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MSEASIVRRASYGPSSPTVGERGASTRSKITAVSLELFGRLGYFDTSVDAIAKGAGVSRATLYQYFKGKD EIFLELLNECGSALFRVARRIGPLGPDEVGFDNLNWWLGEWSWVFEKYSTMFVQWTAIASSDTKVRPEIT RFVRSYNHRIAERLAGSGLQGLDPEVAAMTMTALVHRINLFMHTNRAYGRSAKVAVDTLSVFLQLTLFPD TPPAVLTSLRLHRSGNPSADVDAVEMPDEPNVEGLSISERSAGLSKRAVATVTALAEAGAAQFRARGYRS TSVDDIVEAADVARGTFYKYFSDKQDLLAAVAAEIYGAGIAFAERISDVDPVADESTLRHWLATYVEFYD RYSGCIEAWAEGTTDDPMIVGIGEHGQVMMDVGAARMLIRRPGPYPFDPLVSALILRALVTRVPQAALDL PEPIDADGVVDLLISCIKRGFFGLAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1948 | - | - | 100% (446) | putative transcriptional regulator |
| M. avium 104 | MAV_2650 | - | 0.0 | 85.39% (445) | putative transcriptional regulator |
| M. avium 104 | MAV_2588 | - | 7e-45 | 28.31% (438) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0710c | - | 5e-08 | 42.37% (59) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 2e-11 | 25.75% (299) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0691c | - | 5e-08 | 42.37% (59) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00717 | - | 1e-06 | 33.33% (69) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4027 | - | 2e-09 | 36.17% (94) | TetR/AcrR family transcriptional regulator |
| M. marinum M | MMAR_1492 | - | 9e-08 | 40.62% (64) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 2e-10 | 25.08% (319) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4015 | - | 3e-09 | 25.15% (171) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2448 | - | 2e-07 | 39.06% (64) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 2e-10 | 24.01% (304) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MMAR_1492|M.marinum_M --------------------------------------------------
MUL_2448|M.ulcerans_Agy99 --------------------------------------------------
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
TH_4015|M.thermoresistible__bu -------------------------------------------------V
MAV_1948|M.avium_104 --------------------------------------------------
MAB_4027|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MMAR_1492|M.marinum_M ---------------MPAR------QESRELSSKGRQTRQAIEQAARKLF
MUL_2448|M.ulcerans_Agy99 ---------------MPAR------QESRELSSKGRQTRQAIEQVARKLF
Mb0710c|M.bovis_AF2122/97 ------------------------MPHESRVGRRRSTTPHHISDVAIELF
Rv0691c|M.tuberculosis_H37Rv ------------------------MPHESRVGRRRSTTPHHISDVAIELF
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
TH_4015|M.thermoresistible__bu VPRRRVDNGSNEQGVASDATGGDRMNRPLPPTARGRRSRRALLDAAKEVF
MAV_1948|M.avium_104 ------------MSEASIVRRASYGPSSPTVGERGASTRSKITAVSLELF
MAB_4027|M.abscessus_ATCC_1997 ---------------MASTSSGRRGPGRPPNPARARERQRALTEAAALEF
: . *
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MMAR_1492|M.marinum_M AERGFHGTTLADITSAAGKSSAVFYRYFTDKEDLL---------------
MUL_2448|M.ulcerans_Agy99 AERGFHGTTLADITSAAGKSSAVFYRYFTDKEDLL---------------
Mb0710c|M.bovis_AF2122/97 AAHGFTDVSVDDIARAAGIARRTLFRYYASK-------------------
Rv0691c|M.tuberculosis_H37Rv AAHGFTDVSVDDIARAAGIARRTLFRYYASK-------------------
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDK-------------------
TH_4015|M.thermoresistible__bu ARDGFADARITDIADAAGTAHGSFYRYFDSK-------------------
MAV_1948|M.avium_104 GRLGYFDTSVDAIAKGAGVSRATLYQYFKGKDEIFLELLNECGSALFRVA
MAB_4027|M.abscessus_ATCC_1997 AEKGYHKASITDITQRAGVGRGTFYLYFDTKR------------------
. : . : *: .* . :: :: *
Mflv_0186|M.gilvum_PYR-GCK AGID-------------------------------GDDPEVVLDRLVSAL
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------------------------------GDDPQVVLDRLVSAL
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPEN------------------------SEDAREQLRLLAAAL
MMAR_1492|M.marinum_M --------------------------------------------------
MUL_2448|M.ulcerans_Agy99 --------------------------------------------------
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MAV_1948|M.avium_104 RRIGPLGPDEVGFDNLNWWLGEWSWVFEKYSTMFVQWTAIASSDTKVRPE
MAB_4027|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK IDIALANRSSGGLYRWERRYLRGDDQAELLQQLRTVHHRLQTPVSILRPE
Mvan_0719|M.vanbaalenii_PYR-1 TDTALANRGSGGLYRWEGRYLRGDDQATLLQQIHTVHHRIHRPLSALRPE
MSMEG_0815|M.smegmatis_MC2_155 TDTSLANRESGGLYRWEARYLNEDDQAALNAQMRTVHHRIQRPLQQLRPE
MMAR_1492|M.marinum_M --------------------------------------------------
MUL_2448|M.ulcerans_Agy99 --------------------------------------------------
Mb0710c|M.bovis_AF2122/97 --------------------------------------------------
Rv0691c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
TH_4015|M.thermoresistible__bu --------------------------------------------------
MAV_1948|M.avium_104 ITRFVRSYNHRIAERLAGSGLQGLDPEVAAMTMTALVHRINLFMHTNRAY
MAB_4027|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK LTARQRSTLSTAVLSIVGSIVDHRAKLPAAQIHRVLTQVARAILSTELPD
Mvan_0719|M.vanbaalenii_PYR-1 LTARQRSTLSTAALSIVGSIVDHRAKLPAAQVHALIAQISRAVLGAELS-
MSMEG_0815|M.smegmatis_MC2_155 LISRERWMLSTATLSVIGSVVDHRGKLPAGQIREVLGEIVESVLAADLP-
MMAR_1492|M.marinum_M ------------------------AALAQSFLHDVVTPSGVSLQLPDSP-
MUL_2448|M.ulcerans_Agy99 ------------------------AALAQSFLHDVVTPSGVSLQLPDSP-
Mb0710c|M.bovis_AF2122/97 ------------------------NAIPWGDFSTHLAQLQGLLDNIDSR-
Rv0691c|M.tuberculosis_H37Rv ------------------------NAIPWGDFSTHLAQLQGLLDNIDSR-
MLBr_00717|M.leprae_Br4923 ---------------------------RAFFAAVVKDEADRLYAATNIP-
TH_4015|M.thermoresistible__bu ------------------------EEIFIELLRELVEELRQPVRTDAGTE
MAV_1948|M.avium_104 GRSAKVAVDTLSVFLQLTLFPDTPPAVLTSLRLHRSGNPSADVDAVEMPD
MAB_4027|M.abscessus_ATCC_1997 ------------------------DVLDAVIDSYFQRTVAAVNDTSDLLG
Mflv_0186|M.gilvum_PYR-GCK -AAPPATPAPAAERIRSAAESSKYEALLAESMRLFNLNGYRDTSMEEIAS
Mvan_0719|M.vanbaalenii_PYR-1 -ADPPRYP-PDVVPARPTAEPSKYEALLTASMQLFDRNGYRDTTMEDIAS
MSMEG_0815|M.smegmatis_MC2_155 --ELPELGAAAAPATTPVVSAAKYEALLNESMRLFNKNGYRDTTMEDIAA
MMAR_1492|M.marinum_M ------------------DDDTFFTAVVTGYWNIFKQNIGIMIAVDQLAA
MUL_2448|M.ulcerans_Agy99 ------------------DDDTFFTAVVTGYWNIFKQNIGIMIAVDQLAA
Mb0710c|M.bovis_AF2122/97 ----------------IQLRDALRAALLAFNTFDESETIRHRKRMRVILQ
Rv0691c|M.tuberculosis_H37Rv ----------------IQLRDALRAALLAFNTFDESETIRHRKRMRVILQ
MLBr_00717|M.leprae_Br4923 ----------------PPAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYV
TH_4015|M.thermoresistible__bu ----------------PKNPYERILRANRTYLEAYRANRAIMIVWEQVAS
MAV_1948|M.avium_104 EPNVEGLSISERSAGLSKRAVATVTALAEAGAAQFRARGYRSTSVDDIVE
MAB_4027|M.abscessus_ATCC_1997 -------------------NASDFELHLRTVFTRLFDMLDNSPEIMQVIL
Mflv_0186|M.gilvum_PYR-GCK AVGMPASGIY-KYFSGKNDILAAIFRRASDRVSAETAEIVSTVPDPQEAL
Mvan_0719|M.vanbaalenii_PYR-1 AVGMPTSGIY-KYFSGKSDILATIFRRAADRVSAELASVVATMSDPEEAL
MSMEG_0815|M.smegmatis_MC2_155 AVGMPASGIY-RYFSGKADILAAGFRRAADRLSADMAEILAAGGEPEDVL
MMAR_1492|M.marinum_M TQQRFAAVQN-QFRRFGMDIIAASVRHAQDQG------------------
MUL_2448|M.ulcerans_Agy99 TQQRFAAVQN-QFRRFGMDIIAASVRHAQDQG------------------
Mb0710c|M.bovis_AF2122/97 TPELQAYSMT-MYAGWREVIAKFVARRSGGKT------------------
Rv0691c|M.tuberculosis_H37Rv TPELQAYSMT-MYAGWREVIAKFVARRSGGKT------------------
MLBr_00717|M.leprae_Br4923 GLGRSDPVLLGIDDEAKNRQMEHIMSRIGDVVS-----------------
TH_4015|M.thermoresistible__bu LNEHVEQLRREYSDRFAARIERAIIRWQEAGLA-----------------
MAV_1948|M.avium_104 AADVARGTFY-KYFSDKQDLLAAVAAEIYGAGIAFAERISDVDPVADEST
MAB_4027|M.abscessus_ATCC_1997 REGLLDTAMTKRMFGILDLIEAINVTIIEQAVMDG---------------
Mflv_0186|M.gilvum_PYR-GCK AAVIDAYVTRAFGQPEMESLYYSERLNMSPSDQRIVRDLQRSTVESWVEL
Mvan_0719|M.vanbaalenii_PYR-1 TAVIDGYVQRSFDQPELECVYYSERLNMSAADQRIVRDLQRSTVESWVEL
MSMEG_0815|M.smegmatis_MC2_155 AALIDDYVTRSFDRPELEHVYYTERLNMTPADQKILRDLQRSAVESWVNV
MMAR_1492|M.marinum_M ---------------------YGTELNPDHTAVAIALLFEN-----FTSV
MUL_2448|M.ulcerans_Agy99 ---------------------YGTELNPDHTAVAIALLFEN-----FTSV
Mb0710c|M.bovis_AF2122/97 ---------------------------TDFMPQTVAWTMLG--------V
Rv0691c|M.tuberculosis_H37Rv ---------------------------TDFMPQTVAWTMLG--------V
MLBr_00717|M.leprae_Br4923 ---------------------VVPESKLHPDIERDLRVIVHG----WLAF
TH_4015|M.thermoresistible__bu ----------------------DPAIDPRYAAAALSGMLSN------FAY
MAV_1948|M.avium_104 LRHWLATYVEFYDRYSGCIEAWAEGTTDDPMIVGIGEHGQVMMDVGAARM
MAB_4027|M.abscessus_ATCC_1997 ------------------------AITAAVDIPFLAHAITG--------L
Mflv_0186|M.gilvum_PYR-GCK VAAVRPDWTPGEARFAVHAAMALVIDVGRLVHYAASDEARDTVEGLVDAA
Mvan_0719|M.vanbaalenii_PYR-1 VVAVRPEWSAAEARFAVHAAMALVVDLGRLMRYENSEEARETVSGLVDMT
MSMEG_0815|M.smegmatis_MC2_155 VMPVRPHWSAGQARFAVHAAMALVIDLGRLMGYRNSEQARAVVSTMVDLV
MMAR_1492|M.marinum_M LVGTSGSSGP-----------------GGLGVTITDEDAITTLSRIWKKT
MUL_2448|M.ulcerans_Agy99 LVGTSGSSGP-----------------GGLGVTITDEDAITTLSRIWKKT
Mb0710c|M.bovis_AF2122/97 ALSAYEHWLR-----------------------DESVSLTEALGAAFDVV
Rv0691c|M.tuberculosis_H37Rv ALSAYEHWLR-----------------------DESVSLTEALGAAFDVV
MLBr_00717|M.leprae_Br4923 TFEVCRQRIMDPS------------TDADRLADSCAHALLDAIARVPEIS
TH_4015|M.thermoresistible__bu RWSVQDADYD---------------------LDTAAEQLSLLWANALGVR
MAV_1948|M.avium_104 LIRRPGPYPFDPLVSALILRALVTRVPQAALDLPEPIDADGVVDLLISCI
MAB_4027|M.abscessus_ATCC_1997 SMAATLKAIRG------------------ELEGDAREAYIGSFIQLVRTA
Mflv_0186|M.gilvum_PYR-GCK LRGSYRLRATLPSM-
Mvan_0719|M.vanbaalenii_PYR-1 LLGRYRLRATLPAK-
MSMEG_0815|M.smegmatis_MC2_155 LLGRYRLRTALPAR-
MMAR_1492|M.marinum_M LYGF-----------
MUL_2448|M.ulcerans_Agy99 LYGF-----------
Mb0710c|M.bovis_AF2122/97 GAGLDRLNQ------
Rv0691c|M.tuberculosis_H37Rv GAGLDRLNQ------
MLBr_00717|M.leprae_Br4923 KELADAMAIARQPPQ
TH_4015|M.thermoresistible__bu VPAHHEPAHA-----
MAV_1948|M.avium_104 KRGFFGLAS------
MAB_4027|M.abscessus_ATCC_1997 TTGSTPVANS-----