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TDTATETLVQFDLLIGGESSSAASGLTYDSVDPFTGRPWARVPNAAAADVDRAVGAARAALNGPWGALTA TARGKLLHRLGEIIAREADQLAELEVRDGGKLVREMVGQMRSLPDYYFYYGGLADKLQGDVIPVDKPNYF VYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPTSTLAFAKLFAEAGFPPGVINVV TGWGPETGAALASHPGVDKVAFTGSTATGIHVGKAAIENMTRFSLELGGKSAQVVFADADLDAAANGVIA GVFAATGQTCLAGSRLLVDRSVADALVEKIVARAATIKLGDPKDPTTEMGPVSNLPQYEKVLSHFASARE QGATVAYGGEPASDLGGFFVKPTVLTGVDPSMRAVAEEIFGPVLAVMTFEDEDEAVAAANGTEFGLAAAV WTKDVHRAHRVAAKLRAGTVWVNAYRVVAPHVPFGGIGYSGIGRENGIDAVKDFTETKAVWVELSGETRD PFTLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2608 | - | - | 100% (496) | aldehyde dehydrogenase family protein |
| M. avium 104 | MAV_1897 | - | 0.0 | 86.83% (501) | betaine-aldehyde dehydrogenase |
| M. avium 104 | MAV_2765 | - | 3e-99 | 41.68% (463) | P-cumic aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 2e-90 | 39.51% (486) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3083 | - | 1e-101 | 42.83% (481) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 2e-90 | 39.51% (486) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-58 | 31.02% (461) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 2e-94 | 42.22% (469) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-100 | 41.86% (485) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6297 | - | 1e-128 | 46.41% (487) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3419 | - | 9e-98 | 43.37% (475) | PUTATIVE putative aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 2e-99 | 41.65% (485) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 1e-95 | 41.22% (490) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0467|M.bovis_AF2122/97 ------MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
Rv0458|M.tuberculosis_H37Rv ------MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
MAV_2608|M.avium_104 -------MTDTATET-------LVQFDLLIGGESSSAASGLTYDSVDPFT
MSMEG_6297|M.smegmatis_MC2_155 MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSYEPRS
MMAR_2875|M.marinum_M -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
MUL_2877|M.ulcerans_Agy99 -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
Mvan_0014|M.vanbaalenii_PYR-1 -------------------MSDIPHYRMYIDGAWRDAAD--TIEVRSPAT
Mflv_3083|M.gilvum_PYR-GCK ---------------------MDGDPDLCIGGAWRHACDGGTRDIINPAN
TH_3419|M.thermoresistible__bu --------------VQRTLPDKLPAPRLVIGGGDVISTSGGVYEHHYAAT
MAB_3328|M.abscessus_ATCC_1997 ----------------------MSVPSSWINGR-PVATHGDTHRVINPAT
MLBr_02573|M.leprae_Br4923 ----------------------------------------MSIATINPAT
.
Mb0467|M.bovis_AF2122/97 GQPFCEVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRI
Rv0458|M.tuberculosis_H37Rv GQPFCEVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRI
MAV_2608|M.avium_104 GRPWARVPNAAAADVDRAVGAARAALN-GPWGALTATARGKLLHRLGEII
MSMEG_6297|M.smegmatis_MC2_155 GRVWARLPRANSTDIDRAVRAARAAFE-GPWGAVSPADRGRFLMKIAAVV
MMAR_2875|M.marinum_M ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
MUL_2877|M.ulcerans_Agy99 ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
Mvan_0014|M.vanbaalenii_PYR-1 GELVATVAYGGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNL
Mflv_3083|M.gilvum_PYR-GCK GAVAAVVDEATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLL
TH_3419|M.thermoresistible__bu GGVQAEVPLAGPAEVDAAVAAARAAFP--AWRDLDLNRRRDILQELARRL
MAB_3328|M.abscessus_ATCC_1997 GEAVADLKLATTADVDAAVAAARAAGP--AWASSTPVDRSSVLAKLAAVL
MLBr_02573|M.leprae_Br4923 GETVKTFTPTTQDEVEDAIARAYARFD--NYRHTTFTQRAKWANATADLL
. *: * * : *
Mb0467|M.bovis_AF2122/97 DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEG-ALS
Rv0458|M.tuberculosis_H37Rv DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEG-ALS
MAV_2608|M.avium_104 AREADQLAELEVRDGGKLVREMVG-QMRSLPDYYFYYGGLADKLQG-DVI
MSMEG_6297|M.smegmatis_MC2_155 DRHRDQLTVIESRDNGKPVREVRA-EIDAVVRYFEYFAGVCQTTVG-ETH
MMAR_2875|M.marinum_M DQVTDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPA
MUL_2877|M.ulcerans_Agy99 DQVTDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPA
Mvan_0014|M.vanbaalenii_PYR-1 AARTDELTALQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSG
Mflv_3083|M.gilvum_PYR-GCK QRDKEDLARLETVDTGKTLAESRI-DIDDVTSVFRYYANLVASEAE-RVV
TH_3419|M.thermoresistible__bu VADGERLGAIATLEVGTPNLLASS-SSAMAADWFTYYAGWIGRSAG-EVV
MAB_3328|M.abscessus_ATCC_1997 SANADTLVADEVAQTGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATA
MLBr_02573|M.leprae_Br4923 EAEANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPA
* ::.
Mb0467|M.bovis_AF2122/97 QIDEDTVAYH---FHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVL
Rv0458|M.tuberculosis_H37Rv QIDEDTVAYH---FHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVL
MAV_2608|M.avium_104 PVDKPNYFVY--TRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVV
MSMEG_6297|M.smegmatis_MC2_155 P-QAATAFSY--TRREPVGVVGAIVPWNSPLLMLAWKLSPALAGGNTIIL
MMAR_2875|M.marinum_M PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
MUL_2877|M.ulcerans_Agy99 PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
Mvan_0014|M.vanbaalenii_PYR-1 PLMEAPTLAAGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVL
Mflv_3083|M.gilvum_PYR-GCK DVGDPAVISR--VIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVA
TH_3419|M.thermoresistible__bu PVPAGGALDY--VLDEPLGVIAAIIPWNGPLISIGMKVAPALAAGNCVVL
MAB_3328|M.abscessus_ATCC_1997 EYSADHTSSIR---REAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVI
MLBr_02573|M.leprae_Br4923 EAAAVGASKAL-ARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLL
:. ** : *** *: ..: .* :
Mb0467|M.bovis_AF2122/97 KPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKV
Rv0458|M.tuberculosis_H37Rv KPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKV
MAV_2608|M.avium_104 KPSDHTPTSTLAFAKLFAEAGFPPGVINVVTGWGPETGAALASHPGVDKV
MSMEG_6297|M.smegmatis_MC2_155 KPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAALVAHPDVDKI
MMAR_2875|M.marinum_M KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
MUL_2877|M.ulcerans_Agy99 KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
Mvan_0014|M.vanbaalenii_PYR-1 KPDDQTPLTLLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKV
Mflv_3083|M.gilvum_PYR-GCK KPSEVTPLSTIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQVDFI
TH_3419|M.thermoresistible__bu KPPENAPFSALRFAELAAEAGLPPGVLNVIPG-GAEAGSALCSHPGVDKI
MAB_3328|M.abscessus_ATCC_1997 KPSELTPLTTLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLV
MLBr_02573|M.leprae_Br4923 KHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAA
* . .. : : .* . .: : . * :
Mb0467|M.bovis_AF2122/97 AFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV-----LAAHDD
Rv0458|M.tuberculosis_H37Rv AFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV-----LAAHDD
MAV_2608|M.avium_104 AFTGSTATGIHVGKAAIENMTRFSLELGGKSAQVVFAD-------ADLDA
MSMEG_6297|M.smegmatis_MC2_155 AFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIFDD-------ADLDA
MMAR_2875|M.marinum_M AFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDD-------ADLEM
MUL_2877|M.ulcerans_Agy99 AFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDD-------ADLEM
Mvan_0014|M.vanbaalenii_PYR-1 AFTGSTEVGKSVMRAAADTVKKVTLELGGKGASIVLDD-------ADLDL
Mflv_3083|M.gilvum_PYR-GCK SFTGGLATGRTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDA
TH_3419|M.thermoresistible__bu TFTGGGETARKVFAAAAQALTPVVLELGGKSANIVFPD-------ADLDA
MAB_3328|M.abscessus_ATCC_1997 TFTGSTAVGRKVMAAAAVHGHRTQLELGGKAPFVVFDD-------ADMDA
MLBr_02573|M.leprae_Br4923 TLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS-------ADLDA
::** .. : * :****. . :.: . : :
Mb0467|M.bovis_AF2122/97 FCDKALEG-FTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQ
Rv0458|M.tuberculosis_H37Rv FCDKALEG-FTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQ
MAV_2608|M.avium_104 AANGVIAG-VFAAT---GQTCLAGSRLLVDRSVADALVEKIVARAATIKL
MSMEG_6297|M.smegmatis_MC2_155 AVHRTAYG-IFSAA---GQTCQAASRIFVQDTIHDEFLDRFAALARRIRV
MMAR_2875|M.marinum_M AVEGVLYG-CFAYS---GQVCESGTRALVPTTLYQEFVDRLVKRAATIVV
MUL_2877|M.ulcerans_Agy99 AVEGVLYG-CFAYS---GQVCESGTRALVPTTLYQEFVDRLVKRAATIVV
Mvan_0014|M.vanbaalenii_PYR-1 AVDGSLFA-FLLMS---GQACESGTRLLVHESIHDEFVRRMVARAETLVM
Mflv_3083|M.gilvum_PYR-GCK AVDHVLTG-VFLHS---GQVCSAGTRLIIEESIADEFVAALAARAATIRM
TH_3419|M.thermoresistible__bu AATMAVSAGLMMLS---GQGCILPTRLLVHDDVYDEMVTRVVAGADALTV
MAB_3328|M.abscessus_ATCC_1997 AIAGAVAG-AIINS---GQDCTAATRALVARDLYDDFVAGVGEVMSKVVV
MLBr_02573|M.leprae_Br4923 AVATAVTG-RVQNN---GQSCIAAKRFIAHADIYDEFVEKFVARMETLRV
. *: * .* : : : :: :
Mb0467|M.bovis_AF2122/97 GDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLS
Rv0458|M.tuberculosis_H37Rv GDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLS
MAV_2608|M.avium_104 GDPKDPTTEMGPVSNLPQYEKVLSHFASAREQGATVAYGGE-PASDLG--
MSMEG_6297|M.smegmatis_MC2_155 GDPLSERTQMGAQISAQHRERIAGYVASGIQEGANLVCGGT-QPTEAPLA
MMAR_2875|M.marinum_M GPTRDWDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGE-ALTGGMFD
MUL_2877|M.ulcerans_Agy99 GPTRDWDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGE-ALTGGMFD
Mvan_0014|M.vanbaalenii_PYR-1 GDPMSLASDLGPLVSAKQKARVEKYIALGQEEGCKLAYQGT-VPTDPALA
Mflv_3083|M.gilvum_PYR-GCK GDGLDPASETGPLVSAQHRDKVESYVRLGISEGAQLIAGGC-RPEDPVLA
TH_3419|M.thermoresistible__bu GDPWQPTTMMGPLATAAQLERVTRAVDSALSDKAGKLLAGG--RRPDGLD
MAB_3328|M.abscessus_ATCC_1997 GDPLDPDTDIGPLISAAHRAKVSSIVDRAPAQGGRIVTGAT-----APDL
MLBr_02573|M.leprae_Br4923 GDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGK-----RPDR
* . : *. :: . . .
Mb0467|M.bovis_AF2122/97 GGYYMQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYG
Rv0458|M.tuberculosis_H37Rv GGYYMQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYG
MAV_2608|M.avium_104 -GFFVKPTVLTGVDPSMRAVAEEIFGPVLAVMTFEDEDEAVAAANGTEFG
MSMEG_6297|M.smegmatis_MC2_155 QGYYYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDTEYG
MMAR_2875|M.marinum_M KGFWVAPTILTGVHNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYG
MUL_2877|M.ulcerans_Agy99 KGFWVAPTILTGVHNDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYG
Mvan_0014|M.vanbaalenii_PYR-1 QGHWVPPTILTGATNDMRIAREEIFGPVLVVLTYGDDDEAVAIANDSEYG
Mflv_3083|M.gilvum_PYR-GCK GGYFYRPTIFDRCDRSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEYG
TH_3419|M.thermoresistible__bu AGYFYRPTVFGDVDPASDLAQTEIFGPVLAILRFRSEEEAVELANNTQYG
MAB_3328|M.abscessus_ATCC_1997 PGSFYRPTLIADVAETSEVYRDEIFGPVLTVRPFTDDDDALRQANDTAYG
MLBr_02573|M.leprae_Br4923 PGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFG
* : **:: * ***: : . :*: .* : :*
Mb0467|M.bovis_AF2122/97 LGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGRE
Rv0458|M.tuberculosis_H37Rv LGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGRE
MAV_2608|M.avium_104 LAAAVWTKDVHRAHRVAAKLRAGTVWVNAYRVVAPHVPFGGIGYSGIGRE
MSMEG_6297|M.smegmatis_MC2_155 LAGSVWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGRE
MMAR_2875|M.marinum_M LAASIWTSDNARGLAMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGRE
MUL_2877|M.ulcerans_Agy99 LAASIWTSDNARGLAMAERIRSGSVWINDAHQINCRLLFGGYKQSGVGRE
Mvan_0014|M.vanbaalenii_PYR-1 LSAGVWSADRERALGIARRLQSGTVWVNDWHMINAMYPFGGVKQSGLGRE
Mflv_3083|M.gilvum_PYR-GCK LAAGVRTTDTARGERVVRALRHGTVWLNDFGYYTAAAEWGGFGRSGNGRE
TH_3419|M.thermoresistible__bu LAAYIHTRDLRRAHVMAAALDAGGVAVNGFPIVPSAAPFGGVKQSGFGRE
MAB_3328|M.abscessus_ATCC_1997 LAASAWTRDVYRAQRASREIRAGCVWINDHIPIISEMPHGGFGASGFGKD
MLBr_02573|M.leprae_Br4923 LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
*.. : : : * : :* ** ** *::
Mb0467|M.bovis_AF2122/97 GHQMMLQHYQHTKNLLVSYSDKALGFF-----------
Rv0458|M.tuberculosis_H37Rv GHQMMLQHYQHTKNLLVSYSDKALGFF-----------
MAV_2608|M.avium_104 NGIDAVKDFTETKAVWVELSGETRDPFTLG--------
MSMEG_6297|M.smegmatis_MC2_155 GGQAVMEHYTRIKSVWVDMQDDLPNWYAD---------
MMAR_2875|M.marinum_M LGPDALDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 LGPDTLDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
Mvan_0014|M.vanbaalenii_PYR-1 LGPDALDEYTEPKFIHVDMTDDRRKHVYPVVISAAAQG
Mflv_3083|M.gilvum_PYR-GCK LGPTGLAEYQEIKHIWHNTAPAAAGWFTG---------
TH_3419|M.thermoresistible__bu GGIWGLREFQRTKNVYIGLQ------------------
MAB_3328|M.abscessus_ATCC_1997 MSDYSLEEYLTVKHVMSDITGTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 LSTHGIREFCNIKTVWIA--------------------
: : * :