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MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPWVRAFDRIGGPVYRDHMARTP LGPTTSGSVAVRRRPKDRKAQIARASAEAFSALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVL NLGQQLVDCTAFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNEDDQAALNAQMR TVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHRGKLPAGQIREVLGEIVESVLAADLPELPEL GAAAAPATTPVVSAAKYEALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFRRA ADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTERLNMTPADQKILRDLQRSAVESWV NVVMPVRPHWSAGQARFAVHAAMALVIDLGRLMGYRNSEQARAVVSTMVDLVLLGRYRLRTALPAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0815 | - | - | 100% (486) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0343 | - | 1e-15 | 32.65% (147) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4718 | - | 6e-13 | 29.25% (147) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 7e-37 | 30.59% (376) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 1e-144 | 64.62% (407) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 7e-37 | 30.59% (376) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00717 | - | 2e-07 | 25.93% (216) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 2e-13 | 27.84% (176) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 1e-111 | 51.44% (418) | putative regulatory protein |
| M. avium 104 | MAV_0110 | - | 1e-119 | 56.31% (396) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 1e-104 | 50.25% (394) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-111 | 51.20% (418) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 1e-150 | 66.10% (413) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ----------------MSAAGS---DAHRNGRHRPKNRKALIARASADAF
MMAR_5559|M.marinum_M -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAAT
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Mflv_0186|M.gilvum_PYR-GCK AGID-------GDDPEVVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------GDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAV_0110|M.avium_104 AFADDLPA---DADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVDP---AEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 NIPP----------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
Mvan_0719|M.vanbaalenii_PYR-1 DQATLLQQIHTVHHRIHRPLSALRPELTARQRSTLSTAALSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPPATPAPAAERIRSAAESSKYE
Mvan_0719|M.vanbaalenii_PYR-1 AKLPAAQVHALIAQISRAVLGAELS-ADPPRYP-PDVVPARPTAEPSKYE
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLP--ELPELGAAAAPATTPVVSAAKYE
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELP--TQRGRGSEPARAPTLTSAAGSYE
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLP--TPRRRRAPDPPPPRVTLAAGIYE
MMAR_5559|M.marinum_M ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MAB_4541|M.abscessus_ATCC_1997 ---------------------------MTNLIPESETPNKRERAKADRRD
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Rv1963c|M.tuberculosis_H37Rv TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Mflv_0186|M.gilvum_PYR-GCK ALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIFR
Mvan_0719|M.vanbaalenii_PYR-1 ALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFR
MSMEG_0815|M.smegmatis_MC2_155 ALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFR
MAV_0110|M.avium_104 LLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYR
TH_2795|M.thermoresistible__bu CVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLR
MMAR_5559|M.marinum_M TLLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLR
MUL_3597|M.ulcerans_Agy99 TLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLR
MAB_4541|M.abscessus_ATCC_1997 QLLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLT
MLBr_00717|M.leprae_Br4923 ---PAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGIDD
. :: . . * : . :*
Mb1998c|M.bovis_AF2122/97 RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
Rv1963c|M.tuberculosis_H37Rv RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
Mflv_0186|M.gilvum_PYR-GCK RASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSERL
Mvan_0719|M.vanbaalenii_PYR-1 RAADRVSAELASVVATMSDPEEALTAVIDGYVQRSFDQPELECVYYSERL
MSMEG_0815|M.smegmatis_MC2_155 RAADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTERL
MAV_0110|M.avium_104 RAADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTERH
TH_2795|M.thermoresistible__bu RAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTERR
MMAR_5559|M.marinum_M RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MUL_3597|M.ulcerans_Agy99 RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MAB_4541|M.abscessus_ATCC_1997 DVSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESDLIRVQDRDLD
MLBr_00717|M.leprae_Br4923 EAKNRQMEHIMSRIGD--------------------------VVSVVPES
:
Mb1998c|M.bovis_AF2122/97 HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Rv1963c|M.tuberculosis_H37Rv HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Mflv_0186|M.gilvum_PYR-GCK NMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAMALVID
Mvan_0719|M.vanbaalenii_PYR-1 NMSAADQRIVRDLQRSTVESWVELVVAVRPEWSAAEARFAVHAAMALVVD
MSMEG_0815|M.smegmatis_MC2_155 NMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVID
MAV_0110|M.avium_104 NLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVD
TH_2795|M.thermoresistible__bu NLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTD
MMAR_5559|M.marinum_M NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MUL_3597|M.ulcerans_Agy99 NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MAB_4541|M.abscessus_ATCC_1997 SLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMNS
MLBr_00717|M.leprae_Br4923 KLHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDADRLADSCAHALLDA
: * .* .:
Mb1998c|M.bovis_AF2122/97 VARTWHLT----RYAGVADEISGLALAILTSGAGNLLRA-----------
Rv1963c|M.tuberculosis_H37Rv VARTWHLT----RYAGVADEISGLALAILTSGAGNLLRA-----------
Mflv_0186|M.gilvum_PYR-GCK VGRLVHYA----ASDEARDTVEGLVDAALRGSYRLRATLPSM--------
Mvan_0719|M.vanbaalenii_PYR-1 LGRLMRYE----NSEEARETVSGLVDMTLLGRYRLRATLPAK--------
MSMEG_0815|M.smegmatis_MC2_155 LGRLMGYR----NSEQARAVVSTMVDLVLLGRYRLRTALPAR--------
MAV_0110|M.avium_104 IGRLVYPN----TGAPASTTVRRLMEVTVLG-RPAAASRDGLRGAGRQRR
TH_2795|M.thermoresistible__bu LGRLTDSH----ASPSAQAAVQHLMEVVLLG-G-----------------
MMAR_5559|M.marinum_M LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MUL_3597|M.ulcerans_Agy99 LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MAB_4541|M.abscessus_ATCC_1997 TPYSAGRS----APSQTRTVLRQMVVAALRS-------------------
MLBr_00717|M.leprae_Br4923 IARVPEIS-------------KELADAMAIARQPPQ--------------
: .
Mb1998c|M.bovis_AF2122/97 -----------
Rv1963c|M.tuberculosis_H37Rv -----------
Mflv_0186|M.gilvum_PYR-GCK -----------
Mvan_0719|M.vanbaalenii_PYR-1 -----------
MSMEG_0815|M.smegmatis_MC2_155 -----------
MAV_0110|M.avium_104 -----------
TH_2795|M.thermoresistible__bu -----------
MMAR_5559|M.marinum_M GSSNPGHVARR
MUL_3597|M.ulcerans_Agy99 GSSNPGHVARR
MAB_4541|M.abscessus_ATCC_1997 -----------
MLBr_00717|M.leprae_Br4923 -----------