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VASTADDHGIRRRPKDRKAQIARASAEAFSALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLN LGQQLVDGTAGIEGDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGDDQATLLQQIHTVHHRIHR PLSALRPELTARQRSTLSTAALSIVGSIVDHRAKLPAAQVHALIAQISRAVLGAELSADPPRYPPDVVPA RPTAEPSKYEALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFRRAADRVSAEL ASVVATMSDPEEALTAVIDGYVQRSFDQPELECVYYSERLNMSAADQRIVRDLQRSTVESWVELVVAVRP EWSAAEARFAVHAAMALVVDLGRLMRYENSEEARETVSGLVDMTLLGRYRLRATLPAK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | - | 100% (408) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | 3e-40 | 31.84% (380) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3985 | - | 2e-32 | 27.88% (391) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 1e-35 | 27.53% (385) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 1e-176 | 77.02% (409) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 1e-35 | 27.53% (385) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00815 | - | 4e-06 | 33.87% (62) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 5e-15 | 29.11% (158) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 1e-109 | 52.22% (406) | putative regulatory protein |
| M. avium 104 | MAV_0110 | - | 1e-115 | 54.71% (393) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 1e-150 | 66.10% (413) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 1e-100 | 49.36% (391) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-109 | 51.97% (406) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ---------------MSAAG----SDAHRNGRHRPKNRKALIARASADAF
MMAR_5559|M.marinum_M ----MAGTDSGYGEVMSAASVSP-GAAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 ----MAGTDSGYGEVMSAASVSP-GAAADGIRRRPKDRKAQIARAAAESF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------GDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGD
Mflv_0186|M.gilvum_PYR-GCK AGID-------GDDPEVVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAV_0110|M.avium_104 AFADDLP---ADADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVD---PAEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Mvan_0719|M.vanbaalenii_PYR-1 DQATLLQQIHTVHHRIHRPLSALRPELTARQRSTLSTAALSIVGSIVDHR
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 -------------------------------------------------M
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Mvan_0719|M.vanbaalenii_PYR-1 AKLPAAQVHALIAQISRAVLGAELS-ADPPRYP-PDVVPARPTAEPSKYE
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPPATPAPAAERIRSAAESSKYE
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLP--ELPELGAAAAPATTPVVSAAKYE
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELP--TQRGRGSEPARAPTLTSAAGSYE
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLP--TPRRRRAPDPPPPRVTLAAGIYE
MMAR_5559|M.marinum_M ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MAB_4541|M.abscessus_ATCC_1997 ---------------------------MTNLIPESETPNKRERAKADRRD
MLBr_00815|M.leprae_Br4923 NNLAKAAQRRTVRPIDRGRLSDDIA---------TPNQRSNRLSRDKRRG
Mb1998c|M.bovis_AF2122/97 TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Rv1963c|M.tuberculosis_H37Rv TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Mvan_0719|M.vanbaalenii_PYR-1 ALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFR
Mflv_0186|M.gilvum_PYR-GCK ALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIFR
MSMEG_0815|M.smegmatis_MC2_155 ALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFR
MAV_0110|M.avium_104 LLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYR
TH_2795|M.thermoresistible__bu CVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLR
MMAR_5559|M.marinum_M TLLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLR
MUL_3597|M.ulcerans_Agy99 TLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLR
MAB_4541|M.abscessus_ATCC_1997 QLLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLT
MLBr_00815|M.leprae_Br4923 QLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLE
:* . :: .*: . ::. *:. . :*: *..* :
Mb1998c|M.bovis_AF2122/97 RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
Rv1963c|M.tuberculosis_H37Rv RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
Mvan_0719|M.vanbaalenii_PYR-1 RAADRVSAELASVVATMSDPEEALTAVIDGYVQRSFDQPELECVYYSERL
Mflv_0186|M.gilvum_PYR-GCK RASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSERL
MSMEG_0815|M.smegmatis_MC2_155 RAADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTERL
MAV_0110|M.avium_104 RAADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTERH
TH_2795|M.thermoresistible__bu RAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTERR
MMAR_5559|M.marinum_M RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MUL_3597|M.ulcerans_Agy99 RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MAB_4541|M.abscessus_ATCC_1997 DVSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESDLIRVQDRDLD
MLBr_00815|M.leprae_Br4923 RHMNNLVSSVQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDN
: . * : .. : :
Mb1998c|M.bovis_AF2122/97 HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Rv1963c|M.tuberculosis_H37Rv HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Mvan_0719|M.vanbaalenii_PYR-1 NMSAADQRIVRDLQRSTVESWVELVVAVRPEWSAAEARFAVHAAMALVVD
Mflv_0186|M.gilvum_PYR-GCK NMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAMALVID
MSMEG_0815|M.smegmatis_MC2_155 NMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVID
MAV_0110|M.avium_104 NLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVD
TH_2795|M.thermoresistible__bu NLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTD
MMAR_5559|M.marinum_M NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MUL_3597|M.ulcerans_Agy99 NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MAB_4541|M.abscessus_ATCC_1997 SLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMNS
MLBr_00815|M.leprae_Br4923 ITEPRVAAQVRVATESCIDAVFALIS-ADSRLDPHRARMVAVGLVGISVD
: .* . ..: .
Mb1998c|M.bovis_AF2122/97 VARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA-----------
Rv1963c|M.tuberculosis_H37Rv VARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA-----------
Mvan_0719|M.vanbaalenii_PYR-1 LGRLMRYENSE----EARETVSGLVDMTLLGRYRLRATLPAK--------
Mflv_0186|M.gilvum_PYR-GCK VGRLVHYAASD----EARDTVEGLVDAALRGSYRLRATLPSM--------
MSMEG_0815|M.smegmatis_MC2_155 LGRLMGYRNSE----QARAVVSTMVDLVLLGRYRLRTALPAR--------
MAV_0110|M.avium_104 IGRLVYPNTGA----PASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR-
TH_2795|M.thermoresistible__bu LGRLTDSHASP----SAQAAVQHLMEVVLLGG------------------
MMAR_5559|M.marinum_M LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MUL_3597|M.ulcerans_Agy99 LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MAB_4541|M.abscessus_ATCC_1997 TPYSAGRSAPS----QTRTVLRQMVVAALRS-------------------
MLBr_00815|M.leprae_Br4923 CARYWLDTNRP---ISKSDAVEGTVQFAWGGLSHVPLTRL----------
: .
Mb1998c|M.bovis_AF2122/97 -----------
Rv1963c|M.tuberculosis_H37Rv -----------
Mvan_0719|M.vanbaalenii_PYR-1 -----------
Mflv_0186|M.gilvum_PYR-GCK -----------
MSMEG_0815|M.smegmatis_MC2_155 -----------
MAV_0110|M.avium_104 -----------
TH_2795|M.thermoresistible__bu -----------
MMAR_5559|M.marinum_M GSSNPGHVARR
MUL_3597|M.ulcerans_Agy99 GSSNPGHVARR
MAB_4541|M.abscessus_ATCC_1997 -----------
MLBr_00815|M.leprae_Br4923 -----------