWR-
TH_4015|M.thermoresistible__bu RTDAG-----------------------------TEPKNPYERILRANR-
MAB_4046c|M.abscessus_ATCC_199 ALDDFLEVVGG--------TAGIEERNDIIMEGGRRLYALVDQEPALLKL
MMAR_4325|M.marinum_M ALQMSFYEGPSADPELMKLTSQRPLAIQEAMLQTLRAGRWSGCIRTEIDL
MUL_0135|M.ulcerans_Agy99 ALQMSFYEGPSADPELMKLTSQRPLAIQEAMLQTLRAGRWSGYIRTEIDL
Mflv_0186|M.gilvum_PYR-GCK SGGLYRWERRYLRGDDQAELLQQLRTVHHRLQTPVSILRPELTARQRSTL
Mvan_0719|M.vanbaalenii_PYR-1 SGGLYRWEGRYLRGDDQATLLQQIHTVHHRIHRPLSALRPELTARQRSTL
MSMEG_0815|M.smegmatis_MC2_155 SGGLYRWEARYLNEDDQAALNAQMRTVHHRIQRPLQQLRPELISRERWML
Mb0710c|M.bovis_AF2122/97 -------------------TFDESETIRHRKRMRVILQTPELQAYSMTMY
Rv0691c|M.tuberculosis_H37Rv -------------------TFDESETIRHRKRMRVILQTPELQAYSMTMY
MAV_2650|M.avium_104 ITRFVRGYNHRLAERLAGSGLNGLDPEVAAMAMTALVHRINLFVHTDRAY
MLBr_01070|M.leprae_Br4923 -------------------SAITAFFEVCGTHRAVAVAGAAAKATSPEVR
TH_4015|M.thermoresistible__bu --------------------TYLEAYRANRAIMIVWEQVASLNEHVEQLR
MAB_4046c|M.abscessus_ATCC_199 LTVQSAAADKELKQRVLGIQSMLDSYVQRGLESGRRAGWLPEDAHNQAVL
MMAR_4325|M.marinum_M PTLADRICQTMLQVGLDMMRRNASADQVSGLMCRTILQGLASHAPTDVDL
MUL_0135|M.ulcerans_Agy99 PTFADRICQTMLQVGLDMMRRNASADQVSGLMCRTILQALASHAPTDVDP
Mflv_0186|M.gilvum_PYR-GCK STAVLSIVGSIVDH-----RAKLPAAQIHRVLTQVARAILSTELPDAAPP
Mvan_0719|M.vanbaalenii_PYR-1 STAALSIVGSIVDH-----RAKLPAAQVHALIAQISRAVLGAELS-ADPP
MSMEG_0815|M.smegmatis_MC2_155 STATLSVIGSVVDH-----RGKLPAGQIREVLGEIVESVLAADLP--ELP
Mb0710c|M.bovis_AF2122/97 AGWREVIAKFVARR---------SGGKTTDFMPQTVAWTM----------
Rv0691c|M.tuberculosis_H37Rv AGWREVIAKFVARR---------SGGKTTDFMPQTVAWTM----------
MAV_2650|M.avium_104 GRSAKDAVDTLSVFLQLMLFPDTPRSVLRSLSLHASTDPAADIDALKAPP
MLBr_01070|M.leprae_Br4923 RLWSTVMQQWIDYN-----TAAIQAERKCGVAPDTIP-------------
TH_4015|M.thermoresistible__bu REYSDRFAARIERA--------IIRWQEAGLADPAIDPRY----------
MAB_4046c|M.abscessus_ATCC_199 ARLLPALVLPGFLLAQSRHDNPSTRERFVTTASLIAEKGILRDGVVLEPG
MMAR_4325|M.marinum_M DGSNALSAANDVIATWIDEKDADPSDKAAHVRAVARIEFGRKGYEVTTIR
MUL_0135|M.ulcerans_Agy99 DGSNALSAANDVIATWIDEKDTDPSDKAAHVRAVARMEFGRKGYEVTTVR
Mflv_0186|M.gilvum_PYR-GCK ATPAPAAER---------IRSAAESSKYEALLAESMRLFNLNGYRDTSME
Mvan_0719|M.vanbaalenii_PYR-1 RYP-PDVVP---------ARPTAEPSKYEALLTASMQLFDRNGYRDTTME
MSMEG_0815|M.smegmatis_MC2_155 ELGAAAAPA---------TTPVVSAAKYEALLNESMRLFNKNGYRDTTME
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2650|M.avium_104 APDIAGLSISER----TTSLSKRAVTTVNALADAGAAQFRARGYRSTSVD
MLBr_01070|M.leprae_Br4923 ------------------------------------------------AE
TH_4015|M.thermoresistible__bu --------------------------------------------------
MAB_4046c|M.abscessus_ATCC_199 EGRVAGETVDS-----VHVPLPAAADRRNELLDAALTCFLSDGYHAVGVN
MMAR_4325|M.marinum_M DIASASGLATGTVYRVIGSKDKLLASIMRSFGQKVEAGWVAVLR---SNA
MUL_0135|M.ulcerans_Agy99 DIASASGLGTGTVYRVIGSKDKLLASIMRSFGQKVEAGWVAVRR---SNA
Mflv_0186|M.gilvum_PYR-GCK EIASAVGMPASGIYKYFSGKNDILAAIFRRASDRVSAETAEIVS---TVP
Mvan_0719|M.vanbaalenii_PYR-1 DIASAVGMPTSGIYKYFSGKSDILATIFRRAADRVSAELASVVA---TMS
MSMEG_0815|M.smegmatis_MC2_155 DIAAAVGMPASGIYRYFSGKADILAAGFRRAADRLSADMAEILA---AGG
Mb0710c|M.bovis_AF2122/97 -----LGVALSAYEHWLRDESVSLTEALGAAFDVVGAGLDRLNQ------
Rv0691c|M.tuberculosis_H37Rv -----LGVALSAYEHWLRDESVSLTEALGAAFDVVGAGLDRLNQ------
MAV_2650|M.avium_104 DIVEAANVARGTFYKYFSDKQDLLAAVAAEIYGAGTAFAHRIAD---VDP
MLBr_01070|M.leprae_Br4923 DLAVALQLMTERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYG---S--
TH_4015|M.thermoresistible__bu AAAALSGMLSNFAYRWSVQDADYDLDTAAEQLSLLWANALGVRV---PAH
MAB_4046c|M.abscessus_ATCC_199 EIVEKLGVSHGTFYNYYQNKRDLLDALMVREFSAMEPALSRSVARLDARR
: .
MMAR_4325|M.marinum_M TPIEKLDALSWVNIN-ALDQFSDEFRIQLAWMRQSPPDTPNPGWLYAARL
MUL_0135|M.ulcerans_Agy99 TPIEKLDALSWVNIN-ALDQFSDEFRIQLAWMRQ----------------
Mflv_0186|M.gilvum_PYR-GCK DPQEALAAVIDAYVTRAFGQPEMESLYYSERLNMSPSDQRIVRDLQRSTV
Mvan_0719|M.vanbaalenii_PYR-1 DPEEALTAVIDGYVQRSFDQPELECVYYSERLNMSAADQRIVRDLQRSTV
MSMEG_0815|M.smegmatis_MC2_155 EPEDVLAALIDDYVTRSFDRPELEHVYYTERLNMTPADQKILRDLQRSAV
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2650|M.avium_104 VAKKSTLRHWLRTYVEFYDRYSGCIEAWVEGATDDPTIVSIGENGQVQMD
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
TH_4015|M.thermoresistible__bu HEPAHA--------------------------------------------
MAB_4046c|M.abscessus_ATCC_199 DIEHALAQGFRNALEAVAARLPALIFVCTEAAGVDPEALQSIIQFFRFAS
MMAR_4325|M.marinum_M RQMKSLLSEGLRSAEIQIEPPSITMLARCVIGLQWIPENILHFVGTRAAL
MUL_0135|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK ESWVELVAAVRPDWTPGEARFAVHAAMALVIDVGRLVHYAASDEARDTVE
Mvan_0719|M.vanbaalenii_PYR-1 ESWVELVVAVRPEWSAAEARFAVHAAMALVVDLGRLMRYENSEEARETVS
MSMEG_0815|M.smegmatis_MC2_155 ESWVNVVMPVRPHWSAGQARFAVHAAMALVIDLGRLMGYRNSEQARAVVS
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2650|M.avium_104 IGAARMLIRGPGRYPFDPVVSALILRALVTRVPQAALDLPEPIDADELVD
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MAB_4046c|M.abscessus_ATCC_199 VRSEQSVFSMIGADRINPAMDTEFLGQAFVSLLVGAVTLVVDDDGRTDRV
MMAR_4325|M.marinum_M IHARDTVLRGVAVRGQ----
MUL_0135|M.ulcerans_Agy99 --------------------
Mflv_0186|M.gilvum_PYR-GCK GLVDAALRGSYRLRATLPSM
Mvan_0719|M.vanbaalenii_PYR-1 GLVDMTLLGRYRLRATLPAK
MSMEG_0815|M.smegmatis_MC2_155 TMVDLVLLGRYRLRTALPAR
Mb0710c|M.bovis_AF2122/97 --------------------
Rv0691c|M.tuberculosis_H37Rv --------------------
MAV_2650|M.avium_104 VLMTCINRGFFGRAK-----
MLBr_01070|M.leprae_Br4923 --------------------
TH_4015|M.thermoresistible__bu --------------------
MAB_4046c|M.abscessus_ATCC_199 DEYAQAITQFLLYGLNPVP-