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MSDIPHYRMYIDGAWRDAADTIEVRSPATGELVATVAYGGVTTVDDAVAAAKAADEAGVWRNTSAQQRAD VLDAIADNLAARTDELTALQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPTLAAG MIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLTLLELARAADEVGLPAGVLNVVT GAGPTVGARLAEHPDVRKVAFTGSTEVGKSVMRAAADTVKKVTLELGGKGASIVLDDADLDLAVDGSLFA FLLMSGQACESGTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPLVSAKQKARVEKYIALGQEE GCKLAYQGTVPTDPALAQGHWVPPTILTGATNDMRIAREEIFGPVLVVLTYGDDDEAVAIANDSEYGLSA GVWSADRERALGIARRLQSGTVWVNDWHMINAMYPFGGVKQSGLGRELGPDALDEYTEPKFIHVDMTDDR RKHVYPVVISAAAQG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | - | 100% (505) | betaine-aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0352 | - | e-165 | 56.74% (497) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | e-102 | 44.23% (477) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 2e-94 | 41.19% (471) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3083 | - | 1e-102 | 42.62% (481) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-97 | 41.37% (481) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-62 | 33.76% (465) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 1e-96 | 42.52% (468) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 1e-151 | 52.99% (502) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-101 | 43.29% (492) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0327 | - | 1e-164 | 56.34% (497) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 2e-99 | 44.89% (479) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 1e-148 | 52.19% (502) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0014|M.vanbaalenii_PYR-1 ----------MSDIPHYRMYIDGAWRD--AADTIEVRSPATGELVATVAY
MSMEG_0327|M.smegmatis_MC2_155 ----------MS--EHYSMYIDGKWID--TDEVYEIRSPATEELVATVAK
MMAR_2875|M.marinum_M --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
MUL_2877|M.ulcerans_Agy99 --------MTTVAVPHHAMLIGGESVD--SDRRLSLVDPGDESPVATVAC
Rv0223c|M.tuberculosis_H37Rv --------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPM
TH_3080|M.thermoresistible__bu -------------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAVAA
Mflv_3083|M.gilvum_PYR-GCK MDG------------DPDLCIGGAWRHACDGGTRDIINPANGAVAAVVDE
MAV_1897|M.avium_104 MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSIDPYTALPWARVPD
Mb2883c|M.bovis_AF2122/97 ------------------------------MSTTQLINPATEEVLASVDH
MAB_3328|M.abscessus_ATCC_1997 -------------MSVPSSWINGRPVAT-HGDTHRVINPATGEAVADLKL
MLBr_02573|M.leprae_Br4923 -------------------------------MSIATINPATGETVKTFTP
* .
Mvan_0014|M.vanbaalenii_PYR-1 GGVTTVDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNLAARTDELTA
MSMEG_0327|M.smegmatis_MC2_155 GNTASVDAAVEAAKGAFAEGTWRRTPPAQRAAIINNVAERLGARADELAA
MMAR_2875|M.marinum_M GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
MUL_2877|M.ulcerans_Agy99 GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
Rv0223c|M.tuberculosis_H37Rv AAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTK
TH_3080|M.thermoresistible__bu ACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSELAE
Mflv_3083|M.gilvum_PYR-GCK ATPQDALDAVAAARAAFDQGGWRATAVAERSALLQRIADLLQRDKEDLAR
MAV_1897|M.avium_104 CGPADVDRAVAAARAALR-GPWGQLTGTARGKLLWRLGELIAREAESLAE
Mb2883c|M.bovis_AF2122/97 TDANAVDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAA
MAB_3328|M.abscessus_ATCC_1997 ATTADVDAAVAAARAAGP--AWASSTPVDRSSVLAKLAAVLSANADTLVA
MLBr_02573|M.leprae_Br4923 TTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAA
. *: * . : * .
Mvan_0014|M.vanbaalenii_PYR-1 LQVAENGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPTLA
MSMEG_0327|M.smegmatis_MC2_155 LQTRENGATIRITGALHVGLSVAQLQYLAAIAENYEWETPGPAIEP-VAA
MMAR_2875|M.marinum_M LEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS
MUL_2877|M.ulcerans_Agy99 LEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS
Rv0223c|M.tuberculosis_H37Rv LLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYG---Q
TH_3080|M.thermoresistible__bu LITAQIGAPISFAQRAQVGLPWTMMSAFCTLAENHPWQQTRAGMYG---A
Mflv_3083|M.gilvum_PYR-GCK LETVDTGKTLAES-RIDIDDVTSVFRYYANLVASEAERVVDVGDPA---V
MAV_1897|M.avium_104 LEVRDGGKLVREM-IGQMKALPDYYIYYAGLADKLQGEVVPVDKPN---F
Mb2883c|M.bovis_AF2122/97 LEVANSGHP-IVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGV----
MAB_3328|M.abscessus_ATCC_1997 DEVAQTGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATAEYSAD---H
MLBr_02573|M.leprae_Br4923 LMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAVG-AS
* .
Mvan_0014|M.vanbaalenii_PYR-1 AGMIVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLT
MSMEG_0327|M.smegmatis_MC2_155 DGVVVREPLGVVAAIVPWNIPLLTTVWKIGPALVAGNSVVLKPDEHAPLL
MMAR_2875|M.marinum_M QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
MUL_2877|M.ulcerans_Agy99 QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEHTPLS
Rv0223c|M.tuberculosis_H37Rv SI-VSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLT
TH_3080|M.thermoresistible__bu DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLD
Mflv_3083|M.gilvum_PYR-GCK ISRVIREPIGVCVLIAPWNYPLLQMSWKVAPALAAGCTMVAKPSEVTPLS
MAV_1897|M.avium_104 FVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHTPAS
Mb2883c|M.bovis_AF2122/97 -DVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLT
MAB_3328|M.abscessus_ATCC_1997 TSSIRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLT
MLBr_02573|M.leprae_Br4923 KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQC
:. ** : .** * ..: ** : * *
Mvan_0014|M.vanbaalenii_PYR-1 LLELARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKVAFTGSTEVG
MSMEG_0327|M.smegmatis_MC2_155 ALELAREFDAAGLPPGVLNVVTGDGEPVGAHLSGHPDVRKVAFTGSTAVG
MMAR_2875|M.marinum_M ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
MUL_2877|M.ulcerans_Agy99 ILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTGSTAVG
Rv0223c|M.tuberculosis_H37Rv ANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVG
TH_3080|M.thermoresistible__bu ALLLAELIADSGIPSGVVNVLPG-PAGVGERLVRHPGVDKVSFTGSTAAG
Mflv_3083|M.gilvum_PYR-GCK TIAFAKLLDEAGVPPGVVNLIQGSGATLGPALTDNPQVDFISFTGGLATG
MAV_1897|M.avium_104 TLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGSTATG
Mb2883c|M.bovis_AF2122/97 TMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVG
MAB_3328|M.abscessus_ATCC_1997 TLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVG
MLBr_02573|M.leprae_Br4923 ALYLADVIARGGFPEDCFQTLLISANGVEAILRD-PRVAAATLTGSEPAG
:. *. . .. : : * : :**. .*
Mvan_0014|M.vanbaalenii_PYR-1 KSVMRAAADTVKKVTLELGGKGASIVLDDA-------DLDLAVDGSLFAF
MSMEG_0327|M.smegmatis_MC2_155 KSILRQSADTVRRVTLELGGKGANIILDDA-------DIDMAVDGALFAC
MMAR_2875|M.marinum_M REIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEMAVEGVLYGC
MUL_2877|M.ulcerans_Agy99 REIMRLASGTVKQVTLELGGKGPTIVLDDA-------DLEMAVEGVLYGC
Rv0223c|M.tuberculosis_H37Rv REVGRRAAEMLKPCTLELGGKSAAIILEDV-------DLAAAIPMMVFSG
TH_3080|M.thermoresistible__bu RAVAAAAAAGLKRVSLELGGKSAAVVLSDA-------DPAAVATAVRSAS
Mflv_3083|M.gilvum_PYR-GCK RTIARTAAEHVTKVALELGGKNPHLVFADIRDAGRESGWDAAVDHVLTGV
MAV_1897|M.avium_104 ISVGKAAIDNMTRFTLELGGKSAQVVFDDA-------DLDAAANGVIAGV
Mb2883c|M.bovis_AF2122/97 KRVMAGAAAQVKRVTLELGGKSANIVFHDC-------DLERAATTAPAGV
MAB_3328|M.abscessus_ATCC_1997 RKVMAAAAVHGHRTQLELGGKAPFVVFDDA-------DMDAAIAGAVAGA
MLBr_02573|M.leprae_Br4923 QAVGAIAGNEIKPTVLELGGSDPFIVMPSA-------DLDAAVATAVTGR
: : *****. . ::: . . . .
Mvan_0014|M.vanbaalenii_PYR-1 LLMSGQACESGTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPL
MSMEG_0327|M.smegmatis_MC2_155 MANNGEACEAGTRLLIPASRRDEIVDKLLARASTLRVGDPLDPATHIGPV
MMAR_2875|M.marinum_M FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MUL_2877|M.ulcerans_Agy99 FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
Rv0223c|M.tuberculosis_H37Rv VMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPL
TH_3080|M.thermoresistible__bu LSNSGQICNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPL
Mflv_3083|M.gilvum_PYR-GCK FLHSGQVCSAGTRLIIEESIADEFVAALAARAATIRMGDGLDPASETGPL
MAV_1897|M.avium_104 FAATGQTCLAGSRLLVHESVADALVERIVARASTIKLGDPKDPATEMGPV
Mb2883c|M.bovis_AF2122/97 FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL
MAB_3328|M.abscessus_ATCC_1997 IINSGQDCTAATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPL
MLBr_02573|M.leprae_Br4923 VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL
. *: * .* : : . : :* . :. **:
Mvan_0014|M.vanbaalenii_PYR-1 VSAKQKARVEKYIALGQEEGCKLAYQGTVPTDPALAQGHWVPPTILTGAT
MSMEG_0327|M.smegmatis_MC2_155 ISQTQRDRILNYFRIAAEEGAIAALGGKARSGPEFDKGYWIEPTIYLDVT
MMAR_2875|M.marinum_M IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
MUL_2877|M.ulcerans_Agy99 IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
Rv0223c|M.tuberculosis_H37Rv ISEKQRTRVEGYIAKGIEEGARLVCGG-GRPEG-LDNGFFIQPTVFADVD
TH_3080|M.thermoresistible__bu VARRQQERVRGYIEAGCAEGARLVTGGPGLPAG-VDRGWYVQPTLFADAD
Mflv_3083|M.gilvum_PYR-GCK VSAQHRDKVESYVRLGISEGAQLIAGGCRPEDPVLAGGYFYRPTIFDRCD
MAV_1897|M.avium_104 SNQPQYEKVLSHFASAREQGATVAYGG---EPAGELGGFFVKPTVLTGVD
Mb2883c|M.bovis_AF2122/97 VSRAHRDKVAGYVP----DDAPVAFRG----TAPAGRGFWFPPTVLT-PK
MAB_3328|M.abscessus_ATCC_1997 ISAAHRAKVSSIVDRAPAQGGRIVTGATAPDLP----GSFYRPTLIADVA
MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP----GWFYPPTVITDIT
:: . . . * : **:
Mvan_0014|M.vanbaalenii_PYR-1 NDMRIAREEIFGPVLVVLTYGDDDEAVAIANDSEYGLSAGVWSADRERAL
MSMEG_0327|M.smegmatis_MC2_155 NDMRVAREEVFGPVLVVMTYDTDEDALAVANDTNYGLSAGVWGSE-ERAT
MMAR_2875|M.marinum_M NDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
MUL_2877|M.ulcerans_Agy99 NDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
Rv0223c|M.tuberculosis_H37Rv NKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGI
TH_3080|M.thermoresistible__bu NSMRIAREEIFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGL
Mflv_3083|M.gilvum_PYR-GCK RSMRIVQEETFGPILTVERFTDEAEAVTLGNDTEYGLAAGVRTTDTARGE
MAV_1897|M.avium_104 RSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKDVHRAH
Mb2883c|M.bovis_AF2122/97 RGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRAL
MAB_3328|M.abscessus_ATCC_1997 ETSEVYRDEIFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQ
MLBr_02573|M.leprae_Br4923 KDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQR
. :* ***: : *: .* : :**... : .
Mvan_0014|M.vanbaalenii_PYR-1 GIARRLQSGTVWVNDWHMINAMYPFGGVKQSGLGRELGPDALDEYTEPKF
MSMEG_0327|M.smegmatis_MC2_155 ALARRLEAGMVWVNNWHIIHPAYPFGGYKESGLGREGGPNAIDEYVEEKF
MMAR_2875|M.marinum_M AMAERIQSGSVWINDAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKT
MUL_2877|M.ulcerans_Agy99 AMAERIRSGSVWINDAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVKT
Rv0223c|M.tuberculosis_H37Rv KISQQIRTGTYGIN-WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKS
TH_3080|M.thermoresistible__bu AIAARIRTGTFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKS
Mflv_3083|M.gilvum_PYR-GCK RVVRALRHGTVWLNDFGYYTAAAEWGGFGRSGNGRELGPTGLAEYQEIKH
MAV_1897|M.avium_104 RVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDFTETKA
Mb2883c|M.bovis_AF2122/97 RVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKN
MAB_3328|M.abscessus_ATCC_1997 RASREIRAGCVWINDHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKH
MLBr_02573|M.leprae_Br4923 HFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKT
: * :* ** ** *:: . : *
Mvan_0014|M.vanbaalenii_PYR-1 IHVDMTDDRRKHVYPVVISAAAQG
MSMEG_0327|M.smegmatis_MC2_155 IAVDRSGGIENKAFAIVIDPAGD-
MMAR_2875|M.marinum_M IHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 IHLDLSGGREAKPYDVLLGHPETG
Rv0223c|M.tuberculosis_H37Rv VLLPMGYTVA--------------
TH_3080|M.thermoresistible__bu ISVAPASTT---------------
Mflv_3083|M.gilvum_PYR-GCK IWHNTAPAAAGWFTG---------
MAV_1897|M.avium_104 VWVELSGATRDPFTLG--------
Mb2883c|M.bovis_AF2122/97 VFIAVGEEM---------------
MAB_3328|M.abscessus_ATCC_1997 VMSDITGTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 VWIA--------------------
: