For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
EQLVAQEPPRRGRPPVSGLADRRRQQIVDAAFAAFTENGYEQTSMSDIATRAGMGQGTVYRYVESKREVL DLVFDYGVERLVDTLALDDFLEVVGGTAGIEERNDIIMEGGRRLYALVDQEPALLKLLTVQSAAADKELK QRVLGIQSMLDSYVQRGLESGRRAGWLPEDAHNQAVLARLLPALVLPGFLLAQSRHDNPSTRERFVTTAS LIAEKGILRDGVVLEPGEGRVAGETVDSVHVPLPAAADRRNELLDAALTCFLSDGYHAVGVNEIVEKLGV SHGTFYNYYQNKRDLLDALMVREFSAMEPALSRSVARLDARRDIEHALAQGFRNALEAVAARLPALIFVC TEAAGVDPEALQSIIQFFRFASVRSEQSVFSMIGADRINPAMDTEFLGQAFVSLLVGAVTLVVDDDGRTD RVDEYAQAITQFLLYGLNPVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4046c | - | - | 100% (442) | TetR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1525c | - | 1e-19 | 33.68% (190) | TetR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4946 | - | 1e-17 | 30.73% (192) | putative transcriptional regulator, TetR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3233 | - | 2e-09 | 25.26% (194) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1640 | - | 4e-14 | 27.06% (303) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3208 | - | 2e-09 | 25.26% (194) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 2e-09 | 26.50% (200) | putative TetR-family transcriptional regulator |
| M. marinum M | MMAR_1350 | - | 3e-10 | 26.80% (194) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2650 | - | 4e-10 | 23.78% (328) | putative transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1935 | - | 3e-09 | 24.65% (215) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4573 | - | 2e-09 | 26.18% (191) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2529 | - | 2e-10 | 26.80% (194) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3985 | - | 2e-10 | 25.75% (334) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1350|M.marinum_M --------------------------------------------------
MUL_2529|M.ulcerans_Agy99 --------------------------------------------------
Mb3233|M.bovis_AF2122/97 --------------------------------------------------
Rv3208|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MSMEG_1935|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4046c|M.abscessus_ATCC_199 --------------------MEQLVAQEPPRRGRPPVSGLADRRRQQIVD
Mflv_1640|M.gilvum_PYR-GCK ------------------------MPQPVRQQARTSVR------KQQLSQ
Mvan_3985|M.vanbaalenii_PYR-1 MATRIRGDRAIGCRVSRSHGAAEEGAEGVTSVARPERGTRPSNRRELIGA
MAV_2650|M.avium_104 ------------------MSEASIVRRASYGPSSPAVGARGANTRGRIAE
TH_4573|M.thermoresistible__bu --------------------------------------------------
MMAR_1350|M.marinum_M --------------------------------------------------
MUL_2529|M.ulcerans_Agy99 --------------------------------------------------
Mb3233|M.bovis_AF2122/97 --------------------------------------------------
Rv3208|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MSMEG_1935|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4046c|M.abscessus_ATCC_199 AAFAAFTENGYEQTSMSDIATRAGMGQGTVYRYVESKREVLDLVF--DYG
Mflv_1640|M.gilvum_PYR-GCK AAARLFTDRGYHNVSMDDIASAVGLTGPALYRHFRKKHDILMQVISEQLG
Mvan_3985|M.vanbaalenii_PYR-1 AATELFCTRGYEHVGMGDIAEAVAVGPSALYRHFAGKQELLDFVVAGCLG
MAV_2650|M.avium_104 VSLELFGRVGYFDTSVDAIAKAAGVSRATLYQYFKGKDEIFLELLNECGS
TH_4573|M.thermoresistible__bu --------------------------------------------------
MMAR_1350|M.marinum_M --------------------------------------------------
MUL_2529|M.ulcerans_Agy99 --------------------------------------------------
Mb3233|M.bovis_AF2122/97 --------------------------------------------------
Rv3208|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MSMEG_1935|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4046c|M.abscessus_ATCC_199 VERLVDTLALDDFLEVV---------GGTAGIEERNDIIMEGGRRLYALV
Mflv_1640|M.gilvum_PYR-GCK AVEAVAARAVDAGPTDE---------RAEVFLAALADLLLEREQVLLWKR
Mvan_3985|M.vanbaalenii_PYR-1 S----ATALVDSVDLED---------FDLSLLRAAEVSVSNRYTGILLGR
MAV_2650|M.avium_104 ALFRVARRIGPLGPDEVGFDNLNWWLGEWSWVFDKYSTMFVQWTAIASSD
TH_4573|M.thermoresistible__bu --------------------------------------------------
MMAR_1350|M.marinum_M ------------------------------MSDLAKAAQHRAVRSADRVR
MUL_2529|M.ulcerans_Agy99 ------------------------------MSDLAKAAQHRAVRSADRVR
Mb3233|M.bovis_AF2122/97 ------------------------------MSDLAKTAQRRALRSSGSAR
Rv3208|M.tuberculosis_H37Rv ------------------------------MSDLAKTAQRRALRSSGSAR
MLBr_00815|M.leprae_Br4923 ------------------------------MNNLAKAAQRRTVRPIDRGR
MSMEG_1935|M.smegmatis_MC2_155 ------------------------------MSDLANTAERRGEKRPAGG-
MAB_4046c|M.abscessus_ATCC_199 DQEPALLKLLTVQSAAADKELKQ--RVLGIQSMLDSYVQRGLESGRRAGW
Mflv_1640|M.gilvum_PYR-GCK ERRQLAEEAQRQCRLKLSDVLRLSSQALGLTSGEKPSGQAELRTWAVLGI
Mvan_3985|M.vanbaalenii_PYR-1 EARHLAAGAQARLRVAVRHLIGRIAALLAVLRPDLDKDAADLMAWSVVGI
MAV_2650|M.avium_104 TKVRPEITRFVRGYNHRLAERLAGSGLNGLDPEVAAMAMTALVHRINLFV
TH_4573|M.thermoresistible__bu ------------------------------MATQRATAD-----------
MMAR_1350|M.marinum_M STEGA--------------------TPKARGNRLPRD-------------
MUL_2529|M.ulcerans_Agy99 STEGA--------------------TPKARGNRLPRD-------------
Mb3233|M.bovis_AF2122/97 PDEDVP-------------------APNRRGNRLPRD-------------
Rv3208|M.tuberculosis_H37Rv PDEDVP-------------------APNRRGNRLPRD-------------
MLBr_00815|M.leprae_Br4923 LSDDIA-------------------TPNQRSNRLSRD-------------
MSMEG_1935|M.smegmatis_MC2_155 ---------------------------NRRGNRLPRD-------------
MAB_4046c|M.abscessus_ATCC_199 LPEDAHNQAVLARLLPALVLPGFLLAQSRHDNPSTRERFVTTASLIAEKG
Mflv_1640|M.gilvum_PYR-GCK YSSVAPIRN---------------RVENATAKRLLRAAALNILGCELDTG
Mvan_3985|M.vanbaalenii_PYR-1 VLSPAFSQS---------------DLSDREQARLLAQLIGGILTAEAPVG
MAV_2650|M.avium_104 HTDRAYGRSAKDAVDTLSVFLQLMLFPDTPRSVLRSLSLHASTDPAADID
TH_4573|M.thermoresistible__bu -------------------------VEEQHES------------------
.
MMAR_1350|M.marinum_M -------------------------------ERRGQLLIVASDVFVDRGY
MUL_2529|M.ulcerans_Agy99 -------------------------------ERRGQLLIVASDVFVDRGY
Mb3233|M.bovis_AF2122/97 -------------------------------ERRGQLLVVASDVFVDRGY
Rv3208|M.tuberculosis_H37Rv -------------------------------ERRGQLLVVASDVFVDRGY
MLBr_00815|M.leprae_Br4923 -------------------------------KRRGQLLIVASDVFVDHGY
MSMEG_1935|M.smegmatis_MC2_155 -------------------------------ERRGQLLIAASEVFVDRGY
MAB_4046c|M.abscessus_ATCC_199 ILRDGVVLEPGEGRVAGETVDSVHVPLPAAADRRNELLDAALTCFLSDGY
Mflv_1640|M.gilvum_PYR-GCK ----------------LPRSATPVTHRRQPPGRRERILSTAGRLFHAQSY
Mvan_3985|M.vanbaalenii_PYR-1 ---------------YTIERRRRERTGLLPRSRREALLQEAIRLFAERRY
MAV_2650|M.avium_104 ALKAPPAPDIAG----LSISERTTSLSKRAVTTVNALADAGAAQFRARGY
TH_4573|M.thermoresistible__bu -------------------------------DRRDQILEAANACFAQLGI
: . *
MMAR_1350|M.marinum_M HAAGMDEIAERAGVSKPVLYQHFSSKLELYLAVLNRHVDK-LVAGVQQAL
MUL_2529|M.ulcerans_Agy99 HAAGMDEIAERAGVSKPVLYQHFSSKLELYLAVLNRHVDK-LVAGVQQAL
Mb3233|M.bovis_AF2122/97 HAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVEN-LVSGVHQAL
Rv3208|M.tuberculosis_H37Rv HAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVEN-LVSGVHQAL
MLBr_00815|M.leprae_Br4923 HAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNN-LVSSVQQAL
MSMEG_1935|M.smegmatis_MC2_155 HAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLQRHVDN-LVSGVRQAL
MAB_4046c|M.abscessus_ATCC_199 HAVGVNEIVEKLGVSHGTFYNYYQNKRDLLDALMVREFSA-MEPALSRSV
Mflv_1640|M.gilvum_PYR-GCK HAVGIEEIAAESDTAIATFYQYFNGKGELLHALLNRGAEG-LHYVTNHRL
Mvan_3985|M.vanbaalenii_PYR-1 ASVGIEDVAASLGMAGPSVYNHFDTKMDLLVTALNRGAAY-LYMQASDGL
MAV_2650|M.avium_104 RSTSVDDIVEAANVARGTFYKYFSDKQDLLAAVAAEIYGAGTAFAHRIAD
TH_4573|M.thermoresistible__bu HRTSVQDVARAANVSRGTVYRYFEDRTILIEAAIEYGAQK-FYQEIAAAM
..::::. . : .*.::. : * :
MMAR_1350|M.marinum_M RTTTDNRGRLYAAVQAFFDFIEHDSQGY-RLIFEN------DYVTEPEVA
MUL_2529|M.ulcerans_Agy99 RTTTDNRGRLYAAVQAFFDFIEHDSQGY-RLIFEN------DYVTEPEVA
Mb3233|M.bovis_AF2122/97 STTTDNRQRLHVAVQAFFDFIEHDSQGY-RLIFEN------DFVTEPEVA
Rv3208|M.tuberculosis_H37Rv STTTDNRQRLHVAVQAFFDFIEHDSQGY-RLIFEN------DFVTEPEVA
MLBr_00815|M.leprae_Br4923 RTTTNNRQRLHAAVQAFFDFIEHDGQGY-RLIFEN------DNITEPRVA
MSMEG_1935|M.smegmatis_MC2_155 RTTTDNRQRLRAAVEAFFDFIEHDSQGY-RLIFEN------DYVTEPQVA
MAB_4046c|M.abscessus_ATCC_199 ARLDARRDIEHALAQGFRNALEAVAARLPALIFVCTEAAGVDPEALQSII
Mflv_1640|M.gilvum_PYR-GCK ASAATAQDALDTVASTLIELALGPHQPILAILAAD-------LVYLPDAA
Mvan_3985|M.vanbaalenii_PYR-1 AASDSAQDALSGLVASYVEFALTHPALVDLLVTEVR--------NLPEPH
MAV_2650|M.avium_104 VDPVAKKSTLRHWLRTYVEFYDRYSGCIEAWVEGAT--------DDPTIV
TH_4573|M.thermoresistible__bu AKKSTLAEQLGAMAETHAKILLDHRTRNRLMTDDA--------ELMRHMI
.
MMAR_1350|M.marinum_M AQVRVATES--CIDAVFALISADSGLDPHRARMIAVALVSMSVDCARYWL
MUL_2529|M.ulcerans_Agy99 AQVRVATES--CIDAVFALISADSGLDPHRARMIAVALVSMSVDCARYWL
Mb3233|M.bovis_AF2122/97 AQVRVATES--CIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWL
Rv3208|M.tuberculosis_H37Rv AQVRVATES--CIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWL
MLBr_00815|M.leprae_Br4923 AQVRVATES--CIDAVFALISADSRLDPHRARMVAVGLVGISVDCARYWL
MSMEG_1935|M.smegmatis_MC2_155 AQVKVATEA--CTDAVFDLISRDSGLEAHRARMIAVGLVAISVDSARYWL
MAB_4046c|M.abscessus_ATCC_199 QFFRFASVR--SEQSVFSMIGADRINPAMDTEFLGQAFVSLLVGAVTLVV
Mflv_1640|M.gilvum_PYR-GCK RELIRMSEREYTDEWVAALVGVCPELTPPHARLLARAAIGLITDIT----
Mvan_3985|M.vanbaalenii_PYR-1 RDAALTAQRDYVEEWVHLLRQCHPDRARSAARLQVQAVLSLVNLVARVP-
MAV_2650|M.avium_104 SIGENGQVQ--MDIGAARMLIRGPGRYPFDPVVSALILRALVTRVPQAAL
TH_4573|M.thermoresistible__bu ADADAAVRR--TTEFLMPYVQQAKERGEVGSGVDVKAASEWLARIIYSFT
. .
MMAR_1350|M.marinum_M DSD-RPISKSDAIEGTVQFAWGGLSHVPLARS-
MUL_2529|M.ulcerans_Agy99 DSD-RPISKSDAIEGTVQFAWGGLSHVPLARS-
Mb3233|M.bovis_AF2122/97 DAD-KPISKSDAVEGTVQFAWGGLSHVPLTRS-
Rv3208|M.tuberculosis_H37Rv DAD-KPISKSDAVEGTVQFAWGGLSHVPLTRS-
MLBr_00815|M.leprae_Br4923 DTN-RPISKSDAVEGTVQFAWGGLSHVPLTRL-
MSMEG_1935|M.smegmatis_MC2_155 NND-RPIDKDSAVEGTVQFAWGGLSHVPLTRS-
MAB_4046c|M.abscessus_ATCC_199 DDDGRTDRVDEYAQAITQFLLYGLNPVP-----
Mflv_1640|M.gilvum_PYR-GCK -----QIQKMRMRPGIATELHQLVNAVLAA---
Mvan_3985|M.vanbaalenii_PYR-1 -----HLQATRATAGAVAEMGRHLLAVPPASSA
MAV_2650|M.avium_104 DLP-EPIDADELVDVLMTCINRGFFGRAK----
TH_4573|M.thermoresistible__bu TVN-EGLTFDMSKPATVRRYVERFAVNGLR---
.