For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ARTPDKLRRSGYAPAANHGVGRRGLHTRERILGSAAEVFLANGFHATSLDAIAKTAGASRATVYQYFAGK EEIFRELSALAERDVLAHGEHLGELGPTVDGVDALHRWLVAWADIYDAHAAVFAEFPGIGTATGLAVIDA SSAAAQFHQTVTDRLRRTRLRDLEADDAAAALGRIPHMVHLYRYRDMLPLPARATVTWSLTGALQLMLFP ETPADVLQVVAPARDGCARTTPRALDYAAATPAAVEASGSPIPQDVLSVSSALFAERGYYAIGMEEIAAA ADVSRATLYRYFSTKDKILAELTRRAVAEIEKHAAALPAKAADSLTEWMLGYVRFHRTYRGVIRAWFDGA VAEQLSNADVDHGIGAIFQAVAALLSTVDLPPGIDADVAGAVFVAVLGRMSEPTGASGPNSDEQAAELMV KLLRRSLLREA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2588 | - | - | 100% (432) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2650 | - | 2e-47 | 31.05% (438) | putative transcriptional regulator |
| M. avium 104 | MAV_1948 | - | 7e-45 | 28.31% (438) | putative transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3185c | - | 3e-08 | 37.35% (83) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0186 | - | 1e-16 | 26.85% (324) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3160c | - | 3e-08 | 37.35% (83) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 8e-07 | 32.26% (93) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2061c | - | 6e-09 | 38.10% (84) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 2e-15 | 26.70% (457) | putative regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 3e-15 | 27.84% (334) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 3e-14 | 27.41% (332) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-16 | 27.13% (457) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 6e-16 | 28.78% (337) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
Mb3185c|M.bovis_AF2122/97 --------------------------------------------------
Rv3160c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2588|M.avium_104 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 ------------------------------------------------MN
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MMAR_5559|M.marinum_M -MAGTDSG---YGEVMSAASVSPG-AAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 -MAGTDSG---YGEVMSAASVSPG-AAADGIRRRPKDRKAQIARAAAESF
TH_2795|M.thermoresistible__bu ---------------MSAAG----SDAHRNGRHRPKNRKALIARASADAF
Mb3185c|M.bovis_AF2122/97 -------------------------MPRQAGRWSP--TALRILGAAAELI
Rv3160c|M.tuberculosis_H37Rv -------------------------MPRQAGRWSP--TALRILGAAAELI
MAB_2061c|M.abscessus_ATCC_199 ---------------------------------MAGLRRKLLLEAAADLF
MAV_2588|M.avium_104 ----------MARTPDKLRRSGYAPAANHGVGRRGLHTRERILGSAAEVF
MLBr_00815|M.leprae_Br4923 NLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASDVF
: ::: :
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
Mb3185c|M.bovis_AF2122/97 ALRGYSSTSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLA--------
Rv3160c|M.tuberculosis_H37Rv ALRGYSSTSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLA--------
MAB_2061c|M.abscessus_ATCC_199 ARQGFHAVGIDDIGAAAGVSGPAVYRHFQNKDAILRELCDAAMTELLAGA
MAV_2588|M.avium_104 LANGFHATSLDAIAKTAGASRATVYQYFAGKEEIFRELSALAERDVLAHG
MLBr_00815|M.leprae_Br4923 VDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMN------
*: ... *. .* . ..:*:: * :
Mflv_0186|M.gilvum_PYR-GCK AGID----------------------GDDPEVVLDRLVSALIDIALANRS
Mvan_0719|M.vanbaalenii_PYR-1 AGIE----------------------GDDPQVVLDRLVSALTDTALANRG
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPEN---------------SEDAREQLRLLAAALTDTSLANRE
MMAR_5559|M.marinum_M QLDD----------------------SDDPAQLLDGLIASLIEVTLDNRL
MUL_3597|M.ulcerans_Agy99 QLDD----------------------SDDPAQLLARLIASLIEVTLDNRL
TH_2795|M.thermoresistible__bu DFGDDVDP------------------AEDPHGLLAALVDALINVTIANRT
Mb3185c|M.bovis_AF2122/97 --------------------------VEWPLELFGHITAMPVPAVVK---
Rv3160c|M.tuberculosis_H37Rv --------------------------VEWPLELFGHITAMPVPAVVK---
MAB_2061c|M.abscessus_ATCC_199 RRATT---------------------AGTPTEVLHALVDLHAAFGARRRG
MAV_2588|M.avium_104 EHLGELGPTVDGVDALHRWLVAWADIYDAHAAVFAEFPGIGTATGLAVID
MLBr_00815|M.leprae_Br4923 ----------------------------------NLVSSVQQALRTTTNN
.
Mflv_0186|M.gilvum_PYR-GCK SGGLYRWERRYLRGDDQAELLQQLRTVHHRLQTPVSILRPELTARQRSTL
Mvan_0719|M.vanbaalenii_PYR-1 SGGLYRWEGRYLRGDDQATLLQQIHTVHHRIHRPLSALRPELTARQRSTL
MSMEG_0815|M.smegmatis_MC2_155 SGGLYRWEARYLNEDDQAALNAQMRTVHHRIQRPLQQLRPELISRERWML
MMAR_5559|M.marinum_M SGGLYRWQSRYLRAEDQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWML
MUL_3597|M.ulcerans_Agy99 SGGLYRWQSRYLRAEDQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWML
TH_2795|M.thermoresistible__bu AGGLYRWEGRYLREPDRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTL
Mb3185c|M.bovis_AF2122/97 ---LHRWLTESLDHLHASPYVLVSILITPDLHQESFVAERELVAEMERAL
Rv3160c|M.tuberculosis_H37Rv ---LHRWLTESLDHLHASPYVLVSILITPDLHQESFVAERELVAEMERAL
MAB_2061c|M.abscessus_ATCC_199 LLAVYAREHRSLSPLATRALRRRQHSYESFWVEALVRARGDLDRERAQGL
MAV_2588|M.avium_104 ASSAAAQFHQTVTDRLRRTRLRDLEADDAAAALGRIPHMVHLYRYRDMLP
MLBr_00815|M.leprae_Br4923 RQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPRVAAQVRVATESCIDA
. :
Mflv_0186|M.gilvum_PYR-GCK STAVLSIVGSIVDHRAKLPAAQIHRVLTQVARAILSTELPDAAPPATPAP
Mvan_0719|M.vanbaalenii_PYR-1 STAALSIVGSIVDHRAKLPAAQVHALIAQISRAVLGAELS-ADPPRYP-P
MSMEG_0815|M.smegmatis_MC2_155 STATLSVIGSVVDHRGKLPAGQIREVLGEIVESVLAADLP--ELPELGAA
MMAR_5559|M.marinum_M SAGVLSVIGSIVDHPARLAADEIRALLGEAASAIVCAELP--EPGDVAVR
MUL_3597|M.ulcerans_Agy99 SAGVLSVIGSIVDHPARLAADEIRALLGEAASAIVCAELP--EPGDVAVR
TH_2795|M.thermoresistible__bu TASALSAIGSIADHSAPLSVPGIRSFLASVVEDLLAADLP--TPRRRRAP
Mb3185c|M.bovis_AF2122/97 VGLIETGQG----------EGDVRAMHPLSAARLVQALFD----------
Rv3160c|M.tuberculosis_H37Rv VGLIETGQG----------EGDVRAMHPLSAARLVQALFD----------
MAB_2061c|M.abscessus_ATCC_199 VAAVLSLLN---------------------ASAYMPASLD----------
MAV_2588|M.avium_104 LPARATVTWSLTGALQLMLFPETPADVLQVVAPARDGCARTTPRALDYAA
MLBr_00815|M.leprae_Br4923 VFALISADSRLDPHRARMVAVGLVGISVDCARYWLDTNRP----------
:
Mflv_0186|M.gilvum_PYR-GCK AAERIRSAAESSKYEALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIY
Mvan_0719|M.vanbaalenii_PYR-1 DVVPARPTAEPSKYEALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIY
MSMEG_0815|M.smegmatis_MC2_155 AAPATTPVVSAAKYEALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIY
MMAR_5559|M.marinum_M KASWRIFAEDASVYETLLHASMVLFKDRGYAQTSMAQIASASGVPVSGIY
MUL_3597|M.ulcerans_Agy99 KASWRIFAEDASVYETLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIY
TH_2795|M.thermoresistible__bu DPPPPRVTLAAGIYECVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIY
Mb3185c|M.bovis_AF2122/97 ----------------------------------------ALALPEFAVS
Rv3160c|M.tuberculosis_H37Rv ----------------------------------------ALALPEFAVS
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2588|M.avium_104 ATPAAVEASGSPIPQDVLSVSSALFAERGYYAIGMEEIAAAADVSRATLY
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK KYFSGKNDILAAIFRRASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRA
Mvan_0719|M.vanbaalenii_PYR-1 KYFSGKSDILATIFRRAADRVSAELASVVATMSDPEEALTAVIDGYVQRS
MSMEG_0815|M.smegmatis_MC2_155 RYFSGKADILAAGFRRAADRLSADMAEILAAGGEPEDVLAALIDDYVTRS
MMAR_5559|M.marinum_M RYFSGKCEILATGLRRAADRVSGQLSPIVGALTEPRQALTLLIDAYVATS
MUL_3597|M.ulcerans_Agy99 RYFSGKCEILATGLRRAADRVSGQLSPIVGALTEPRQALTLLIDAYVATS
TH_2795|M.thermoresistible__bu RYFPGKADILAASLRRAVDRTSQDLARITAATADPHTALTQLVRAYLDQF
Mb3185c|M.bovis_AF2122/97 ----------------------------------PDEIVEFAMTALLSDP
Rv3160c|M.tuberculosis_H37Rv ----------------------------------PDEIVEFAMTALLSDP
MAB_2061c|M.abscessus_ATCC_199 -------------------------------------------DATIEAM
MAV_2588|M.avium_104 RYFSTKDKILAELTRRAVAEIEKHAAALP---AKAADSLTEWMLGYVRFH
MLBr_00815|M.leprae_Br4923 ----------------------------------------------ISKS
:
Mflv_0186|M.gilvum_PYR-GCK FGQPEMESLYYSERLNMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPG
Mvan_0719|M.vanbaalenii_PYR-1 FDQPELECVYYSERLNMSAADQRIVRDLQRSTVESWVELVVAVRPEWSAA
MSMEG_0815|M.smegmatis_MC2_155 FDRPELEHVYYTERLNMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAG
MMAR_5559|M.marinum_M FANPELAAVYYTERANLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSAT
MUL_3597|M.ulcerans_Agy99 FANPELAAVYYTERANLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSAT
TH_2795|M.thermoresistible__bu RERPALAYVQHTERRNLPESEARVVERIEQSLVDSWARLVTEQRPELTVA
Mb3185c|M.bovis_AF2122/97 DRLAEIRAAADALEIQTAPPDRGL--------------------------
Rv3160c|M.tuberculosis_H37Rv DRLAEIRAAADALEIQTAPPDRGL--------------------------
MAB_2061c|M.abscessus_ATCC_199 LAAAAVAALFSRAVTQQVDGAPHRI-------------------------
MAV_2588|M.avium_104 RTYRGVIRAWFDGAVAEQLSNADVDHGIGAIFQAVAALLSTVDLPPGIDA
MLBr_00815|M.leprae_Br4923 DAVEGTVQFAWGGLSHVPLTRL----------------------------
Mflv_0186|M.gilvum_PYR-GCK EARFAVHAAMALVIDVGRLVHYAASD----EARDTVEGLVDAALRG----
Mvan_0719|M.vanbaalenii_PYR-1 EARFAVHAAMALVVDLGRLMRYENSE----EARETVSGLVDMTLLG----
MSMEG_0815|M.smegmatis_MC2_155 QARFAVHAAMALVIDLGRLMGYRNSE----QARAVVSTMVDLVLLG----
MMAR_5559|M.marinum_M RARFLVHAAMALVVDLGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPA
MUL_3597|M.ulcerans_Agy99 RARFLVHAAMALVVDLGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPA
TH_2795|M.thermoresistible__bu TARYAVYCAFALVTDLGRLTDSHASP----SAQAAVQHLMEVVLLGG---
Mb3185c|M.bovis_AF2122/97 --------------------------------------------------
Rv3160c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2588|M.avium_104 DVAGAVFVAVLGRMSEPTGASGPNSD---EQAAELMVKLLRRSLLREA--
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK -----------SYRLRATLPSM----
Mvan_0719|M.vanbaalenii_PYR-1 -----------RYRLRATLPAK----
MSMEG_0815|M.smegmatis_MC2_155 -----------RYRLRTALPAR----
MMAR_5559|M.marinum_M QADAAPPPPPGRRRRGSSNPGHVARR
MUL_3597|M.ulcerans_Agy99 QADAAPPPPPGRRRRGSSNPGHVARR
TH_2795|M.thermoresistible__bu --------------------------
Mb3185c|M.bovis_AF2122/97 --------------------------
Rv3160c|M.tuberculosis_H37Rv --------------------------
MAB_2061c|M.abscessus_ATCC_199 --------------------------
MAV_2588|M.avium_104 --------------------------
MLBr_00815|M.leprae_Br4923 --------------------------