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AHSAEDNGIRRRPKDRKAQIARASAEAFSELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNL GQQLVDGTAGIDGDDPEVVLDRLVSALIDIALANRSSGGLYRWERRYLRGDDQAELLQQLRTVHHRLQTP VSILRPELTARQRSTLSTAVLSIVGSIVDHRAKLPAAQIHRVLTQVARAILSTELPDAAPPATPAPAAER IRSAAESSKYEALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIFRRASDRVSAE TAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSERLNMSPSDQRIVRDLQRSTVESWVELVAAVR PDWTPGEARFAVHAAMALVIDVGRLVHYAASDEARDTVEGLVDAALRGSYRLRATLPSM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0186 | - | - | 100% (410) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0013 | - | e-113 | 52.82% (390) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1640 | - | 7e-35 | 27.06% (388) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 5e-40 | 28.64% (391) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 5e-40 | 28.64% (391) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_02457 | - | 7e-07 | 30.69% (101) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 1e-16 | 26.34% (186) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 1e-111 | 54.91% (377) | putative regulatory protein |
| M. avium 104 | MAV_0110 | - | 1e-115 | 54.06% (394) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 1e-144 | 64.62% (407) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 2e-96 | 48.12% (399) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-110 | 54.64% (377) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 1e-176 | 77.02% (409) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ---------------MSAAG----SDAHRNGRHRPKNRKALIARASADAF
MMAR_5559|M.marinum_M ----MAGTDSGYGEVMSAASVSP-GAAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 ----MAGTDSGYGEVMSAASVSP-GAAADGIRRRPKDRKAQIARAAAESF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Mflv_0186|M.gilvum_PYR-GCK AGID-------GDDPEVVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------GDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAV_0110|M.avium_104 AFADDLP---ADADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVD---PAEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
Mvan_0719|M.vanbaalenii_PYR-1 DQATLLQQIHTVHHRIHRPLSALRPELTARQRSTLSTAALSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02457|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPPATPAPAAERIRSAAESSKYE
Mvan_0719|M.vanbaalenii_PYR-1 AKLPAAQVHALIAQISRAVLGAELS-ADPPRYP-PDVVPARPTAEPSKYE
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLP--ELPELGAAAAPATTPVVSAAKYE
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELP--TQRGRGSEPARAPTLTSAAGSYE
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLP--TPRRRRAPDPPPPRVTLAAGIYE
MMAR_5559|M.marinum_M ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MAB_4541|M.abscessus_ATCC_1997 ---------------------------MTNLIPESETPNKRERAKADRRD
MLBr_02457|M.leprae_Br4923 -------------------MAEHIP---AVAVKTDGRKRRWHQHKVERRN
:
Mb1998c|M.bovis_AF2122/97 TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Rv1963c|M.tuberculosis_H37Rv TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Mflv_0186|M.gilvum_PYR-GCK ALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIFR
Mvan_0719|M.vanbaalenii_PYR-1 ALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFR
MSMEG_0815|M.smegmatis_MC2_155 ALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFR
MAV_0110|M.avium_104 LLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYR
TH_2795|M.thermoresistible__bu CVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLR
MMAR_5559|M.marinum_M TLLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLR
MUL_3597|M.ulcerans_Agy99 TLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLR
MAB_4541|M.abscessus_ATCC_1997 QLLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLT
MLBr_02457|M.leprae_Br4923 ELVDGTIDAIRRQG-RFLSMDEIAGKIGVSKTVLYRYFIDKNDLTTAVMM
:: : .* ::. *:. . :*: * .* :
Mb1998c|M.bovis_AF2122/97 RLDEW-RCLECIRALRANQQAAQRLRGLVQGHVRISLDAPD----LVAVS
Rv1963c|M.tuberculosis_H37Rv RLDEW-RCLECIRALRANQQAAQRLRGLVQGHVRISLDAPD----LVAVS
Mflv_0186|M.gilvum_PYR-GCK RASDR-VSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPE----MESLY
Mvan_0719|M.vanbaalenii_PYR-1 RAADR-VSAELASVVATMSDPEEALTAVIDGYVQRSFDQPE----LECVY
MSMEG_0815|M.smegmatis_MC2_155 RAADR-LSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPE----LEHVY
MAV_0110|M.avium_104 RAADQ-LSADLSSILATSSDPEQALARLIEAYVTRSFANPE----LACVY
TH_2795|M.thermoresistible__bu RAVDR-TSQDLARITAATADPHTALTQLVRAYLDQFRERPA----LAYVQ
MMAR_5559|M.marinum_M RAADR-VSGQLSPIVGALTEPRQALTLLIDAYVATSFANPE----LAAVY
MUL_3597|M.ulcerans_Agy99 RAADR-VSGQLSPIVGALTEPRQALTLLIDAYVATSFANPE----LAAVY
MAB_4541|M.abscessus_ATCC_1997 DVSRR-LLEGGMTVAAAASSPAEALDGLIDFHLDFALNESD----LIRVQ
MLBr_02457|M.leprae_Br4923 RFAQTTLIPNMAAALSTNLDGFDLTREIIRVYVKTVAAEPEPYQFVMANS
: . :: :: . :
Mb1998c|M.bovis_AF2122/97 VTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAI
Rv1963c|M.tuberculosis_H37Rv VTELSHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAI
Mflv_0186|M.gilvum_PYR-GCK YSERLNMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAM
Mvan_0719|M.vanbaalenii_PYR-1 YSERLNMSAADQRIVRDLQRSTVESWVELVVAVRPEWSAAEARFAVHAAM
MSMEG_0815|M.smegmatis_MC2_155 YTERLNMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAM
MAV_0110|M.avium_104 YTERHNLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAF
TH_2795|M.thermoresistible__bu HTERRNLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAF
MMAR_5559|M.marinum_M YTERANLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAM
MUL_3597|M.ulcerans_Agy99 YTERANLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAM
MAB_4541|M.abscessus_ATCC_1997 DRDLDSLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAF
MLBr_02457|M.leprae_Br4923 SASKSKVIADSERIIARMLAVMIRRRMQEAG-MDAGGVEPWAYLIVGGVQ
. . . .
Mb1998c|M.bovis_AF2122/97 SFIEDVARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA------
Rv1963c|M.tuberculosis_H37Rv SFIEDVARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA------
Mflv_0186|M.gilvum_PYR-GCK ALVIDVGRLVHYAASD----EARDTVEGLVDAALRGSYRLRATLPSM---
Mvan_0719|M.vanbaalenii_PYR-1 ALVVDLGRLMRYENSE----EARETVSGLVDMTLLGRYRLRATLPAK---
MSMEG_0815|M.smegmatis_MC2_155 ALVIDLGRLMGYRNSE----QARAVVSTMVDLVLLGRYRLRTALPAR---
MAV_0110|M.avium_104 ALAVDIGRLVYPNTGA----PASTTVRRLMEVTVLGRPAAASRDGLRGAG
TH_2795|M.thermoresistible__bu ALVTDLGRLTDSHASP----SAQAAVQHLMEVVLLGG-------------
MMAR_5559|M.marinum_M ALVVDLGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPP
MUL_3597|M.ulcerans_Agy99 ALVVDLGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPP
MAB_4541|M.abscessus_ATCC_1997 GLMNSTPYSAGRSAPS----QTRTVLRQMVVAALRS--------------
MLBr_02457|M.leprae_Br4923 LATHSWMSDPRMSADELIDYLTMLSWNALCGIVEVGGSLEKFRKQPHPSP
. . : .
Mb1998c|M.bovis_AF2122/97 ----------------
Rv1963c|M.tuberculosis_H37Rv ----------------
Mflv_0186|M.gilvum_PYR-GCK ----------------
Mvan_0719|M.vanbaalenii_PYR-1 ----------------
MSMEG_0815|M.smegmatis_MC2_155 ----------------
MAV_0110|M.avium_104 RQRR------------
TH_2795|M.thermoresistible__bu ----------------
MMAR_5559|M.marinum_M GRRRRGSSNPGHVARR
MUL_3597|M.ulcerans_Agy99 GRRRRGSSNPGHVARR
MAB_4541|M.abscessus_ATCC_1997 ----------------
MLBr_02457|M.leprae_Br4923 IIPPRGP---------