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MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSYEPRSGRVWARLPRANSTDIDRAVR AARAAFEGPWGAVSPADRGRFLMKIAAVVDRHRDQLTVIESRDNGKPVREVRAEIDAVVRYFEYFAGVCQ TTVGETHPQAATAFSYTRREPVGVVGAIVPWNSPLLMLAWKLSPALAGGNTIILKPAEETSVSAVVFAQL IAEVGLPDGVFNVVTGIGEEAGAALVAHPDVDKIAFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIF DDADLDAAVHRTAYGIFSAAGQTCQAASRIFVQDTIHDEFLDRFAALARRIRVGDPLSERTQMGAQISAQ HRERIAGYVASGIQEGANLVCGGTQPTEAPLAQGYYYSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEA DAVAKANDTEYGLAGSVWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGREGGQAVMEH YTRIKSVWVDMQDDLPNWYAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6297 | - | - | 100% (511) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6874 | - | e-112 | 43.64% (472) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6491 | - | e-107 | 42.98% (470) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 1e-103 | 43.57% (482) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3083 | - | 1e-103 | 40.89% (494) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 1e-103 | 43.57% (482) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-63 | 30.11% (455) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0972 | - | 1e-103 | 42.13% (489) | putative aldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-104 | 40.96% (481) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-130 | 46.94% (490) | betaine-aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3284 | - | 5e-99 | 42.47% (478) | PUTATIVE eptc-inducible aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 1e-102 | 40.75% (481) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 1e-110 | 43.67% (490) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6297|M.smegmatis_MC2_155 MTVTTFRPSDVATLTNPDAASDVADLSMFIAGEAVSAADGATFDSYEPRS
MAV_1897|M.avium_104 MTDTTISNG---------VTEQLVHFDLVIGGESVAAESGRTYDSIDPYT
Mflv_3083|M.gilvum_PYR-GCK ---------------------MDGDPDLCIGGAWRHACDGGTRDIINPAN
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAG------ALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAG------ALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
TH_3284|M.thermoresistible__bu -------------------MSFESRYDNFIGGEWVAPVGGEYFENPSPVT
MAB_0972|M.abscessus_ATCC_1997 MAKYAAPGTEG------SAVTFAPRYDNFIGGEWVAPADGQYFENASPID
MMAR_2875|M.marinum_M -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
MUL_2877|M.ulcerans_Agy99 -----------------MTTVAVPHHAMLIGGESVDSDR--RLSLVDPGD
Mvan_0014|M.vanbaalenii_PYR-1 -------------------MSDIPHYRMYIDGAWRDAAD--TIEVRSPAT
MLBr_02573|M.leprae_Br4923 ----------------------------------------MSIATINPAT
*
MSMEG_6297|M.smegmatis_MC2_155 GRVWARLPRANSTDIDRAVRAARAAFE-GPWGAVSPADRGRFLMKIAAVV
MAV_1897|M.avium_104 ALPWARVPDCGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELI
Mflv_3083|M.gilvum_PYR-GCK GAVAAVVDEATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLL
Mb0467|M.bovis_AF2122/97 GQPFCEVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRI
Rv0458|M.tuberculosis_H37Rv GQPFCEVPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRI
TH_3284|M.thermoresistible__bu GQPFCEVARSTEADIDKALDAAHAAAP--AWGKTAPAERALILNRIADRI
MAB_0972|M.abscessus_ATCC_1997 GKVFTRVARGTAPDIEKALDAAHAAAE--AWGNTSAAERSNALLRIADRM
MMAR_2875|M.marinum_M ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
MUL_2877|M.ulcerans_Agy99 ESPVATVACGDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAA
Mvan_0014|M.vanbaalenii_PYR-1 GELVATVAYGGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNL
MLBr_02573|M.leprae_Br4923 GETVKTFTPTTQDEVEDAIARAYARFD--NYRHTTFTQRAKWANATADLL
. *: * * : : *.
MSMEG_6297|M.smegmatis_MC2_155 DRHRDQLTVIESRDNGKPVREVR-AEIDAVVRYFEYFAGVCQTTVGE---
MAV_1897|M.avium_104 AREAESLAELEVRDGGKLVREMI-GQMKALPDYYIYYAGLADKLQGE---
Mflv_3083|M.gilvum_PYR-GCK QRDKEDLARLETVDTGKTLAESR-IDIDDVTSVFRYYANLVASEAER---
Mb0467|M.bovis_AF2122/97 DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGA---
Rv0458|M.tuberculosis_H37Rv DKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGA---
TH_3284|M.thermoresistible__bu EANLESIALAESWDNGKPIRETLNADIPLAVDHFRYFAGAIRAQEGS---
MAB_0972|M.abscessus_ATCC_1997 EQHIERLAVAETWDNGKPIRESLNADIPLAIDHFRYFAGVLRAQEGS---
MMAR_2875|M.marinum_M DQVTDELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPA
MUL_2877|M.ulcerans_Agy99 DQVTDELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPA
Mvan_0014|M.vanbaalenii_PYR-1 AARTDELTALQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSG
MLBr_02573|M.leprae_Br4923 EAEANQSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEP-
* : : *:*
MSMEG_6297|M.smegmatis_MC2_155 THP-QAATAFSYTRREPVGVVGAIVPWNSPLLMLAWKLSPALAGGNTIIL
MAV_1897|M.avium_104 VVPVDKPNFFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVV
Mflv_3083|M.gilvum_PYR-GCK VVDVGDPAVISRVIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVA
Mb0467|M.bovis_AF2122/97 LSQIDEDT-VAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVL
Rv0458|M.tuberculosis_H37Rv LSQIDEDT-VAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVL
TH_3284|M.thermoresistible__bu LSQIDDDT-VAYHFHEPLGVVGQIIPWNFPILMATWKLAPALAAGNAVVL
MAB_0972|M.abscessus_ATCC_1997 ISEIDHDT-VAYHFHEPLGVVGQIIPWNFPLLMAVWKLAPALAAGNCVVL
MMAR_2875|M.marinum_M PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
MUL_2877|M.ulcerans_Agy99 PIETFPVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVV
Mvan_0014|M.vanbaalenii_PYR-1 PLMEAPTLAAGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVL
MLBr_02573|M.leprae_Br4923 AEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLL
:*:** : *** *: ...: .* :
MSMEG_6297|M.smegmatis_MC2_155 KPAEETSVSAVVFAQLIAEVGLPDGVFNVVTGIGEEAGAALVAHPDVDKI
MAV_1897|M.avium_104 KPSDHTPASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKI
Mflv_3083|M.gilvum_PYR-GCK KPSEVTPLSTIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQVDFI
Mb0467|M.bovis_AF2122/97 KPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKV
Rv0458|M.tuberculosis_H37Rv KPAEQTPASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKV
TH_3284|M.thermoresistible__bu KPAEQTPASVMYLMSLIGDL-LPPGVVNVVNGFGVEAGKPLASSNRIAKI
MAB_0972|M.abscessus_ATCC_1997 KPAEQTPASILVLMELIADL-LPSGTVNVVNGFGVEAGKPLASSPRIAKI
MMAR_2875|M.marinum_M KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
MUL_2877|M.ulcerans_Agy99 KPDEHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKI
Mvan_0014|M.vanbaalenii_PYR-1 KPDDQTPLTLLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKV
MLBr_02573|M.leprae_Br4923 KHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAA
* . .. : : .* . .: : . * :
MSMEG_6297|M.smegmatis_MC2_155 AFTGSTEVGKQIAATAASDLKLVTFELGGKSPTVIFDDA-------DLDA
MAV_1897|M.avium_104 AFTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDA-------DLDA
Mflv_3083|M.gilvum_PYR-GCK SFTGGLATGRTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDA
Mb0467|M.bovis_AF2122/97 AFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAH--DDFCD
Rv0458|M.tuberculosis_H37Rv AFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAH--DDFCD
TH_3284|M.thermoresistible__bu AFTGETTTGRLIMQYASQNLIPVTLELGGKSPNIFFADVMAAS--DDFCD
MAB_0972|M.abscessus_ATCC_1997 AFTGETTTGRLIMQYATENIIPVTLELGGKSPNIFMPDVMAAD--DAFLD
MMAR_2875|M.marinum_M AFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEM
MUL_2877|M.ulcerans_Agy99 AFTGSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEM
Mvan_0014|M.vanbaalenii_PYR-1 AFTGSTEVGKSVMRAAADTVKKVTLELGGKGASIVLDDA-------DLDL
MLBr_02573|M.leprae_Br4923 TLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSA-------DLDA
::** .* : * : .:****... :.: .
MSMEG_6297|M.smegmatis_MC2_155 AVHRTAYGIFSAAGQTCQAASRIFVQDTIHDEFLDRFAALARRIRVGDPL
MAV_1897|M.avium_104 AANGVIAGVFAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPK
Mflv_3083|M.gilvum_PYR-GCK AVDHVLTGVFLHSGQVCSAGTRLIIEESIADEFVAALAARAATIRMGDGL
Mb0467|M.bovis_AF2122/97 KALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPL
Rv0458|M.tuberculosis_H37Rv KALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPL
TH_3284|M.thermoresistible__bu KALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELATIRTKAVRQGDPL
MAB_0972|M.abscessus_ATCC_1997 KALEGFTMFALNQGEVCTCPSRALVHASIYDEFIARAITRVEAIVGGDPL
MMAR_2875|M.marinum_M AVEGVLYGCFAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTR
MUL_2877|M.ulcerans_Agy99 AVEGVLYGCFAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTR
Mvan_0014|M.vanbaalenii_PYR-1 AVDGSLFAFLLMSGQACESGTRLLVHESIHDEFVRRMVARAETLVMGDPM
MLBr_02573|M.leprae_Br4923 AVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPT
. *: * . .* : : : :: : *
MSMEG_6297|M.smegmatis_MC2_155 SERTQMGAQISAQHRERIAGYVASGIQEGANLVCGGTQPTEAPLAQG-YY
MAV_1897|M.avium_104 DPATEMGPVSNQPQYEKVLSHFASAREQGATVAYGGEP---AGELGG-FF
Mflv_3083|M.gilvum_PYR-GCK DPASETGPLVSAQHRDKVESYVRLGISEGAQLIAGGCRPEDPVLAGG-YF
Mb0467|M.bovis_AF2122/97 DTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYY
Rv0458|M.tuberculosis_H37Rv DTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYY
TH_3284|M.thermoresistible__bu DTETMVGAQASNDQLEKILSYIDIGRSEGATVVTGGERAELGGDLSGGYY
MAB_0972|M.abscessus_ATCC_1997 DEDTMIGAQASNDQYEKILSYIDIGRQEGAQVLTGGDARKVS-EYPDGAY
MMAR_2875|M.marinum_M DWDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKG-FW
MUL_2877|M.ulcerans_Agy99 DWDTDLGPVIDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKG-FW
Mvan_0014|M.vanbaalenii_PYR-1 SLASDLGPLVSAKQKARVEKYIALGQEEGCKLAYQGTVPTDPALAQG-HW
MLBr_02573|M.leprae_Br4923 DPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP-----GWF
. : *. :: . . *. : * :
MSMEG_6297|M.smegmatis_MC2_155 YSPTILDGVNRDMRMIREEIFGPVTGVMSFTDEADAVAKANDTEYGLAGS
MAV_1897|M.avium_104 VKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAG
Mflv_3083|M.gilvum_PYR-GCK YRPTIFDRCDRSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEYGLAAG
Mb0467|M.bovis_AF2122/97 MQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAG
Rv0458|M.tuberculosis_H37Rv MQPTIFTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAG
TH_3284|M.thermoresistible__bu VQPTIFTGDN-SMRIFQEEIFGPVVAVTSFTDYDDAIRIANDTLYGLGAG
MAB_0972|M.abscessus_ATCC_1997 IQPTVFAGTN-NMRIFQEEIFGPVLSVAKFDSLDEALKIANDTLYGLGAG
MMAR_2875|M.marinum_M VAPTILTGVHNDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAAS
MUL_2877|M.ulcerans_Agy99 VAPTILTGVHNDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAAS
Mvan_0014|M.vanbaalenii_PYR-1 VPPTILTGATNDMRIAREEIFGPVLVVLTYGDDDEAVAIANDSEYGLSAG
MLBr_02573|M.leprae_Br4923 YPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSN
**:: .* :* ***: * . :*: .* : :**...
MSMEG_6297|M.smegmatis_MC2_155 VWTRDVSRAHRVAASIAAGLIWVNTTRTINHLVPFGGYKQSGYGREGGQA
MAV_1897|M.avium_104 VWTKDVHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGID
Mflv_3083|M.gilvum_PYR-GCK VRTTDTARGERVVRALRHGTVWLNDFGYYTAAAEWGGFGRSGNGRELGPT
Mb0467|M.bovis_AF2122/97 VWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQM
Rv0458|M.tuberculosis_H37Rv VWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQM
TH_3284|M.thermoresistible__bu VWSRDGNTAYRAGRDIKAGRVWTNCYHVYPAHAAFGGYKQSGIGRENHTM
MAB_0972|M.abscessus_ATCC_1997 VWSRDMTNAYRLGRGIKAGRVWTNCYHQYPAHAAFGGYKKSGIGRENHKM
MMAR_2875|M.marinum_M IWTSDNARGLAMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGRELGPD
MUL_2877|M.ulcerans_Agy99 IWTSDNARGLAMAERIRSGSVWINDAHQINCRLLFGGYKQSGVGRELGPD
Mvan_0014|M.vanbaalenii_PYR-1 VWSADRERALGIARRLQSGTVWVNDWHMINAMYPFGGVKQSGLGRELGPD
MLBr_02573|M.leprae_Br4923 AWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTH
: : : * :: * :** :** ***
MSMEG_6297|M.smegmatis_MC2_155 VMEHYTRIKSVWVDMQDDLPNWYAD---------
MAV_1897|M.avium_104 AVKDFTETKAVWVELSGATRDPFTLG--------
Mflv_3083|M.gilvum_PYR-GCK GLAEYQEIKHIWHNTAPAAAGWFTG---------
Mb0467|M.bovis_AF2122/97 MLQHYQHTKNLLVSYSDKALGFF-----------
Rv0458|M.tuberculosis_H37Rv MLQHYQHTKNLLVSYSDKALGFF-----------
TH_3284|M.thermoresistible__bu MLDHYQQTKNLLVSYSTKAQGFF-----------
MAB_0972|M.abscessus_ATCC_1997 MLDHYQQTKNILVSYSPDAAGFF-----------
MMAR_2875|M.marinum_M ALDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 TLDAYTEVKTIHLDLSGGREAKPYDVLLGHPETG
Mvan_0014|M.vanbaalenii_PYR-1 ALDEYTEPKFIHVDMTDDRRKHVYPVVISAAAQG
MLBr_02573|M.leprae_Br4923 GIREFCNIKTVWIA--------------------
: : . * :